Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging
Sato, Shogo, Solanas, Guiomar, Peixoto, Francisca Oliveira, Bee, Leonardo, Symeonidi, Aikaterini, Schmidt, Mark S., Brenner, Charles, Masri, Selma, Benitah, Salvador Aznar, Sassone-Corsi, Paolo
Published in Cell (10.08.2017)
Published in Cell (10.08.2017)
Get full text
Journal Article
Nicotinamide riboside is uniquely and orally bioavailable in mice and humans
Trammell, Samuel A. J., Schmidt, Mark S., Weidemann, Benjamin J., Redpath, Philip, Jaksch, Frank, Dellinger, Ryan W., Li, Zhonggang, Abel, E. Dale, Migaud, Marie E., Brenner, Charles
Published in Nature communications (10.10.2016)
Published in Nature communications (10.10.2016)
Get full text
Journal Article
A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects
Dollerup, Ole L, Christensen, Britt, Svart, Mads, Schmidt, Mark S, Sulek, Karolina, Ringgaard, Steffen, Stødkilde-Jørgensen, Hans, Møller, Niels, Brenner, Charles, Treebak, Jonas T, Jessen, Niels
Published in The American journal of clinical nutrition (01.08.2018)
Published in The American journal of clinical nutrition (01.08.2018)
Get full text
Journal Article
Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity
Heer, Collin D., Sanderson, Daniel J., Voth, Lynden S., Alhammad, Yousef M.O., Schmidt, Mark S., Trammell, Samuel A.J., Perlman, Stanley, Cohen, Michael S., Fehr, Anthony R., Brenner, Charles
Published in The Journal of biological chemistry (25.12.2020)
Published in The Journal of biological chemistry (25.12.2020)
Get full text
Journal Article
NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging
Levine, Daniel C., Hong, Heekyung, Weidemann, Benjamin J., Ramsey, Kathryn M., Affinati, Alison H., Schmidt, Mark S., Cedernaes, Jonathan, Omura, Chiaki, Braun, Rosemary, Lee, Choogon, Brenner, Charles, Peek, Clara Bien, Bass, Joseph
Published in Molecular cell (04.06.2020)
Published in Molecular cell (04.06.2020)
Get full text
Journal Article
Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy
Pirinen, Eija, Auranen, Mari, Khan, Nahid A., Brilhante, Virginia, Urho, Niina, Pessia, Alberto, Hakkarainen, Antti, Kuula, Juho, Heinonen, Ulla, Schmidt, Mark S., Haimilahti, Kimmo, Piirilä, Päivi, Lundbom, Nina, Taskinen, Marja-Riitta, Brenner, Charles, Velagapudi, Vidya, Pietiläinen, Kirsi H., Suomalainen, Anu
Published in Cell metabolism (02.06.2020)
Published in Cell metabolism (02.06.2020)
Get full text
Journal Article
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures
Elhassan, Yasir S., Kluckova, Katarina, Fletcher, Rachel S., Schmidt, Mark S., Garten, Antje, Doig, Craig L., Cartwright, David M., Oakey, Lucy, Burley, Claire V., Jenkinson, Ned, Wilson, Martin, Lucas, Samuel J.E., Akerman, Ildem, Seabright, Alex, Lai, Yu-Chiang, Tennant, Daniel A., Nightingale, Peter, Wallis, Gareth A., Manolopoulos, Konstantinos N., Brenner, Charles, Philp, Andrew, Lavery, Gareth G.
Published in Cell reports (Cambridge) (13.08.2019)
Published in Cell reports (Cambridge) (13.08.2019)
Get full text
Journal Article
Pharmacological bypass of NAD⁺ salvage pathway protects neurons from chemotherapy-induced degeneration
Liu, Hui-wen, Smith, Chadwick B., Schmidt, Mark S., Cambronne, Xiaolu A., Cohen, Michael S., Migaud, Marie E., Brenner, Charles, Goodman, Richard H.
Published in Proceedings of the National Academy of Sciences - PNAS (16.10.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (16.10.2018)
Get full text
Journal Article
Efficacy, Safety, and Pharmacokinetics of Coadministered Diethylcarbamazine, Albendazole, and Ivermectin for Treatment of Bancroftian Filariasis
Thomsen, Edward K., Sanuku, Nelly, Baea, Manasseh, Satofan, Samson, Maki, Elit, Lombore, Bart, Schmidt, Mark S., Siba, Peter M., Weil, Gary J., Kazura, James W., Fleckenstein, Lawrence L., King, Christopher L.
Published in Clinical infectious diseases (01.02.2016)
Published in Clinical infectious diseases (01.02.2016)
Get full text
Journal Article
Nicotinamide riboside, a form of vitamin B3 and NAD+ precursor, relieves the nociceptive and aversive dimensions of paclitaxel-induced peripheral neuropathy in female rats
Hamity, Marta V, White, Stephanie R, Walder, Roxanne Y, Schmidt, Mark S, Brenner, Charles, Hammond, Donna L
Published in Pain (Amsterdam) (01.05.2017)
Published in Pain (Amsterdam) (01.05.2017)
Get full text
Journal Article
Boosting NAD+ blunts TLR4-induced type I IFN in control and systemic lupus erythematosus monocytes
Wu, Jing, Singh, Komudi, Lin, Amy, Meadows, Allison M, Wu, Kaiyuan, Shing, Vivian, Bley, Maximilian, Hassanzadeh, Shahin, Huffstutler, Rebecca D, Schmidt, Mark S, Blanco, Luz P, Tian, Rong, Brenner, Charles, Pirooznia, Mehdi, Kaplan, Mariana J, Sack, Michael N
Published in The Journal of clinical investigation (01.03.2022)
Published in The Journal of clinical investigation (01.03.2022)
Get full text
Journal Article
PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma
Fons, Nathan R., Sundaram, Ranjini K., Breuer, Gregory A., Peng, Sen, McLean, Ryan L., Kalathil, Aravind N., Schmidt, Mark S., Carvalho, Diana M., Mackay, Alan, Jones, Chris, Carcaboso, Ángel M., Nazarian, Javad, Berens, Michael E., Brenner, Charles, Bindra, Ranjit S.
