Antimicrobial Resistance Trends in Urine Escherichia coli Isolates From Adult and Adolescent Females in the United States From 2011 to 2019: Rising ESBL Strains and Impact on Patient Management
Kaye, Keith S, Gupta, Vikas, Mulgirigama, Aruni, Joshi, Ashish V, Scangarella-Oman, Nicole E, Yu, Kalvin, Ye, Gang, Mitrani-Gold, Fanny S
Published in Clinical infectious diseases (06.12.2021)
Published in Clinical infectious diseases (06.12.2021)
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Older patient age and prior antimicrobial use strongly predict antimicrobial resistance in Escherichia coli isolates recovered from urinary tract infections among female outpatients
Mitrani-Gold, Fanny S, Kaye, Keith S, Gupta, Vikas, Mulgirigama, Aruni, Trautner, Barbara W, Scangarella-Oman, Nicole E, Yu, Kalvin C, Ye, Gang, Joshi, Ashish V
Published in PloS one (11.05.2023)
Published in PloS one (11.05.2023)
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Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections
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Published in Antimicrobial agents and chemotherapy (01.01.2015)
Published in Antimicrobial agents and chemotherapy (01.01.2015)
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Microbiome recovery in adult females with uncomplicated urinary tract infections in a randomised phase 2A trial of the novel antibiotic gepotidacin (GSK140944)
Nuzzo, Andrea, Van Horn, Stephanie, Traini, Christopher, Perry, Caroline R, Dumont, Etienne F, Scangarella-Oman, Nicole E, Gardiner, David F, Brown, James R
Published in BMC microbiology (15.06.2021)
Published in BMC microbiology (15.06.2021)
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Comparison of minimum inhibitory concentration results for gepotidacin obtained using agar dilution and broth microdilution methods
Arends, S.J. Ryan, Canino, Michele A., Mendes, Rodrigo, Scangarella-Oman, Nicole E., Flamm, Robert K.
Published in Diagnostic microbiology and infectious disease (01.10.2020)
Published in Diagnostic microbiology and infectious disease (01.10.2020)
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Prevalence, regional distribution, and trends of antimicrobial resistance among female outpatients with urine Klebsiella spp. isolates: a multicenter evaluation in the United States between 2011 and 2019
Kaye, Keith S, Gupta, Vikas, Mulgirigama, Aruni, Joshi, Ashish V, Ye, Gang, Scangarella-Oman, Nicole E, Yu, Kalvin, Mitrani-Gold, Fanny S
Published in Antimicrobial resistance & infection control (14.02.2024)
Published in Antimicrobial resistance & infection control (14.02.2024)
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Efficacy and Safety of Gepotidacin as Treatment of Uncomplicated Urogenital Gonorrhea (EAGLE-1): Design of a Randomized, Comparator-Controlled, Phase 3 Study
Perry, Caroline R., Scangarella-Oman, Nicole E., Millns, Helen, Flight, William, Gatsi, Sally, Jakielaszek, Charles, Janmohamed, Salim, Lewis, David A.
Published in Infectious diseases and therapy (01.09.2023)
Published in Infectious diseases and therapy (01.09.2023)
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Co-resistance Among Escherichia coli and Klebsiella pneumoniae Urine Isolates from Female Outpatients with Presumed UTI: A Retrospective US Cohort Study
Kaye, Keith S., Gupta, Vikas, Mulgirigama, Aruni, Joshi, Ashish V., Scangarella-Oman, Nicole E., Yu, Kalvin, Watts, Janet, Mitrani-Gold, Fanny S.
