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Discovery, Optimization, and Preclinical Pharmacology of EP652, a METTL3 Inhibitor with Efficacy in Liquid and Solid Tumor Models
Dutheuil, Guillaume, Oukoloff, Killian, Korac, Julien, Lenoir, François, El Bousmaqui, Mohamed, Probst, Nicolas, Lapin, Alexey, Nakhabina, Galina, Sorlet, Catherine, Parmentier, Nicolas, Karila, Delphine, Ghavtadze, Nugzar, Casault, Paméla, Claridge, Stephen, Sapmaz, Selma, Slater, Martin J., Fraser, Graeme L.
Published in Journal of medicinal chemistry (13.02.2025)
Published in Journal of medicinal chemistry (13.02.2025)
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Dual vicinal functionalisation of heterocycles via an interrupted Pummerer coupling/[3,3]-sigmatropic rearrangement cascadeElectronic supplementary information (ESI) available: Full experimental details, NMR spectra, CCDC numbers for X-ray structures. CCDC 1570504, 1570698. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc04723a
Šiau iulis, Mindaugas, Sapmaz, Selma, Pulis, Alexander P, Procter, David J
Year of Publication 17.01.2018
Year of Publication 17.01.2018
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Defining Target Engagement Required for Efficacy In Vivo at the Retinoic Acid Receptor-Related Orphan Receptor C2 (RORγt)
Lugar, Charles W, Clarke, Christian A, Morphy, Richard, Rudyk, Helene, Sapmaz, Selma, Stites, Ryan E, Vaught, Grant M, Furness, Kelly, Broughton, Howard B, Durst, Greg L, Clawson, David K, Stout, Stephanie L, Guo, Sherry Y, Durbin, Jim D, Stayrook, Keith R, Edmondson, Denise D, Kikly, Kristy, New, Nicole E, Bina, Holly A, Chambers, Mark G, Shetler, Pamela, Chang, William Y, Chang, Veavi Ching-Yun, Barr, Rob, Gough, Wendy H, Steele, Jimmy P, Getman, Brian, Patel, Nita, Mathes, Brian M, Richardson, Timothy I
Published in Journal of medicinal chemistry (13.05.2021)
Published in Journal of medicinal chemistry (13.05.2021)
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3-SUBSTITUTED-6-(PYRIDINYLMETHOXY)-PYRROLOPYRIDINE COMPOUNDS
RICHARDS SIMON JAMES, SAPMAZ SELMA, WALTER MAGNUS WILHELM, LAMAS PETEIRA CARLOS
Year of Publication 05.08.2013
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Year of Publication 05.08.2013
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COMPOUNDS USEFUL FOR INHIBITING ROR-GAMMA-T
RICHARDSON, Timothy Ivo, MORPHY, John Richard, SAPMAZ, Selma, LUGAR, Charles Willis III, RUDYK, Helene, STITES, Ryan Edward
Year of Publication 14.04.2021
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Year of Publication 14.04.2021
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Reactivity of the TMM Entity in the Cyclopentene Series − Observation of a Reversed Regioselectivity in Palladium-Catalyzed [3+2] Cycloadditions
Romero, Juan Manuel López, Sapmaz, Selma, Fensterbank, Louis, Malacria, Max
Published in European journal of organic chemistry (01.02.2001)
Published in European journal of organic chemistry (01.02.2001)
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Compounds useful for inhibiting RORγt
Richardson, Timothy Ivo, Sapmaz, Selma, Lugar, III, Charles Willis, Morphy, John Richard, Stites, Ryan Edward, Vaught, Grant Mathews, Rudyk, Helene, Clarke, Christian Alexander
Year of Publication 18.05.2021
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Year of Publication 18.05.2021
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Compounds useful for inhibiting ROR-gamma-t
Richardson, Timothy Ivo, Sapmaz, Selma, Lugar, III, Charles Willis, Rudyk, Helene Catherine Eugenie, Morphy, John Richard, Stites, Ryan Edward
Year of Publication 31.03.2020
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Year of Publication 31.03.2020
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COMPOUNDS USEFUL FOR INHIBITING ROR-GAMMA-T
Richardson, Timothy Ivo, Sapmaz, Selma, Lugar, III, Charles Willis, Rudyk, Helene Catherine Eugenie, Morphy, John Richard, Stites, Ryan Edward
Year of Publication 09.01.2020
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Year of Publication 09.01.2020
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COMPOUNDS USEFUL FOR INHIBITING ROR-GAMMA-T
RICHARDSON, Timothy Ivo, MORPHY, John Richard, SAPMAZ, Selma, LUGAR, Charles Willis III, RUDYK, Helene, STITES, Ryan Edward
Year of Publication 08.01.2020
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Year of Publication 08.01.2020
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COMPOUNDS USEFUL FOR INHIBITING ROR-GAMMA-T
RICHARDSON, Timothy Ivo, MORPHY, John Richard, SAPMAZ, Selma, LUGAR, Charles Willis III, RUDYK, Helene, STITES, Ryan Edward
Year of Publication 07.09.2018
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Year of Publication 07.09.2018
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compostos de 6-(piridinilmetóxi)-pirrolopiridina substitu-ídos em 3
CARLOS LAMAS-PETEIRA, SIMON JAMES RICHARDS, MAGNUS WILHELM WALTER, SELMA SAPMAZ
Year of Publication 06.09.2016
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Year of Publication 06.09.2016
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