Treatment with a VEGFR-2 antibody results in intra-tumor immune modulation and enhances anti-tumor efficacy of PD-L1 blockade in syngeneic murine tumor models
Li, Yanxia, Amaladas, Nelusha, O'Mahony, Marguerita, Manro, Jason R, Inigo, Ivan, Li, Qi, Rasmussen, Erik R, Brahmachary, Manisha, Doman, Thompson N, Hall, Gerald, Kalos, Michael, Novosiadly, Ruslan, Puig, Oscar, Pytowski, Bronislaw, Schaer, David A
Published in PloS one (18.07.2022)
Published in PloS one (18.07.2022)
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Journal Article
The CDK4/6 Inhibitor Abemaciclib Induces a T Cell Inflamed Tumor Microenvironment and Enhances the Efficacy of PD-L1 Checkpoint Blockade
Schaer, David A., Beckmann, Richard P., Dempsey, Jack A., Huber, Lysiane, Forest, Amelie, Amaladas, Nelusha, Li, Yanxia, Wang, Ying Cindy, Rasmussen, Erik R., Chin, Darin, Capen, Andrew, Carpenito, Carmine, Staschke, Kirk A., Chung, Linda A., Litchfield, Lacey M., Merzoug, Farhana F., Gong, Xueqian, Iversen, Philip W., Buchanan, Sean, de Dios, Alfonso, Novosiadly, Ruslan D., Kalos, Michael
Published in Cell reports (Cambridge) (13.03.2018)
Published in Cell reports (Cambridge) (13.03.2018)
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Journal Article
Modulation of GITR for cancer immunotherapy
Schaer, David A, Murphy, Judith T, Wolchok, Jedd D
Published in Current opinion in immunology (01.04.2012)
Published in Current opinion in immunology (01.04.2012)
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Journal Article
Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade
Holmgaard, Rikke B, Schaer, David A, Li, Yanxia, Castaneda, Stephen P, Murphy, Mary Y, Xu, Xiaohong, Inigo, Ivan, Dobkin, Julie, Manro, Jason R, Iversen, Philip W, Surguladze, David, Hall, Gerald E, Novosiadly, Ruslan D, Benhadji, Karim A, Plowman, Gregory D, Kalos, Michael, Driscoll, Kyla E
Published in Journal for immunotherapy of cancer (04.06.2018)
Published in Journal for immunotherapy of cancer (04.06.2018)
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Journal Article
Agonist anti-GITR monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulation
Cohen, Adam D, Schaer, David A, Liu, Cailian, Li, Yanyun, Hirschhorn-Cymmerman, Daniel, Kim, Soo Chong, Diab, Adi, Rizzuto, Gabrielle, Duan, Fei, Perales, Miguel A, Merghoub, Taha, Houghton, Alan N, Wolchok, Jedd D
Published in PloS one (03.05.2010)
Published in PloS one (03.05.2010)
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Journal Article
Targeting tumor-necrosis factor receptor pathways for tumor immunotherapy
Schaer, David A, Hirschhorn-Cymerman, Daniel, Wolchok, Jedd D
Published in Journal for Immunotherapy of Cancer (15.04.2014)
Published in Journal for Immunotherapy of Cancer (15.04.2014)
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Journal Article
Book Review
Detection of intra-tumor self antigen recognition during melanoma tumor progression in mice using advanced multimode confocal/two photon microscope
Schaer, David A, Li, Yongbiao, Merghoub, Taha, Rizzuto, Gabrielle A, Shemesh, Amos, Cohen, Adam D, Li, Yanyun, Avogadri, Francesca, Toledo-Crow, Ricardo, Houghton, Alan N, Wolchok, Jedd D
Published in PloS one (22.06.2011)
Published in PloS one (22.06.2011)
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Journal Article
Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment
Budhu, Sadna, Schaer, David A, Li, Yongbiao, Toledo-Crow, Ricardo, Panageas, Katherine, Yang, Xia, Zhong, Hong, Houghton, Alan N, Silverstein, Samuel C, Merghoub, Taha, Wolchok, Jedd D
Published in Science signaling (29.08.2017)
Published in Science signaling (29.08.2017)
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Journal Article
The Folate Pathway Inhibitor Pemetrexed Pleiotropically Enhances Effects of Cancer Immunotherapy
Schaer, David A, Geeganage, Sandaruwan, Amaladas, Nelusha, Lu, Zhao Hai, Rasmussen, Erik R, Sonyi, Andreas, Chin, Darin, Capen, Andrew, Li, Yanxia, Meyer, Catalina M, Jones, Bonita D, Huang, Xiaodong, Luo, Shuang, Carpenito, Carmine, Roth, Kenneth D, Nikolayev, Alexander, Tan, Bo, Brahmachary, Manisha, Chodavarapu, Krishna, Dorsey, Frank C, Manro, Jason R, Doman, Thompson N, Donoho, Gregory P, Surguladze, David, Hall, Gerald E, Kalos, Michael, Novosiadly, Ruslan D
Published in Clinical cancer research (01.12.2019)
Published in Clinical cancer research (01.12.2019)
