Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A
Steadman, Victoria A, Pettit, Simon B, Poullennec, Karine G, Lazarides, Linos, Keats, Andrew J, Dean, David K, Stanway, Steven J, Austin, Carol A, Sanvoisin, Jonathan A, Watt, Gregory M, Fliri, Hans G, Liclican, Albert C, Jin, Debi, Wong, Melanie H, Leavitt, Stephanie A, Lee, Yu-Jen, Tian, Yang, Frey, Christian R, Appleby, Todd C, Schmitz, Uli, Jansa, Petr, Mackman, Richard L, Schultz, Brian E
Published in Journal of medicinal chemistry (09.02.2017)
Published in Journal of medicinal chemistry (09.02.2017)
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Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle
Mackman, Richard L, Steadman, Victoria A, Dean, David K, Jansa, Petr, Poullennec, Karine G, Appleby, Todd, Austin, Carol, Blakemore, Caroline A, Cai, Ruby, Cannizzaro, Carina, Chin, Gregory, Chiva, Jean-Yves C, Dunbar, Neil A, Fliri, Hans, Highton, Adrian J, Hui, Hon, Ji, Mingzhe, Jin, Haolun, Karki, Kapil, Keats, Andrew J, Lazarides, Linos, Lee, Yu-Jen, Liclican, Albert, Mish, Michael, Murray, Bernard, Pettit, Simon B, Pyun, Peter, Sangi, Michael, Santos, Rex, Sanvoisin, Jonathan, Schmitz, Uli, Schrier, Adam, Siegel, Dustin, Sperandio, David, Stepan, George, Tian, Yang, Watt, Gregory M, Yang, Hai, Schultz, Brian E
Published in Journal of medicinal chemistry (08.11.2018)
Published in Journal of medicinal chemistry (08.11.2018)
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Fragment screening using capillary electrophoresis (CEfrag) for hit identification of heat shock protein 90 ATPase inhibitors
Austin, Carol, Pettit, Simon N, Magnolo, Sharon K, Sanvoisin, Jonathan, Chen, Wenjie, Wood, Stephen P, Freeman, Lauren D, Pengelly, Reuben J, Hughes, Dallas E
Published in Journal of biomolecular screening (01.08.2012)
Published in Journal of biomolecular screening (01.08.2012)
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Uracil recognition by replicative DNA polymerases is limited to the archaea, not occurring with bacteria and eukarya
Wardle, Josephine, Burgers, Peter M.J, Cann, Isaac K.O, Darley, Kate, Heslop, Pauline, Johansson, Erik, Lin, Li-Jung, McGlynn, Peter, Sanvoisin, Jonathan, Stith, Carrie M, Connolly, Bernard A
Published in Nucleic acids research (01.02.2008)
Published in Nucleic acids research (01.02.2008)
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MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES
SANVOISIN JONATHAN, WATT GREGORY M, FLIRI HANS G, LAZARIDES LINOS, KEATS ANDREW J, MACKMAN RICHARD L, APPLEBY TODD, PETTIT SIMON N, STEADMAN VICTORIA A, POULLENNEC KARINE G
Year of Publication 13.03.2014
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Year of Publication 13.03.2014
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Catechol dioxygenases from Escherichia coli (MhpB) and Alcaligenes eutrophus (MpcI): sequence analysis and biochemical properties of a third family of extradiol dioxygenases
Spence, E L, Kawamukai, M, Sanvoisin, J, Braven, H, Bugg, T D
Published in Journal of Bacteriology (01.09.1996)
Published in Journal of Bacteriology (01.09.1996)
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Serine-threonine protein phosphatase inhibitors derived from nodularin: role of the 2-methyl and 3-diene groups in the Adda residue and the effect of macrocyclic conformational restraint
O'Donnell, ME, Sanvoisin, J, Gani, D
Published in Perkin 1 : an international journal of organic and bio-organic chemistry (01.01.2001)
Published in Perkin 1 : an international journal of organic and bio-organic chemistry (01.01.2001)
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Macrocyclic inhibitors of Flaviviridae viruses
Keats, Andrew J, Mackman, Richard L, Appleby, Todd, Steadman, Victoria A, Lazarides, Linos, Poullennec, Karine G, Fliri, Hans G, Pettit, Simon N, Watt, Gregory M, Sanvoisin, Jonathan
Year of Publication 15.12.2016
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Year of Publication 15.12.2016
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inibidores macrocíclicos do vírus flaviviridae
ANDREW J. KEATS, GREGORY M. WATT, JONATHAN SANVOISIN, LINOS LAZARIDES, HANS G. FLIRI, RICHARD L. MACKMAN, KARINE G. POULLENNEC, TODD APPLEBY, VICTORIA A. STEADMAN, SIMON N. PETTIT
Year of Publication 13.09.2016
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Year of Publication 13.09.2016
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MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES
SANVOISIN, JONATHAN, LAZARIDES, LINOS, POULLENNEC, KARINE G, STEADMAN, VICTORIA A, APPLEBY, TODD, PETTIT, SIMON N, WATT, GREGORY M, FLIRI, HANS G, MACKMAN, RICHARD L, KEATS, ANDREW J
Year of Publication 31.08.2015
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Year of Publication 31.08.2015
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MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES
SANVOISIN JONATHAN, WATT GREGORY M, FLIRI HANS G, LAZARIDES LINOS, KEATS ANDREW J, MACKMAN RICHARD L, APPLEBY TODD, PETTIT SIMON N, STEADMAN VICTORIA A, POULLENNEC KARINE G
Year of Publication 31.07.2015
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Year of Publication 31.07.2015
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Macrocyclic inhibitors of flaviviridae viruses
SANVOISIN JONATHAN, WATT GREGORY M, FLIRI HANS G, LAZARIDES LINOS, KEATS ANDREW J, MACKMAN RICHARD L, APPLEBY TODD, PETTIT SIMON N, STEADMAN VICTORIA A, POULLENNEC KARINE G
Year of Publication 31.07.2015
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Year of Publication 31.07.2015
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MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES
ANDREW J. KEATS, JONATHAN SANVOISIN, GREGORY M. WATT, LINOS LAZARIDES, HANS G. FLIRI, RICHARD L. MACKMAN, KARINE G. POULLENNEC, TODD APPLEBY, VICTORIA A. STEADMAN, SIMON N. PETTIT
Year of Publication 02.06.2015
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Year of Publication 02.06.2015
Patent
Macrocyclic inhibitors of flaviviridae viruses
SANVOISIN JONATHAN, WATT GREGORY M, FLIRI HANS G, LAZARIDES LINOS, KEATS ANDREW J, MACKMAN RICHARD L, APPLEBY TODD, PETTIT SIMON N, STEADMAN VICTORIA A, POULLENNEC KARINE G
Year of Publication 13.01.2015
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Year of Publication 13.01.2015
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MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES
ANDREW J. KEATS, JONATHAN SANVOISIN, GREGORY M. WATT, LINOS LAZARIDES, HANS G. FLIRI, RICHARD L. MACKMAN, KARINE G. POULLENNEC, TODD APPLEBY, VICTORIA A. STEADMAN, SIMON N. PETTIT
Year of Publication 18.07.2014
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Year of Publication 18.07.2014
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MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES
SANVOISIN JONATHAN, KAETS ANDREW J, WATT GREGORY M, FLIRI HANS G, LAZARIDES LINOS, MACKMAN RICHARD L, APPLEBY TODD, PETTIT SIMON N, STEADMAN VICTORIA A, POULLENNEC KARINE G
Year of Publication 23.01.2014
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Year of Publication 23.01.2014
Patent