Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer
Watson, Philip A., Arora, Vivek K., Sawyers, Charles L.
Published in Nature reviews. Cancer (01.12.2015)
Published in Nature reviews. Cancer (01.12.2015)
Get full text
Journal Article
Glucocorticoid Receptor Confers Resistance to Antiandrogens by Bypassing Androgen Receptor Blockade
Arora, Vivek K., Schenkein, Emily, Murali, Rajmohan, Subudhi, Sumit K., Wongvipat, John, Balbas, Minna D., Shah, Neel, Cai, Ling, Efstathiou, Eleni, Logothetis, Chris, Zheng, Deyou, Sawyers, Charles L.
Published in Cell (05.12.2013)
Published in Cell (05.12.2013)
Get full text
Journal Article
Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures
Karthaus, Wouter R., Iaquinta, Phillip J., Drost, Jarno, Gracanin, Ana, van Boxtel, Ruben, Wongvipat, John, Dowling, Catherine M., Gao, Dong, Begthel, Harry, Sachs, Norman, Vries, Robert G.J., Cuppen, Edwin, Chen, Yu, Sawyers, Charles L., Clevers, Hans C.
Published in Cell (25.09.2014)
Published in Cell (25.09.2014)
Get full text
Journal Article
Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer
Carver, Brett S., Chapinski, Caren, Wongvipat, John, Hieronymus, Haley, Chen, Yu, Chandarlapaty, Sarat, Arora, Vivek K., Le, Carl, Koutcher, Jason, Scher, Howard, Scardino, Peter T., Rosen, Neal, Sawyers, Charles L.
Published in Cancer cell (17.05.2011)
Published in Cancer cell (17.05.2011)
Get full text
Journal Article
FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes
Adams, Elizabeth J., Karthaus, Wouter R., Hoover, Elizabeth, Liu, Deli, Gruet, Antoine, Zhang, Zeda, Cho, Hyunwoo, DiLoreto, Rose, Chhangawala, Sagar, Liu, Yang, Watson, Philip A., Davicioni, Elai, Sboner, Andrea, Barbieri, Christopher E., Bose, Rohit, Leslie, Christina S., Sawyers, Charles L.
Published in Nature (London) (01.07.2019)
Published in Nature (London) (01.07.2019)
Get full text
Journal Article
Patient derived organoids to model rare prostate cancer phenotypes
Puca, Loredana, Bareja, Rohan, Prandi, Davide, Shaw, Reid, Benelli, Matteo, Karthaus, Wouter R., Hess, Judy, Sigouros, Michael, Donoghue, Adam, Kossai, Myriam, Gao, Dong, Cyrta, Joanna, Sailer, Verena, Vosoughi, Aram, Pauli, Chantal, Churakova, Yelena, Cheung, Cynthia, Deonarine, Lesa Dayal, McNary, Terra J., Rosati, Rachele, Tagawa, Scott T., Nanus, David M., Mosquera, Juan Miguel, Sawyers, Charles L., Chen, Yu, Inghirami, Giorgio, Rao, Rema A., Grandori, Carla, Elemento, Olivier, Sboner, Andrea, Demichelis, Francesca, Rubin, Mark A., Beltran, Himisha
Published in Nature communications (19.06.2018)
Published in Nature communications (19.06.2018)
Get full text
Journal Article
Tumor copy number alteration burden is a pan-cancer prognostic factor associated with recurrence and death
Hieronymus, Haley, Murali, Rajmohan, Tin, Amy, Yadav, Kamlesh, Abida, Wassim, Moller, Henrik, Berney, Daniel, Scher, Howard, Carver, Brett, Scardino, Peter, Schultz, Nikolaus, Taylor, Barry, Vickers, Andrew, Cuzick, Jack, Sawyers, Charles L
Published in eLife (04.09.2018)
Published in eLife (04.09.2018)
Get full text
Journal Article
Identification of an oncogenic RAB protein
Wheeler, Douglas B., Zoncu, Roberto, Root, David E., Sabatini, David M., Sawyers, Charles L.
