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Sequential drug treatment targeting cell cycle and cell fate regulatory programs blocks non-genetic cancer evolution in acute lymphoblastic leukemia
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PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer
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FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma
Suryo Rahmanto, Aldwin, Savov, Vasil, Brunner, Andrä, Bolin, Sara, Weishaupt, Holger, Malyukova, Alena, Rosén, Gabriela, Čančer, Matko, Hutter, Sonja, Sundström, Anders, Kawauchi, Daisuke, Jones, David TW, Spruck, Charles, Taylor, Michael D, Cho, Yoon-Jae, Pfister, Stefan M, Kool, Marcel, Korshunov, Andrey, Swartling, Fredrik J, Sangfelt, Olle
Published in The EMBO journal (17.10.2016)
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FBXW7/hCDC4 is a general tumor suppressor in human cancer
AKHOONDI, Shahab, DAHUI SUN, MUELLER-HOLZNER, Elisabeth, CORCORAN, Martin, DAGNELL, Markus, SEPIDEH ZABIHI NEJAD, BABAK NOORI NAYER, MOHAMMAD REZA ZALI, HANSSON, Johan, EGYHAZI, Susanne, PETERSSON, Fredrik, SANGFELT, Per, VON DER LEHR, Natalie, NORDGREN, Hans, GRANDER, Dan, REED, Steven I, WIDSCHWENDTER, Martin, SANGFELT, Olle, SPRUCK, Charles, APOSTOLIDOU, Sophia, KLOTZ, Kathleen, MALJUKOVA, Alena, CEPEDA, Diana, FIEGL, Heidi, DOFOU, Dimitra, MARTH, Christian
Published in Cancer research (Chicago, Ill.) (01.10.2007)
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A novel combination therapy targeting ubiquitin-specific protease 5 in MYCN-driven neuroblastoma
Cheung, Belamy B., Kleynhans, Ane, Mittra, Rituparna, Kim, Patrick Y., Holien, Jessica K., Nagy, Zsuzsanna, Ciampa, Olivia C., Seneviratne, Janith A., Mayoh, Chelsea, Raipuria, Mukesh, Gadde, Satyanarayana, Massudi, Hassina, Wong, Iris Poh Ling, Tan, Owen, Gong, Andrew, Suryano, Aldwin, Diakiw, Sonya M., Liu, Bing, Arndt, Greg M., Liu, Tao, Kumar, Naresh, Sangfelt, Olle, Zhu, Shizhen, Norris, Murray D., Haber, Michelle, Carter, Daniel R., Parker, Michael W., Marshall, Glenn M.
Published in Oncogene (01.04.2021)
Published in Oncogene (01.04.2021)
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Mäkelä, Rami, Arjonen, Antti, Suryo Rahmanto, Aldwin, Härmä, Ville, Lehtiö, Janne, Kuopio, Teijo, Helleday, Thomas, Sangfelt, Olle, Kononen, Juha, Rantala, Juha K.
Published in Neoplasia (New York, N.Y.) (01.09.2020)
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DLEU2, frequently deleted in malignancy, functions as a critical host gene of the cell cycle inhibitory microRNAs miR-15a and miR-16-1
Lerner, Mikael, Harada, Masako, Lovén, Jakob, Castro, Juan, Davis, Zadie, Oscier, David, Henriksson, Marie, Sangfelt, Olle, Grandér, Dan, Corcoran, Martin M.
Published in Experimental cell research (15.10.2009)
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PTENP1-AS contributes to BRAF inhibitor resistance and is associated with adverse clinical outcome in stage III melanoma
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Published in Scientific reports (26.05.2021)
Published in Scientific reports (26.05.2021)
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MiRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progression
Lerner, Mikael, Lundgren, Josefin, Akhoondi, Shahab, Jahn, Angelina, Ng, Hwee-Fang, Moqadam, Farhad Akbari, Oude Vrielink, Joachim A.F., Agami, Reuven, Den Boer, Monique L., Grandér, Dan, Sangfelt, Olle
Published in Cell cycle (Georgetown, Tex.) (01.07.2011)
Published in Cell cycle (Georgetown, Tex.) (01.07.2011)
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Ablation of Key Oncogenic Pathways by RITA-Reactivated p53 Is Required for Efficient Apoptosis
Grinkevich, Vera V., Nikulenkov, Fedor, Shi, Yao, Enge, Martin, Bao, Wenjie, Maljukova, Alena, Gluch, Angela, Kel, Alexander, Sangfelt, Olle, Selivanova, Galina
Published in Cancer cell (05.05.2009)
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Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activities
Mehtonen, Juha, Teppo, Susanna, Lahnalampi, Mari, Kokko, Aleksi, Kaukonen, Riina, Oksa, Laura, Bouvy-Liivrand, Maria, Malyukova, Alena, Mäkinen, Artturi, Laukkanen, Saara, Mäkinen, Petri I, Rounioja, Samuli, Ruusuvuori, Pekka, Sangfelt, Olle, Lund, Riikka, Lönnberg, Tapio, Lohi, Olli, Heinäniemi, Merja
Published in Genome medicine (20.11.2020)
Published in Genome medicine (20.11.2020)
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Fbw7α and Fbw7γ Collaborate To Shuttle Cyclin E1 into the Nucleolus for Multiubiquitylation
Bhaskaran, Nimesh, van Drogen, Frank, Ng, Hwee-Fang, Kumar, Raman, Ekholm-Reed, Susanna, Peter, Matthias, Sangfelt, Olle, Reed, Steven I
Published in Molecular and Cellular Biology (01.01.2013)
Published in Molecular and Cellular Biology (01.01.2013)
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Ubiquitylation of Cyclin E Requires the Sequential Function of SCF Complexes Containing Distinct hCdc4 Isoforms
van Drogen, Frank, Sangfelt, Olle, Malyukova, Aljona, Matskova, Ludmila, Yeh, Elizabeth, Means, Anthony R., Reed, Steven I.
Published in Molecular cell (07.07.2006)
Published in Molecular cell (07.07.2006)
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SCFFbxw7/hCdc4 targets cyclin E2 for ubiquitin-dependent proteolysis
Klotz, Kathleen, Cepeda, Diana, Tan, YingMeei, Sun, Dahui, Sangfelt, Olle, Spruck, Charles
Published in Experimental cell research (01.07.2009)
Published in Experimental cell research (01.07.2009)
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Mechanisms of interferon-alpha induced apoptosis in malignant cells
THYRELL, Lena, ERICKSON, Sven, ZHIVOTOVSKY, Boris, POKROVSKAJA, Katja, SANGFELT, Olle, CASTRO, Juan, EINHORN, Stefan, GRANDER, Dan
Published in Oncogene (14.02.2002)
Published in Oncogene (14.02.2002)
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