NTRK fusion-positive cancers and TRK inhibitor therapy
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Published in Nature reviews. Clinical oncology (01.12.2018)
Published in Nature reviews. Clinical oncology (01.12.2018)
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Molecular Pathways: AXL, a Membrane Receptor Mediator of Resistance to Therapy
Scaltriti, Maurizio, Elkabets, Moshe, Baselga, José
Published in Clinical cancer research (15.03.2016)
Published in Clinical cancer research (15.03.2016)
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Loss of the FAT1 Tumor Suppressor Promotes Resistance to CDK4/6 Inhibitors via the Hippo Pathway
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Published in Cancer cell (10.12.2018)
Published in Cancer cell (10.12.2018)
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PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D
Toska, Eneda, Osmanbeyoglu, Hatice U., Castel, Pau, Chan, Carmen, Hendrickson, Ronald C., Elkabets, Moshe, Dickler, Maura N., Scaltriti, Maurizio, Leslie, Christina S., Armstrong, Scott A., Baselga, José
Published in Science (American Association for the Advancement of Science) (24.03.2017)
Published in Science (American Association for the Advancement of Science) (24.03.2017)
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Colorectal Carcinomas Containing Hypermethylated MLH1 Promoter and Wild-Type BRAF/KRAS Are Enriched for Targetable Kinase Fusions
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Published in Cancer research (Chicago, Ill.) (15.03.2019)
Published in Cancer research (Chicago, Ill.) (15.03.2019)
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Resistance to TRK inhibition mediated by convergent MAPK pathway activation
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Published in Nature medicine (01.09.2019)
Published in Nature medicine (01.09.2019)
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ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer
Xu, Guotai, Chhangawala, Sagar, Cocco, Emiliano, Razavi, Pedram, Cai, Yanyan, Otto, Jordan E, Ferrando, Lorenzo, Selenica, Pier, Ladewig, Erik, Chan, Carmen, Da Cruz Paula, Arnaud, Witkin, Matthew, Cheng, Yuanming, Park, Jane, Serna-Tamayo, Cristian, Zhao, HuiYong, Wu, Fan, Sallaku, Mirna, Qu, Xuan, Zhao, Alison, Collings, Clayton K, D’Avino, Andrew R., Jhaveri, Komal, Koche, Richard, Levine, Ross L., Reis-Filho, Jorge S., Kadoch, Cigall, Scaltriti, Maurizio, Leslie, Christina S., Baselga, José, Toska, Eneda
Published in Nature genetics (01.02.2020)
Published in Nature genetics (01.02.2020)
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Cell-free DNA analysis in healthy individuals by next-generation sequencing: a proof of concept and technical validation study
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Published in Cell death & disease (11.07.2019)
Published in Cell death & disease (11.07.2019)
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PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor-positive breast cancer
Bosch, Ana, Li, Zhiqiang, Bergamaschi, Anna, Ellis, Haley, Toska, Eneda, Prat, Aleix, Tao, Jessica J, Spratt, Daniel E, Viola-Villegas, Nerissa T, Castel, Pau, Minuesa, Gerard, Morse, Natasha, Rodón, Jordi, Ibrahim, Yasir, Cortes, Javier, Perez-Garcia, Jose, Galvan, Patricia, Grueso, Judit, Guzman, Marta, Katzenellenbogen, John A, Kharas, Michael, Lewis, Jason S, Dickler, Maura, Serra, Violeta, Rosen, Neal, Chandarlapaty, Sarat, Scaltriti, Maurizio, Baselga, José
Published in Science translational medicine (15.04.2015)
Published in Science translational medicine (15.04.2015)
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mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling
Rodrik-Outmezguine, Vanessa S, Chandarlapaty, Sarat, Pagano, Nen C, Poulikakos, Poulikos I, Scaltriti, Maurizio, Moskatel, Elizabeth, Baselga, José, Guichard, Sylvie, Rosen, Neal
Published in Cancer discovery (01.08.2011)
Published in Cancer discovery (01.08.2011)
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P-selectin is a nanotherapeutic delivery target in the tumor microenvironment
Shamay, Yosi, Elkabets, Moshe, Li, Hongyan, Shah, Janki, Brook, Samuel, Wang, Feng, Adler, Keren, Baut, Emily, Scaltriti, Maurizio, Jena, Prakrit V, Gardner, Eric E, Poirier, John T, Rudin, Charles M, Baselga, José, Haimovitz-Friedman, Adriana, Heller, Daniel A
