Effects of pH and Low Density Lipoprotein (LDL) on PCSK9-dependent LDL Receptor Regulation
Fisher, Timothy S., Surdo, Paola Lo, Pandit, Shilpa, Mattu, Marco, Santoro, Joseph C., Wisniewski, Doug, Cummings, Richard T., Calzetta, Alessandra, Cubbon, Rose M., Fischer, Paul A., Tarachandani, Anil, De Francesco, Raffaele, Wright, Samuel D., Sparrow, Carl P., Carfi, Andrea, Sitlani, Ayesha
Published in The Journal of biological chemistry (13.07.2007)
Published in The Journal of biological chemistry (13.07.2007)
Get full text
Journal Article
Structural and Biochemical Characterization of the Wild Type PCSK9-EGF(AB) Complex and Natural Familial Hypercholesterolemia Mutants
Bottomley, Matthew J., Cirillo, Agostino, Orsatti, Laura, Ruggeri, Lionello, Fisher, Timothy S., Santoro, Joseph C., Cummings, Richard T., Cubbon, Rose M., Lo Surdo, Paola, Calzetta, Alessandra, Noto, Alessia, Baysarowich, Jennifer, Mattu, Marco, Talamo, Fabio, De Francesco, Raffaele, Sparrow, Carl P., Sitlani, Ayesha, Carfí, Andrea
Published in The Journal of biological chemistry (09.01.2009)
Published in The Journal of biological chemistry (09.01.2009)
Get full text
Journal Article
Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors
Ma, Bin, Metrick, Claire M., Gu, Chungang, Hoemberger, Marc, Bajrami, Bekim, Bame, Eris, Huang, Jiansheng, Mingueneau, Michael, Murugan, Paramasivam, Santoro, Joseph C., Tang, Hao, Wang, Ti, Hopkins, Brian T.
Published in Bioorganic & medicinal chemistry letters (15.03.2022)
Published in Bioorganic & medicinal chemistry letters (15.03.2022)
Get full text
Journal Article
Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis
Hopkins, Brian T, Bame, Eris, Bajrami, Bekim, Black, Cheryl, Bohnert, Tonika, Boiselle, Carrie, Burdette, Doug, Burns, Jeremy C, Delva, Luisette, Donaldson, Douglas, Grater, Richard, Gu, Chungang, Hoemberger, Marc, Johnson, Josh, Kapadnis, Sudarshan, King, Kris, Lulla, Mukesh, Ma, Bin, Marx, Isaac, Magee, Tom, Meissner, Robert, Metrick, Claire M, Mingueneau, Michael, Murugan, Paramasivam, Otipoby, Kevin L, Polack, Evelyne, Poreci, Urjana, Prince, Robin, Roach, Allie M, Rowbottom, Chris, Santoro, Joseph C, Schroeder, Patricia, Tang, Hao, Tien, Eric, Zhang, Fengmei, Lyssikatos, Joseph
Published in Journal of medicinal chemistry (27.01.2022)
Published in Journal of medicinal chemistry (27.01.2022)
Get full text
Journal Article
Corrigendum to “Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors” [Bioorg. Med. Chem. Lett. 60 (2022) 128549]
Ma, Bin, Metrick, Claire M., Gu, Chungang, Hoemberger, Marc, Bajrami, Bekim, Bame, Eris, Huang, Jiansheng, Mingueneau, Michael, Murugan, Paramasivam, Nevalainen, Marta, Santoro, Joseph C., Tang, Hao, Wang, Ti, Hopkins, Brian T.
Published in Bioorganic & medicinal chemistry letters (15.09.2022)
Published in Bioorganic & medicinal chemistry letters (15.09.2022)
Get full text
Journal Article
Rational Design and Optimization of a Novel Class of Macrocyclic Apoptosis Signal-Regulating Kinase 1 Inhibitors
Himmelbauer, Martin K, Xin, Zhili, Jones, J. Howard, Enyedy, Istvan, King, Kristopher, Marcotte, Douglas J, Murugan, Paramasivam, Santoro, Joseph C, Hesson, Thomas, Spilker, Kerri, Johnson, Joshua L, Luzzio, Michael J, Gilfillan, Rab, de Turiso, Felix Gonzalez-Lopez
Published in Journal of medicinal chemistry (12.12.2019)
Published in Journal of medicinal chemistry (12.12.2019)
Get full text
Journal Article
Human PLD structures enable drug design and characterization of isoenzyme selectivity
Metrick, Claire M., Peterson, Emily A., Santoro, Joseph C., Enyedy, Istvan J., Murugan, Paramasivam, Chen, TeYu, Michelsen, Klaus, Cullivan, Michael, Spilker, Kerri A., Kumar, P. Rajesh, May-Dracka, Tricia L., Chodaparambil, Jayanth V.
