New central targets for the treatment of obesity
Sargent, Bruce J., Moore, Nicholas A.
Published in British journal of clinical pharmacology (01.12.2009)
Published in British journal of clinical pharmacology (01.12.2009)
Get full text
Journal Article
CSTI-300 (SMP-100); a Novel 5-HT 3 Receptor Partial Agonist with Potential to Treat Patients with Irritable Bowel Syndrome or Carcinoid Syndrome
Roberts, Alexander, Grafton, Gillian, Powell, Andrew D, Brock, Kristian, Chen, Chunlin, Xie, Dejian, Huang, Jinkun, Liu, Shuang, Cooper, Alison J, Brady, Catherine A, Qureshi, Omar, Stamataki, Zania, Manning, David D, Moore, Nicholas A, Sargent, Bruce J, Guzzo, Peter R, Barnes, Nicholas M
Published in The Journal of pharmacology and experimental therapeutics (01.04.2020)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2020)
Get full text
Journal Article
Synthesis and Biological Evaluation of N‑((1-(4-(Sulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide Inhibitors of Glycine Transporter‑1
Cioffi, Christopher L, Liu, Shuang, Wolf, Mark A, Guzzo, Peter R, Sadalapure, Kashinath, Parthasarathy, Visweswaran, Loong, David T. J, Maeng, Jun-Ho, Carulli, Edmund, Fang, Xiao, Karunakaran, Kalesh, Matta, Lakshman, Choo, Sok Hui, Panduga, Shailijia, Buckle, Ronald N, Davis, Randall N, Sakwa, Samuel A, Gupta, Priya, Sargent, Bruce J, Moore, Nicholas A, Luche, Michele M, Carr, Grant J, Khmelnitsky, Yuri L, Ismail, Jiffry, Chung, Mark, Bai, Mei, Leong, Wei Yee, Sachdev, Nidhi, Swaminathan, Srividya, Mhyre, Andrew J
Published in Journal of medicinal chemistry (22.09.2016)
Published in Journal of medicinal chemistry (22.09.2016)
Get full text
Journal Article
Design, Synthesis, and Structure−Activity Relationships of Novel 2-Substituted Pyrazinoylguanidine Epithelial Sodium Channel Blockers: Drugs for Cystic Fibrosis and Chronic Bronchitis
Hirsh, Andrew J, Molino, Bruce F, Zhang, Jianzhong, Astakhova, Nadezhda, Geiss, William B, Sargent, Bruce J, Swenson, Brian D, Usyatinsky, Alexander, Wyle, Michael J, Boucher, Richard C, Smith, Rick T, Zamurs, Andra, Johnson, M. Ross
Published in Journal of medicinal chemistry (13.07.2006)
Published in Journal of medicinal chemistry (13.07.2006)
Get full text
Journal Article
Partial Agonism of 5‑HT3 Receptors: A Novel Approach to the Symptomatic Treatment of IBS‑D
Moore, Nicholas A, Sargent, Bruce J, Manning, David D, Guzzo, Peter R
Published in ACS chemical neuroscience (16.01.2013)
Published in ACS chemical neuroscience (16.01.2013)
Get full text
Journal Article
From preclinical to clinical development: The example of a novel treatment for obesity
Moore, Nicholas A, Sargent, Bruce J, Guzzo, Peter R, Surman, Matthew D
Published in Neurobiology of disease (01.01.2014)
Published in Neurobiology of disease (01.01.2014)
Get full text
Journal Article
Design and Synthesis of 4‑Heteroaryl 1,2,3,4-Tetrahydroisoquinolines as Triple Reuptake Inhibitors
Liu, Shuang, Zha, Congxiang, Nacro, Kassoum, Hu, Min, Cui, Wenge, Yang, Yuh-Lin, Bhatt, Ulhas, Sambandam, Aruna, Isherwood, Matthew, Yet, Larry, Herr, Michael T, Ebeltoft, Sarah, Hassler, Carla, Fleming, Linda, Pechulis, Anthony D, Payen-Fornicola, Anne, Holman, Nicholas, Milanowski, Dennis, Cotterill, Ian, Mozhaev, Vadim, Khmelnitsky, Yuri, Guzzo, Peter R, Sargent, Bruce J, Molino, Bruce F, Olson, Richard, King, Dalton, Lelas, Snjezana, Li, Yu-Wen, Johnson, Kim, Molski, Thaddeus, Orie, Anitra, Ng, Alicia, Haskell, Roy, Clarke, Wendy, Bertekap, Robert, O’Connell, Jonathan, Lodge, Nicholas, Sinz, Michael, Adams, Stephen, Zaczek, Robert, Macor, John E
Published in ACS medicinal chemistry letters (10.07.2014)
Published in ACS medicinal chemistry letters (10.07.2014)
Get full text
Journal Article
Synthesis and SAR of heterocyclic carboxylic acid isosteres based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity
Hadden, Mark, Goodman, Allan, Guo, Cheng, Guzzo, Peter R., Henderson, Alan J., Pattamana, Kevin, Ruenz, Megan, Sargent, Bruce J., Swenson, Brian, Yet, Larry, Liu, Jian, He, Shuwen, Sebhat, Iyassu K., Lin, Linus S., Tamvakopoulos, Constantin, Peng, Qianping, Kan, Yanqing, Palyha, Oksana, Kelly, Theresa M., Guan, Xiao-Ming, Metzger, Joseph M., Reitman, Marc L., Nargund, Ravi P.
