Discovery and Characterization of SY-1365, a Selective, Covalent Inhibitor of CDK7
Hu, Shanhu, Marineau, Jason J, Rajagopal, Nisha, Hamman, Kristin B, Choi, Yoon Jong, Schmidt, Darby R, Ke, Nan, Johannessen, Liv, Bradley, Michael J, Orlando, David A, Alnemy, Sydney R, Ren, Yixuan, Ciblat, Stephane, Winter, Dana K, Kabro, Anzhelika, Sprott, Kevin T, Hodgson, J Graeme, Fritz, Christian C, Carulli, John P, di Tomaso, Emmanuelle, Olson, Eric R
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group
Lobera, Mercedes, Madauss, Kevin P, Pohlhaus, Denise T, Wright, Quentin G, Trocha, Mark, Schmidt, Darby R, Baloglu, Erkan, Trump, Ryan P, Head, Martha S, Hofmann, Glenn A, Murray-Thompson, Monique, Schwartz, Benjamin, Chakravorty, Subhas, Wu, Zining, Mander, Palwinder K, Kruidenier, Laurens, Reid, Robert A, Burkhart, William, Turunen, Brandon J, Rong, James X, Wagner, Craig, Moyer, Mary B, Wells, Carrow, Hong, Xuan, Moore, John T, Williams, Jon D, Soler, Dulce, Ghosh, Shomir, Nolan, Michael A
Published in Nature chemical biology (01.05.2013)
Published in Nature chemical biology (01.05.2013)
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Journal Article
1442 Exploring novel ferroptosis inducer as a promising strategy for sarcoma treatment
Munteanu, Maria Cristina, Dubash, Taronish, Nunez, Cristian, Farah, Shrouq, Brown, Gabriel, Upadhyay, Aesha, Radetich, Branko, Choi, Yeon Sook, Marincola, Francesco, Schmidt, Darby, Gurvich, Nadia
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
Catalytic Asymmetric Silane Alcoholysis: Practical Access to Chiral Silanes
Schmidt, Darby R, O'Malle, Steven J, Leighton, James L
Published in Journal of the American Chemical Society (05.02.2003)
Published in Journal of the American Chemical Society (05.02.2003)
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Journal Article
Total Synthesis of Dolabelide D
Park, Peter K, O'Malley, Steven J, Schmidt, Darby R, Leighton, James L
Published in Journal of the American Chemical Society (08.03.2006)
Published in Journal of the American Chemical Society (08.03.2006)
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Journal Article
Case studies in rare disease small molecule discovery and development
Schmidt, Darby, Thompson, Christopher
Published in Bioorganic & medicinal chemistry letters (01.11.2020)
Published in Bioorganic & medicinal chemistry letters (01.11.2020)
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Journal Article
Targeting immunogenic cell stress and death for cancer therapy
Galluzzi, Lorenzo, Guilbaud, Emma, Schmidt, Darby, Kroemer, Guido, Marincola, Francesco M.
Published in Nature reviews. Drug discovery (01.06.2024)
Published in Nature reviews. Drug discovery (01.06.2024)
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Journal Article
Discovery of SY-5609: A Selective, Noncovalent Inhibitor of CDK7
Marineau, Jason J, Hamman, Kristin B, Hu, Shanhu, Alnemy, Sydney, Mihalich, Janessa, Kabro, Anzhelika, Whitmore, Kenneth Matthew, Winter, Dana K, Roy, Stephanie, Ciblat, Stephane, Ke, Nan, Savinainen, Anneli, Wilsily, Ashraf, Malojcic, Goran, Zahler, Robert, Schmidt, Darby, Bradley, Michael J, Waters, Nigel J, Chuaqui, Claudio
Published in Journal of medicinal chemistry (27.01.2022)
Published in Journal of medicinal chemistry (27.01.2022)
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Journal Article
Pharmacologic inhibition of RORγt regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivo
Skepner, Jill, Ramesh, Radha, Trocha, Mark, Schmidt, Darby, Baloglu, Erkan, Lobera, Mercedes, Carlson, Thaddeus, Hill, Jonathan, Orband-Miller, Lisa A, Barnes, Ashley, Boudjelal, Mohamed, Sundrud, Mark, Ghosh, Shomir, Yang, Jianfei
Published in The Journal of immunology (1950) (15.03.2014)
Published in The Journal of immunology (1950) (15.03.2014)
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Journal Article
Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms
Xiao, Sheng, Yosef, Nir, Yang, Jianfei, Wang, Yonghui, Zhou, Ling, Zhu, Chen, Wu, Chuan, Baloglu, Erkan, Schmidt, Darby, Ramesh, Radha, Lobera, Mercedes, Sundrud, Mark S., Tsai, Pei-Yun, Xiang, Zhijun, Wang, Jinsong, Xu, Yan, Lin, Xichen, Kretschmer, Karsten, Rahl, Peter B., Young, Richard A., Zhong, Zhong, Hafler, David A., Regev, Aviv, Ghosh, Shomir, Marson, Alexander, Kuchroo, Vijay K.