Published in Nature chemical biology (01.04.2020)
Published in Nature chemical biology (01.04.2020)
Get full text
Journal Article
Discovery of Potent, Selective, and Brain-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors that Modulate Brain Inflammation In Vivo
Jones, J. Howard, Xin, Zhili, Himmelbauer, Martin, Dechantsreiter, Michael, Enyedy, Istvan, Hedde, Joseph, Fang, Terry, Coomaraswamy, Janaky, King, Kristopher W, Murugan, Paramasivam, Santoro, Joseph C, Hesson, Thomas, Walther, Dirk M, Wei, Ru, Zheng, Fengmei, Marcotte, Douglas J, Spilker, Kerri, Kumar, P. Rajesh, Liu, Ying, Gilfillan, Rab, Gonzalez-Lopez de Turiso, Felix
Published in Journal of medicinal chemistry (28.10.2021)
Published in Journal of medicinal chemistry (28.10.2021)
Get full text
Journal Article
Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis
Himmelbauer, Martin K., Bajrami, Bekim, Basile, Rebecca, Capacci, Andrew, Chen, TeYu, Choi, Colin K., Gilfillan, Rab, Gonzalez-Lopez de Turiso, Felix, Gu, Chungang, Hoemberger, Marc, Johnson, Douglas S., Jones, J. Howard, Kadakia, Ekta, Kirkland, Melissa, Lin, Edward Y., Liu, Ying, Ma, Bin, Magee, Tom, Mantena, Srinivasa, Marx, Isaac E., Metrick, Claire M., Mingueneau, Michael, Murugan, Paramasivam, Muste, Cathy A., Nadella, Prasad, Nevalainen, Marta, Parker Harp, Chelsea R., Pattaropong, Vatee, Pietrasiewicz, Alicia, Prince, Robin J., Purgett, Thomas J., Santoro, Joseph C., Schulz, Jurgen, Sciabola, Simone, Tang, Hao, Vandeveer, H. George, Wang, Ti, Yousaf, Zain, Helal, Christopher J., Hopkins, Brian T.
Published in Journal of medicinal chemistry (23.05.2024)
Published in Journal of medicinal chemistry (23.05.2024)
Get full text
Journal Article
Discovery of CNS-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors
Xin, Zhili, Himmelbauer, Martin K, Jones, J. Howard, Enyedy, Istvan, Gilfillan, Rab, Hesson, Thomas, King, Kristopher, Marcotte, Douglas J, Murugan, Paramasivam, Santoro, Joseph C, Gonzalez-Lopez de Turiso, Felix
Published in ACS medicinal chemistry letters (09.04.2020)
Published in ACS medicinal chemistry letters (09.04.2020)
Get full text
Journal Article
Functional analysis of sites within PCSK9 responsible for hypercholesterolemia
Pandit, Shilpa, Wisniewski, Doug, Santoro, Joseph C, Ha, Sookhee, Ramakrishnan, Vijayalakshmi, Cubbon, Rose M, Cummings, Richard T, Wright, Samuel D, Sparrow, Carl P, Sitlani, Ayesha, Fisher, Timothy S
Published in Journal of lipid research (01.06.2008)
Published in Journal of lipid research (01.06.2008)
Get full text
Journal Article
A Proprotein Convertase Subtilisin-like/Kexin Type 9 (PCSK9) C-terminal Domain Antibody Antigen-binding Fragment Inhibits PCSK9 Internalization and Restores Low Density Lipoprotein Uptake
Ni, Yan G., Condra, Jon H., Orsatti, Laura, Shen, Xun, Di Marco, Stefania, Pandit, Shilpa, Bottomley, Matthew J., Ruggeri, Lionello, Cummings, Richard T., Cubbon, Rose M., Santoro, Joseph C., Ehrhardt, Anka, Lewis, Dale, Fisher, Timothy S., Ha, Sookhee, Njimoluh, Leila, Wood, Dana D., Hammond, Holly A., Wisniewski, Douglas, Volpari, Cinzia, Noto, Alessia, Lo Surdo, Paola, Hubbard, Brian, Carfí, Andrea, Sitlani, Ayesha
Published in The Journal of biological chemistry (23.04.2010)
Published in The Journal of biological chemistry (23.04.2010)
Get full text
Journal Article
Route and method of delivery of DNA vaccine influence immune responses in mice and non-human primates
McCluskie, M J, Brazolot Millan, C L, Gramzinski, R A, Robinson, H L, Santoro, J C, Fuller, J T, Widera, G, Haynes, J R, Purcell, R H, Davis, H L
Published in Molecular medicine (Cambridge, Mass.) (01.05.1999)
Published in Molecular medicine (Cambridge, Mass.) (01.05.1999)
Get full text
Journal Article
Functional analysis of sites within PCSK9 responsible for hypercholesterolemias
Pandit, Shilpa, Wisniewski, Doug, Santoro, Joseph C., Ha, Sookhee, Ramakrishnan, Vijayalakshmi, Cubbon, Rose M., Cummings, Richard T., Wright, Samuel D., Sparrow, Carl P., Sitlani, Ayesha, Fisher, Timothy S.