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Get full text
Journal Article
Synthesis of 7-benzyl-5-(piperidin-1-yl)-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c]-[2,7]naphthyridin-1-ylamine and its analogs as bombesin receptor subtype-3 agonists
CHENG GUO, GUZZO, Peter R, GAGEN, Karen, METZGER, Joseph M, DRAGOVIC, Jasminka, LYONS, Kathryn, LIN, Linus S, NARGUND, Ravi P, HADDEN, Mark, SARGENT, Bruce J, YET, Larry, YANQING KAN, PALYHA, Oksana, KELLY, Theresa M, XIAOMING GUAN, ROSKO, Kim
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Get full text
Journal Article
Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity
Liu, Jian, He, Shuwen, Jian, Tianying, Dobbelaar, Peter H., Sebhat, Iyassu K., Lin, Linus S., Goodman, Allan, Guo, Cheng, Guzzo, Peter R., Hadden, Mark, Henderson, Alan J., Pattamana, Kevin, Ruenz, Megan, Sargent, Bruce J, Swenson, Brian, Yet, Larry, Tamvakopoulos, Constantin, Peng, Qianping, Pan, Jie, Kan, Yanqing, Palyha, Oksana, Kelly, Theresa M., Guan, Xiao-Ming, Howard, Andrew D., Marsh, Donald J., Metzger, Joseph M., Reitman, Marc L., Wyvratt, Matthew J., Nargund, Ravi P.
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Get full text
Journal Article
Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists
He, Shuwen, Dobbelaar, Peter H., Liu, Jian, Jian, Tianying, Sebhat, Iyassu K., Lin, Linus S., Goodman, Allan, Guo, Cheng, Guzzo, Peter R., Hadden, Mark, Henderson, Alan J., Ruenz, Megan, Sargent, Bruce J., Yet, Larry, Kelly, Theresa M., Palyha, Oksana, Kan, Yanqing, Pan, Jie, Chen, Howard, Marsh, Donald J., Shearman, Lauren P., Strack, Alison M., Metzger, Joseph M., Feighner, Scott D., Tan, Carina, Howard, Andrew D., Tamvakopoulos, Constantin, Peng, Qianping, Guan, Xiao-Ming, Reitman, Marc L., Patchett, Arthur A., Wyvratt, Matthew J., Nargund, Ravi P.
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
Get full text
Journal Article
Oxidative decarbonylation of β-arylpyruvic acids using sodium perborate
Morrow, Nicholas, Ramsden, Christopher A, Sargent, Bruce J, Wallett, Christiaan D
Published in Tetrahedron (13.08.1998)
Published in Tetrahedron (13.08.1998)
Get full text
Journal Article
Partial Agonism of 5-HT 3 Receptors: A Novel Approach to the Symptomatic Treatment of IBS-D
Moore, Nicholas A., Sargent, Bruce J., Manning, David D., Guzzo, Peter R.
Published in ACS chemical neuroscience (16.01.2013)
Published in ACS chemical neuroscience (16.01.2013)
Get full text
Journal Article
Synthesis of 7-benzyl-5-(piperidin-1-yl)-6,7,8,9-tetrahydro-3 H-pyrazolo[3,4- c][2,7]naphthyridin-1-ylamine and its analogs as bombesin receptor subtype-3 agonists
Guo, Cheng, Guzzo, Peter R., Hadden, Mark, Sargent, Bruce J., Yet, Larry, Kan, Yanqing, Palyha, Oksana, Kelly, Theresa M., Guan, Xiaoming, Rosko, Kim, Gagen, Karen, Metzger, Joseph M., Dragovic, Jasminka, Lyons, Kathryn, Lin, Linus S., Nargund, Ravi P.
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
Get full text
Journal Article
NEW CAPPED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS
SARGENT, BRUCE, ZHANG, JIANZHONG, MOLINO, BRUCE F, JOHNSON, MICHAEL R
Year of Publication 28.02.2014
Get full text
Year of Publication 28.02.2014
Patent
NEW CAPPED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS
SARGENT, BRUCE, ZHANG, JIANZHONG, MOLINO, BRUCE F, JOHNSON, MICHAEL R
Year of Publication 31.12.2013
Get full text
Year of Publication 31.12.2013
Patent