Antiviral Drug Discovery for the Treatment of COVID-19 Infections
Ng, Teresa I, Correia, Ivan, Seagal, Jane, DeGoey, David A, Schrimpf, Michael R, Hardee, David J, Noey, Elizabeth L, Kati, Warren M
Published in Viruses (04.05.2022)
Published in Viruses (04.05.2022)
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Development of a sensitive high-throughput enzymatic assay capable of measuring sub-nanomolar inhibitors of SARS-CoV2 Mpro
Kovar, Peter, Richardson, Paul L, Korepanova, Alla, Afanador, Gustavo A, Stojkovic, Vladimir, Li, Tao, Schrimpf, Michael R, Ng, Teresa I, Degoey, David A, Gopalakrishnan, Sujatha M, Chen, Jun
Published in SLAS discovery (01.09.2024)
Published in SLAS discovery (01.09.2024)
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SAR of α7 nicotinic receptor agonists derived from tilorone: Exploration of a novel nicotinic pharmacophore
Schrimpf, Michael R., Sippy, Kevin B., Briggs, Clark A., Anderson, David J., Li, Tao, Ji, Jianguo, Frost, Jennifer M., Surowy, Carol S., Bunnelle, William H., Gopalakrishnan, Murali, Meyer, Michael D.
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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Structure−Activity Studies and Analgesic Efficacy of N-(3-Pyridinyl)-Bridged Bicyclic Diamines, Exceptionally Potent Agonists at Nicotinic Acetylcholine Receptors
Bunnelle, William H, Daanen, Jerome F, Ryther, Keith B, Schrimpf, Michael R, Dart, Michael J, Gelain, Arianna, Meyer, Michael D, Frost, Jennifer M, Anderson, David J, Buckley, Michael, Curzon, Peter, Cao, Ying-Jun, Puttfarcken, Pamela, Searle, Xenia, Ji, Jianguo, Putman, C. Brent, Surowy, Carol, Toma, Lucio, Barlocco, Daniela
Published in Journal of medicinal chemistry (26.07.2007)
Published in Journal of medicinal chemistry (26.07.2007)
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Metabolism and Disposition of a Novel Selective α7 Neuronal Acetylcholine Receptor Agonist ABT-126 in Humans: Characterization of the Major Roles for Flavin-Containing Monooxygenases and UDP-Glucuronosyl Transferase 1A4 and 2B10 in Catalysis
Liu, Hong, Stresser, David M, Michmerhuizen, Melissa J, Li, Xiaofeng, Othman, Ahmed A, Reed, Aimee D, Schrimpf, Michael R, Sydor, Jens, Lee, Anthony J
Published in Drug metabolism and disposition (01.04.2018)
Published in Drug metabolism and disposition (01.04.2018)
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Journal Article
Metabolism and Disposition of a Novel Selective α 7 Neuronal Acetylcholine Receptor Agonist ABT-126 in Humans: Characterization of the Major Roles for Flavin-Containing Monooxygenases and UDP-Glucuronosyl Transferase 1A4 and 2B10 in Catalysis
Liu, Hong, Stresser, David M, Michmerhuizen, Melissa J, Li, Xiaofeng, Othman, Ahmed A, Reed, Aimee D, Schrimpf, Michael R, Sydor, Jens, Lee, Anthony J
Published in Drug metabolism and disposition (01.04.2018)
Published in Drug metabolism and disposition (01.04.2018)
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Journal Article
SAR of alpha 7 nicotinic receptor agonists derived from tilorone: Exploration of a novel nicotinic pharmacophore
Schrimpf, Michael R, Sippy, Kevin B, Briggs, Clark A, Anderson, David J, Li, Tao, Ji, Jianguo, Frost, Jennifer M, Surowy, Carol S, Bunnelle, William H, Gopalakrishnan, Murali, Meyer, Michael D
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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Synthesis and evaluation of new radioligands [11 C]A-833834 and [11 C]A-752274 for positron-emission tomography of α7-nicotinic acetylcholine receptors
Horti, Andrew G, Ravert, Hayden T, Gao, Yongjun, Holt, Daniel P, Bunnelle, William H, Schrimpf, Michael R, Li, Tao, Ji, Jianguo, Valentine, Heather, Scheffel, Ursula, Kuwabara, Hiroto, Wong, Dean F, Dannals, Robert F
Published in Nuclear medicine and biology (01.04.2013)
Published in Nuclear medicine and biology (01.04.2013)
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Asymmetric transformation in synthesis: chiral amino acid enolate equivalents