Published in Journal of lipid research (01.06.2008)
Published in Journal of lipid research (01.06.2008)
Get full text
Journal Article
Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity
Smith, Cameron J., Ali, Amjad, Balkovec, James M., Graham, Donald W., Hammond, Milton L., Patel, Gool F., Rouen, Gregory P., Smith, Scott K., Tata, James R., Einstein, Monica, Ge, Lan, Harris, Georgianna S., Kelly, Theresa M., Mazur, Paul, Thompson, Chris M., Wang, Chuanlin F., Williamson, Joanne M., Miller, Douglas K., Pandit, Shilpa, Santoro, Joseph C., Sitlani, Ayesha, Yamin, Ting-ting D., O’Neill, Edward A., Zaller, Dennis M., Carballo-Jane, Ester, Forrest, Michael J., Luell, Silvi
Published in Bioorganic & medicinal chemistry letters (02.06.2005)
Published in Bioorganic & medicinal chemistry letters (02.06.2005)
Get full text
Journal Article
Skeletal muscle: a dual system to measure glucocorticoid-dependent transactivation and transrepression of gene regulation
Carballo-Jane, Ester, Pandit, Shilpa, Santoro, Joseph C, Freund, Concetta, Luell, Silvi, Harris, Georgianna, Forrest, Michael J, Sitlani, Ayesha
Published in The Journal of steroid biochemistry and molecular biology (01.02.2004)
Published in The Journal of steroid biochemistry and molecular biology (01.02.2004)
Get full text
Journal Article
Protection Against Rotavirus Infections By DNA Vaccination
Herrmann, John E., Chen, Shing C., Fynan, Ellen F., Santoro, Joseph C., Greenberg, Harry B., Wang, Shixia, Robinson, Harriet L.
Published in The Journal of infectious diseases (01.09.1996)
Published in The Journal of infectious diseases (01.09.1996)
Get full text
Journal Article
Conference Proceeding
HIV-1 Env Glycoproteins from Two Series of Primary Isolates: Replication Phenotype and Immunogenicity
Mustafa, Farah, Richmond, Joan F.L, Fernandez-Larsson, Roberto, Lu, Shan, Fredriksson, Robert, Fenyö, Eva Maria, O'connell, Maryellen, Johnson, Eric, Weng, Jiayu, Santoro, Joseph C, Robinson, Harriet L
Published in Virology (New York, N.Y.) (03.03.1997)
Published in Virology (New York, N.Y.) (03.03.1997)
Get full text
Journal Article
DNA Vaccines: Protective Immunizations by Parenteral, Mucosal, and Gene-Gun Inoculations
Fynan, Ellen F., Webster, Robert G., Fuller, Deborah H., Haynes, Joel R., Santoro, Joseph C., Robinson, Harriet L.
Published in Proceedings of the National Academy of Sciences - PNAS (15.12.1993)
Published in Proceedings of the National Academy of Sciences - PNAS (15.12.1993)
Get full text
Journal Article
Abstract 831: Functional Analysis of S127 and D374 Residues of PCSK9: Distinct Hot Spots for Gain of Function
Fisher, Timothy S, Pandit, Shilpa, Wisniewski, Douglas, Santoro, Joseph C, Cubbon, Rose M, Ha, Sookhee, Cummings, Richard T, Wright, Samuel D, Sparrow, Carl P, Sitlani, Ayesha
Published in Circulation (New York, N.Y.) (16.10.2007)
Published in Circulation (New York, N.Y.) (16.10.2007)
Get full text
Journal Article