Crystal structure of human stearoyl–coenzyme A desaturase in complex with substrate
Wang, Hui, Klein, Michael G, Zou, Hua, Lane, Weston, Snell, Gyorgy, Levin, Irena, Li, Ke, Sang, Bi-Ching
Published in Nature structural & molecular biology (01.07.2015)
Published in Nature structural & molecular biology (01.07.2015)
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Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein
Aertgeerts, Kathleen, Skene, Robert, Yano, Jason, Sang, Bi-Ching, Zou, Hua, Snell, Gyorgy, Jennings, Andy, Iwamoto, Keiji, Habuka, Noriyuki, Hirokawa, Aki, Ishikawa, Tomoyasu, Tanaka, Toshimasa, Miki, Hiroshi, Ohta, Yoshikazu, Sogabe, Satoshi
Published in The Journal of biological chemistry (27.05.2011)
Published in The Journal of biological chemistry (27.05.2011)
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Design, Synthesis, and Evaluation of the Highly Selective and Potent G‑Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure
Okawa, Tomohiro, Aramaki, Yoshio, Yamamoto, Mitsuo, Kobayashi, Toshitake, Fukumoto, Shoji, Toyoda, Yukio, Henta, Tsutomu, Hata, Akito, Ikeda, Shota, Kaneko, Manami, Hoffman, Isaac D, Sang, Bi-Ching, Zou, Hua, Kawamoto, Tetsuji
Published in Journal of medicinal chemistry (24.08.2017)
Published in Journal of medicinal chemistry (24.08.2017)
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Design and Synthesis of Conformationally Constrained RORγt Inverse Agonists
Sato, Ayumu, Fukase, Yoshiyuki, Kono, Mitsunori, Ochida, Atsuko, Oda, Tsuneo, Sasaki, Yusuke, Ishii, Naoki, Tomata, Yoshihide, Fukumoto, Shoji, Imai, Yumi N., Uga, Keiko, Shibata, Akira, Yamasaki, Masashi, Nakagawa, Hideyuki, Shirasaki, Mikio, Skene, Robert, Hoffman, Isaac, Sang, Bi‐Ching, Snell, Gyorgy, Shirai, Junya, Yamamoto, Satoshi
Published in ChemMedChem (20.11.2019)
Published in ChemMedChem (20.11.2019)
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Structural Basis for the Autoinhibition and STI-571 Inhibition of c-Kit Tyrosine Kinase
Mol, Clifford D, Dougan, Douglas R, Schneider, Thomas R, Skene, Robert J, Kraus, Michelle L, Scheibe, Daniel N, Snell, Gyorgy P, Zou, Hua, Sang, Bi-Ching, Wilson, Keith P
Published in The Journal of biological chemistry (23.07.2004)
Published in The Journal of biological chemistry (23.07.2004)
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Characterization of the two catalytic domains in histone deacetylase 6
Zou, Hua, Wu, Yiqin, Navre, Marc, Sang, Bi-Ching
Published in Biochemical and biophysical research communications (03.03.2006)
Published in Biochemical and biophysical research communications (03.03.2006)
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Structure‐Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5‐b]Pyridin‐2‐one‐Based p38 MAP Kinase Inhibitors: Part 2
Kaieda, Akira, Takahashi, Masashi, Fukuda, Hiromi, Okamoto, Rei, Morimoto, Shinji, Gotoh, Masayuki, Miyazaki, Takahiro, Hori, Yuri, Unno, Satoko, Kawamoto, Tomohiro, Tanaka, Toshimasa, Itono, Sachiko, Takagi, Terufumi, Sugimoto, Hiroshi, Okada, Kengo, Lane, Weston, Sang, Bi‐Ching, Saikatendu, Kumar, Matsunaga, Shinichiro, Miwatashi, Seiji
Published in ChemMedChem (17.12.2019)
Published in ChemMedChem (17.12.2019)
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Structure‐Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5‐b]pyridin‐2‐one‐Based p38 MAP Kinase Inhibitors: Part 1
Kaieda, Akira, Takahashi, Masashi, Fukuda, Hiromi, Okamoto, Rei, Morimoto, Shinji, Gotoh, Masayuki, Miyazaki, Takahiro, Hori, Yuri, Unno, Satoko, Kawamoto, Tomohiro, Tanaka, Toshimasa, Itono, Sachiko, Takagi, Terufumi, Sugimoto, Hiroshi, Okada, Kengo, Snell, Gyorgy, Bertsch, Ryan, Nguyen, Jasmine, Sang, Bi‐Ching, Miwatashi, Seiji
Published in ChemMedChem (17.05.2019)
Published in ChemMedChem (17.05.2019)
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Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation
Aertgeerts, Kathleen, Ye, Sheng, Tennant, Mike G., Kraus, Michelle L., Rogers, Joe, Sang, Bi‐Ching, Skene, Robert J., Webb, David R., Prasad, G. Sridhar
Published in Protein science (01.02.2004)
Published in Protein science (01.02.2004)
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Structure of a c-Kit Product Complex Reveals the Basis for Kinase Transactivation
Mol, Clifford D., Lim, Kheng B., Sridhar, Vandana, Zou, Hua, Chien, Ellen Y.T., Sang, Bi-Ching, Nowakowski, Jacek, Kassel, Daniel B., Cronin, Ciarán N., McRee, Duncan E.
Published in The Journal of biological chemistry (22.08.2003)
Published in The Journal of biological chemistry (22.08.2003)
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Structures of the Cancer-Related Aurora-A, FAK, and EphA2 Protein Kinases from Nanovolume Crystallography
Nowakowski, Jacek, Cronin, Ciarán N., McRee, Duncan E., Knuth, Mark W., Nelson, Christian G., Pavletich, Nikola P., Rogers, Joe, Sang, Bi-Ching, Scheibe, Daniel N., Swanson, Ronald V., Thompson, Devon A.
