Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma
Mazur, Pawel K, Herner, Alexander, Mello, Stephano S, Wirth, Matthias, Hausmann, Simone, Sánchez-Rivera, Francisco J, Lofgren, Shane M, Kuschma, Timo, Hahn, Stephan A, Vangala, Deepak, Trajkovic-Arsic, Marija, Gupta, Aayush, Heid, Irina, Noël, Peter B, Braren, Rickmer, Erkan, Mert, Kleeff, Jörg, Sipos, Bence, Sayles, Leanne C, Heikenwalder, Mathias, Heßmann, Elisabeth, Ellenrieder, Volker, Esposito, Irene, Jacks, Tyler, Bradner, James E, Khatri, Purvesh, Sweet-Cordero, E Alejandro, Attardi, Laura D, Schmid, Roland M, Schneider, Guenter, Sage, Julien, Siveke, Jens T
Published in Nature medicine (01.10.2015)
Published in Nature medicine (01.10.2015)
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Genome-Informed Targeted Therapy for Osteosarcoma
Sayles, Leanne C, Breese, Marcus R, Koehne, Amanda L, Leung, Stanley G, Lee, Alex G, Liu, Heng-Yi, Spillinger, Aviv, Shah, Avanthi T, Tanasa, Bogdan, Straessler, Krystal, Hazard, Florette K, Spunt, Sheri L, Marina, Neyssa, Kim, Grace E, Cho, Soo-Jin, Avedian, Raffi S, Mohler, David G, Kim, Mi-Ok, DuBois, Steven G, Hawkins, Douglas S, Sweet-Cordero, E Alejandro
Published in Cancer discovery (01.01.2019)
Published in Cancer discovery (01.01.2019)
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Molecular definition of a metastatic lung cancer state reveals a targetable CD109–Janus kinase–Stat axis
Chuang, Chen-Hua, Greenside, Peyton G, Rogers, Zoë N, Brady, Jennifer J, Yang, Dian, Ma, Rosanna K, Caswell, Deborah R, Chiou, Shin-Heng, Winters, Aidan F, Grüner, Barbara M, Ramaswami, Gokul, Spencley, Andrew L, Kopecky, Kimberly E, Sayles, Leanne C, Sweet-Cordero, E Alejandro, Li, Jin Billy, Kundaje, Anshul, Winslow, Monte M
Published in Nature medicine (01.03.2017)
Published in Nature medicine (01.03.2017)
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An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer
Vallejo, Adrian, Perurena, Naiara, Guruceaga, Elisabet, Mazur, Pawel K., Martinez-Canarias, Susana, Zandueta, Carolina, Valencia, Karmele, Arricibita, Andrea, Gwinn, Dana, Sayles, Leanne C., Chuang, Chen-Hua, Guembe, Laura, Bailey, Peter, Chang, David K., Biankin, Andrew, Ponz-Sarvise, Mariano, Andersen, Jesper B., Khatri, Purvesh, Bozec, Aline, Sweet-Cordero, E. Alejandro, Sage, Julien, Lecanda, Fernando, Vicent, Silve
Published in Nature communications (21.02.2017)
Published in Nature communications (21.02.2017)
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Antitumor activity of an engineered decoy receptor targeting CLCF1–CNTFR signaling in lung adenocarcinoma
Kim, Jun W., Marquez, Cesar P., Kostyrko, Kaja, Koehne, Amanda L., Marini, Kieren, Simpson, David R., Lee, Alex G., Leung, Stanley G., Sayles, Leanne C., Shrager, Joseph, Ferrer, Irene, Paz-Ares, Luis, Gephart, Melanie Hayden, Vicent, Silvestre, Cochran, Jennifer R., Sweet-Cordero, E. Alejandro
Published in Nature medicine (01.11.2019)
Published in Nature medicine (01.11.2019)
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Pharmacologic inhibition of eIF4A blocks NRF2 synthesis to prevent osteosarcoma metastasis
Lizardo, Michael M, Hughes, Christopher, Huang, Yue Z, Shyp, Taras, Delaidelli, Alberto, Zhang, Hai-Feng, Shaool, Sol Snir, Renner, Annalena F, Burwag, Fares, Sayles, Leanne C, Lee, Alex G, Sweet-Cordero, E Alejandro, Sorensen, Poul H
Published in Clinical cancer research (01.10.2024)
Published in Clinical cancer research (01.10.2024)
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Direct transposition of native DNA for sensitive multimodal single-molecule sequencing
Nanda, Arjun S., Wu, Ke, Irkliyenko, Iryna, Woo, Brian, Ostrowski, Megan S., Clugston, Andrew S., Sayles, Leanne C., Xu, Lingru, Satpathy, Ansuman T., Nguyen, Hao G., Alejandro Sweet-Cordero, E., Goodarzi, Hani, Kasinathan, Sivakanthan, Ramani, Vijay
Published in Nature genetics (01.06.2024)
Published in Nature genetics (01.06.2024)
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Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non-Small Cell Lung Cancer In Vivo
