A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy
Ronan, Baptiste, Flamand, Odile, Vescovi, Lionel, Dureuil, Christine, Durand, Laurence, Fassy, Florence, Bachelot, Marie-France, Lamberton, Annabelle, Mathieu, Magali, Bertrand, Thomas, Marquette, Jean-Pierre, El-Ahmad, Youssef, Filoche-Romme, Bruno, Schio, Laurent, Garcia-Echeverria, Carlos, Goulaouic, Hélène, Pasquier, Benoit
Published in Nature chemical biology (01.12.2014)
Published in Nature chemical biology (01.12.2014)
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N-Heterocyclic Carbene-Amine Pt(II) Complexes, a New Chemical Space for the Development of Platinum-Based Anticancer Drugs
Skander, Myriem, Retailleau, Pascal, Bourrié, Bernard, Schio, Laurent, Mailliet, Patrick, Marinetti, Angela
Published in Journal of medicinal chemistry (11.03.2010)
Published in Journal of medicinal chemistry (11.03.2010)
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Ionic Liquids for Fast and Solvent‐Free Nucleophilic Trifluoromethylthiolation of Alkyl Halides and Alcohols
Anselmi, Elsa, Simon, Cédric, Marrot, Jérôme, Bernardelli, Patrick, Schio, Laurent, Pégot, Bruce, Magnier, Emmanuel
Published in European journal of organic chemistry (16.11.2017)
Published in European journal of organic chemistry (16.11.2017)
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Discovery of (2S)‑8-[(3R)‑3-Methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro‑2H‑pyrimido[1,2‑a]pyrimidin-6-one: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors
Pasquier, Benoit, El-Ahmad, Youssef, Filoche-Rommé, Bruno, Dureuil, Christine, Fassy, Florence, Abecassis, Pierre-Yves, Mathieu, Magali, Bertrand, Thomas, Benard, Tsiala, Barrière, Cédric, El Batti, Samira, Letallec, Jean-Philippe, Sonnefraud, Véronique, Brollo, Maurice, Delbarre, Laurence, Loyau, Véronique, Pilorge, Fabienne, Bertin, Luc, Richepin, Patrick, Arigon, Jérôme, Labrosse, Jean-Robert, Clément, Jacques, Durand, Florence, Combet, Romain, Perraut, Pierre, Leroy, Vincent, Gay, Frédéric, Lefrançois, Dominique, Bretin, François, Marquette, Jean-Pierre, Michot, Nadine, Caron, Anne, Castell, Christelle, Schio, Laurent, McCort, Gary, Goulaouic, Hélène, Garcia-Echeverria, Carlos, Ronan, Baptiste
Published in Journal of medicinal chemistry (08.01.2015)
Published in Journal of medicinal chemistry (08.01.2015)
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Differential Water Thermodynamics Determine PI3K-Beta/Delta Selectivity for Solvent-Exposed Ligand Modifications
Robinson, Daniel, Bertrand, Thomas, Carry, Jean-Christophe, Halley, Frank, Karlsson, Andreas, Mathieu, Magali, Minoux, Hervé, Perrin, Marc-Antoine, Robert, Benoit, Schio, Laurent, Sherman, Woody
Published in Journal of chemical information and modeling (23.05.2016)
Published in Journal of chemical information and modeling (23.05.2016)
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Discovery and Pharmacokinetic and Pharmacological Properties of the Potent and Selective MET Kinase Inhibitor 1‑{6-[6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3‑b]pyridazin-3-ylsulfanyl]benzothiazol-2-yl}-3-(2-morpholin-4-ylethyl)urea (SAR125844)
Ugolini, Antonio, Kenigsberg, Mireille, Rak, Alexey, Vallée, Francois, Houtmann, Jacques, Lowinski, Maryse, Capdevila, Cécile, Khider, Jean, Albert, Eva, Martinet, Nathalie, Nemecek, Conception, Grapinet, Sandrine, Bacqué, Eric, Roesner, Manfred, Delaisi, Christine, Calvet, Loreley, Bonche, Fabrice, Semiond, Dorothée, Egile, Coumaran, Goulaouic, Hélène, Schio, Laurent
Published in Journal of medicinal chemistry (11.08.2016)
Published in Journal of medicinal chemistry (11.08.2016)
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Preparation and optimization of pyrazolo[1,5-a]pyrimidines as new potent PDE4 inhibitors
Le Roux, Jacques, Leriche, Caroline, Chamiot-Clerc, Philippe, Feutrill, John, Halley, Frank, Papin, David, Derimay, Nathalie, Mugler, Christelle, Grépin, Claudine, Schio, Laurent