Published in Science translational medicine (29.06.2016)
Published in Science translational medicine (29.06.2016)
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FOXA1 Mutations Reveal Distinct Chromatin Profiles and Influence Therapeutic Response in Breast Cancer
Arruabarrena-Aristorena, Amaia, Maag, Jesper L.V., Kittane, Srushti, Cai, Yanyan, Karthaus, Wouter R., Ladewig, Erik, Park, Jane, Kannan, Srinivasaraghavan, Ferrando, Lorenzo, Cocco, Emiliano, Ho, Sik Y., Tan, Daisylyn S., Sallaku, Mirna, Wu, Fan, Acevedo, Barbara, Selenica, Pier, Ross, Dara S., Witkin, Matthew, Sawyers, Charles L., Reis-Filho, Jorge S., Verma, Chandra S., Jauch, Ralf, Koche, Richard, Baselga, José, Razavi, Pedram, Toska, Eneda, Scaltriti, Maurizio
Published in Cancer cell (12.10.2020)
Published in Cancer cell (12.10.2020)
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Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma
Mizrachi, Aviram, Shamay, Yosi, Shah, Janki, Brook, Samuel, Soong, Joanne, Rajasekhar, Vinagolu K., Humm, John L., Healey, John H., Powell, Simon N., Baselga, José, Heller, Daniel A., Haimovitz-Friedman, Adriana, Scaltriti, Maurizio
Published in Nature communications (13.02.2017)
Published in Nature communications (13.02.2017)
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Systematic Functional Characterization of Resistance to PI3K Inhibition in Breast Cancer
Le, Xiuning, Antony, Rajee, Razavi, Pedram, Treacy, Daniel J, Luo, Flora, Ghandi, Mahmoud, Castel, Pau, Scaltriti, Maurizio, Baselga, Jose, Garraway, Levi A
Published in Cancer discovery (01.10.2016)
Published in Cancer discovery (01.10.2016)
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PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA-proficient triple-negative breast cancer to PARP inhibition
Ibrahim, Yasir H, García-García, Celina, Serra, Violeta, He, Lei, Torres-Lockhart, Kristine, Prat, Aleix, Anton, Pilar, Cozar, Patricia, Guzmán, Marta, Grueso, Judit, Rodríguez, Olga, Calvo, Maria Teresa, Aura, Claudia, Díez, Orland, Rubio, Isabel T, Pérez, José, Rodón, Jordi, Cortés, Javier, Ellisen, Leif W, Scaltriti, Maurizio, Baselga, José
Published in Cancer discovery (01.11.2012)
Published in Cancer discovery (01.11.2012)
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Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target
Cook, Peter J., Thomas, Rozario, Kannan, Ram, de Leon, Esther Sanchez, Drilon, Alexander, Rosenblum, Marc K., Scaltriti, Maurizio, Benezra, Robert, Ventura, Andrea
Published in Nature communications (11.07.2017)
Published in Nature communications (11.07.2017)
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Pertuzumab Monotherapy After Trastuzumab-Based Treatment and Subsequent Reintroduction of Trastuzumab: Activity and Tolerability in Patients With Advanced Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer
CORTES, Javier, FUMOLEAU, Pierre, SALVAGNI, Stefania, SERVENT, Veronique, GIANNI, Luca, SCALTRITI, Maurizio, ROSS, Graham A, DIXON, Joanna, SZADO, Tania, BASELGA, José, VALERIA BIANCHI, Giulia, PETRELLA, Teresa M, GELMON, Karen, PIVOT, Xavier, VERMA, Shailendra, ALBANELL, Joan, CONTE, Pierfranco, LLUCH, Ana
Published in Journal of clinical oncology (10.05.2012)
Published in Journal of clinical oncology (10.05.2012)
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Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2⁺ breast cancer patients
Scaltriti, Maurizio, Eichhorn, Pieter J, Cortés, Javier, Prudkin, Ludmila, Aura, Claudia, Jiménez, José, Chandarlapaty, Sarat, Serra, Violeta, Prat, Aleix, Ibrahim, Yasir H, Guzmán, Marta, Gili, Magui, Rodríguez, Olga, Rodríguez, Sonia, Pérez, José, Green, Simon R, Mai, Sabine, Rosen, Neal, Hudis, Clifford, Baselga, José
Published in Proceedings of the National Academy of Sciences - PNAS (01.03.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (01.03.2011)
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Dual mTORC1/2 and HER2 Blockade Results in Antitumor Activity in Preclinical Models of Breast Cancer Resistant to Anti-HER2 Therapy
GARCIA-GARCIA, Celina, IBRAHIM, Yasir H, ROMMEL, Christian, TABERNERO, Josep, BASELGA, Jose, SCALTRITI, Maurizio, SERRA, Violeta, CALVO, Maria Teresa, GUZMAN, Marta, GRUESO, Judit, AURA, Claudia, PEREZ, José, JESSEN, Katti, YI LIU
Published in Clinical cancer research (01.05.2012)
Published in Clinical cancer research (01.05.2012)
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