S1097 Correlation of miR-124 Upregulation and PK Parameters in Blood of Patients With Moderate-to-Severe Ulcerative Colitis Receiving Obefazimod for 16 Weeks
Santo, Julien, Flatres, Aurélien, Gineste, Paul, Scherrer, Didier, Nitcheu, Josianne, Sloan, Sheldon, Ehrlich, Hartmut J., Sands, Bruce E., Vermeire, Séverine
Published in The American journal of gastroenterology (01.10.2023)
Published in The American journal of gastroenterology (01.10.2023)
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Journal Article
S1096 Long-Term Upregulation of miR-124 in Blood and Rectal Biopsies of Patients With Moderate-to-Severe Ulcerative Colitis Receiving Obefazimod 50mg Daily for 96 Weeks
Santo, Julien, Flatres, Aurélien, Gineste, Paul, Scherrer, Didier, Nitcheu, Josianne, Sloan, Sheldon, Ehrlich, Hartmut J., Sands, Bruce E., Vermeire, Séverine
Published in The American journal of gastroenterology (01.10.2023)
Published in The American journal of gastroenterology (01.10.2023)
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Journal Article
Both anti-inflammatory and antiviral properties of novel drug candidate ABX464 are mediated by modulation of RNA splicing
Vautrin, Audrey, Manchon, Laurent, Garcel, Aude, Campos, Noëlie, Lapasset, Laure, Laaref, Abdelhamid Mahdi, Bruno, Roman, Gislard, Marie, Dubois, Emeric, Scherrer, Didier, Ehrlich, J Hartmut, Tazi, Jamal
Published in Scientific reports (28.01.2019)
Published in Scientific reports (28.01.2019)
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Journal Article
The Anti-Hiv Candidate Abx464 Dampens Intestinal Inflammation by Triggering Il-22 Production in Activated Macrophages
Chebli, Karim, Papon, Laura, Paul, Conception, Garcel, Aude, Campos, Noëlie, Scherrer, Didier, J. Ehrlich, Hartmut, Hahne, Michael, Tazi, Jamal
Published in Scientific reports (07.07.2017)
Published in Scientific reports (07.07.2017)
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Journal Article
Safety, tolerability and impact on viral reservoirs of the addition to antiretroviral therapy of ABX464, an investigational antiviral drug, in individuals living with HIV-1: a Phase IIa randomised controlled study
Rutsaert, Sofie, Steens, Jean-Marc, Gineste, Paul, Cole, Basiel, Kint, Sam, Barrett, P Noel, Tazi, Jamal, Scherrer, Didier, Ehrlich, Hartmut J, Vandekerckhove, Linos
Published in Journal of Virus Eradication (01.01.2019)
Published in Journal of Virus Eradication (01.01.2019)
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Journal Article
RabGEF1 is a negative regulator of mast cell activation and skin inflammation
Tam, See-Ying, Galli, Stephen J, Tsai, Mindy, Snouwaert, John N, Kalesnikoff, Janet, Scherrer, Didier, Nakae, Susumu, Chatterjea, Devavani, Bouley, Donna M
Published in Nature immunology (01.08.2004)
Published in Nature immunology (01.08.2004)
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Journal Article
P3 Early evidence of antiviral activity and safety of ABX464 in HIV treatment-naïve patients
Scherrer, Didier, Steens, Jean-Marc, Kuanchai, Supparatpinyo, Winai, Ratanasuwan, Ruxrungtham, Kiat, Rouzier, Regine, Tazi, Jamal, Gineste, Paul, Ehrlich, Hartmut, Murphy, Robert
Published in Journal of Virus Eradication (01.09.2016)
Published in Journal of Virus Eradication (01.09.2016)
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Sa1206 OBEFAZIMOD AND ITS ACTIVE METABOLITES ABX-464-N-GLU ACT BY STABILIZING PROTEIN-PROTEIN INTERACTION AMONG KEY RNA BIOGENESIS PARTNERS, CBC AND ARS2
Bron, Patrick, Martin, Kevin, Sloan, Sheldon, Scherrer, Didier, Tazi, Jamal
Published in Gastroenterology (New York, N.Y. 1943) (18.05.2024)
Published in Gastroenterology (New York, N.Y. 1943) (18.05.2024)
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Sa1238 OBEFAZIMOD REDUCES TOTAL NUMBER OF TUMORS AND HIGH-GRADE ADENOMAS IN A MURINE COLITIS ASSOCIATED COLORECTAL CANCER MODEL
Apolit, Cécile, Lemmers, Bénédicte, Lattanzio, Rossano, Campos, Noélie, Scherrer, Didier, Hahne, Michael, Garcel, Aude
Published in Gastroenterology (New York, N.Y. 1943) (18.05.2024)
Published in Gastroenterology (New York, N.Y. 1943) (18.05.2024)
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Journal Article
