Discovery and Mechanistic Elucidation of NQO1‐Bioactivatable Small Molecules That Overcome Resistance to Degraders
Barbosa, Bárbara M. G., Sfyaki, Aikaterini, Rafael, Sergi, José‐Duran, Ferran, Pous, Joan, Sánchez‐Zarzalejo, Carolina, Perez‐Lopez, Carles, Vilanova, Mar, Cigler, Marko, Gay, Marina, Vilaseca, Marta, Winter, Georg E., Riera, Antoni, Mayor‐Ruiz, Cristina
Published in Angewandte Chemie International Edition (18.03.2024)
Published in Angewandte Chemie International Edition (18.03.2024)
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Rational optimization of a transcription factor activation domain inhibitor
Basu, Shaon, Martínez-Cristóbal, Paula, Frigolé-Vivas, Marta, Pesarrodona, Mireia, Lewis, Michael, Szulc, Elzbieta, Bañuelos, C. Adriana, Sánchez-Zarzalejo, Carolina, Bielskutė, Stasė, Zhu, Jiaqi, Pombo-García, Karina, Garcia-Cabau, Carla, Zodi, Levente, Dockx, Hannes, Smak, Jordann, Kaur, Harpreet, Batlle, Cristina, Mateos, Borja, Biesaga, Mateusz, Escobedo, Albert, Bardia, Lídia, Verdaguer, Xavier, Ruffoni, Alessandro, Mawji, Nasrin R., Wang, Jun, Obst, Jon K., Tam, Teresa, Brun-Heath, Isabelle, Ventura, Salvador, Meierhofer, David, García, Jesús, Robustelli, Paul, Stracker, Travis H., Sadar, Marianne D., Riera, Antoni, Hnisz, Denes, Salvatella, Xavier
Published in Nature structural & molecular biology (01.12.2023)
Published in Nature structural & molecular biology (01.12.2023)
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Inside Cover: Discovery and Mechanistic Elucidation of NQO1‐Bioactivatable Small Molecules That Overcome Resistance to Degraders (Angew. Chem. Int. Ed. 12/2024)
Barbosa, Bárbara M. G., Sfyaki, Aikaterini, Rafael, Sergi, José‐Duran, Ferran, Pous, Joan, Sánchez‐Zarzalejo, Carolina, Perez‐Lopez, Carles, Vilanova, Mar, Cigler, Marko, Gay, Marina, Vilaseca, Marta, Winter, Georg E., Riera, Antoni, Mayor‐Ruiz, Cristina
Published in Angewandte Chemie International Edition (18.03.2024)
Published in Angewandte Chemie International Edition (18.03.2024)
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Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation
Donoghue, Craig, Cubillos-Rojas, Monica, Gutierrez-Prat, Nuria, Sanchez-Zarzalejo, Carolina, Verdaguer, Xavier, Riera, Antoni, Nebreda, Angel R.
Published in European journal of medicinal chemistry (01.09.2020)
Published in European journal of medicinal chemistry (01.09.2020)
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Journal Article
Discovery and Mechanistic Elucidation of NQO1‐Bioactivatable Small Molecules That Overcome Resistance to Degraders
Barbosa, Bárbara M. G., Sfyaki, Aikaterini, Rafael, Sergi, José‐Duran, Ferran, Pous, Joan, Sánchez‐Zarzalejo, Carolina, Perez‐Lopez, Carles, Vilanova, Mar, Cigler, Marko, Gay, Marina, Vilaseca, Marta, Winter, Georg E., Riera, Antoni, Mayor‐Ruiz, Cristina
Published in Angewandte Chemie (18.03.2024)
Published in Angewandte Chemie (18.03.2024)
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Innentitelbild: Discovery and Mechanistic Elucidation of NQO1‐Bioactivatable Small Molecules That Overcome Resistance to Degraders (Angew. Chem. 12/2024)
Barbosa, Bárbara M. G., Sfyaki, Aikaterini, Rafael, Sergi, José‐Duran, Ferran, Pous, Joan, Sánchez‐Zarzalejo, Carolina, Perez‐Lopez, Carles, Vilanova, Mar, Cigler, Marko, Gay, Marina, Vilaseca, Marta, Winter, Georg E., Riera, Antoni, Mayor‐Ruiz, Cristina
Published in Angewandte Chemie (18.03.2024)
Published in Angewandte Chemie (18.03.2024)
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New Potent Inhibitor of Transforming Growth Factor-Beta (TGFβ) Signaling that is Efficacious against Microsatellite Stable Colorectal Cancer Metastasis in Combination with Immune Checkpoint Therapy in Mice