Published in Structure (London) (01.12.2002)
Published in Structure (London) (01.12.2002)
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N‐linked glycosylation of dipeptidyl peptidase IV (CD26): Effects on enzyme activity, homodimer formation, and adenosine deaminase binding
Aertgeerts, Kathleen, Ye, Sheng, Shi, Lihong, Prasad, Sridhar G., Witmer, Darbi, Chi, Ellen, Sang, Bi‐Ching, Wijnands, Robert A., Webb, David R., Swanson, Ronald V.
Published in Protein science (01.01.2004)
Published in Protein science (01.01.2004)
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Discovery of [cis-3-({(5R)‑5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro‑1H‑inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5H)‑yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist
Kono, Mitsunori, Ochida, Atsuko, Oda, Tsuneo, Imada, Takashi, Banno, Yoshihiro, Taya, Naohiro, Masada, Shinichi, Kawamoto, Tetsuji, Yonemori, Kazuko, Nara, Yoshi, Fukase, Yoshiyuki, Yukawa, Tomoya, Tokuhara, Hidekazu, Skene, Robert, Sang, Bi-Ching, Hoffman, Isaac D, Snell, Gyorgy P, Uga, Keiko, Shibata, Akira, Igaki, Keiko, Nakamura, Yoshiki, Nakagawa, Hideyuki, Tsuchimori, Noboru, Yamasaki, Masashi, Shirai, Junya, Yamamoto, Satoshi
Published in Journal of medicinal chemistry (12.04.2018)
Published in Journal of medicinal chemistry (12.04.2018)
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Discovery of a Selective Kinase Inhibitor (TAK-632) Targeting Pan-RAF Inhibition: Design, Synthesis, and Biological Evaluation of C‑7-Substituted 1,3-Benzothiazole Derivatives
Okaniwa, Masanori, Hirose, Masaaki, Arita, Takeo, Yabuki, Masato, Nakamura, Akito, Takagi, Terufumi, Kawamoto, Tomohiro, Uchiyama, Noriko, Sumita, Akihiko, Tsutsumi, Shunichirou, Tottori, Tsuneaki, Inui, Yoshitaka, Sang, Bi-Ching, Yano, Jason, Aertgeerts, Kathleen, Yoshida, Sei, Ishikawa, Tomoyasu
Published in Journal of medicinal chemistry (22.08.2013)
Published in Journal of medicinal chemistry (22.08.2013)
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Identification of novel quinazolinedione derivatives as RORγt inverse agonist
Fukase, Yoshiyuki, Sato, Ayumu, Tomata, Yoshihide, Ochida, Atsuko, Kono, Mitsunori, Yonemori, Kazuko, Koga, Keiko, Okui, Toshitake, Yamasaki, Masashi, Fujitani, Yasushi, Nakagawa, Hideyuki, Koyama, Ryoukichi, Nakayama, Masaharu, Skene, Robert, Sang, Bi-Ching, Hoffman, Isaac, Shirai, Junya, Yamamoto, Satoshi
Published in Bioorganic & medicinal chemistry (01.02.2018)
Published in Bioorganic & medicinal chemistry (01.02.2018)
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Discovery and optimization of 1,7-disubstituted-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-ones as potent and selective PKCθ inhibitors
Katoh, Taisuke, Takai, Takafumi, Yukawa, Takafumi, Tsukamoto, Tetsuya, Watanabe, Etsurou, Mototani, Hideyuki, Arita, Takeo, Hayashi, Hiroki, Nakagawa, Hideyuki, Klein, Michael G., Zou, Hua, Sang, Bi-Ching, Snell, Gyorgy, Nakada, Yoshihisa
Published in Bioorganic & medicinal chemistry (01.06.2016)
Published in Bioorganic & medicinal chemistry (01.06.2016)
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Structure of Human GIVD Cytosolic Phospholipase A2 Reveals Insights into Substrate Recognition
Wang, Hui, Klein, Michael G., Snell, Gyorgy, Lane, Weston, Zou, Hua, Levin, Irena, Li, Ke, Sang, Bi-Ching
Published in Journal of molecular biology (03.07.2016)
Published in Journal of molecular biology (03.07.2016)
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Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors
Kaieda, Akira, Takahashi, Masashi, Takai, Takafumi, Goto, Masayuki, Miyazaki, Takahiro, Hori, Yuri, Unno, Satoko, Kawamoto, Tomohiro, Tanaka, Toshimasa, Itono, Sachiko, Takagi, Terufumi, Hamada, Teruki, Shirasaki, Mikio, Okada, Kengo, Snell, Gyorgy, Bragstad, Ken, Sang, Bi-Ching, Uchikawa, Osamu, Miwatashi, Seiji
Published in Bioorganic & medicinal chemistry (01.02.2018)
Published in Bioorganic & medicinal chemistry (01.02.2018)
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Biochemical Properties of TAK-828F, a Potent and Selective Retinoid-Related Orphan Receptor Gamma t Inverse Agonist
Nakagawa, Hideyuki, Koyama, Ryoukichi, Kamada, Yusuke, Ochida, Atsuko, Kono, Mitsunori, Shirai, Junya, Yamamoto, Satoshi, Ambrus-Aikelin, Geza, Sang, Bi-Ching, Nakayama, Masaharu
Published in Pharmacology (01.11.2018)
Published in Pharmacology (01.11.2018)
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