Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH)
Tully, David C, Rucker, Paul V, Chianelli, Donatella, Williams, Jennifer, Vidal, Agnès, Alper, Phil B, Mutnick, Daniel, Bursulaya, Badry, Schmeits, James, Wu, Xiangdong, Bao, Dingjiu, Zoll, Jocelyn, Kim, Young, Groessl, Todd, McNamara, Peter, Seidel, H. Martin, Molteni, Valentina, Liu, Bo, Phimister, Andrew, Joseph, Sean B, Laffitte, Bryan
Published in Journal of medicinal chemistry (28.12.2017)
Published in Journal of medicinal chemistry (28.12.2017)
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Journal Article
Tropifexor‐Mediated Abrogation of Steatohepatitis and Fibrosis Is Associated With the Antioxidative Gene Expression Profile in Rodents
Hernandez, Eloy D., Zheng, Lianxing, Kim, Young, Fang, Bin, Liu, Bo, Valdez, Reginald A., Dietrich, William F., Rucker, Paul V., Chianelli, Donatella, Schmeits, James, Bao, Dingjiu, Zoll, Jocelyn, Dubois, Claire, Federe, Glenn C., Chen, Lihao, Joseph, Sean B., Klickstein, Lloyd B., Walker, John, Molteni, Valentina, McNamara, Peter, Meeusen, Shelly, Tully, David C., Badman, Michael K., Xu, Jie, Laffitte, Bryan
Published in Hepatology communications (01.08.2019)
Published in Hepatology communications (01.08.2019)
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Journal Article
Germ-line msh6 mutations in colorectal cancer families
KOLODNER, R. D, TYTELL, J. D, GARBER, J. E, SYNGAL, S, ANTON-CULVER, H, LI, F. P, SCHMEITS, J. L, KANE, M. F, GUPTA, R. D, WEGER, J, WAHLBERG, S, FOX, E. A, PEEL, D, ZIOGAS, A
Published in Cancer research (Chicago, Ill.) (15.10.1999)
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Published in Cancer research (Chicago, Ill.) (15.10.1999)
Journal Article
Structure−Function Relationships in Anabaena Ferredoxin: Correlations between X-ray Crystal Structures, Reduction Potentials, and Rate Constants of Electron Transfer to Ferredoxin:NADP+ Reductase for Site-Specific Ferredoxin Mutants
Hurley, John K, Weber-Main, Anne M, Stankovich, Marian T, Benning, Matthew M, Thoden, James B, Vanhooke, Janeen L, Holden, Hazel M, Chae, Young Kee, Xia, Bin, Cheng, Hong, Markley, John L, Martinez-Júlvez, Marta, Gómez-Moreno, Carlos, Schmeits, James L, Tollin, Gordon
Published in Biochemistry (Easton) (16.09.1997)
Published in Biochemistry (Easton) (16.09.1997)
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Journal Article
Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis
Chianelli, Donatella, Rucker, Paul V, Roland, Jason, Tully, David C, Nelson, John, Liu, Xiaodong, Bursulaya, Badry, Hernandez, Eloy D, Wu, Jane, Prashad, Mahavir, Schlama, Thierry, Liu, Yugang, Chu, Alan, Schmeits, James, Huang, David J, Hill, Robert, Bao, Dingjiu, Zoll, Jocelyn, Kim, Young, Groessl, Todd, McNamara, Peter, Liu, Bo, Richmond, Wendy, Sancho-Martinez, Ignacio, Phimister, Andrew, Seidel, H. Martin, Badman, Michael K, Joseph, Sean B, Laffitte, Bryan, Molteni, Valentina
Published in Journal of medicinal chemistry (23.04.2020)
Published in Journal of medicinal chemistry (23.04.2020)
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Journal Article
Evaluation of microsatellite instability and immunohistochemistry for the prediction of germ-line MSH2 and MLH1 mutations in hereditary nonpolyposis colon cancer families
WAHLBERG, Siobhan S, SCHMEITS, James, THOMAS, George, LODA, Massimo, GARBER, Judy, SYNGAL, Sapna, KOLODNER, Richard D, FOX, Edward
Published in Cancer research (Chicago, Ill.) (15.06.2002)
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Published in Cancer research (Chicago, Ill.) (15.06.2002)
Journal Article
Charge Reversal Mutations in a Conserved Acidic Patch inAnabaenaFerredoxin Can Attenuate or Enhance Electron Transfer to Ferredoxin:NADP+Reductase by Altering Protein/Protein Orientation within the Intermediate Complex
Hurley, John K., Schmeits, James L., Genzor, Carlos, Gómez-Moreno, Carlos, Tollin, Gordon
Published in Archives of biochemistry and biophysics (01.09.1996)
Published in Archives of biochemistry and biophysics (01.09.1996)
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Journal Article
Bicyclic cyanothiazolidines as novel dipeptidyl peptidase 4 inhibitors
Betancort, Juan M., Winn, David T., Liu, Ruzhang, Xu, Quansheng, Liu, Junjuan, Liao, Wensheng, Chen, Shu-Hui, Carney, David, Hanway, Denise, Schmeits, James, Li, Xinqiang, Gordon, Eric, Campbell, David A.