Published in Bioorganic & medicinal chemistry letters (15.01.2016)
Published in Bioorganic & medicinal chemistry letters (15.01.2016)
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Journal Article
SAR156497, an Exquisitely Selective Inhibitor of Aurora Kinases
Carry, Jean-Christophe, Clerc, François, Minoux, Hervé, Schio, Laurent, Mauger, Jacques, Nair, Anil, Parmantier, Eric, Le Moigne, Ronan, Delorme, Cécile, Nicolas, Jean-Paul, Krick, Alain, Abécassis, Pierre-Yves, Crocq-Stuerga, Véronique, Pouzieux, Stéphanie, Delarbre, Laure, Maignan, Sébastien, Bertrand, Thomas, Bjergarde, Kirsten, Ma, Nina, Lachaud, Sylvette, Guizani, Houlfa, Lebel, Rémi, Doerflinger, Gilles, Monget, Sylvie, Perron, Sébastien, Gasse, Francis, Angouillant-Boniface, Odile, Filoche-Rommé, Bruno, Murer, Michel, Gontier, Sylvie, Prévost, Céline, Monteiro, Marie-Line, Combeau, Cécile
Published in Journal of medicinal chemistry (08.01.2015)
Published in Journal of medicinal chemistry (08.01.2015)
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Combination of PIM and JAK2 inhibitors synergistically suppresses cell proliferation and overcomes drug resistance of myeloproliferative neoplasms
Huang, Shih-Min A., Wang, Anlai, Greco, Rita, Li, Zhifang, Sun, Fangxian, Barberis, Claude, Tabart, Michel, Patel, Vinod, Schio, Laurent, Hurley, Raelene, Chen, Bo, Cheng, Hong, Lengauer, Christoph, Pollard, Jack, Watters, James, Garcia-Echeverria, Carlos, Wiederschain, Dmitri, Adrian, Francisco, Zhang, JingXin
Published in Oncotarget (08.05.2014)
Published in Oncotarget (08.05.2014)
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Synthesis of trifluoromethyl N,N-aminals from nitrogen containing heterocycles by using a plasma flow microreactor
Abedelnour, Elias, Ognier, Stephanie, Venier, Olivier, Schio, Laurent, Tatoulian, Michael, Cossy, Janine
Published in Chemical communications (Cambridge, England) (04.04.2023)
Published in Chemical communications (Cambridge, England) (04.04.2023)
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Synthesis of trifluoromethyl ,-aminals from nitrogen containing heterocycles by using a plasma flow microreactor
Abedelnour, Elias, Ognier, Stephanie, Venier, Olivier, Schio, Laurent, Tatoulian, Michael, Cossy, Janine
Published in Chemical communications (Cambridge, England) (04.04.2023)
Published in Chemical communications (Cambridge, England) (04.04.2023)
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Phosphine-Catalyzed Synthesis of 3,3-Spirocyclopenteneoxindoles from γ‑Substituted Allenoates: Systematic Studies and Targeted Applications
Gomez, Catherine, Gicquel, Maxime, Carry, Jean-Christophe, Schio, Laurent, Retailleau, Pascal, Voituriez, Arnaud, Marinetti, Angela
Published in Journal of organic chemistry (15.02.2013)
Published in Journal of organic chemistry (15.02.2013)
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Journal Article
SAR439859, a Novel Selective Estrogen Receptor Degrader (SERD), Demonstrates Effective and Broad Antitumor Activity in Wild-Type and Mutant ER-Positive Breast Cancer Models
Shomali, Maysoun, Cheng, Jane, Sun, Fangxian, Koundinya, Malvika, Guo, Zhuyan, Hebert, Andrew T, McManus, Jessica, Levit, Mikhail N, Hoffmann, Dietmar, Courjaud, Albane, Arrebola, Rosalia, Cao, Hui, Pollard, Jack, Lee, Joon Sang, Besret, Laurent, Caron, Anne, Bangari, Dinesh S, Abecassis, Pierre-Yves, Schio, Laurent, El-Ahmad, Youssef, Halley, Frank, Tabart, Michel, Certal, Victor, Thompson, Fabienne, McCort, Gary, Filoche-Rommé, Bruno, Cheng, Hong, Garcia-Echeverria, Carlos, Debussche, Laurent, Bouaboula, Monsif
Published in Molecular cancer therapeutics (01.02.2021)
Published in Molecular cancer therapeutics (01.02.2021)
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Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3 S )-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7 H -benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer
El-Ahmad, Youssef, Tabart, Michel, Halley, Frank, Certal, Victor, Thompson, Fabienne, Filoche-Rommé, Bruno, Gruss-Leleu, Florence, Muller, Claire, Brollo, Maurice, Fabien, Laurence, Loyau, Véronique, Bertin, Luc, Richepin, Patrick, Pilorge, Fabienne, Desmazeau, Pascal, Girardet, Chrystelle, Beccari, Sylvie, Louboutin, Audrey, Lebourg, Gilles, Le-Roux, Jacques, Terrier, Corinne, Vallée, François, Steier, Valérie, Mathieu, Magali, Rak, Alexey, Abecassis, Pierre-Yves, Vicat, Pascale, Benard, Tsiala, Bouaboula, Monsif, Sun, Fangxian, Shomali, Maysoun, Hebert, Andrew, Levit, Mikhail, Cheng, Hong, Courjaud, Albane, Ginesty, Celine, Perrault, Christelle, Garcia-Echeverria, Carlos, McCort, Gary, Schio, Laurent
Published in Journal of medicinal chemistry (23.01.2020)
Published in Journal of medicinal chemistry (23.01.2020)
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Journal Article
Discovery of 6‑(2,4-Dichlorophenyl)-5-[4-[(3S)‑1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro‑7H‑benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer
El-Ahmad, Youssef, Tabart, Michel, Halley, Frank, Certal, Victor, Thompson, Fabienne, Filoche-Rommé, Bruno, Gruss-Leleu, Florence, Muller, Claire, Brollo, Maurice, Fabien, Laurence, Loyau, Véronique, Bertin, Luc, Richepin, Patrick, Pilorge, Fabienne, Desmazeau, Pascal, Girardet, Chrystelle, Beccari, Sylvie, Louboutin, Audrey, Lebourg, Gilles, Le-Roux, Jacques, Terrier, Corinne, Vallée, François, Steier, Valérie, Mathieu, Magali, Rak, Alexey, Abecassis, Pierre-Yves, Vicat, Pascale, Benard, Tsiala, Bouaboula, Monsif, Sun, Fangxian, Shomali, Maysoun, Hebert, Andrew, Levit, Mikhail, Cheng, Hong, Courjaud, Albane, Ginesty, Celine, Perrault, Christelle, Garcia-Echeverria, Carlos, McCort, Gary, Schio, Laurent
Published in Journal of medicinal chemistry (23.01.2020)
Published in Journal of medicinal chemistry (23.01.2020)
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Abstract PS17-16: Sar439859, a novel selective estrogen receptor degrader (serd), demonstrates effective and broad antitumor activity in wild-type and mutant er-positive breast cancer models
Shomali, Maysoun, Sun, Fangxian, Levit, Mikhail, Pollard, Jack, Lee, Joon Sang, Schio, Laurent, El-Ahmad, Youssef, Soria, Chris, Cohen, Patrick, Debussche, Laurent, Bouaboula, Monsif
Published in Cancer research (Chicago, Ill.) (15.02.2021)
Published in Cancer research (Chicago, Ill.) (15.02.2021)
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An innovative sequential flow platform for automated multi-step chemical processes - proof of concept with the separation of amine/alkene model mixtures
Arveiler, Maël, Ognier, Stephanie, Venier, Olivier, Schio, Laurent, Tatoulian, Michael
Published in Reaction chemistry & engineering (24.10.2023)
Published in Reaction chemistry & engineering (24.10.2023)
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Abstract 739: Preclinical and clinical activity of SAR439859, Amcenestrant, a next generation SERD
Shomali, Maysoun, Sun, Fangxian, Besret, Laurent, Caron, Anne, Lee, Joon Sang, El-Ahmed, Youssef, Schio, Laurent, Pollard, Jack, Pelekanou, Vasiliki, Cohen, Patrick, Celanovic, Marina, Herold, Christina, Soria, Chris, Debussche, Laurent, Bouaboula, Monsif
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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In vitro ion channel profile and ex vivo cardiac electrophysiology properties of the R(-) and S(+) enantiomers of hydroxychloroquine
Ballet, Véronique, Bohme, G. Andrees, Brohan, Eric, Boukaiba, Rachid, Chambard, Jean-Marie, Angouillant-Boniface, Odile, Carriot, Thierry, Chantoiseau, Céline, Fouconnier, Sophie, Houtmann, Sylvie, Prévost, Céline, Schombert, Brigitte, Schio, Laurent, Partiseti, Michel
Published in European journal of pharmacology (15.01.2022)
Published in European journal of pharmacology (15.01.2022)
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