VICENT, Silvestre, SAYLES, Leanne C, SHRAGER, Joseph, HOANG, Chuong D, PLEVRITIS, Sylvia, BUTTE, Atul J, ALEJANDRO SWEET-CORDERO, E, VAKA, Dedeepya, KHATRI, Purvesh, GEVAERT, Olivier, CHEN, Ron, ZHENG, Yanyan, GILLESPIE, Anna K, CLARKE, Nicole, YUE XU
Published in Cancer research (Chicago, Ill.) (15.11.2012)
Published in Cancer research (Chicago, Ill.) (15.11.2012)
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Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities
Sun, Claire Xin, Daniel, Paul, Bradshaw, Gabrielle, Shi, Hui, Loi, Melissa, Chew, Nicole, Parackal, Sarah, Tsui, Vanessa, Liang, Yuqing, Koptyra, Mateusz, Adjumain, Shazia, Sun, Christie, Chong, Wai Chin, Fernando, Dasun, Drinkwater, Caroline, Tourchi, Motahhareh, Habarakada, Dilru, Sooraj, Dhanya, Carvalho, Diana, Storm, Phillip B., Baubet, Valerie, Sayles, Leanne C., Fernandez, Elisabet, Nguyen, Thy, Pörksen, Mia, Doan, Anh, Crombie, Duncan E., Panday, Monty, Zhukova, Nataliya, Dun, Matthew D., Ludlow, Louise E., Day, Bryan, Stringer, Brett W., Neeman, Naama, Rubens, Jeffrey A., Raabe, Eric H., Vinci, Maria, Tyrrell, Vanessa, Fletcher, Jamie I., Ekert, Paul G., Dumevska, Biljana, Ziegler, David S., Tsoli, Maria, Syed Sulaiman, Nur Farhana, Loh, Amos Hong Pheng, Low, Sharon Yin Yee, Sweet-Cordero, E. Alejandro, Monje, Michelle, Resnick, Adam, Jones, Chris, Downie, Peter, Williams, Bryan, Rosenbluh, Joseph, Gough, Daniel, Cain, Jason E., Firestein, Ron
Published in Cancer cell (10.04.2023)
Published in Cancer cell (10.04.2023)
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The Mir181ab1 cluster promotes KRAS-driven oncogenesis and progression in lung and pancreas
Valencia, Karmele, Erice, Oihane, Kostyrko, Kaja, Hausmann, Simone, Guruceaga, Elizabeth, Tathireddy, Anuradha, Flores, Natasha M, Sayles, Leanne C, Lee, Alex G, Fragoso, Rita, Sun, Tian-Qiang, Vallejo, Adrian, Roman, Marta, Entrialgo-Cadierno, Rodrigo, Migueliz, Itziar, Razquin, Nerea, Fortes, Puri, Lecanda, Fernando, Lu, Jun, Ponz-Sarvise, Mariano, Chen, Chang-Zheng, Mazur, Pawel K, Sweet-Cordero, E Alejandro, Vicent, Silvestre
Published in The Journal of clinical investigation (01.04.2020)
Published in The Journal of clinical investigation (01.04.2020)
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Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer
Oliver, Trudy G, Mercer, Kim L, Sayles, Leanne C, Burke, James R, Mendus, Diana, Lovejoy, Katherine S, Cheng, Mei-Hsin, Subramanian, Aravind, Mu, David, Powers, Scott, Crowley, Denise, Bronson, Roderick T, Whittaker, Charles A, Bhutkar, Arjun, Lippard, Stephen J, Golub, Todd, Thomale, Juergen, Jacks, Tyler, Sweet-Cordero, E Alejandro
Published in Genes & development (15.04.2010)
Published in Genes & development (15.04.2010)
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Discovery Proteomics Analysis Determines That Driver Oncogenes Suppress Antiviral Defense Pathways Through Reduction in Interferon-β Autocrine Stimulation
Solomon, Paige E., Kirkemo, Lisa L., Wilson, Gary M., Leung, Kevin K., Almond, Mark H., Sayles, Leanne C., Sweet-Cordero, E. Alejandro, Rosenberg, Oren S., Coon, Joshua J., Wells, James A.
Published in Molecular & cellular proteomics (01.07.2022)
Published in Molecular & cellular proteomics (01.07.2022)
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Author Correction: Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma
Mazur, Pawel K., Herner, Alexander, Mello, Stephano S., Wirth, Matthias, Hausmann, Simone, Sánchez-Rivera, Francisco J., Lofgren, Shane M., Kuschma, Timo, Hahn, Stephan A., Vangala, Deepak, Trajkovic-Arsic, Marija, Gupta, Aayush, Heid, Irina, Noël, Peter B., Braren, Rickmer, Erkan, Mert, Kleeff, Jörg, Sipos, Bence, Sayles, Leanne C., Heikenwalder, Mathias, Heßmann, Elisabeth, Ellenrieder, Volker, Esposito, Irene, Jacks, Tyler, Bradner, James E., Khatri, Purvesh, Sweet-Cordero, E. Alejandro, Attardi, Laura D., Schmid, Roland M., Schneider, Guenter, Sage, Julien, Siveke, Jens T.