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Journal Article
One-megabase sequence analysis of the human immunoglobulin lambda gene locus
Kawasaki, K, Minoshima, S, Nakato, E, Shibuya, K, Shintani, A, Schmeits, J L, Wang, J, Shimizu, N
Published in Genome research (01.03.1997)
Published in Genome research (01.03.1997)
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Journal Article
Mononucleotide microsatellite instability and germline MSH6 mutation analysis in early onset colorectal cancer
Verma, L, Kane, M F, Brassett, C, Schmeits, J, Evans, D G, Kolodner, R D, Maher, E R
Published in Journal of medical genetics (01.09.1999)
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Published in Journal of medical genetics (01.09.1999)
Journal Article
An endomembrane-localized small heat-shock protein from Arabidopsis thaliana
Kenneth W. Helm, James Schmeits, Vierling, Elizabeth
Published in Plant physiology (Bethesda) (1995)
Published in Plant physiology (Bethesda) (1995)
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Journal Article
Mononucleotide microsatellite instability and germlineMSH6 mutation analysis in early onset colorectal cancer
Verma, Loveena, Kane, Michael F, Brassett, Cecilia, Schmeits, James, Evans, D Gareth R, Kolodner, Richard D, Maher, Eamonn R
Published in Journal of medical genetics (01.09.1999)
Published in Journal of medical genetics (01.09.1999)
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Journal Article
Charge reversal mutations in a conserved acidic patch in Anabaena ferredoxin can attenuate or enhance electron transfer to ferredoxin:NADP+ reductase by altering protein/protein orientation within the intermediate complex
Hurley, J K, Schmeits, J L, Genzor, C, Gómez-Moreno, C, Tollin, G
Published in Archives of biochemistry and biophysics (01.09.1996)
Published in Archives of biochemistry and biophysics (01.09.1996)
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Journal Article
"HOSPEDEIRO RECOMBINANTE E MÉTODO PARA CONTROLAR UMA PESTE LEPIDOPTERANA"
KENNETH E. NARVA, DAVID LOEWER, STACEY FINSTAD-LEE, JERALD S. FEITELSON, JAMES SCHMEITS, GEORGE MORRILL, JUDY MULLER-COHN, CHARLES JOSEPH DULLUM, LISA STAMP, H. ERNEST SCHNEPF, BRIAN A. STOCKHOFF
Year of Publication 14.10.2014
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Year of Publication 14.10.2014
Patent
Bacillus thuringiensis-toksin, der er aktivt mod lepidoptera-skadedyr
SCHNEPF, ERNEST H, FINSTAD-LEE, STACEY, FEITELSON, JERALD S, LOEWER, DAVID, MORERA, LISA M, MULLER-COHN, JUDY, MORRILL, GEORGE, SCHMEITS, JAMES, STOCKHOFF, BRIAN A, NARVA, KENNETH E, DULLUM, CHARLES JOSEPH
Year of Publication 04.06.2012
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Year of Publication 04.06.2012
Patent
BACILLUS THURINGIENSIS TOXIN DAS GEGEN LEPIDOPTERA AKTIV IST
FINSTAD-LEE, STACEY, FEITELSON, JERALD S, LOEWER, DAVID, MORERA, LISA M, SCHNEPF, H. ERNEST, MULLER-COHN, JUDY, MORRILL, GEORGE, STOCKHOFF, BRIAN A, SCHMEITS, JAMES, NARVA, KENNETH E, DULLUM, CHARLES JOSEPH
Year of Publication 15.05.2012
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Year of Publication 15.05.2012
Patent
Bacillus thuringiensis toxin active against Lepidopteran pests
FINSTAD-LEE, STACEY, FEITELSON, JERALD S, LOEWER, DAVID, MORERA, LISA M, SCHNEPF, H. ERNEST, MULLER-COHN, JUDY, MORRILL, GEORGE, STOCKHOFF, BRIAN A, SCHMEITS, JAMES, NARVA, KENNETH E, DULLUM, CHARLES JOSEPH
Year of Publication 02.05.2012
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Year of Publication 02.05.2012
Patent
Gene Expression Microarrays: Improvements and Applications towards Agricultural Gene Discovery
Zhu, Tong, Chang, Hur-Song, Schmeits, James, Gil, Pedro, Shi, Liang, Budworth, Paul, Zou, Guangzhou, Chen, Xi, Wang, Xun
Published in Journal of Laboratory Automation (01.12.2001)
Published in Journal of Laboratory Automation (01.12.2001)
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Journal Article
Bacillus thuringiensis toxin active against Lepidopteran pests
FINSTAD-LEE, STACEY, FEITELSON, JERALD S, LOEWER, DAVID, MORERA, LISA M, SCHNEPF, H. ERNEST, MULLER-COHN, JUDY, MORRILL, GEORGE, STOCKHOFF, BRIAN A, SCHMEITS, JAMES, NARVA, KENNETH E, DULLUM, CHARLES JOSEPH
Year of Publication 02.06.2010
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Year of Publication 02.06.2010
Patent