A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models
Singh, Dharaminder, Deosarkar, Sudhir P, Cadogan, Elaine, Flemington, Vikki, Bray, Alysha, Zhang, Jingwen, Reiserer, Ronald S, Schaffer, David K, Gerken, Gregory B, Britt, Clayton M, Werner, Erik M, Gibbons, Francis D, Kostrzewski, Tomasz, Chambers, Christopher E, Davies, Emma J, Montoya, Antonio Ramos, Fok, Jacqueline H L, Hughes, David, Fabre, Kristin, Wagoner, Matthew P, Wikswo, John P, Scott, Clay W
Published in PLoS biology (01.05.2022)
Published in PLoS biology (01.05.2022)
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Journal Article
Application of a Human Blood Brain Barrier Organ-on-a-Chip Model to Evaluate Small Molecule Effectiveness against Venezuelan Equine Encephalitis Virus
Boghdeh, Niloufar A, Risner, Kenneth H, Barrera, Michael D, Britt, Clayton M, Schaffer, David K, Alem, Farhang, Brown, Jacquelyn A, Wikswo, John P, Narayanan, Aarthi
Published in Viruses (01.12.2022)
Published in Viruses (01.12.2022)
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Journal Article
Gravity-perfused airway-on-a-chip optimized for quantitative BSL-3 studies of SARS-CoV-2 infection: barrier permeability, cytokine production, immunohistochemistry, and viral load assays
Faley, Shannon L, Boghdeh, Niloufar A, Schaffer, David K, Spivey, Eric C, Alem, Farhang, Narayanan, Aarthi, Wikswo, John P, Brown, Jacquelyn A
Published in Lab on a chip (12.03.2024)
Published in Lab on a chip (12.03.2024)
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Journal Article
Engineering Challenges for Instrumenting and Controlling Integrated Organ-on-Chip Systems
Wikswo, John P., Reiserer, Ronald S., Samson, Philip C., Schaffer, David K., Seale, Kevin T., Sherrod, Stacy D., Block III, Frank E., Cliffel, David E., Goodwin, Cody R., Marasco, Christina C., Markov, Dmitry A., McLean, David L., McLean, John A., McKenzie, Jennifer R.
Published in IEEE transactions on biomedical engineering (01.03.2013)
Published in IEEE transactions on biomedical engineering (01.03.2013)
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Journal Article
A bistable, multiport valve enables microformulators creating microclinical analyzers that reveal aberrant glutamate metabolism in astrocytes derived from a tuberous sclerosis patient
Miller, Dusty R., Schaffer, David K., Neely, M. Diana, McClain, Ethan S., Travis, Adam R., Block, Frank E., McKenzie, Jennifer R., Werner, Erik M., Armstrong, Laura, Markov, Dmitry A., Bowman, Aaron B., Ess, Kevin C., Cliffel, David E., Wikswo, John P.
Published in Sensors and actuators. B, Chemical (15.08.2021)
Published in Sensors and actuators. B, Chemical (15.08.2021)
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Journal Article
Microfluidic platform for real-time signaling analysis of multiple single T cells in parallel
Faley, Shannon, Seale, Kevin, Hughey, Jacob, Schaffer, David K, VanCompernolle, Scott, McKinney, Brett, Baudenbacher, Franz, Unutmaz, Derya, Wikswo, John P
Published in Lab on a chip (2008)
Published in Lab on a chip (2008)
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Journal Article
Engineered microfluidic bioreactor for examining the three-dimensional breast tumor microenvironment
Rogers, Matthew, Sobolik, Tammy, Schaffer, David K., Samson, Philip C., Johnson, Andrew C., Owens, Philip, Codreanu, Simona G., Sherrod, Stacy D., McLean, John A., Wikswo, John P., Richmond, Ann
Published in Biomicrofluidics (01.05.2018)
Published in Biomicrofluidics (01.05.2018)
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Journal Article
Thin-film IrOx pH microelectrode for microfluidic-based microsystems
GES, Igor A, IVANOV, Borislav L, SCHAFFER, David K, LIMA, Eduardo A, WERDICH, Andreas A, BAUDENBACHER, Franz J
Published in Biosensors & bioelectronics (15.08.2005)
Published in Biosensors & bioelectronics (15.08.2005)
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Journal Article
A metering rotary nanopump for microfluidic systems
Darby, Scott G, Moore, Matthew R, Friedlander, Troy A, Schaffer, David K, Reiserer, Ron S, Wikswo, John P, Seale, Kevin T
Published in Lab on a chip (07.12.2010)
Published in Lab on a chip (07.12.2010)
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Journal Article
Development of novel murine mammary imaging windows to examine wound healing effects on leukocyte trafficking in mammary tumors with intravital imaging
Sobolik, Tammy, Su, Ying-Jun, Ashby, Will, Schaffer, David K., Wells, Sam, Wikswo, John P., Zijlstra, Andries, Richmond, Ann
Published in Intravital (02.01.2016)
Published in Intravital (02.01.2016)
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Journal Article
A pulsed source-sink fluid mixing device
Cola, B.A., Schaffer, D.K., Fisher, T.S., Stremler, M.A.
Published in Journal of microelectromechanical systems (01.02.2006)
Published in Journal of microelectromechanical systems (01.02.2006)
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Journal Article
Thin-film IrO sub()xpH microelectrode for microfluidic-based microsystems
Ges, Igor A, Ivanov, Borislav L, Schaffer, David K, Lima, Eduardo A, Werdich, Andreas A, Baudenbacher, Franz J
Published in Biosensors & bioelectronics (01.08.2005)
Published in Biosensors & bioelectronics (01.08.2005)
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Journal Article
Continuous automated perfusion culture analysis system (CAPCAS) and applications of same
Schaffer, David K, Reiserer, Ronald S, Gerken, Gregory B, Wikswo, John P
Year of Publication 26.03.2024
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Year of Publication 26.03.2024
Patent
Massively parallel, multiple-organ perfusion control system
Schaffer, David K, Reiserer, Ronald S, Gerken, Gregory B, Wikswo, John P
Year of Publication 05.09.2023
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Year of Publication 05.09.2023
Patent
MICROFLUIDIC SYSTEMS FOR MULTIPLE BIOREACTORS AND APPLICATIONS OF SAME
Schaffer, David K, Geuy, Michael D, Reiserer, Ronald S, Wikswo, John P
Year of Publication 31.08.2023
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Year of Publication 31.08.2023
Patent
MICROFLUIDIC SYSTEMS FOR MULTIPLE BIOREACTORS AND APPLICATIONS OF SAME
WIKSWO, John P, SCHAFFER, David K, REISERER, Ronald S, GEUY, Michael D
Year of Publication 24.05.2023
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Year of Publication 24.05.2023
Patent
MASSIVELY PARALLEL, MULTIPLE-ORGAN PERFUSION CONTROL SYSTEM
Schaffer, David K, Reiserer, Ronald S, Gerken, Gregory B, Wikswo, John P
Year of Publication 20.04.2023
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Year of Publication 20.04.2023
Patent