Published in Nature medicine (01.07.2024)
Published in Nature medicine (01.07.2024)
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Osteosarcoma PDX-Derived Cell Line Models for Preclinical Drug Evaluation Demonstrate Metastasis Inhibition by Dinaciclib through a Genome-Targeted Approach
Schott, Courtney R, Koehne, Amanda L, Sayles, Leanne C, Young, Elizabeth P, Luck, Cuyler, Yu, Katherine, Lee, Alex G, Breese, Marcus R, Leung, Stanley G, Xu, Hang, Shah, Avanthi Tayi, Liu, Heng-Yi, Spillinger, Aviv, Behroozfard, Inge H, Marini, Kieren D, Dinh, Phuong T, Pons Ventura, María V, Vanderboon, Emma N, Hazard, Florette K, Cho, Soo-Jin, Avedian, Raffi S, Mohler, David G, Zimel, Melissa, Wustrack, Rosanna, Curtis, Christina, Sirota, Marina, Sweet-Cordero, E Alejandro
Published in Clinical cancer research (16.02.2024)
Published in Clinical cancer research (16.02.2024)
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A rare population of CD24(+)ITGB4(+)Notch(hi) cells drives tumor propagation in NSCLC and requires Notch3 for self-renewal
Zheng, Yanyan, de la Cruz, Cecile C, Sayles, Leanne C, Alleyne-Chin, Chris, Vaka, Dedeepya, Knaak, Tim D, Bigos, Marty, Xu, Yue, Hoang, Chuong D, Shrager, Joseph B, Fehling, Hans Joerg, French, Dorothy, Forrest, William, Jiang, Zhaoshi, Carano, Richard A D, Barck, Kai H, Jackson, Erica L, Sweet-Cordero, E Alejandro
Published in Cancer cell (08.07.2013)
Published in Cancer cell (08.07.2013)
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Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models
Vicent, Silvestre, Chen, Ron, Sayles, Leanne C, Lin, Chenwei, Walker, Randal G, Gillespie, Anna K, Subramanian, Aravind, Hinkle, Gregory, Yang, Xiaoping, Saif, Sakina, Root, David E, Huff, Vicki, Hahn, William C, Sweet-Cordero, E Alejandro
Published in The Journal of clinical investigation (01.11.2010)
Published in The Journal of clinical investigation (01.11.2010)
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A 3D Osteosarcoma Model with Bone-Mimicking Cues Reveals a Critical Role of Bone Mineral and Informs Drug Discovery
González Díaz, Eva C, Lee, Alex G, Sayles, Leanne C, Feria, Criselle, Sweet-Cordero, E Alejandro, Yang, Fan
Published in Advanced healthcare materials (01.09.2022)
Published in Advanced healthcare materials (01.09.2022)
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Journal Article
A Rare Population of CD24+ITGB4+Notchhi Cells Drives Tumor Propagation in NSCLC and Requires Notch3 for Self-Renewal
Zheng, Yanyan, de la Cruz, Cecile C., Sayles, Leanne C., Alleyne-Chin, Chris, Vaka, Dedeepya, Knaak, Tim D., Bigos, Marty, Xu, Yue, Hoang, Chuong D., Shrager, Joseph B., Fehling, Hans Joerg, French, Dorothy, Forrest, William, Jiang, Zhaoshi, Carano, Richard A.D., Barck, Kai H., Jackson, Erica L., Sweet-Cordero, E. Alejandro
Published in Cancer cell (01.07.2013)
Published in Cancer cell (01.07.2013)
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Journal Article
An integrative cross-tumors approach identifies FOSL1 as an oncogene dependency in KRAS-driven lung cancer
Vallejo, Adrian, Perurena, Naiara, Guruceaga, Elizabeth, Mazur, Pawel K., Martinez-Canarias, Susana, Zandueta, Carolina, Gwinn, Dana, Sayles, Leanne C., Chuang, Chen-Hua, Andersen, Jesper B., Bozec, Aline, Sweet-Cordero, Alejandro, Sage, Julien, Lecanda, Fernando, Vicent, Silvestre
Published in Journal of thoracic oncology (01.02.2016)
Published in Journal of thoracic oncology (01.02.2016)
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Journal Article
Expression of Ndi1p, an alternative NADH:ubiquinone oxidoreductase, increases mitochondrial membrane potential in a C. elegans model of mitochondrial disease
DeCorby, Adrienne, Gášková, Dana, Sayles, Leanne C., Lemire, Bernard D.
Published in Biochimica et biophysica acta (01.09.2007)
Published in Biochimica et biophysica acta (01.09.2007)
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