Development of a ligand for in vivo imaging of mutant huntingtin in Huntington's disease
Bertoglio, Daniele, Bard, Jonathan, Hessmann, Manuela, Liu, Longbin, Gärtner, Annette, De Lombaerde, Stef, Huscher, Britta, Zajicek, Franziska, Miranda, Alan, Peters, Finn, Herrmann, Frank, Schaertl, Sabine, Vasilkovska, Tamara, Brown, Christopher J, Johnson, Peter D, Prime, Michael E, Mills, Matthew R, Van der Linden, Annemie, Mrzljak, Ladislav, Khetarpal, Vinod, Wang, Yuchuan, Marchionini, Deanna M, Skinbjerg, Mette, Verhaeghe, Jeroen, Dominguez, Celia, Staelens, Steven, Munoz-Sanjuan, Ignacio
Published in Science translational medicine (02.02.2022)
Published in Science translational medicine (02.02.2022)
Get more information
Journal Article
A Novel and Cross-Species Active Mammalian INDY (NaCT) Inhibitor Ameliorates Hepatic Steatosis in Mice with Diet-Induced Obesity
Zahn, Grit, Willmes, Diana M, El-Agroudy, Nermeen N, Yarnold, Christopher, Jarjes-Pike, Richard, Schaertl, Sabine, Schreiter, Kay, Gehrmann, Wiebke, Wong, Andrea Kuan Cie, Zordan, Tommaso, König, Jörg, Jordan, Jens, Birkenfeld, Andreas L
Published in Metabolites (01.08.2022)
Published in Metabolites (01.08.2022)
Get full text
Journal Article
A Profiling Platform for the Characterization of Transglutaminase 2 (TG2) Inhibitors
Schaertl, Sabine, Prime, Michael, Wityak, John, Dominguez, Celia, Munoz-Sanjuan, Ignacio, Pacifici, Robert E., Courtney, Stephen, Scheel, Andreas, Macdonald, Douglas
Published in Journal of biomolecular screening (01.06.2010)
Published in Journal of biomolecular screening (01.06.2010)
Get full text
Journal Article
Exploiting differences in caspase-2 and -3 S₂ subsites for selectivity: Structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors
Maillard, Michel C, Brookfield, Frederick A, Courtney, Stephen M, Eustache, Florence M, Gemkow, Mark J, Handel, Rebecca K, Johnson, Laura C, Johnson, Peter D, Kerry, Mark A, Krieger, Florian, Meniconi, Mirco, Muñoz-Sanjuán, Ignacio, Palfrey, Jordan J, Park, Hyunsun, Schaertl, Sabine, Taylor, Malcolm G, Weddell, Derek, Dominguez, Celia
Published in Bioorganic & medicinal chemistry (01.10.2011)
Published in Bioorganic & medicinal chemistry (01.10.2011)
Get full text
Journal Article
Novel MK2 inhibitors by fragment screening
Keminer, Oliver, Kraemer, Joachim, Kahmann, Jan, Sternberger, Ina, Scheich, Christoph, Jungmann, Joern, Schaert, Sabine, Winkler, Dirk, Ichihara, Osamu, Whittaker, Mark, Ullmann, Dirk, Hesterkamp, Thomas
Published in Combinatorial chemistry & high throughput screening (01.08.2009)
Published in Combinatorial chemistry & high throughput screening (01.08.2009)
Get more information
Journal Article
A Point Mutation of Human Nucleoside Diphosphate Kinase A Found in Aggressive Neuroblastoma Affects Protein Folding
Lascu, Ioan, Schaertl, Sabine, Wang, Chanquing, Sarger, Claude, Giartosio, Anna, Briand, Gilberd, Lacombe, Marie-Lise, Konrad, Manfred
Published in The Journal of biological chemistry (20.06.1997)
Published in The Journal of biological chemistry (20.06.1997)
Get full text
Journal Article
Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand
