Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1
Biondi, Ricardo M, Hindie, Valerie, Stroba, Adriana, Zhang, Hua, Lopez-Garcia, Laura A, Idrissova, Leila, Zeuzem, Stefan, Hirschberg, Daniel, Schaeffer, Francis, Jørgensen, Thomas J D, Engel, Matthias, Alzari, Pedro M
Published in Nature chemical biology (01.10.2009)
Published in Nature chemical biology (01.10.2009)
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Molecular Recognition and Interfacial Catalysis by the Essential Phosphatidylinositol Mannosyltransferase PimA from Mycobacteria
Guerin, Marcelo E., Kordulakova, Jana, Schaeffer, Francis, Svetlikova, Zuzana, Buschiazzo, Alejandro, Giganti, David, Gicquel, Brigitte, Mikusova, Katarina, Jackson, Mary, Alzari, Pedro M.
Published in The Journal of biological chemistry (13.07.2007)
Published in The Journal of biological chemistry (13.07.2007)
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Structural basis for feed-forward transcriptional regulation of membrane lipid homeostasis in Staphylococcus aureus
Albanesi, Daniela, Reh, Georgina, Guerin, Marcelo E, Schaeffer, Francis, Debarbouille, Michel, Buschiazzo, Alejandro, Schujman, Gustavo E, de Mendoza, Diego, Alzari, Pedro M
Published in PLoS pathogens (01.01.2013)
Published in PLoS pathogens (01.01.2013)
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Structural basis of lipid biosynthesis regulation in Gram-positive bacteria
Schujman, Gustavo E, Guerin, Marcelo, Buschiazzo, Alejandro, Schaeffer, Francis, Llarrull, Leticia I, Reh, Georgina, Vila, Alejandro J, Alzari, Pedro M, de Mendoza, Diego
Published in The EMBO journal (06.09.2006)
Published in The EMBO journal (06.09.2006)
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Remodeling a DNA-binding protein as a specific in vivo inhibitor of bacterial secretin PulD
Mouratou, Barbara, Schaeffer, Francis, Guilvout, Ingrid, Tello-Manigne, Diana, Pugsley, Anthony P, Alzari, Pedro M, Pecorari, Frédéric
Published in Proceedings of the National Academy of Sciences - PNAS (13.11.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (13.11.2007)
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Crystal Structure, Catalytic Mechanism, and Mitogenic Properties of Trypanosoma Cruzi Proline Racemase
Buschiazzo, Alejandro, Goytia, Maira, Schaeffer, Francis, Degrave, Wim, Shepard, William, Grégoire, Christophe, Chamond, Nathalie, Cosson, Alain, Berneman, Armand, Coatnoan, Nicolas, Alzari, Pedro M., Minoprio, Paola
Published in Proceedings of the National Academy of Sciences - PNAS (07.02.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (07.02.2006)
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A Novel Role of Malonyl-ACP in Lipid Homeostasis
Martinez, Mariano A, Zaballa, María-Eugenia, Schaeffer, Francis, Bellinzoni, Marco, Albanesi, Daniela, Schujman, Gustavo E, Vila, Alejandro J, Alzari, Pedro M, de Mendoza, Diego
Published in Biochemistry (Easton) (13.04.2010)
Published in Biochemistry (Easton) (13.04.2010)
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Substrate-induced Conformational Changes in the Essential Peripheral Membrane-associated Mannosyltransferase PimA from Mycobacteria
Guerin, Marcelo E., Schaeffer, Francis, Chaffotte, Alain, Gest, Petra, Giganti, David, Korduláková, Jana, van der Woerd, Mark, Jackson, Mary, Alzari, Pedro M.