Published in Immunity (Cambridge, Mass.) (17.04.2014)
Published in Immunity (Cambridge, Mass.) (17.04.2014)
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Journal Article
Abstract B099: Targeting Non Small Cell Lung Cancer EGFR-Mutant and EGFR-Inhibitor resistant cell lines by ferroptosis induction: A potential therapeutic approach
Dubash, Taronish, Munteanu, Maria Cristina, Nunez, Cristian, Farah, Shrouq, Jadin, Laurence, Radetich, Branko, Marincola, Francesco M, Schmidt, Darby, Gurvich, Nadia
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Journal Article
TRPML의 조정제, 그의 조성물 및 사용 방법
MCCOMAS CASEY CAMERON, GRAZIOTTO JOHN J, LEE THOMAS WAI HO, IYENGAR RAJESH R, SCHMIDT DARBY R
Year of Publication 21.05.2024
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Year of Publication 21.05.2024
Patent
Abstract 1668: Targeting drug-induced tolerant & resistant cell populations by novel ferroptosis inducer
Dubash, Taronish, Munteanu, Maria Cristina, Farah, Shrouq, Nunez, Cristian, Jadin, Laurence, Radetich, Branko, Schmidt, Darby, Gurvich, Nadia
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
타노트랜스미션을 촉진시키도록 엔지니어링된 면역 세포 및 이의 용도
SCHMIDT DARBY RYE, NAGARAJAN NIRANJANA ADITI, HUBAUD ALEXIS BENOIT, KAISER WILLIAM JOSEPH, GOUGH PETER JOSEPH, DHAKAL SABIN
Year of Publication 28.02.2024
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Year of Publication 28.02.2024
Patent
타노트랜스미션 폴리펩티드 및 암의 치료에서의 이의 용도
SCHMIDT DARBY RYE, NAGARAJAN NIRANJANA ADITI, HUBAUD ALEXIS BENOIT, KAISER WILLIAM JOSEPH, GOUGH PETER JOSEPH, DHAKAL SABIN
Year of Publication 05.12.2023
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Year of Publication 05.12.2023
Patent
Targeting Transcriptional Dependency in Acute Myeloid Leukemia (AML) with a Covalent Inhibitor of Transcriptional Kinase CDK7
Ren, Yixuan, Brown, Victoria, Hu, Shanhu, Lopez, Jeremy, Miljovska, Sofija, Schmidt, Darby, Bradley, Michael, Sprott, Kevin, Olson, Eric, Fritz, Christian C., Choi, Yoon Jong
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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Journal Article
Abstract 4820: Selective CDK7 inhibitors suppress super enhancer-genes, induce massive apoptosis in acute myeloid leukemia and demonstrate durable in vivo efficacy
Hu, Shanhu, Ke, Nan, Ren, Yixuan, Lopez, Jeremy, Miljovska, Sofija, Orlando, David, Schmidt, Darby, Bradley, Michael, Sprott, Kevin, Olson, Eric, Fritz, Christian C., Choi, Yoon Jong
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article