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Journal Article
GITR pathway activation abrogates tumor immune suppression through loss of regulatory T cell lineage stability
Schaer, David A, Budhu, Sadna, Liu, Cailian, Bryson, Campbell, Malandro, Nicole, Cohen, Adam, Zhong, Hong, Yang, Xia, Houghton, Alan N, Merghoub, Taha, Wolchok, Jedd D
Published in Cancer immunology research (01.11.2013)
Published in Cancer immunology research (01.11.2013)
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Journal Article
Hiding the road signs that lead to tumor immunity
Schaer, David A, Lesokhin, Alexander M, Wolchok, Jedd D
Published in The Journal of experimental medicine (26.09.2011)
Published in The Journal of experimental medicine (26.09.2011)
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Journal Article
FcγRIIIa-dependent IFN-γ release in whole blood assay is predictive of therapeutic IgG1 antibodies safety
Alakhras, Nada S, Qiu, Jiabin, Rocha, Guilherme V, Witcher, Derrick R, Koester, Anja, You, Jinsam, Schaer, David A, Holmgaard, Rikke B, Driscoll, Kyla, Willy, Jeffrey A, Malherbe, Laurent P
Published in mAbs (18.08.2018)
Published in mAbs (18.08.2018)
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Journal Article
Calcitonin Gene-Related Peptide Decreases Expression of HLA-DR and CD86 by Human Dendritic Cells and Dampens Dendritic Cell-Driven T Cell-Proliferative Responses Via the Type I Calcitonin Gene-Related Peptide Receptor
Carucci, John A, Ignatius, Ralf, Wei, Yang, Cypess, Aaron M, Schaer, David A, Pope, Melissa, Steinman, Ralph M, Mojsov, Svetlana
Published in The Journal of immunology (1950) (01.04.2000)
Published in The Journal of immunology (1950) (01.04.2000)
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Journal Article
First-in-human phase 1 single-dose study of TRX-518, an anti-human glucocorticoid-induced tumor necrosis factor receptor (GITR) monoclonal antibody in adults with advanced solid tumors
Koon, Henry B., Shepard, Dale Randall, Merghoub, Taha, Schaer, David A., Sirard, Cynthia A., Wolchok, Jedd D.
Published in Journal of clinical oncology (20.05.2016)
Published in Journal of clinical oncology (20.05.2016)
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Journal Article
Abstract 3632: Combination of EGFR antibody with PD-1 pathway inhibitors improves anti-tumor efficacy and enhances intra-tumor immune response in preclinical mouse tumor models
Kandaswamy, Veena, Forest, Amelie, Deroose, Marianne, Schaer, David A., Chen, Ting, Liu, Shengwu, Surguladze, David, Yao, Yung-mae, Doman, Thompson, Hall, Gerald, Wong, Kwok-Kin, Kalos, Michael, Novosiadly, Ruslan D.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 3945: The folate pathway inhibitor pemetrexed pleiotropically enhances effects of cancer immunotherapy via immunogenic tumor cell death and T cell-intrinsic mechanisms
Schaer, David A., Amaladas, Nelusha, Lu, Zhao Hai, Rasmussen, Erik, Sonyi, Andreas, Chin, Darin, Capen, Andrew, Li, Yanxia, Meyer, Catalina, Jones, Bonita, Hong, Xiaodong, Luo, Shuang, Carpenito, Carmine, Roth, Kenneth, Nikolayev, Alexander, Tan, Bo, Brahmachary, Manisha, Chodavarapu, Krishna, Dorsey, Frank Charles, Manro, Jason, Doman, Thompson, Donoho, Greg, Surguladze, David, Hall, Gerald, Geeganage, Sandaruwan, Kalos, Michael, Novosiadly, Ruslan
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract CT018: Intratumor and peripheral Treg modulation as a pharmacodynamic biomarker of the GITR agonist antibody TRX-518 in the first in-human trial
Zappasodi, Roberta, Li, Yanyun, Abu-Akeel, Mohsen, Qi, Jingjing, Wong, Philip, Sirard, Cynthia, Postow, Michael, Schaer, David A., Newman, Walter, Koon, Henry, Velcheti, Vamsidhar, Callahan, Margaret K., Wolchok, Jedd D., Merghoub, Taha
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Abstract 583: The CDK4/6 inhibitor abemaciclib induces synergistic immune activation and antitumor efficacy in combination with PD-L1 blockade
Dempsey, Jack, Huber, Lysiane, Forest, Amelie, Stephens, Jennifer R., Doman, Thompson N., Manro, Jason, Capen, Andrew, Flack, Robert S., Donoho, Gregory P., Buchanan, Sean, Dios, Alfonso De, Driscoll, Kyla, Kalos, Michael, Novosiadly, Ruslan, Beckmann, Richard P., Schaer, David A.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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