Published in Nature communications (22.08.2019)
Published in Nature communications (22.08.2019)
Get full text
Journal Article
Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy
Pirinen, Eija, Auranen, Mari, Khan, Nahid A., Brilhante, Virginia, Urho, Niina, Pessia, Alberto, Hakkarainen, Antti, Ulla Heinonen, Juho Kuula, Schmidt, Mark S., Haimilahti, Kimmo, Piirilä, Päivi, Lundbom, Nina, Taskinen, Marja-Riitta, Brenner, Charles, Velagapudi, Vidya, Pietiläinen, Kirsi H., Suomalainen, Anu
Published in Cell metabolism (07.07.2020)
Published in Cell metabolism (07.07.2020)
Get full text
Journal Article
Nicotinamide Adenine Dinucleotide Metabolome Is Functionally Depressed in Patients Undergoing Liver Transplantation for Alcohol‐Related Liver Disease
Parker, Richard, Schmidt, Mark S., Cain, Owen, Gunson, Bridget, Brenner, Charles
Published in Hepatology communications (01.08.2020)
Published in Hepatology communications (01.08.2020)
Get full text
Journal Article
Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study
Lapatto, Helena A K, Kuusela, Minna, Heikkinen, Aino, Muniandy, Maheswary, van der Kolk, Birgitta W, Gopalakrishnan, Swetha, Pöllänen, Noora, Sandvik, Martin, Schmidt, Mark S, Heinonen, Sini, Saari, Sina, Kuula, Juho, Hakkarainen, Antti, Tampio, Janne, Saarinen, Tuure, Taskinen, Marja-Riitta, Lundbom, Nina, Groop, Per-Henrik, Tiirola, Marja, Katajisto, Pekka, Lehtonen, Marko, Brenner, Charles, Kaprio, Jaakko, Pekkala, Satu, Ollikainen, Miina, Pietiläinen, Kirsi H, Pirinen, Eija
Published in Science advances (13.01.2023)
Published in Science advances (13.01.2023)
Get full text
Journal Article
Nicotinamide riboside first alleviates symptoms but later downregulates dopamine metabolism in proteasome inhibition mouse model of Parkinson's disease
Turconi, Giorgio, Alam, Farhan, SenGupta, Tanima, Pirnes-Karhu, Sini, Olfat, Soophie, Schmidt, Mark S., Mätlik, Kärt, Montaño-Rodriguez, Ana, Heiskanen, Vladimir, Garton, Daniel, Piepponen, Petteri T., Brenner, Charles, Holmberg, Carina I., Nilsen, Hilde, Pirinen, Eija, Andressoo, Jaan-Olle
Published in Heliyon (30.07.2024)
Published in Heliyon (30.07.2024)
Get full text
Journal Article
Nicotinamide riboside, a form of vitamin B 3 , protects against excitotoxicity-induced axonal degeneration
Vaur, Pauline, Brugg, Bernard, Mericskay, Mathias, Li, Zhenlin, Schmidt, Mark S, Vivien, Denis, Orset, Cyrille, Jacotot, Etienne, Brenner, Charles, Duplus, Eric
Published in The FASEB journal (01.12.2017)
Published in The FASEB journal (01.12.2017)
Get more information
Journal Article
Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice
Mitchell, Sarah J., Bernier, Michel, Aon, Miguel A., Cortassa, Sonia, Kim, Eun Young, Fang, Evandro F., Palacios, Hector H., Ali, Ahmed, Navas-Enamorado, Ignacio, Di Francesco, Andrea, Kaiser, Tamzin A., Waltz, Tyler B., Zhang, Ning, Ellis, James L., Elliott, Peter J., Frederick, David W., Bohr, Vilhelm A., Schmidt, Mark S., Brenner, Charles, Sinclair, David A., Sauve, Anthony A., Baur, Joseph A., de Cabo, Rafael
Published in Cell metabolism (06.03.2018)
Published in Cell metabolism (06.03.2018)
Get full text
Journal Article
Senescent cells promote tissue NAD + decline during ageing via the activation of CD38 + macrophages
Covarrubias, Anthony J, Kale, Abhijit, Perrone, Rosalba, Lopez-Dominguez, Jose Alberto, Pisco, Angela Oliveira, Kasler, Herbert G, Schmidt, Mark S, Heckenbach, Indra, Kwok, Ryan, Wiley, Christopher D, Wong, Hoi-Shan, Gibbs, Eddy, Iyer, Shankar S, Basisty, Nathan, Wu, Qiuxia, Kim, Ik-Jung, Silva, Elena, Vitangcol, Kaitlyn, Shin, Kyong-Oh, Lee, Yong-Moon, Riley, Rebeccah, Ben-Sahra, Issam, Ott, Melanie, Schilling, Birgit, Scheibye-Knudsen, Morten, Ishihara, Katsuhiko, Quake, Stephen R, Newman, John, Brenner, Charles, Campisi, Judith, Verdin, Eric
Published in Nature metabolism (01.11.2020)
Published in Nature metabolism (01.11.2020)
Get more information
Journal Article