Published in Science (American Association for the Advancement of Science) (09.10.2015)
Published in Science (American Association for the Advancement of Science) (09.10.2015)
Get full text
Journal Article
The Role of Lineage Plasticity in Prostate Cancer Therapy Resistance
Beltran, Himisha, Hruszkewycz, Andrew, Scher, Howard I, Hildesheim, Jeffrey, Isaacs, Jennifer, Yu, Evan Y, Kelly, Kathleen, Lin, Daniel, Dicker, Adam, Arnold, Julia, Hecht, Toby, Wicha, Max, Sears, Rosalie, Rowley, David, White, Richard, Gulley, James L, Lee, John, Diaz Meco, Maria, Small, Eric J, Shen, Michael, Knudsen, Karen, Goodrich, David W, Lotan, Tamara, Zoubeidi, Amina, Sawyers, Charles L, Rudin, Charles M, Loda, Massimo, Thompson, Timothy, Rubin, Mark A, Tawab-Amiri, Abdul, Dahut, William, Nelson, Peter S
Published in Clinical cancer research (01.12.2019)
Published in Clinical cancer research (01.12.2019)
Get full text
Journal Article
Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor
Watson, Philip A., Chen, Yinan F., Balbas, Minna D., Wongvipat, John, Socci, Nicholas D., Viale, Agnes, Kim, Kwanghee, Sawyers, Charles L.
Published in Proceedings of the National Academy of Sciences - PNAS (28.09.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (28.09.2010)
Get full text
Journal Article
Feedback Suppression of PI3Kα Signaling in PTEN-Mutated Tumors Is Relieved by Selective Inhibition of PI3Kβ
Schwartz, Sarit, Wongvipat, John, Trigwell, Cath B., Hancox, Urs, Carver, Brett S., Rodrik-Outmezguine, Vanessa, Will, Marie, Yellen, Paige, de Stanchina, Elisa, Baselga, José, Scher, Howard I., Barry, Simon T., Sawyers, Charles L., Chandarlapaty, Sarat, Rosen, Neal
Published in Cancer cell (12.01.2015)
Published in Cancer cell (12.01.2015)
Get full text
Journal Article
Copy number alteration burden predicts prostate cancer relapse
Hieronymus, Haley, Schultz, Nikolaus, Gopalan, Anuradha, Carver, Brett S., Chang, Matthew T., Xiao, Yonghong, Heguy, Adriana, Huberman, Kety, Bernstein, Melanie, Assel, Melissa, Murali, Rajmohan, Vickers, Andrew, Scardino, Peter T., Sander, Chris, Reuter, Victor, Taylor, Barry S., Sawyers, Charles L.
Published in Proceedings of the National Academy of Sciences - PNAS (29.07.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (29.07.2014)
Get full text
Journal Article
ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss
Chen, Yu, Chi, Ping, Rockowitz, Shira, Iaquinta, Phillip J, Shamu, Tambudzai, Shukla, Shipra, Gao, Dong, Sirota, Inna, Carver, Brett S, Wongvipat, John, Scher, Howard I, Zheng, Deyou, Sawyers, Charles L
Published in Nature medicine (01.08.2013)
Published in Nature medicine (01.08.2013)
Get full text
Journal Article
Integrative Genomic Profiling of Human Prostate Cancer
Taylor, Barry S., Schultz, Nikolaus, Hieronymus, Haley, Gopalan, Anuradha, Xiao, Yonghong, Carver, Brett S., Arora, Vivek K., Kaushik, Poorvi, Cerami, Ethan, Reva, Boris, Antipin, Yevgeniy, Mitsiades, Nicholas, Landers, Thomas, Dolgalev, Igor, Major, John E., Wilson, Manda, Socci, Nicholas D., Lash, Alex E., Heguy, Adriana, Eastham, James A., Scher, Howard I., Reuter, Victor E., Scardino, Peter T., Sander, Chris, Sawyers, Charles L., Gerald, William L.
Published in Cancer cell (13.07.2010)
Published in Cancer cell (13.07.2010)
Get full text
Journal Article
Structure−Activity Relationship for Thiohydantoin Androgen Receptor Antagonists for Castration-Resistant Prostate Cancer (CRPC)
Jung, Michael E, Ouk, Samedy, Yoo, Dongwon, Sawyers, Charles L, Chen, Charlie, Tran, Chris, Wongvipat, John
Published in Journal of medicinal chemistry (08.04.2010)
Published in Journal of medicinal chemistry (08.04.2010)
Get full text
Journal Article