Engineered therapeutic antibodies with improved effector functions
Kubota, Tsuguo, Niwa, Rinpei, Satoh, Mitsuo, Akinaga, Shiro, Shitara, Kenya, Hanai, Nobuo
Published in Cancer science (01.09.2009)
Published in Cancer science (01.09.2009)
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Improving effector functions of antibodies for cancer treatment: Enhancing ADCC and CDC
Natsume, Akito, Niwa, Rinpei, Satoh, Mitsuo
Published in Drug design, development and therapy (21.09.2009)
Published in Drug design, development and therapy (21.09.2009)
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Non-fucosylated therapeutic antibodies as next-generation therapeutic antibodies
Satoh, Mitsuo, Iida, Shigeru, Shitara, Kenya
Published in Expert opinion on biological therapy (01.11.2006)
Published in Expert opinion on biological therapy (01.11.2006)
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Journal Article
Structural Comparison of Fucosylated and Nonfucosylated Fc Fragments of Human Immunoglobulin G1
Matsumiya, Shigeki, Yamaguchi, Yoshiki, Saito, Jun-ichi, Nagano, Mayumi, Sasakawa, Hiroaki, Otaki, Shizuo, Satoh, Mitsuo, Shitara, Kenya, Kato, Koichi
Published in Journal of molecular biology (04.05.2007)
Published in Journal of molecular biology (04.05.2007)
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Journal Article
The Absence of Fucose but Not the Presence of Galactose or Bisecting N-Acetylglucosamine of Human IgG1 Complex-type Oligosaccharides Shows the Critical Role of Enhancing Antibody-dependent Cellular Cytotoxicity
Shinkawa, Toyohide, Nakamura, Kazuyasu, Yamane, Naoko, Shoji-Hosaka, Emi, Kanda, Yutaka, Sakurada, Mikiko, Uchida, Kazuhisa, Anazawa, Hideharu, Satoh, Mitsuo, Yamasaki, Motoo, Hanai, Nobuo, Shitara, Kenya
Published in The Journal of biological chemistry (31.01.2003)
Published in The Journal of biological chemistry (31.01.2003)
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Journal Article
Importance of the Side Chain at Position 296 of Antibody Fc in Interactions with FcγRIIIa and Other Fcγ Receptors
Isoda, Yuya, Yagi, Hirokazu, Satoh, Tadashi, Shibata-Koyama, Mami, Masuda, Kazuhiro, Satoh, Mitsuo, Kato, Koichi, Iida, Shigeru
Published in PloS one (07.10.2015)
Published in PloS one (07.10.2015)
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A Peptidomics Strategy for Discovering Endogenous Bioactive Peptides
Sasaki, Kazuki, Takahashi, Noriyuki, Satoh, Mitsuo, Yamasaki, Motoo, Minamino, Naoto
Published in Journal of proteome research (01.10.2010)
Published in Journal of proteome research (01.10.2010)
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Journal Article
Nonfucosylated Therapeutic IgG1 Antibody Can Evade the Inhibitory Effect of Serum Immunoglobulin G on Antibody-Dependent Cellular Cytotoxicity through its High Binding to FcγRIIIa
IIDA, Shigeru, MISAKA, Hirofumi, INOUE, Miho, SHIBATA, Mami, NAKANO, Ryosuke, YAMANE-OHNUKI, Naoko, WAKITANI, Masako, YANO, Keiichi, SHITARA, Kenya, SATOH, Mitsuo
Published in Clinical cancer research (01.05.2006)
Published in Clinical cancer research (01.05.2006)
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Two mechanisms of the enhanced antibody-dependent cellular cytotoxicity (ADCC) efficacy of non-fucosylated therapeutic antibodies in human blood
Iida, Shigeru, Kuni-Kamochi, Reiko, Mori, Katsuhiro, Misaka, Hirofumi, Inoue, Miho, Okazaki, Akira, Shitara, Kenya, Satoh, Mitsuo