Liu, Longbin, Prime, Michael E, Lee, Matt R, Khetarpal, Vinod, Brown, Christopher J, Johnson, Peter D, Miranda-Azpiazu, Patricia, Chen, Xuemei, Clark-Frew, Daniel, Coe, Samuel, Davis, Randall, Dickie, Anthony, Ebneth, Andreas, Esposito, Simone, Gadouleau, Elise, Gai, Xinjie, Galan, Sebastien, Green, Samantha, Greenaway, Catherine, Giles, Paul, Halldin, Christer, Hayes, Sarah, Herbst, Todd, Herrmann, Frank, Heßmann, Manuela, Jia, Zhisheng, Kiselyov, Alexander, Kotey, Adrian, Krulle, Thomas, Mangette, John E, Marston, Richard W, Menta, Sergio, Mills, Matthew R, Monteagudo, Edith, Nag, Sangram, Nibbio, Martina, Orsatti, Laura, Schaertl, Sabine, Scheich, Christoph, Sproston, Joanne, Stepanov, Vladimir, Svedberg, Marie, Takano, Akihiro, Taylor, Malcolm, Thomas, Wayne, Toth, Miklós, Vaidya, Darshan, Vanräs, Katarina, Weddell, Derek, Wigginton, Ian, Wityak, John, Mrzljak, Ladislav, Munoz-Sanjuan, Ignacio, Bard, Jonathan A, Dominguez, Celia
Published in Journal of medicinal chemistry (13.08.2020)
Published in Journal of medicinal chemistry (13.08.2020)
Get full text
Journal Article
Experiences in implementing uHTS--cutting edge technology meets the real world
Gribbon, Philip, Schaertl, Sabine, Wickenden, Malcolm, Williams, Gareth, Grimley, Rachel, Stuhmeier, Frank, Preckel, Hartwig, Eggeling, Christian, Kraemer, Joachim, Everett, Jeremy, Keighley, Wilma W, Sewing, Andreas
Published in Current drug discovery technologies (01.01.2004)
Published in Current drug discovery technologies (01.01.2004)
Get more information
Journal Article
Design and Evaluation of [18F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin Aggregates
Liu, Longbin, Johnson, Peter D., Prime, Michael E., Khetarpal, Vinod, Brown, Christopher J., Anzillotti, Luca, Bertoglio, Daniele, Chen, Xuemei, Coe, Samuel, Davis, Randall, Dickie, Anthony P., Esposito, Simone, Gadouleau, Elise, Giles, Paul R., Greenaway, Catherine, Haber, James, Halldin, Christer, Haller, Scott, Hayes, Sarah, Herbst, Todd, Herrmann, Frank, Heßmann, Manuela, Hsai, Ming Min, Khani, Yaser, Kotey, Adrian, Lembo, Angelo, Mangette, John E., Marriner, Gwendolyn A., Marston, Richard W., Mills, Matthew R., Monteagudo, Edith, Forsberg-Morén, Anton, Nag, Sangram, Orsatti, Laura, Sandiego, Christine, Schaertl, Sabine, Sproston, Joanne, Staelens, Steven, Tookey, Jack, Turner, Penelope A., Vecchi, Andrea, Veneziano, Maria, Muñoz-Sanjuan, Ignacio, Bard, Jonathan, Dominguez, Celia
Published in Journal of medicinal chemistry (12.01.2023)
Published in Journal of medicinal chemistry (12.01.2023)
Get full text
Journal Article
Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates
Herrmann, Frank, Hessmann, Manuela, Schaertl, Sabine, Berg-Rosseburg, Karola, Brown, Christopher J, Bursow, Galina, Chiki, Anass, Ebneth, Andreas, Gehrmann, Miriam, Hoeschen, Nicole, Hotze, Madlen, Jahn, Stefanie, Johnson, Peter D, Khetarpal, Vinod, Kiselyov, Alex, Kottig, Karsten, Ladewig, Stefanie, Lashuel, Hilal, Letschert, Sven, Mills, Matthew R, Petersen, Kathrin, Prime, Michael E, Scheich, Christoph, Schmiedel, Gerhard, Wityak, John, Liu, Longbin, Dominguez, Celia, Muñoz-Sanjuán, Ignacio, Bard, Jonathan A
Published in Scientific reports (09.09.2021)
Published in Scientific reports (09.09.2021)
Get full text
Journal Article
Discovery and Structure–Activity Relationship of Potent and Selective Covalent Inhibitors of Transglutaminase 2 for Huntington’s Disease
Prime, Michael E, Andersen, Ole A, Barker, John J, Brooks, Mark A, Cheng, Robert K. Y, Toogood-Johnson, Ian, Courtney, Stephen M, Brookfield, Frederick A, Yarnold, Christopher J, Marston, Richard W, Johnson, Peter D, Johnsen, Siw F, Palfrey, Jordan J, Vaidya, Darshan, Erfan, Sayeh, Ichihara, Osamu, Felicetti, Brunella, Palan, Shilpa, Pedret-Dunn, Anna, Schaertl, Sabine, Sternberger, Ina, Ebneth, Andreas, Scheel, Andreas, Winkler, Dirk, Toledo-Sherman, Leticia, Beconi, Maria, Macdonald, Douglas, Muñoz-Sanjuan, Ignacio, Dominguez, Celia, Wityak, John