Vedejs, Edwin, Fields, Stephen C, Schrimpf, Michael R
Published in Journal of the American Chemical Society (01.12.1993)
Published in Journal of the American Chemical Society (01.12.1993)
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Preparation and characterization of N-(3-pyridinyl) spirocyclic diamines as ligands for nicotinic acetylcholine receptors
SIPPY, Kevin B, ANDERSON, David J, BUNNELLE, William H, HUTCHINS, Charles W, SCHRIMPF, Michael R
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
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Synthesis and Structure−Activity Relationship Studies of 3,6-Diazabicyclo[3.2.0]heptanes as Novel α4β2 Nicotinic Acetylcholine Receptor Selective Agonists
Ji, Jianguo, Schrimpf, Michael R, Sippy, Kevin B, Bunnelle, William H, Li, Tao, Anderson, David J, Faltynek, Connie, Surowy, Carol S, Dyhring, Tino, Ahring, Philip K, Meyer, Michael D
Published in Journal of medicinal chemistry (01.11.2007)
Published in Journal of medicinal chemistry (01.11.2007)
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Synthesis and SAR of 4-aminocyclopentapyrrolidines as orally active N-type calcium channel inhibitors for inflammatory and neuropathic pain
Beebe, Xenia, Yeung, Clinton M., Darczak, Daria, Shekhar, Shashank, Vortherms, Timothy A., Miller, Loan, Milicic, Ivan, Swensen, Andrew M., Zhu, Chang Z., Banfor, Patricia, Wetter, Jill M., Marsh, Kennan C., Jarvis, Michael F., Scott, Victoria E., Schrimpf, Michael R., Lee, Chih-Hung
Published in Bioorganic & medicinal chemistry letters (01.09.2013)
Published in Bioorganic & medicinal chemistry letters (01.09.2013)
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Journal Article
Syntheses and structure–activity relationship (SAR) studies of 2,5-diazabicyclo[2.2.1]heptanes as novel α7 neuronal nicotinic receptor (NNR) ligands
Li, Tao, Bunnelle, William H., Ryther, Keith B., Anderson, David J., Malysz, John, Helfrich, Rosalind, Grønlien, Jens H., Håkerud, Monika, Peters, Dan, Schrimpf, Michael R., Gopalakrishnan, Murali, Ji, Jianguo
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
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Structure–activity relationships of N-substituted ligands for the α7 nicotinic acetylcholine receptor
Mortell, Kathleen H., Schrimpf, Michael R., Bunnelle, William H., Anderson, David J., Gronlien, Jens Halvard, Hagene, Kirsten Thorin, Gopalakrishnan, Murali
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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An automated electrophysiological assay for differentiating Ca(v)2.2 inhibitors based on state dependence and kinetics
Swensen, Andrew M, Niforatos, Wende, Vortherms, Timothy A, Perner, Richard J, Li, Tao, Schrimpf, Michael R, Scott, Victoria E, Lee, Lance, Jarvis, Michael F, McGaraughty, Steve
Published in Assay and drug development technologies (01.12.2012)
Published in Assay and drug development technologies (01.12.2012)
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Journal Article
Discovery of fused azetidines as novel selective α4β2 neuronal nicotinic receptor (NNR) agonists
Ji, Jianguo, Bunnelle, William H., Li, Tao, Pace, Jennifer M., Schrimpf, Michael R., Sippy, Kevin B., Anderson, David J., Meyer, Michael D.
Published in Pure and applied chemistry (01.01.2005)
Published in Pure and applied chemistry (01.01.2005)
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DIAZEPINE DERIVATIVES USEFUL AS CALCIUM CHANNEL BLOCKERS IN THE TREATMENT OF PAIN
SCHRIMPF MICHAEL R, ZHANG QUINWEI I, BHATIA PRAMILA A, RANDOLPH JOHN T
Year of Publication 17.08.2015
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Year of Publication 17.08.2015
Patent
Generation of reactive borenium ions in the 2,3-benzazaborolidine series
Vedejs, E, Nguyen, T, Powell, DR, Schrimpf, MR
Published in Chemical communications (Cambridge, England) (1996)
Published in Chemical communications (Cambridge, England) (1996)
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