Discovery and characterization of COVA322, a clinical-stage bispecific TNF/IL-17A inhibitor for the treatment of inflammatory diseases
Silacci, Michela, Lembke, Wibke, Woods, Richard, Attinger-Toller, Isabella, Baenziger-Tobler, Nadja, Batey, Sarah, Santimaria, Roger, von der Bey, Ulrike, Koenig-Friedrich, Susann, Zha, Wenjuan, Schlereth, Bernd, Locher, Mathias, Bertschinger, Julian, Grabulovski, Dragan
Published in mAbs (01.01.2016)
Published in mAbs (01.01.2016)
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Journal Article
Protein N-glycosylation, protein folding, and protein quality control
Roth, Jurgen, Yonsei University, Seoul, Republic of Korea, Zuber, Christian, University of Zurich, Zurich, Switzerland, Park, S.J., Yonsei University, Seoul, Republic of Korea, Jang, I.S., Yonsei University, Seoul, Republic of Korea, Lee, Y.S., Yonsei University, Seoul, Republic of Korea, Kysela, Katarina Gaplovska, University of Zurich, Zurich, Switzerland, Fourn, Valerie Le, University of Zurich, Zurich, Switzerland, Santimaria, Roger, University of Zurich, Zurich, Switzerland, Guhl, Bruno, University of Zurich, Zurich, Switzerland, Cho, J.W., Yonsei University, Seoul, Republic of Korea
Published in Molecules and cells (01.12.2010)
Published in Molecules and cells (01.12.2010)
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Journal Article
Relevance of Periostin Splice Variants in Renal Cell Carcinoma
Morra, Laura, Rechsteiner, Markus, Casagrande, Silvia, Duc Luu, Van, Santimaria, Roger, Diener, Pierre A, Sulser, Tullio, Kristiansen, Glen, Schraml, Peter, Moch, Holger, Soltermann, Alex
Published in The American journal of pathology (01.09.2011)
Published in The American journal of pathology (01.09.2011)
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Journal Article
EDEM1 reveals a quality control vesicular transport pathway out of the endoplasmic reticulum not involving the COPII exit sites
Zuber, Christian, Cormier, James H, Guhl, Bruno, Santimaria, Roger, Hebert, Daniel N, Roth, Jürgen
Published in Proceedings of the National Academy of Sciences - PNAS (13.03.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (13.03.2007)
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Journal Article
Bispecific CD3/HER2 Targeting FynomAb Induces Redirected T Cell-Mediated Cytolysis with High Potency and Enhanced Tumor Selectivity
Wuellner, Ulrich, Klupsch, Kristina, Buller, Fabian, Attinger-Toller, Isabella, Santimaria, Roger, Zbinden, Irene, Henne, Patricia, Grabulovski, Dragan, Bertschinger, Julian, Brack, Simon
Published in Antibodies (Basel) (08.12.2015)
Published in Antibodies (Basel) (08.12.2015)
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Journal Article
Induced prion protein controls immune-activated retroviruses in the mouse spleen
Lötscher, Marius, Recher, Mike, Lang, Karl S, Navarini, Alexander, Hunziker, Lukas, Santimaria, Roger, Glatzel, Markus, Schwarz, Petra, Böni, Jürg, Zinkernagel, Rolf M
Published in PloS one (07.11.2007)
Published in PloS one (07.11.2007)
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Journal Article
Abstract 1842: CD79b targeting ADC with superior pharmacokinetic profile and anti-tumor activity
Spycher, Philipp René, Probst, Philipp, Bertrand, Romain, Stark, Ramona, Santimaria, Roger, Grabulovski, Dragan, Attinger-Toller, Isabella
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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A CD79b Targeting ADC with Superior Anti-Tumor Activity and Safety Resulting in Significantly Improved Therapeutic Index (TI): Safe and Efficacious CD79b ADC
Schlereth, Bernd, Attinger-toller, Isabella, Probst, Philipp, Bertrand, Romain, Stark, Ramona, Santimaria, Roger, Renard, Emma, Fay, Rachael, Sharman, Jeff P., Grabulovski, Dragan, Spycher, Philipp
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Protein N-Glycosylation, Protein Folding, and Protein Quality Control
Roth, Jurgen, Zuber, Christian, Park, Su-Jin, Jang, In-Sook, Lee, Yang-Sin, Kysela, Katarina Gaplovska, Le Fourn, Valerie, Santimaria, Roger, Guhl, Bruno, Cho, Jin-Won
Published in Molecules and cells (2010)
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Published in Molecules and cells (2010)
Journal Article
Abstract LB221: Novel peptide linker-based nectin-4 targeting ADC shows improved tolerability with long-lasting anti-tumor efficacy at low doses
Attinger-Toller, Isabella, Probst, Philipp, Bertrand, Romain, Renard, Emma, Stark, Ramona, Santimaria, Roger, Grabulovski, Dragan, Schlereth, Bernd, Spycher, Philipp Rene
Published in Cancer research (Chicago, Ill.) (14.04.2023)
Published in Cancer research (Chicago, Ill.) (14.04.2023)
