Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization
Klein, Florian, Diskin, Ron, Scheid, Johannes F., Gaebler, Christian, Mouquet, Hugo, Georgiev, Ivelin S., Pancera, Marie, Zhou, Tongqing, Incesu, Reha-Baris, Fu, Brooks Zhongzheng, Gnanapragasam, Priyanthi N.P., Oliveira, Thiago Y., Seaman, Michael S., Kwong, Peter D., Bjorkman, Pamela J., Nussenzweig, Michel C.
Published in Cell (28.03.2013)
Published in Cell (28.03.2013)
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Journal Article
Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy
West, Anthony P., Scharf, Louise, Scheid, Johannes F., Klein, Florian, Bjorkman, Pamela J., Nussenzweig, Michel C.
Published in Cell (13.02.2014)
Published in Cell (13.02.2014)
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Journal Article
Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01
Zhou, Tongqing, Georgiev, Ivelin, Wu, Xueling, Yang, Zhi-Yong, Dai, Kaifan, Finzi, Andrés, Do Kwon, Young, Scheid, Johannes F, Shi, Wei, Xu, Ling, Yang, Yongping, Zhu, Jiang, Nussenzweig, Michel C, Sodroski, Joseph, Shapiro, Lawrence, Nabel, Gary J, Mascola, John R, Kwong, Peter D
Published in Science (American Association for the Advancement of Science) (13.08.2010)
Published in Science (American Association for the Advancement of Science) (13.08.2010)
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Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies
Zhou, Tongqing, Zhu, Jiang, Wu, Xueling, Moquin, Stephanie, Zhang, Baoshan, Acharya, Priyamvada, Georgiev, Ivelin S., Altae-Tran, Han R., Chuang, Gwo-Yu, Joyce, M. Gordon, Do Kwon, Young, Longo, Nancy S., Louder, Mark K., Luongo, Timothy, McKee, Krisha, Schramm, Chaim A., Skinner, Jeff, Yang, Yongping, Yang, Zhongjia, Zhang, Zhenhai, Zheng, Anqi, Bonsignori, Mattia, Haynes, Barton F., Scheid, Johannes F., Nussenzweig, Michel C., Simek, Melissa, Burton, Dennis R., Koff, Wayne C., Mullikin, James C., Connors, Mark, Shapiro, Lawrence, Nabel, Gary J., Mascola, John R., Kwong, Peter D.
Published in Immunity (Cambridge, Mass.) (22.08.2013)
Published in Immunity (Cambridge, Mass.) (22.08.2013)
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Journal Article
Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies
Mouquet, Hugo, Scharf, Louise, Euler, Zelda, Liu, Yan, Eden, Caroline, Scheid, Johannes F., Halper-Stromberg, Ariel, Gnanapragasam, Priyanthi N. P., Spencer, Daniel I. R., Seaman, Michael S., Schuitemaker, Hanneke, Feizi, Ten, Nussenzweig, Michel C., Bjorkman, Pamela J.
Published in Proceedings of the National Academy of Sciences - PNAS (20.11.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (20.11.2012)
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Journal Article
Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bNAbs
Hoot, Sam, McGuire, Andrew T, Cohen, Kristen W, Strong, Roland K, Hangartner, Lars, Klein, Florian, Diskin, Ron, Scheid, Johannes F, Sather, D Noah, Burton, Dennis R, Stamatatos, Leonidas
Published in PLoS pathogens (01.01.2013)
Published in PLoS pathogens (01.01.2013)
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Journal Article
A robust pipeline for rapid production of versatile nanobody repertoires
Fridy, Peter C, Li, Yinyin, Keegan, Sarah, Thompson, Mary K, Nudelman, Ilona, Scheid, Johannes F, Oeffinger, Marlene, Nussenzweig, Michel C, Fenyö, David, Chait, Brian T, Rout, Michael P
Published in Nature methods (01.12.2014)
Published in Nature methods (01.12.2014)
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Journal Article
Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies
McGuire, Andrew T, Hoot, Sam, Dreyer, Anita M, Lippy, Adriana, Stuart, Andrew, Cohen, Kristen W, Jardine, Joseph, Menis, Sergey, Scheid, Johannes F, West, Anthony P, Schief, William R, Stamatatos, Leonidas
Published in The Journal of experimental medicine (08.04.2013)
Published in The Journal of experimental medicine (08.04.2013)
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Journal Article
Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117
Caskey, Marina, Klein, Florian, Lorenzi, Julio C. C., Seaman, Michael S., West, Anthony P., Buckley, Noreen, Kremer, Gisela, Nogueira, Lilian, Braunschweig, Malte, Scheid, Johannes F., Horwitz, Joshua A., Shimeliovich, Irina, Ben-Avraham, Sivan, Witmer-Pack, Maggi, Platten, Martin, Lehmann, Clara, Burke, Leah A., Hawthorne, Thomas, Gorelick, Robert J., Walker, Bruce D., Keler, Tibor, Gulick, Roy M., Fätkenheuer, Gerd, Schlesinger, Sarah J., Nussenzweig, Michel C.
Published in Nature (London) (25.06.2015)
Published in Nature (London) (25.06.2015)
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Journal Article
Antibody 8ANC195 Reveals a Site of Broad Vulnerability on the HIV-1 Envelope Spike
Scharf, Louise, Scheid, Johannes F., Lee, Jeong Hyun, West, Anthony P., Chen, Courtney, Gao, Han, Gnanapragasam, Priyanthi N.P., Mares, René, Seaman, Michael S., Ward, Andrew B., Nussenzweig, Michel C., Bjorkman, Pamela J.
