Pridopidine, a clinic‐ready compound, reduces 3,4‐dihydroxyphenylalanine‐induced dyskinesia in Parkinsonian macaques
Johnston, Tom H., Geva, Michal, Steiner, Lilach, Orbach, Aric, Papapetropoulos, Spyros, Savola, Juha‐Matti, Reynolds, Ian J., Ravenscroft, Paula, Hill, Michael, Fox, Susan H., Brotchie, Jonathan M., Laufer, Ralph, Hayden, Michael R.
Published in Movement disorders (01.05.2019)
Published in Movement disorders (01.05.2019)
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Safety and efficacy of laquinimod for Huntington's disease (LEGATO-HD): a multicentre, randomised, double-blind, placebo-controlled, phase 2 study
Reilmann, Ralf, Anderson, Karen E, Feigin, Andrew, Tabrizi, Sarah J, Leavitt, Blair R, Stout, Julie C, Piccini, Paola, Schubert, Robin, Loupe, Pippa, Wickenberg, Anna, Borowsky, Beth, Rynkowski, Gail, Volkinshtein, Rita, Li, Thomas, Savola, Juha-Matti, Hayden, Michael, Gordon, Mark Forrest, Guttman, Mark, Raymond, Lynn, Mendis, Tilak, Suchowersky, Oksana, Corey-Bloom, Jody, Geschwind, Michael D, Marshall, Frederick J, Marder, Karen S, Nance, Martha, Racette, Brad, Bang, Jee, Segro, Victoria, McDonell, Katherine, Kamholz, John, LeDoux, Mark S, Sanchez-Ramos, Juan, DeMichele, Giuseppe, Mariotti, Caterina, Squitieri, Ferdinando, Soliveri, Paola, Cortelli, Pietro, Muñoz García, José Esteban, Kulisevsky Bojarski, Jaime, López-Sendón Moreno, José Luis, Berganzo Corrales, Koldo, Cubo, Esther, García Moreno, José Manuel, Orth, Michael, Priller, Josef, Saft, Carsten, Weindl, Adolf, Winkler, Juergen, Craufurd, David, Miedzybrodzka, Zofia, Rickards, Hugh, Davies, Rhys Richard, Lahiri, Nayana, Ruddy, Deborah, Komati, Suresh K, Quarrell, Oliver William John, Correira Guedes, Leonor, Roos, Raymund A C, Zalyalova, Zuleykha, Illarioshkin, Sergey, Gustov, Aleksandr, Klempir, Jiri
Published in Lancet neurology (01.03.2024)
Published in Lancet neurology (01.03.2024)
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Pharmacokinetic and Metabolic Profile of Deutetrabenazine (TEV‐50717) Compared With Tetrabenazine in Healthy Volunteers
Schneider, Frank, Bradbury, Margaret, Baillie, Thomas A., Stamler, David, Hellriegel, Edward, Cox, Donna S., Loupe, Pippa S., Savola, Juha‐Matti, Rabinovich‐Guilatt, Laura
Published in Clinical and translational science (01.07.2020)
Published in Clinical and translational science (01.07.2020)
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Sigma-1 and dopamine D2/D3 receptor occupancy of pridopidine in healthy volunteers and patients with Huntington disease: a [18F] fluspidine and [18F] fallypride PET study
Grachev, Igor D., Meyer, Philipp M., Becker, Georg A., Bronzel, Marcus, Marsteller, Doug, Pastino, Gina, Voges, Ole, Rabinovich, Laura, Knebel, Helena, Zientek, Franziska, Rullmann, Michael, Sattler, Bernhard, Patt, Marianne, Gerhards, Thilo, Strauss, Maria, Kluge, Andreas, Brust, Peter, Savola, Juha-Matti, Gordon, Mark F., Geva, Michal, Hesse, Swen, Barthel, Henryk, Hayden, Michael R., Sabri, Osama
Published in European journal of nuclear medicine and molecular imaging (01.04.2021)
Published in European journal of nuclear medicine and molecular imaging (01.04.2021)
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Pharmacokinetics, metabolism and safety of deuterated L‐DOPA (SD‐1077)/carbidopa compared to L‐DOPA/carbidopa following single oral dose administration in healthy subjects
Schneider, Frank, Erisson, Lavi, Beygi, Hooman, Bradbury, Margaret, Cohen‐Barak, Orit, Grachev, Igor D., Guzy, Serge, Loupe, Pippa S., Levi, Micha, McDonald, Mirna, Savola, Juha‐Matti, Papapetropoulos, Spyros, Tracewell, William G., Velinova, Maria, Spiegelstein, Ofer
Published in British journal of clinical pharmacology (01.10.2018)
Published in British journal of clinical pharmacology (01.10.2018)
