Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974
Liu, Jun, Pan, Shifeng, Hsieh, Mindy H., Ng, Nicholas, Sun, Fangxian, Wang, Tao, Kasibhatla, Shailaja, Schuller, Alwin G., Li, Allen G., Cheng, Dai, Li, Jie, Tompkins, Celin, Pferdekamper, AnneMarie, Steffy, Auzon, Cheng, Jane, Kowal, Colleen, Van Phung, Guo, Guirong, Wang, Yan, Graham, Martin P., Flynn, Shannon, Brenner, J. Chad, Li, Chun, Villarroel, M. Cristina, Schultz, Peter G., Xu Wu, McNamara, Peter, Sellers, William R., Petruzzelli, Lilli, Boral, Anthony L., Seidel, H. Martin, McLaughlin, Margaret E., Che, Jianwei, Carey, Thomas E., Vanasse, Gary, Harris, Jennifer L.
Published in Proceedings of the National Academy of Sciences - PNAS (10.12.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (10.12.2013)
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Pharmacokinetic/Pharmacodynamic Analysis of Savolitinib plus Osimertinib in an EGFR Mutation-Positive, MET-Amplified Non-Small Cell Lung Cancer Model
Jones, Rhys D O, Petersson, Klas, Tabatabai, Areya, Bao, Larry, Tomkinson, Helen, Schuller, Alwin G
Published in Molecular cancer therapeutics (04.05.2023)
Published in Molecular cancer therapeutics (04.05.2023)
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Preclinical evaluation of the WEE1 inhibitor MK-1775 as single-agent anticancer therapy
Guertin, Amy D, Li, Jing, Liu, Yaping, Hurd, Melissa S, Schuller, Alwin G, Long, Brian, Hirsch, Heather A, Feldman, Igor, Benita, Yair, Toniatti, Carlo, Zawel, Leigh, Fawell, Stephen E, Gilliland, D Gary, Shumway, Stuart D
Published in Molecular cancer therapeutics (01.08.2013)
Published in Molecular cancer therapeutics (01.08.2013)
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Diminished Growth and Enhanced Glucose Metabolism in Triple Knockout Mice Containing Mutations of Insulin-Like Growth Factor Binding Protein-3, -4, and -5
Ning, Yun, Schuller, Alwin G. P, Bradshaw, Sheri, Rotwein, Peter, Ludwig, Thomas, Frystyk, Jan, Pintar, John E
Published in Molecular endocrinology (Baltimore, Md.) (01.09.2006)
Published in Molecular endocrinology (Baltimore, Md.) (01.09.2006)
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Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade
Yang, Rui, Elsaadi, Samah, Misund, Kristine, Abdollahi, Pegah, Vandsemb, Esten Nymoen, Moen, Siv Helen, Kusnierczyk, Anna, Slupphaug, Geir, Standal, Therese, Waage, Anders, Slørdahl, Tobias S, Rø, Torstein Baade, Rustad, Even, Sundan, Anders, Hay, Carl, Cooper, Zachary, Schuller, Alwin G, Woessner, Richard, Borodovsky, Alexandra, Menu, Eline, Børset, Magne, Sponaas, Anne Marit
Published in Journal for immunotherapy of cancer (01.05.2020)
Published in Journal for immunotherapy of cancer (01.05.2020)
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AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia
Balachander, Srividya B., Criscione, Steven W., Byth, Kate F., Cidado, Justin, Adam, Ammar, Lewis, Paula, Macintyre, Terry, Wen, Shenghua, Lawson, Deborah, Burke, Kathleen, Lubinski, Tristan, Tyner, Jeffrey W., Kurtz, Stephen E., McWeeney, Shannon K., Varnes, Jeffrey, Diebold, R. Bruce, Gero, Thomas, Ioannidis, Stephanos, Hennessy, Edward J., McCoull, William, Saeh, Jamal C., Tabatabai, Areya, Tavana, Omid, Su, Nancy, Schuller, Alwin, Garnett, Mathew J., Jaaks, Patricia, Coker, Elizabeth A., Gregory, Gareth P., Newbold, Andrea, Johnstone, Ricky W., Gangl, Eric, Wild, Martin, Zinda, Michael, Secrist, J. Paul, Davies, Barry R., Fawell, Stephen E., Gibbons, Francis D.
Published in Clinical cancer research (15.12.2020)
Published in Clinical cancer research (15.12.2020)
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Biomarker-driven strategy for MCL1 inhibition in T-cell lymphomas
Koch, Raphael, Christie, Amanda L., Crombie, Jennifer L., Palmer, Adam C., Plana, Deborah, Shigemori, Kay, Morrow, Sara N., Van Scoyk, Alexandria, Wu, Wenchao, Brem, Elizabeth A., Secrist, J. Paul, Drew, Lisa, Schuller, Alwin G., Cidado, Justin, Letai, Anthony, Weinstock, David M.