Published in Journal of medicinal chemistry (09.02.2012)
Published in Journal of medicinal chemistry (09.02.2012)
Get full text
Journal Article
Exploiting differences in caspase-2 and -3 S 2 subsites for selectivity: Structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors
Maillard, Michel C., Brookfield, Frederick A., Courtney, Stephen M., Eustache, Florence M., Gemkow, Mark J., Handel, Rebecca K., Johnson, Laura C., Johnson, Peter D., Kerry, Mark A., Krieger, Florian, Meniconi, Mirco, Muñoz-Sanjuán, Ignacio, Palfrey, Jordan J., Park, Hyunsun, Schaertl, Sabine, Taylor, Malcolm G., Weddell, Derek, Dominguez, Celia
Published in Bioorganic & medicinal chemistry (01.10.2011)
Published in Bioorganic & medicinal chemistry (01.10.2011)
Get full text
Journal Article
SAR Development of Lysine-Based Irreversible Inhibitors of Transglutaminase 2 for Huntington's Disease
Wityak, John, Prime, Michael E, Brookfield, Frederick A, Courtney, Stephen M, Erfan, Sayeh, Johnsen, Siw, Johnson, Peter D, Li, Marie, Marston, Richard W, Reed, Laura, Vaidya, Darshan, Schaertl, Sabine, Pedret-Dunn, Anna, Beconi, Maria, Macdonald, Douglas, Muñoz-Sanjuan, Ignacio, Dominguez, Celia
Published in ACS medicinal chemistry letters (13.12.2012)
Published in ACS medicinal chemistry letters (13.12.2012)
Get full text
Journal Article
A label-free LC/MS/MS-based enzymatic activity assay for the detection of genuine caspase inhibitors and SAR development
Maillard, Michel C, Dominguez, Celia, Gemkow, Mark J, Krieger, Florian, Park, Hyunsun, Schaertl, Sabine, Winkler, Dirk, Muñoz-Sanjuán, Ignacio
Published in Journal of biomolecular screening (01.09.2013)
Published in Journal of biomolecular screening (01.09.2013)
Get full text
Journal Article
Irreversible 4‑Aminopiperidine Transglutaminase 2 Inhibitors for Huntington's Disease
Prime, Michael E, Brookfield, Frederick A, Courtney, Stephen M, Gaines, Simon, Marston, Richard W, Ichihara, Osamu, Li, Marie, Vaidya, Darshan, Williams, Helen, Pedret-Dunn, Anna, Reed, Laura, Schaertl, Sabine, Toledo-Sherman, Leticia, Beconi, Maria, Macdonald, Douglas, Muñoz-Sanjuan, Ignacio, Dominguez, Celia, Wityak, John
Published in ACS medicinal chemistry letters (13.09.2012)
Published in ACS medicinal chemistry letters (13.09.2012)
Get full text
Journal Article
Exploiting differences in caspase-2 and -3 S sub(2 subsites for selectivity: Structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors)
Maillard, Michel C, Brookfield, Frederick A, Courtney, Stephen M, Eustache, Florence M, Gemkow, Mark J, Handel, Rebecca K, Johnson, Laura C, Johnson, Peter D, Kerry, Mark A, Krieger, Florian, Meniconi, Mirco, Munoz-Sanjuan, Ignacio, Palfrey, Jordan J, Park, Hyunsun, Schaertl, Sabine, Taylor, Malcolm G, Weddell, Derek, Dominguez, Celia
Published in Bioorganic & medicinal chemistry (01.10.2011)
Published in Bioorganic & medicinal chemistry (01.10.2011)
Get full text
Journal Article
CITRATE TRANSPORTER MODULATORS AND USES THEREOF
CRAFT, Russell, KHOR, Someina, ZAHN, Grit, SCHREITER, Kay, SCHAERTL, Sabine, BROMIDGE, Steven Mark, YARNOLD, Christopher John, JARJES-PIKE, Richard
Year of Publication 03.08.2023
Get full text
Year of Publication 03.08.2023
Patent