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Abstract LB219: Inducing significant and efficient tumor growth inhibition vs trastuzumab deruxtecan with low drug-load topoisomerase 1 inhibitor ADC using novel peptide linkers for payload conjugation
Attinger-Toller, Isabella, Fay, Rachael, Bertrand, Romain, Probst, Philipp, Stark, Ramona, Santimaria, Roger, Grabulovski, Dragan, Schlereth, Bernd, Spycher, Philipp Rene
Published in Cancer research (Chicago, Ill.) (14.04.2023)
Published in Cancer research (Chicago, Ill.) (14.04.2023)
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Journal Article
Abstract LB124: Targeting NaPi2b with a novel dual TOP1i ADC that shows excellent biophysical properties and high efficacy in vivo
Attinger-Toller, Isabella, Probst, Philipp, Kallenberger, Lia, Renard, Emma, Bertrand, Romain, Fay, Rachael, Santimaria, Roger, Maurhofer, Patrick, Grabulovski, Dragan, Schlereth, Bernd, Spycher, Philipp Rene
Published in Cancer research (Chicago, Ill.) (05.04.2024)
Published in Cancer research (Chicago, Ill.) (05.04.2024)
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Journal Article
Abstract 2600: Novel dual TOP1i ADC inducing superior tumour growth inhibition at low-drug load vs. trastuzumab deruxtecan
Spycher, Philipp, Fay, Rachael, Bertrand, Romain, Probst, Philipp, Stark, Ramona, Santimaria, Roger, Maurhofer, Patrick, Kallenberger, Lia, Renard, Emma, Schlereth, Bernd, Grabulovski, Dragan, Attinger-Toller, Isabella
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Abstract LB174: Inducing complete and long-lasting tumor eradications at safe and well tolerated doses of a nectin-4 ADC generated with novel peptide linkers for payload conjugation
Attinger-Toller, Isabella, Probst, Philipp, Bertrand, Romain, Stark, Ramona, Santimaria, Roger, Grabulovski, Dragan, Schlereth, Bernd, Spycher, Philipp
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
COVA4231, a potent CD3/CD33 bispecific FynomAb with IgG-like pharmacokinetics for the treatment of acute myeloid leukemia
Klupsch, Kristina, Baeriswyl, Vanessa, Scholz, Roland, Dannenberg, Joana, Santimaria, Roger, Senn, David, Kage, Elena, Zumsteg, Adrian, Attinger-Toller, Isabella, von der Bey, Ulrike, König-Friedrich, Susann, Dupuy, Fanny, Lembke, Wibke, Albani, Clara, Wendelspiess, Severin, Dinkel, Lucijana, Saro, Dorina, Hepler, Robert W., Laszlo, George S., Gudgeon, Chelsea J., Bertschinger, Julian, Brack, Simon, Walter, Roland B.
Published in Leukemia (01.03.2019)
Published in Leukemia (01.03.2019)
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Journal Article
Abstract 2910: A CD79b targeting ADC with superior anti-tumor activity and therapeutic index
Attinger-Toller, Isabella, Probst, Philipp, Bertrand, Romain, Stark, Ramona, Santimaria, Roger, Renard, Emma, Fay, Rachael, Grabulovski, Dragan, Schlereth, Bernd, Spycher, Philipp René
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Abstract 1787: COVA4231, a potent CD3/CD33 bispecific FynomAb with IgG-like pharmacokinetics for the treatment of acute myeloid leukemia
Klupsch, Kristina, Baeriswyl, Vanessa, Scholz, Roland, Dannenberg, Joana, Santimaria, Roger, Senn, David, Kage, Elena, Zumsteg, Adrian, Attinger-Toller, Isabella, Bey, Ulrike von der, König-Friedrich, Susann, Dupuy, Fanny, Lembke, Wibke, Albani, Clara, Wendelspiess, Severin, Dinkel, Lucijana, Gudgeon, Chelsea J., Walter, Roland B., Bertschinger, Julian, Brack, Simon
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 656: A bispecific HER2/CD3 targeting FynomAb with excellent tumor killing and favorable pharmacokinetic properties
Wuellner, Ulrich, Buller, Fabian, Klupsch, Kristina, Brack, Simon, Zbinden, Irene, Santimaria, Roger, Attinger-Toller, Isabella, König-Friedrich, Susann, Bertschinger, Julian, Grabulovski, Dragan
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Fynomer-antibody fusions targeting HER2 and CD3 for selective killing of HER2 overexpressing tumor cells
Woods, Richard, Brack, Simon, Klupsch, Kristina, Wuellner, Ulrich, Buller, Fabian, Santimaria, Roger, Attinger-Toller, Isabella, Koenig-Friedrich, Susann, Zbinden, Irene, Bertschinger-Ehrler, Julian, Grabulovski, Dragan
Published in Journal of clinical oncology (20.05.2014)
Published in Journal of clinical oncology (20.05.2014)
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Journal Article
Protein quality control: the who’s who, the where’s and therapeutic escapes
Roth, Jürgen, Yam, Gary Hin-Fai, Fan, Jingyu, Hirano, Kiyoko, Gaplovska-Kysela, Katarina, Le Fourn, Valerie, Guhl, Bruno, Santimaria, Roger, Torossi, Tania, Ziak, Martin, Zuber, Christian
Published in Histochemistry and cell biology (01.02.2008)
Published in Histochemistry and cell biology (01.02.2008)
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