Published in Blood (07.02.2019)
Published in Blood (07.02.2019)
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AZ1366: An Inhibitor of Tankyrase and the Canonical Wnt Pathway that Limits the Persistence of Non-Small Cell Lung Cancer Cells Following EGFR Inhibition
Scarborough, Hannah A, Helfrich, Barbara A, Casás-Selves, Matias, Schuller, Alwin G, Grosskurth, Shaun E, Kim, Jihye, Tan, Aik-Choon, Chan, Daniel C, Zhang, Zhiyong, Zaberezhnyy, Vadym, Bunn, Paul A, DeGregori, James
Published in Clinical cancer research (15.03.2017)
Published in Clinical cancer research (15.03.2017)
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The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient-Derived Xenograft Models
Schuller, Alwin G, Barry, Evan R, Jones, Rhys D O, Henry, Ryan E, Frigault, Melanie M, Beran, Garry, Linsenmayer, David, Hattersley, Maureen, Smith, Aaron, Wilson, Joanne, Cairo, Stefano, Déas, Olivier, Nicolle, Delphine, Adam, Ammar, Zinda, Michael, Reimer, Corinne, Fawell, Stephen E, Clark, Edwin A, D'Cruz, Celina M
Published in Clinical cancer research (15.06.2015)
Published in Clinical cancer research (15.06.2015)
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MCL1 and BCL-xL levels in solid tumors are predictive of dinaciclib-induced apoptosis
Booher, Robert N, Hatch, Harold, Dolinski, Brian M, Nguyen, Thi, Harmonay, Lauren, Al-Assaad, Ali-Samer, Ayers, Mark, Nebozhyn, Michael, Loboda, Andrey, Hirsch, Heather A, Zhang, Theresa, Shi, Bin, Merkel, Carrie E, Angagaw, Minilik H, Wang, Yaolin, Long, Brian J, Lennon, Xianlu Q, Miselis, Nathan, Pucci, Vincenzo, Monahan, James W, Lee, Junghoon, Kondic, Anna Georgieva, Im, Eun Kyung, Mauro, David, Blanchard, Rebecca, Gilliland, Gary, Fawell, Stephen E, Zawel, Leigh, Schuller, Alwin G, Strack, Peter
Published in PloS one (07.10.2014)
Published in PloS one (07.10.2014)
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Small molecule AZD4635 inhibitor of A2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunity
Borodovsky, Alexandra, Barbon, Christine M, Wang, Yanjun, Ye, Minwei, Prickett, Laura, Chandra, Dinesh, Shaw, Joseph, Deng, Nanhua, Sachsenmeier, Kris, Clarke, James D, Bolan Linghu, Brown, Giles A, Brown, James, Congreve, Miles, Cheng, Robert KY, Dore, Andrew S, Hurrell, Edward, Shao, Wenlin, Woessner, Richard, Reimer, Corinne, Drew, Lisa, Fawell, Stephen, Schuller, Alwin G, Mele, Deanna A
Published in Journal for immunotherapy of cancer (01.07.2020)
Published in Journal for immunotherapy of cancer (01.07.2020)
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Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination Partners
Doshi, Aatman S, Cantin, Susan, Hernandez, Marylens, Srinivasan, Srimathi, Tentarelli, Sharon, Griffin, Matthew, Wang, Yanjun, Pop-Damkov, Petar, Prickett, Laura B, Kankkonen, Cecilia, Shen, Minhui, Martin, Maryann San, Wu, Song, Castaldi, M Paola, Ghadially, Hormas, Varnes, Jeffrey, Gales, Sonya, Henry, David, Hoover, Clare, Mele, Deanna A, Simpson, Iain, Gangl, Eric T, Mlynarski, Scott N, Finlay, M Raymond V, Drew, Lisa, Fawell, Stephen E, Shao, Wenlin, Schuller, Alwin G
Published in Molecular cancer therapeutics (04.05.2023)
Published in Molecular cancer therapeutics (04.05.2023)
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Delayed Mammary Gland Involution in Mice with Mutation of the Insulin-Like Growth Factor Binding Protein 5 Gene
Ning, Yun, Hoang, Bao, Schuller, Alwin G. P, Cominski, Tara P, Hsu, Ming-Sing, Wood, Teresa L, Pintar, John E
Published in Endocrinology (Philadelphia) (01.05.2007)
Published in Endocrinology (Philadelphia) (01.05.2007)
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Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies
Ettenberg, Seth A., Charlat, Olga, Daley, Michael P., Liu, Shanming, Vincent, Karen J., Stuart, Darrin D., Schuller, Alwin G., Yuan, Jing, Ospina, Beatriz, Green, John, Yu, Qunyan, Walsh, Renee, Li, Sharon, Schmitz, Rita, Heine, Holger, Bilic, Sanela, Ostrom, Lance, Mosher, Rebecca, Hartlepp, K. Felix, Zhu, Zhenping, Fawell, Stephen, Yao, Yung-Mae, Stover, David, Finan, Peter M., Porter, Jeffery A., Sellers, William R., Klagge, Ingo M., Cong, Feng, Nusse, Roeland
Published in Proceedings of the National Academy of Sciences - PNAS (31.08.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (31.08.2010)
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Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of EGFR -mutant lung cancer
Eser, Pınar Özden, Paranal, Raymond M, Son, Jieun, Ivanova, Elena, Kuang, Yanan, Haikala, Heidi M, To, Ciric, Okoro, Jeffrey J, Dholakia, Kshiti H, Choi, Jihyun, Eum, Yoonji, Ogino, Atsuko, Missios, Pavlos, Ercan, Dalia, Xu, Man, Poitras, Michael J, Wang, Stephen, Ngo, Kenneth, Dills, Michael, Yanagita, Masahiko, Lopez, Timothy, Lin, Mika, Tsai, Jeanelle, Floch, Nicolas, Chambers, Emily S, Heng, Jennifer, Anjum, Rana, Santucci, Alison D, Michael, Kesi, Schuller, Alwin G, Cross, Darren, Smith, Paul D, Oxnard, Geoffrey R, Barbie, David A, Sholl, Lynette M, Bahcall, Magda, Palakurthi, Sangeetha, Gokhale, Prafulla C, Paweletz, Cloud P, Daley, George Q, Jänne, Pasi A
Published in Science translational medicine (01.09.2021)
Published in Science translational medicine (01.09.2021)
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Journal Article
Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia
Tron, Adriana E, Belmonte, Matthew A, Adam, Ammar, Aquila, Brian M, Boise, Lawrence H, Chiarparin, Elisabetta, Cidado, Justin, Embrey, Kevin J, Gangl, Eric, Gibbons, Francis D, Gregory, Gareth P, Hargreaves, David, Hendricks, J Adam, Johannes, Jeffrey W, Johnstone, Ricky W, Kazmirski, Steven L, Kettle, Jason G, Lamb, Michelle L, Matulis, Shannon M, Nooka, Ajay K, Packer, Martin J, Peng, Bo, Rawlins, Philip B, Robbins, Daniel W, Schuller, Alwin G, Su, Nancy, Yang, Wenzhan, Ye, Qing, Zheng, Xiaolan, Secrist, J Paul, Clark, Edwin A, Wilson, David M, Fawell, Stephen E, Hird, Alexander W
Published in Nature communications (17.12.2018)
Published in Nature communications (17.12.2018)
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Quantitative Evaluation of Dendritic Nanoparticles in Mice: Biodistribution Dynamics and Downstream Tumor Efficacy Outcomes
Vasalou, Christina, Ferguson, Douglas, Li, Weimin, Muse, Victorine, Gibbons, Francis D, Sonzini, Silvia, Zhang, Guangnong, Pop-Damkov, Petar, Gangl, Eric, Balachander, Srividya B, Wen, Shenghua, Schuller, Alwin G, Puri, Sanyogitta, Mazza, Mariarosa, Ashford, Marianne, Fretland, Adrian J, McGinnity, Dermot F, Jones, Rhys D. O
Published in Molecular pharmaceutics (03.01.2022)
Published in Molecular pharmaceutics (03.01.2022)
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Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma
Graziano, Vincenzo, Dannhorn, Andreas, Hulme, Heather, Williamson, Kate, Buckley, Hannah, Karim, Saadia A, Wilson, Matthew, Lee, Sheng Y, Kaistha, Brajesh P, Islam, Sabita, Thaventhiran, James E D, Richards, Frances M, Goodwin, Richard, Brais, Rebecca, Morton, Jennifer P, Dovedi, Simon J, Schuller, Alwin G, Eyles, Jim, Jodrell, Duncan I
Published in Journal for immunotherapy of cancer (01.08.2023)
Published in Journal for immunotherapy of cancer (01.08.2023)
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The novel tankyrase inhibitor (AZ1366) enhances irinotecan activity in tumors that exhibit elevated tankyrase and irinotecan resistance
Quackenbush, Kevin S, Bagby, Stacey, Tai, Wai Meng, Messersmith, Wells A, Schreiber, Anna, Greene, Justin, Kim, Jihye, Wang, Guoliang, Purkey, Alicia, Pitts, Todd M, Nguyen, Anna, Gao, Dexiang, Blatchford, Patrick, Capasso, Anna, Schuller, Alwin G, Eckhardt, S Gail, Arcaroli, John J
Published in Oncotarget (10.05.2016)
Published in Oncotarget (10.05.2016)
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