Potent Transient Inhibition of BCR-ABL by Dasatinib Leads to Complete Cytogenetic Remissions in Patients with Chronic Myeloid Leukemia: Implications for Patient Management and Drug Development
Shah, Neil P., Nicoll, John M., Bleickardt, Eric, Nicaise, Claude, Paquette, Ronald L., Sawyers, Charles L.
Published in Blood (16.11.2006)
Published in Blood (16.11.2006)
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Abstract LB-203: Phase I/II study of the androgen receptor antagonist MDV3100 in castration-resistant prostate cancer
Scher, Howard I., Beer, Thomasz, Higano, Celestia S, Danila, Daniel C, Shelkey, Julia, Hirmand, Mohammed, Hung, David, Morris, Michael J, Larson, Steve M, Sawyers, Charles L
Published in Cancer research (Chicago, Ill.) (15.05.2008)
Published in Cancer research (Chicago, Ill.) (15.05.2008)
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PHA-739358, an Aurora Kinase Inhibitor, Induces Clinical Responses in Chronic Myeloid Leukemia Harboring T315I Mutations of BCR-ABL
Paquette, Ronald L., Shah, Neil P., Sawyers, Charles L., Martinelli, Giovanni, John, Nicoll, Chalukya, Meenal, Rocchetti, Maurizio, Fiocchi, Carina, Comis, Sylvia, Capolongo, Laura, Laffranchi, Bernard
Published in Blood (16.11.2007)
Published in Blood (16.11.2007)
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Journal Article
The Most Common Dasatinib-Resistant BCR-ABL Kinase Domain Mutations in Patients with Chronic Myeloid Leukemia Are Sensitive to VX-680: Rationale for Early Combination Kinase Inhibitor Therapy
Shah, Neil P., Skaggs, Brian, Branford, Susan, Hughes, Timothy P., Nicoll, John M., Paquette, Ronald L., Sawyers, Charles L.
Published in Blood (16.11.2006)
Published in Blood (16.11.2006)
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Journal Article
Sequential Kinase Inhibitor Therapy in CML Patients Can Select for Cells Harboring Compound BCR-ABL Kinase Domain Mutations with Increased Oncogenic Potency: Rationale for Early Combination Therapy of ABL Kinase Inhibitors
Shah, Neil P., Skaggs, Brian, Branford, Susan, Hughes, Timothy P., Nicoll, John M., Paquette, Ronald L., Sawyers, Charles L.
Published in Blood (16.11.2006)
Published in Blood (16.11.2006)
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Journal Article
Altered Oncogenic Fitness of Imatinib- and Dasatinib-Resistant BCR-ABL Mutants Is Due to Differential Intrinsic Kinase Activity and Signaling Pathway Selection Defined by Phosphoproteome Profiling
Skaggs, Brian J., Burgess, Michael R., Gorre, Mercedes E., Graeber, Thomas G., Sawyers, Charles L.
Published in Blood (16.11.2005)
Published in Blood (16.11.2005)
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The NF-κB Pathway Controls Progression of Prostate Cancer to Androgen Independent Growth
Jin, Ren Jie, Lho, Yongsoo, Connelly, Linda, Wang, Yongqing, Yu, Xiuping, Jean, Leshana Saint, Case, Thomas C., Ellwood-Yen, Katharine, Sawyers, Charles L., Bhowmick, Neil A., Blackwell, Timothy S., Yull, Fiona E., Matusik, Robert J.
Published in Cancer research (Chicago, Ill.) (15.08.2008)
Published in Cancer research (Chicago, Ill.) (15.08.2008)
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IkappaB kinase beta inhibition induces cell death in Imatinib-resistant and T315I Dasatinib-resistant BCR-ABL+ cells
Duncan, Elizabeth A, Goetz, Christine A, Stein, Sarah J, Mayo, Katie J, Skaggs, Brian J, Ziegelbauer, Karl, Sawyers, Charles L, Baldwin, Albert S
Published in Molecular cancer therapeutics (01.02.2008)
Published in Molecular cancer therapeutics (01.02.2008)
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Journal Article
I Kappa B kinase beta inhibition induces cell death in Imatinib-resistant and T315I Dasatinib-resistant BCR-ABL super(+) cells
Duncan, Elizabeth A, Goetz, Christine A, Stein, Sarah J, Mayo, Katie J, Skaggs, Brian J, Ziegelbauer, Karl, Sawyers, Charles L, Baldwin, Albert S
Published in Molecular cancer therapeutics (01.02.2008)
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Published in Molecular cancer therapeutics (01.02.2008)
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Chronic myelogenous leukemia
Druker, B J, Sawyers, C L, Capdeville, R, Ford, J M, Baccarani, M, Goldman, J M
Published in Hematology (2001)
Published in Hematology (2001)
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A prostatic intraepithelial neoplasia-dependent p27kip1 checkpoint induces senescence, inhibits cell proliferation and cancer progression
Majumder, Pradip K., Grisanzio, Chiara, O’Connell, Fionnuala, Barry, Marc, Brito, Joseph M., Xu, Qing, Guney, Isil, Berger, Raanan, Herman, Paula, Bikoff, Rachel, Fedele, Giuseppe, Baek, Won-Ki, Wang, Shunyou, Ellwood-Yen, Katharine, Wu, Hong, Sawyers, Charles L., Signoretti, Sabina, Hahn, William C., Loda, Massimo, Sellers, William R.
Published in Cancer cell (12.08.2008)
Published in Cancer cell (12.08.2008)
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Cancer treatment in the STI571 era : What will change?
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Conference Proceeding
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SUBSTITUTED DIAZASPIROALKANES AS ANDROGEN RECEPTOR MODULATORS
Sawyers, Charles L, Wongvipat, John, Jung, Michael E, Ouk, Samedy, Tran, Chris
Year of Publication 05.09.2024
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Year of Publication 05.09.2024
Patent
The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1
Romero, Rodrigo, Chu, Tinyi, González-Robles, Tania J, Smith, Perianne, Xie, Yubin, Kaur, Harmanpreet, Yoder, Sara, Zhao, Huiyong, Mao, Chenyi, Kang, Wenfei, Pulina, Maria V, Lawrence, Kayla E, Gopalan, Anuradha, Zaidi, Samir, Yoo, Kwangmin, Choi, Jungmin, Fan, Ning, Gerstner, Olivia, Karthaus, Wouter R, DeStanchina, Elisa, Ruggles, Kelly V, Westcott, Peter M K, Chaligné, Ronan, Pe'er, Dana, Sawyers, Charles L
Published in bioRxiv (11.04.2024)
Published in bioRxiv (11.04.2024)
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