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Pharmacokinetics of Deutetrabenazine and Tetrabenazine: Dose Proportionality and Food Effect
Schneider, Frank, Stamler, David, Bradbury, Margaret, Loupe, Pippa S., Hellriegel, Edward, Cox, Donna S., Savola, Juha‐Matti, Gordon, Mark Forrest, Rabinovich‐Guilatt, Laura
Published in Clinical pharmacology in drug development (01.06.2021)
Published in Clinical pharmacology in drug development (01.06.2021)
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Sembragiline in Moderate Alzheimer’s Disease: Results of a Randomized, Double-Blind, Placebo-Controlled Phase II Trial (MAyflOwer RoAD)
Nave, Stephane, Doody, Rachelle S., Boada, Mercè, Grimmer, Timo, Savola, Juha-Matti, Delmar, Paul, Pauly-Evers, Meike, Nikolcheva, Tania, Czech, Christian, Borroni, Edilio, Ricci, Benedicte, Dukart, Juergen, Mannino, Marie, Carey, Tracie, Moran, Emma, Gilaberte, Inma, Muelhardt, Nicoletta Milani, Gerlach, Irene, Santarelli, Luca, Ostrowitzki, Susanne, Fontoura, Paulo
Published in Journal of Alzheimer's disease (01.01.2017)
Published in Journal of Alzheimer's disease (01.01.2017)
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Safety and Efficacy of Long-Term Deutetrabenazine Use in Children and Adolescents with Tics Associated with Tourette Syndrome: An Open-Label Extension Study
Jankovic, Joseph, Coffey, Barbara, Claassen, Daniel O, Jimenez-Shahed, Joohi, Gertz, Barry J, Garofalo, Elizabeth A, Stamler, David A, Wieman, Maria, Savola, Juha-Matti, Harary, Eran, Alexander, Jessica, Barkay, Hadas, Gordon, Mark Forrest
Published in Movement disorders clinical practice (Hoboken, N.J.) (01.09.2023)
Published in Movement disorders clinical practice (Hoboken, N.J.) (01.09.2023)
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Comparison of Safety and Tolerability of Deutetrabenazine During Titration and Maintenance in Patients with Tardive Dyskinesia
Wilhelm, Amanda, Anderson, Karen E., Fernandez, Hubert H., Barkay, Hadas, Chaijale, Nayla, Send, Alexander F., Savola, Juha-Matti, Gordon, Mark Forrest
Published in CNS spectrums (01.04.2021)
Published in CNS spectrums (01.04.2021)
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Long-Term Efficacy and Safety of Deutetrabenazine for Chorea in Huntington’s Disease: Results From the ARC-HD Open-label Study
Frank, Samuel, Testa, Claudia M., Stamler, David, Kayson, Elise, Oakes, David, Vaughan, Christina, Goldstein, Jody, Whaley, Jacquelyn, Davis, Mat D., Gordon, Mark Forrest, Savola, Juha-Matti
Published in CNS spectrums (01.04.2021)
Published in CNS spectrums (01.04.2021)
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Characterizing patient compliance over six months in remote digital trials of Parkinson's and Huntington disease
Cohen, Shani, Waks, Zeev, Elm, Jordan J, Gordon, Mark Forrest, Grachev, Igor D, Navon-Perry, Leehee, Fine, Shai, Grossman, Iris, Papapetropoulos, Spyros, Savola, Juha-Matti
Published in BMC medical informatics and decision making (20.12.2018)
Published in BMC medical informatics and decision making (20.12.2018)
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152 Development of Deutetrabenazine as a Potential New Non-Antipsychotic Treatment for Tourette Syndrome in Children and Adolescents
Jankovic, Joseph, Coffey, Barbara, Claassen, Daniel O, Stamler, David, Gertz, Barry J, Garofalo, Elisabeth A, Wieman, Maria, Gordon, Mark Forrest, Savola, Juha-Matti
Published in CNS spectrums (01.04.2020)
Published in CNS spectrums (01.04.2020)
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Evaluation of the Safety of Deutetrabenazine at Higher Doses to Treat Chorea in Huntington’s Disease
Frank, Samuel, Vaughan, Christina, Stamler, David, Oakes, David, Davis, Mat D., Gross, Nicholas, Gordon, Mark Forrest, Savola, Juha-Matti, Wieman, Maria, Eberly, Shirley, Kayson, Elise, Whaley, Jacquelyn, Goldstein, Jody, Testa, Claudia M.