Published in The Journal of biological chemistry (07.08.2009)
Published in The Journal of biological chemistry (07.08.2009)
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Calorimetric and Crystallographic Analysis of the Oligomeric Structure of Escherichia coli GMP Kinase
Hible, Guillaume, Renault, Louis, Schaeffer, Francis, Christova, Petya, Zoe Radulescu, Adriana, Evrin, Cécile, Gilles, Anne-Marie, Cherfils, Jacqueline
Published in Journal of molecular biology (07.10.2005)
Published in Journal of molecular biology (07.10.2005)
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Pseudo-native Motifs in the Noncovalent Heme-Apocytochrome c Complex
Goldberg, Michel E., Schaeffer, Francis, Guillou, Yvonne, Djavadi-Ohaniance, Lisa
Published in The Journal of biological chemistry (04.06.1999)
Published in The Journal of biological chemistry (04.06.1999)
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3,5-Diphenylpent-2-enoic Acids as Allosteric Activators of the Protein Kinase PDK1: Structure-Activity Relationships and Thermodynamic Characterization of Binding as Paradigms for PIF-Binding Pocket-Targeting Compounds
Stroba, Adriana, Schaeffer, Francis, Hindie, Valerie, Lopez-Garcia, Laura, Adrian, Iris, Froehner, Wolfgang, Hartmann, Rolf W., Biondi, Ricardo M., Engel, Matthias
Published in Journal of medicinal chemistry (13.08.2009)
Published in Journal of medicinal chemistry (13.08.2009)
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Journal Article
Allosteric activation of the protein kinase PDK1 with low molecular weight compounds
Engel, Matthias, Hindie, Valerie, Lopez-Garcia, Laura A, Stroba, Adriana, Schaeffer, Francis, Adrian, Iris, Imig, Jochen, Idrissova, Leila, Nastainczyk, Wolfgang, Zeuzem, Stefan, Alzari, Pedro M, Hartmann, Rolf W, Piiper, Albrecht, Biondi, Ricardo M
Published in The EMBO journal (29.11.2006)
Published in The EMBO journal (29.11.2006)
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Journal Article
Substrate-induced Conformational Changes in the Essential Peripheral Membrane-associated Mannosyltransferase PimA from Mycobacteria: IMPLICATIONS FOR CATALYSIS
Guerin, Marcelo E, Schaeffer, Francis, Chaffotte, Alain, Gest, Petra, Giganti, David, Korduláková, Jana, van der Woerd, Mark, Jackson, Mary, Alzari, Pedro M
Published in The Journal of biological chemistry (07.08.2009)
Published in The Journal of biological chemistry (07.08.2009)
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Mechanistic Insights into the Retaining Glucosyl-3-phosphoglycerate Synthase from Mycobacteria
Urresti, Saioa, Albesa-Jové, David, Schaeffer, Francis, Pham, Ha T., Kaur, Devinder, Gest, Petra, van der Woerd, Mark J., Carreras-González, Ana, López-Fernández, Sonia, Alzari, Pedro M., Brennan, Patrick J., Jackson, Mary, Guerin, Marcelo E.
Published in The Journal of biological chemistry (13.07.2012)
Published in The Journal of biological chemistry (13.07.2012)
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Journal Article
3,5-Diphenylpent-2-enoic Acids as Allosteric Activators of the Protein Kinase PDK1: Structure−Activity Relationships and Thermodynamic Characterization of Binding as Paradigms for PIF-Binding Pocket-Targeting Compounds†PDB code of 2Z with PDK1: 3HRF
Stroba, Adriana, Schaeffer, Francis, Hindie, Valerie, Lopez-Garcia, Laura, Adrian, Iris, Fröhner, Wolfgang, Hartmann, Rolf W., Biondi, Ricardo M., Engel, Matthias
Published in Journal of medicinal chemistry (13.08.2009)
Published in Journal of medicinal chemistry (13.08.2009)
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Duplicated Dockerin Subdomains of Clostridium thermocellum Endoglucanase CelD Bind to a Cohesin Domain of the Scaffolding Protein CipA with Distinct Thermodynamic Parameters and a Negative Cooperativity
Schaeffer, Francis, Matuschek, Markus, Guglielmi, Gérard, Miras, Isabelle, Alzari, Pedro M, Béguin, Pierre
Published in Biochemistry (Easton) (19.02.2002)
Published in Biochemistry (Easton) (19.02.2002)
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The crystal structure of M. leprae ML2640c defines a large family of putative S‐adenosylmethionine‐dependent methyltransferases in mycobacteria
Graña, Martin, Haouz, Ahmed, Buschiazzo, Alejandro, Miras, Isabelle, Wehenkel, Annemarie, Bondet, Vincent, Shepard, William, Schaeffer, Francis, Cole, Stewart T., Alzari, Pedro M.
Published in Protein science (01.09.2007)
Published in Protein science (01.09.2007)
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