Published in BMC cancer (18.02.2009)
Published in BMC cancer (18.02.2009)
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Double knockdown of α1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC
Imai-Nishiya, Harue, Mori, Katsuhiro, Inoue, Miho, Wakitani, Masako, Iida, Shigeru, Shitara, Kenya, Satoh, Mitsuo
Published in BMC biotechnology (30.11.2007)
Published in BMC biotechnology (30.11.2007)
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Journal Article
A Nonfucosylated Anti-HER2 Antibody Augments Antibody-Dependent Cellular Cytotoxicity in Breast Cancer Patients
SUZUKI, Eiji, NIWA, Rinpei, TOI, Masakazu, SAJI, Shigehira, MUTA, Mariko, HIROSE, Makiko, IIDA, Shigeru, SHIOTSU, Yukimasa, SATOH, Mitsuo, SHITARA, Kenya, KONDO, Masahide
Published in Clinical cancer research (15.03.2007)
Published in Clinical cancer research (15.03.2007)
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Journal Article
Establishment of a GDP-mannose 4,6-dehydratase ( GMD) knockout host cell line: A new strategy for generating completely non-fucosylated recombinant therapeutics
Kanda, Yutaka, Imai-Nishiya, Harue, Kuni-Kamochi, Reiko, Mori, Katsuhiro, Inoue, Miho, Kitajima-Miyama, Kazuko, Okazaki, Akira, Iida, Shigeru, Shitara, Kenya, Satoh, Mitsuo
Published in Journal of biotechnology (30.06.2007)
Published in Journal of biotechnology (30.06.2007)
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Journal Article
Engineering Chinese hamster ovary cells to maximize effector function of produced antibodies using FUT8 siRNA
Mori, Katsuhiro, Kuni-Kamochi, Reiko, Yamane-Ohnuki, Naoko, Wakitani, Masako, Yamano, Kazuya, Imai, Harue, Kanda, Yutaka, Niwa, Rinpei, Iida, Shigeru, Uchida, Kazuhisa, Shitara, Kenya, Satoh, Mitsuo
Published in Biotechnology and bioengineering (30.12.2004)
Published in Biotechnology and bioengineering (30.12.2004)
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Journal Article
Non-fucosylated therapeutic antibodies : the next generation of therapeutic antibodies
MORI, Katsuhiro, IIDA, Shigeru, NIWA, Rinpei, SHITARA, Kenya, SATOH, Mitsuo, YAMANE-OHNUKI, Naoko, KANDA, Yutaka, KUNI-KAMOCHI, Reiko, NAKANO, Ryosuke, IMAI-NISHIYA, Harue, OKAZAKI, Akira, SHINKAWA, Toyohide, NATSUME, Akihito
Published in Cytotechnology (Dordrecht) (01.12.2007)
Published in Cytotechnology (Dordrecht) (01.12.2007)
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Conference Proceeding
Journal Article
Fucose Removal from Complex-Type Oligosaccharide Enhances the Antibody-Dependent Cellular Cytotoxicity of Single-Gene-Encoded Bispecific Antibody Comprising of Two Single-Chain Antibodies Linked to the Antibody Constant Region
Natsume, Akito, Wakitani, Masako, Yamane-Ohnuki, Naoko, Shoji-Hosaka, Emi, Niwa, Rinpei, Uchida, Kazuhisa, Satoh, Mitsuo, Shitara, Kenya
Published in Journal of biochemistry (Tokyo) (01.09.2006)
Published in Journal of biochemistry (Tokyo) (01.09.2006)
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Journal Article
Identification of the functional expression of adenosine A₃ receptor in pancreas using transgenic mice expressing jellyfish apoaequorin
Yamano, Kazuya, Mori, Katsuhiro, Nakano, Ryosuke, Kusunoki, Machi, Inoue, Miho, Satoh, Mitsuo
Published in Transgenic research (01.08.2007)
Published in Transgenic research (01.08.2007)
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