Specific and selective induction of miR-124 in immune cells by the quinoline ABX464: a transformative therapy for inflammatory diseases
Tazi, Jamal, Begon-Pescia, Christina, Campos, Noëlie, Apolit, Cécile, Garcel, Aude, Scherrer, Didier
Published in Drug discovery today (01.04.2021)
Published in Drug discovery today (01.04.2021)
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Journal Article
EP148 OBEFAZIMOD UPREGULATES MIR-124 AND DOWNREGULATES THE EXPRESSION OF SOME CYTOKINES IN BLOOD AND RECTAL BIOPSIES OF PATIENTS WITH MODERATE-TO-SEVERE ULCERATIVE COLITIS
Santo, Julien, Gineste, Paul, Scherrer, Didier, Nitcheu, Josianne, Ehrlich, Hartmut, Sands, Bruce E., Vermeire, Séverine
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2023)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2023)
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Demonstration of the Antitumor Activity of the iNKT Agonist ABX196, a Novel Enhancer of Cancer Immunotherapy, in Melanoma and Hepatocarcinoma Mouse Models
Scherrer, Didier, Barrett, Noel, Teyton, Luc, Pearce, Tillman, Nitcheu, Josianne, Pouletty, Philippe, Santo, Julien, Ehrlich, Hartmut J
Published in Molecular cancer therapeutics (02.12.2022)
Published in Molecular cancer therapeutics (02.12.2022)
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Journal Article
Safety and efficacy of the miR-124 upregulator ABX464 (obefazimod, 50 and 100 mg per day) in patients with active rheumatoid arthritis and inadequate response to methotrexate and/or anti-TNFα therapy: a placebo-controlled phase II study
Daien, Claire, Krogulec, Marek, Gineste, Paul, Steens, Jean-Marc, Desroys du Roure, Laurence, Biguenet, Sophie, Scherrer, Didier, Santo, Julien, Ehrlich, Hartmut, Durez, Patrick
Published in Annals of the rheumatic diseases (01.08.2022)
Published in Annals of the rheumatic diseases (01.08.2022)
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Journal Article
Impact of Obefazimod on Viral Persistence, Inflammation, and Immune Activation in People With Human Immunodeficiency Virus on Suppressive Antiretroviral Therapy
Bernal, Silvia, Puertas, Maria C, Morón-López, Sara, Cranston, Ross D, Urrea, Víctor, Dalmau, Judith, Salgado, María, Gálvez, Cristina, Erkizia, Itziar, McGowan, Ian, Scherrer, Didier, Revollo, Boris, Sirera, Guillem, Santos, José Ramón, Clotet, Bonaventura, Paredes, Roger, Martinez-Picado, Javier
Published in The Journal of infectious diseases (02.11.2023)
Published in The Journal of infectious diseases (02.11.2023)
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Journal Article
Safety, Pharmacokinetics, and Antiviral Activity of a Novel HIV Antiviral, ABX464, in Treatment-Naive HIV-Infected Subjects in a Phase 2 Randomized, Controlled Study
Steens, Jean-Marc, Scherrer, Didier, Gineste, Paul, Barrett, P Noel, Khuanchai, Supparatpino, Winai, Ratanasuwan, Ruxrungtham, Kiat, Tazi, Jamal, Murphy, Robert, Ehrlich, Hartmut
Published in Antimicrobial agents and chemotherapy (01.07.2017)
Published in Antimicrobial agents and chemotherapy (01.07.2017)
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Journal Article
Obefazimod: A First-in-class Drug for the Treatment of Ulcerative Colitis
Vermeire, Séverine, Solitano, Virginia, Peyrin-Biroulet, Laurent, Tilg, Herbert, Danese, Silvio, Ehrlich, Hartmut, Scherrer, Didier, Gineste, Paul, d’Agay, Laurence, Sands, Bruce E
Published in Journal of Crohn's and colitis (08.11.2023)
Published in Journal of Crohn's and colitis (08.11.2023)
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Journal Article
코로나바이러스과 감염을 치료 또는 예방하기 위한 화합물, 및 코로나바이러스과 감염의 발생을 평가하기 위한 방법 및 용도
EHRLICH HARTMUT, SCHERRER DIDIER, POULETTY PHILIPPE, SANTO JULIEN, TAZI JAMAL
Year of Publication 15.11.2022
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Year of Publication 15.11.2022
Patent
ABX464 (Obefazimod) Upregulates miR-124 to Reduce Proinflammatory Markers in Inflammatory Bowel Diseases
Apolit, Cécile, Campos, Noëlie, Vautrin, Audrey, Begon-Pescia, Christina, Lapasset, Laure, Scherrer, Didier, Gineste, Paul, Ehrlich, Hartmut, Garcel, Aude, Santo, Julien, Tazi, Jamal
Published in Clinical and translational gastroenterology (01.04.2023)
Published in Clinical and translational gastroenterology (01.04.2023)
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