Published in CNS spectrums (01.04.2021)
Published in CNS spectrums (01.04.2021)
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Long-Term Deutetrabenazine Treatment for Tardive Dyskinesia Is Associated With Sustained Benefits and Safety: A 3-Year, Open-Label Extension Study
Hauser, Robert A, Barkay, Hadas, Fernandez, Hubert H, Factor, Stewart A, Jimenez-Shahed, Joohi, Gross, Nicholas, Marinelli, Leslie, Wilhelm, Amanda, Alexander, Jessica, Gordon, Mark Forrest, Savola, Juha-Matti, Anderson, Karen E
Published in Frontiers in neurology (23.02.2022)
Published in Frontiers in neurology (23.02.2022)
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Journal Article
Safety and Efficacy of Flexible-Dose Deutetrabenazine in Children and Adolescents With Tourette Syndrome: A Randomized Clinical Trial
Jankovic, Joseph, Coffey, Barbara, Claassen, Daniel O, Jimenez-Shahed, Joohi, Gertz, Barry J, Garofalo, Elizabeth A, Stamler, David A, Wieman, Maria, Savola, Juha-Matti, Gordon, Mark Forrest, Alexander, Jessica, Barkay, Hadas, Harary, Eran
Published in JAMA network open (01.10.2021)
Published in JAMA network open (01.10.2021)
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Journal Article
Efficacy and Safety of Fixed-Dose Deutetrabenazine in Children and Adolescents for Tics Associated With Tourette Syndrome: A Randomized Clinical Trial
Coffey, Barbara, Jankovic, Joseph, Claassen, Daniel O, Jimenez-Shahed, Joohi, Gertz, Barry J, Garofalo, Elizabeth A, Stamler, David A, Wieman, Maria, Savola, Juha-Matti, Gordon, Mark Forrest, Alexander, Jessica K, Barkay, Hadas, Harary, Eran
Published in JAMA network open (01.10.2021)
Published in JAMA network open (01.10.2021)
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Journal Article
Additional Safety and Exploratory Efficacy Data at 48 and 60 Months from Open-HART, an Open-Label Extension Study of Pridopidine in Huntington Disease
McGarry, Andrew, Auinger, Peggy, Kieburtz, Karl, Geva, Michal, Mehra, Munish, Abler, Victor, Grachev, Igor D., Gordon, Mark Forrest, Savola, Juha-Matti, Gandhi, Sanjay, Papapetropoulos, Spyridon, Hayden, Michael
Published in Journal of Huntington's disease (01.01.2020)
Published in Journal of Huntington's disease (01.01.2020)
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151 Confirmed Safety of Deutet.rabenazine for Tardive Dyskinesia in a 3-Year Open-Label Extension Study
Fernandez, Hubert H, Barkay, Hadas, Hauser, Robert A, Factor, Stewart A, Jimenez-Shahed, Joohi, Gross, Nicholas, Marinelli, Leslie, Gordon, Mark Forrest, Savola, Juha-Matti, Anderson, Karen E
Published in CNS spectrums (01.04.2020)
Published in CNS spectrums (01.04.2020)
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134 Long-Term Deutetrabenazine Treatment Is Associated with Sustained Treatment Response in Tardive Dyskinesia: Results from an Open-Label Extension Study
Hauser, Robert A, Barkay, Hadas, Fernandez, Hubert H, Factor, Stewart A, Jimenez-Shahed, Joohi, Gross, Nicholas, Marinelli, Leslie, Forrest Gordon, Mark, Savola, Juha-Matti, Anderson, Karen E
Published in CNS spectrums (01.04.2020)
Published in CNS spectrums (01.04.2020)
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Journal Article
Safety of Deutetrabenazine for the Treatment of Tardive Dyskinesia and Chorea Associated with Huntington Disease
Frank, Samuel, Anderson, Karen E., Fernandez, Hubert H., Hauser, Robert A., Claassen, Daniel O., Stamler, David, Factor, Stewart A., Jimenez-Shahed, Joohi, Barkay, Hadas, Wilhelm, Amanda, Alexander, Jessica K., Chaijale, Nayla, Barash, Steve, Savola, Juha-Matti, Gordon, Mark Forrest, Chen, Maria
Published in Neurology and therapy (01.06.2024)
Published in Neurology and therapy (01.06.2024)
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