Published in Infectious diseases and therapy (01.07.2024)
Published in Infectious diseases and therapy (01.07.2024)
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Gepotidacin for the Treatment of Uncomplicated Urogenital Gonorrhea: A Phase 2, Randomized, Dose-Ranging, Single-Oral Dose Evaluation
Taylor, Stephanie N, Morris, David H, Avery, Ann K, Workowski, Kimberly A, Batteiger, Byron E, Tiffany, Courtney A, Perry, Caroline R, Raychaudhuri, Aparna, Scangarella-Oman, Nicole E, Hossain, Mohammad, Dumont, Etienne F
Published in Clinical infectious diseases (01.08.2018)
Published in Clinical infectious diseases (01.08.2018)
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Dose Selection for Phase III Clinical Evaluation of Gepotidacin (GSK2140944) in the Treatment of Uncomplicated Urinary Tract Infections
Scangarella-Oman, Nicole E, Hossain, Mohammad, Hoover, Jennifer L, Perry, Caroline R, Tiffany, Courtney, Barth, Aline, Dumont, Etienne F
Published in Antimicrobial agents and chemotherapy (15.03.2022)
Published in Antimicrobial agents and chemotherapy (15.03.2022)
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Oral gepotidacin versus nitrofurantoin in patients with uncomplicated urinary tract infection (EAGLE-2 and EAGLE-3): two randomised, controlled, double-blind, double-dummy, phase 3, non-inferiority trials
Wagenlehner, Florian, Perry, Caroline R, Hooton, Thomas M, Scangarella-Oman, Nicole E, Millns, Helen, Powell, Marcy, Jarvis, Emily, Dennison, Jeremy, Sheets, Amanda, Butler, Deborah, Breton, John, Janmohamed, Salim
Published in The Lancet (British edition) (24.02.2024)
Published in The Lancet (British edition) (24.02.2024)
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Phase 2a Pharmacokinetic, Safety, and Exploratory Efficacy Evaluation of Oral Gepotidacin (GSK2140944) in Female Participants With Uncomplicated Urinary Tract Infection (Acute Uncomplicated Cystitis)
Overcash, J Scott, Tiffany, Courtney A, Scangarella-Oman, Nicole E, Perry, Caroline R, Tao, Yu, Hossain, Mohammad, Barth, Aline, Dumont, Etienne F
Published in Antimicrobial agents and chemotherapy (23.06.2020)
Published in Antimicrobial agents and chemotherapy (23.06.2020)
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Microbiological Analysis from a Phase 2 Randomized Study in Adults Evaluating Single Oral Doses of Gepotidacin in the Treatment of Uncomplicated Urogenital Gonorrhea Caused by Neisseria gonorrhoeae
Scangarella-Oman, Nicole E, Hossain, Mohammad, Dixon, Paula B, Ingraham, Karen, Min, Sharon, Tiffany, Courtney A, Perry, Caroline R, Raychaudhuri, Aparna, Dumont, Etienne F, Huang, Jianzhong, Hook, 3rd, Edward W, Miller, Linda A
Published in Antimicrobial agents and chemotherapy (01.12.2018)
Published in Antimicrobial agents and chemotherapy (01.12.2018)
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Dose selection for a phase III study evaluating gepotidacin (GSK2140944) in the treatment of uncomplicated urogenital gonorrhoea
Scangarella-Oman, Nicole E, Hossain, Mohammad, Perry, Caroline R, Tiffany, Courtney, Powell, Marcy, Swift, Brandon, Dumont, Etienne F
Published in Sexually transmitted infections (01.02.2023)
Published in Sexually transmitted infections (01.02.2023)
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Analysis of the effect of urine on the in vitro activity of gepotidacin and levofloxacin against Escherichia coli, Staphylococcus epidermidis, and Staphylococcus saprophyticus
Koeth, Laura M., DiFranco-Fisher, Jeanna M., Scangarella-Oman, Nicole E.
Published in Diagnostic microbiology and infectious disease (01.07.2023)
Published in Diagnostic microbiology and infectious disease (01.07.2023)
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Relationship between Gepotidacin Exposure and Prevention of On-Therapy Resistance Amplification in a Neisseria gonorrhoeae Hollow-Fiber In Vitro Infection Model
VanScoy, Brian D, Scangarella-Oman, Nicole E, Fikes, Steven, Min, Sharon, Huang, Jianzhong, Ingraham, Karen, Bhavnani, Sujata M, Conde, Haley, Ambrose, Paul G
Published in Antimicrobial agents and chemotherapy (21.09.2020)
Published in Antimicrobial agents and chemotherapy (21.09.2020)
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Analysis of antimicrobial susceptibility testing methods and variables and in vitro activity of gepotidacin against urogenital Neisseria gonorrhoeae in men
Scangarella-Oman, Nicole E., Dixon, Paula, Koeth, Laura M., DiFranco-Fisher, Jeanna, Miller, Linda A.
Published in Diagnostic microbiology and infectious disease (01.12.2021)
Published in Diagnostic microbiology and infectious disease (01.12.2021)
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Gepotidacin Pharmacokinetics-Pharmacodynamics against Escherichia coli in the One-Compartment and Hollow-Fiber In Vitro Infection Model Systems
VanScoy, Brian D, Lakota, Elizabeth A, Conde, Haley, Fikes, Steven, Bhavnani, Sujata M, Elefante, Philippa B, Scangarella-Oman, Nicole E, Ambrose, Paul G
Published in Antimicrobial agents and chemotherapy (17.11.2021)
Published in Antimicrobial agents and chemotherapy (17.11.2021)
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