Published in Cell reports (Cambridge) (01.05.2014)
Published in Cell reports (Cambridge) (01.05.2014)
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Journal Article
B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV
Scheid, Johannes F., Barnes, Christopher O., Eraslan, Basak, Hudak, Andrew, Keeffe, Jennifer R., Cosimi, Lisa A., Brown, Eric M., Muecksch, Frauke, Weisblum, Yiska, Zhang, Shuting, Delorey, Toni, Woolley, Ann E., Ghantous, Fadi, Park, Sung-Moo, Phillips, Devan, Tusi, Betsabeh, Huey-Tubman, Kathryn E., Cohen, Alexander A., Gnanapragasam, Priyanthi N.P., Rzasa, Kara, Hatziioanno, Theodora, Durney, Michael A., Gu, Xiebin, Tada, Takuya, Landau, Nathaniel R., West, Anthony P., Rozenblatt-Rosen, Orit, Seaman, Michael S., Baden, Lindsey R., Graham, Daniel B., Deguine, Jacques, Bieniasz, Paul D., Regev, Aviv, Hung, Deborah, Bjorkman, Pamela J., Xavier, Ramnik J.
Published in Cell (10.06.2021)
Published in Cell (10.06.2021)
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Antigen modification regulates competition of broad and narrow neutralizing HIV antibodies
McGuire, Andrew T., Dreyer, Anita M., Carbonetti, Sara, Lippy, Adriana, Glenn, Jolene, Scheid, Johannes F., Mouquet, Hugo, Stamatatos, Leonidas
Published in Science (American Association for the Advancement of Science) (12.12.2014)
Published in Science (American Association for the Advancement of Science) (12.12.2014)
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Journal Article
HIV therapy by a combination of broadly neutralizing antibodies in humanized mice
Klein, Florian, Halper-Stromberg, Ariel, Horwitz, Joshua A., Gruell, Henning, Scheid, Johannes F., Bournazos, Stylianos, Mouquet, Hugo, Spatz, Linda A., Diskin, Ron, Abadir, Alexander, Zang, Trinity, Dorner, Marcus, Billerbeck, Eva, Labitt, Rachael N., Gaebler, Christian, Marcovecchio, Paola M., Incesu, Reha-Baris, Eisenreich, Thomas R., Bieniasz, Paul D., Seaman, Michael S., Bjorkman, Pamela J., Ravetch, Jeffrey V., Ploss, Alexander, Nussenzweig, Michel C.
Published in Nature (London) (06.12.2012)
Published in Nature (London) (06.12.2012)
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Journal Article
Prolonged viral suppression with anti-HIV-1 antibody therapy
Gaebler, Christian, Nogueira, Lilian, Stoffel, Elina, Oliveira, Thiago Y., Breton, Gaëlle, Millard, Katrina G., Turroja, Martina, Butler, Allison, Ramos, Victor, Seaman, Michael S., Reeves, Jacqueline D., Petroupoulos, Christos J., Shimeliovich, Irina, Gazumyan, Anna, Jiang, Caroline S., Jilg, Nikolaus, Scheid, Johannes F., Gandhi, Rajesh, Walker, Bruce D., Sneller, Michael C., Fauci, Anthony, Chun, Tae-Wook, Caskey, Marina, Nussenzweig, Michel C.
Published in Nature (London) (09.06.2022)
Published in Nature (London) (09.06.2022)
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Journal Article
Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design
Diskin, Ron, Scheid, Johannes F., Marcovecchio, Paola M., West, Anthony P., Klein, Florian, Gao, Han, Gnanapragasam, Priyanthi N. P., Abadir, Alexander, Seaman, Michael S., Nussenzweig, Michel C., Bjorkman, Pamela J.
Published in Science (American Association for the Advancement of Science) (02.12.2011)
Published in Science (American Association for the Advancement of Science) (02.12.2011)
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Journal Article
Non-neutralizing Antibodies Alter the Course of HIV-1 Infection In Vivo
Horwitz, Joshua A., Bar-On, Yotam, Lu, Ching-Lan, Fera, Daniela, Lockhart, Ainsley A.K., Lorenzi, Julio C.C., Nogueira, Lilian, Golijanin, Jovana, Scheid, Johannes F., Seaman, Michael S., Gazumyan, Anna, Zolla-Pazner, Susan, Nussenzweig, Michel C.
Published in Cell (10.08.2017)
Published in Cell (10.08.2017)
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Journal Article
Broadly neutralizing antibodies that inhibit HIV-1 cell to cell transmission
Malbec, Marine, Porrot, Françoise, Rua, Rejane, Horwitz, Joshua, Klein, Florian, Halper-Stromberg, Ari, Scheid, Johannes F, Eden, Caroline, Mouquet, Hugo, Nussenzweig, Michel C, Schwartz, Olivier
Published in The Journal of experimental medicine (16.12.2013)
Published in The Journal of experimental medicine (16.12.2013)
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Journal Article
HIV-specific B cell response in patients with broadly neutralizing serum activity
Scheid, Johannes F
Published in Science (American Association for the Advancement of Science) (04.12.2015)
Published in Science (American Association for the Advancement of Science) (04.12.2015)
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Journal Article
Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding
Scheid, Johannes F., Mouquet, Hugo, Ueberheide, Beatrix, Diskin, Ron, Klein, Florian, Oliveira, Thiago Y. K., Pietzsch, John, Fenyo, David, Abadir, Alexander, Velinzon, Klara, Hurley, Arlene, Myung, Sunnie, Boulad, Farid, Poignard, Pascal, Burton, Dennis R., Pereyra, Florencia, Ho, David D., Walker, Bruce D., Seaman, Michael S., Bjorkman, Pamela J., Chait, Brian T., Nussenzweig, Michel C.
Published in Science (American Association for the Advancement of Science) (16.09.2011)
Published in Science (American Association for the Advancement of Science) (16.09.2011)
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