Tauriello, Daniele V. F., Sancho, Elena, Byrom, Daniel, Sanchez-Zarzalejo, Carolina, Salvany, Maria, Henriques, Ana, Palomo-Ponce, Sergio, Sevillano, Marta, Hernando-Momblona, Xavier, Matarin, Joan A., Ramos, Israel, Ruano, Irene, Prats, Neus, Batlle, Eduard, Riera, Antoni
Published in ACS pharmacology & translational science (01.10.2024)
Published in ACS pharmacology & translational science (01.10.2024)
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A Useful Allene for the Stereoselective Synthesis of Protected Quaternary 2‑Amino-2-vinyl-1,3-diols
Rodríguez, Aleix, Ariza, Xavier, Contreras, Miguel A, Garcia, Jordi, Lloyd-Williams, Paul, Mercadal, Nerea, Sánchez, Carolina
Published in Journal of organic chemistry (03.02.2017)
Published in Journal of organic chemistry (03.02.2017)
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HYDROXYPHENYL-ETHYNYL-PHENOL DERIVATIVES AS AR (ANDROGEN RECEPTOR) TRANSCRIPTIONAL ACTIVITY MODULATORS FOR USE IN THE TREATMENT OF I.A. PROSTATE CANCER
SALVATELLA GIRALT, XAVIER, FRIGOLE VIVAS, MARTA, VERDAGUER ESPAULELLA, FRANCESC XAVIER, RIERA ESCALE, ANTONI, MAWJI, NASRIN, SADAR, MARIANNE DOROTHY, SANCHEZ ZARZALEJO, CAROLINA, RUFFONI, ALESSANDRO, BANUELOS, CARMEN ADRIANA
Year of Publication 20.04.2023
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Year of Publication 20.04.2023
Patent
Total Synthesis of (−)-Isoavenaciolide
Santos, David, Ariza, Xavier, Garcia, Jordi, Lloyd-Williams, Paul, Martínez-Laporta, Agustín, Sánchez, Carolina
Published in Journal of organic chemistry (15.02.2013)
Published in Journal of organic chemistry (15.02.2013)
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A new synthetic approach to the lactol moiety of halichoblelide
Santos, David, Ariza, Xavier, Garcia, Jordi, Sánchez, Carolina
Published in Tetrahedron (22.07.2011)
Published in Tetrahedron (22.07.2011)
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Journal Article
Rational optimization of a transcription factor activation domain inhibitor
Basu, Shaon, Martinez-Cristobal, Paula, Pesarrodona, Mireia, Frigole-Vivas, Marta, Szulc, Elzbieta, Lewis, Michael, Banuelos, Adriana, Sanchez-Zarzalejo, Carolina, Bielskute, Stase, Zhu, Jiaqi, Pombo-Garcia, Karina, Garcia-Cabau, Carla, Batlle, Cristina, Mateos, Borja, Biesaga, Mateusz, Escobedo, Albert, Bardia, Lidia, Verdaguer, Xavier, Ruffoni, Alessandro, Mawji, Nasrin R, Wang, Juan, Tam, Teresa, Brun-Heath, Isabelle, Ventura, Salvador, Meierhofer, David, Garcia, Jesus, Robustelli, Paul, Stracker, Travis H, Sadar, Marianne D, Riera, Antoni, Hnisz, Denes, Salvatella, Xavier
Published in bioRxiv (21.11.2022)
Published in bioRxiv (21.11.2022)
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Paper
Convenient synthesis of C75, an inhibitor of FAS and CPT1
Sánchez, Carolina, Makowski, Kamil, Mera, Paula, Farràs, Jaume, Nicolás, Ernesto, Herrero, Laura, Asins, Guillermina, Serra, Dolors, Hegardt, Fausto G., Ariza, Xavier, Garcia, Jordi
Published in RSC advances (01.01.2013)
Published in RSC advances (01.01.2013)
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Journal Article
HYDROXYPHENYL-ETHYNYL-PHENOL DERIVATIVES AS AR (ANDROGEN RECEPTOR) TRANSCRIPTIONAL ACTIVITY MODULATORS FOR USE IN THE TREATMENT OF I.A. PROSTATE CANCER
VERDAGUER ESPAULELLA, Francesc Xavier, SADAR, Marianne Dorothy, SÁNCHEZ ZARZALEJO, Carolina, RIERA ESCALÉ, Antoni, FRIGOLÉ VIVAS, Marta, SALVATELLA GIRALT, Xavier, RUFFONI, Alessandro, BANUELOS, Carmen Adriana, MAWJI, Nasrin
Year of Publication 20.04.2023
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Year of Publication 20.04.2023
Patent
COMPOUNDS AND THEIR USE IN A METHOD FOR MODULATING AR (ANDROGEN RECEPTOR) TRANSCRIPTIONAL ACTIVITY
VERDAGUER ESPAULELLA, Francesc Xavier, SADAR, Marianne Dorothy, SÁNCHEZ ZARZALEJO, Carolina, RIERA ESCALÉ, Antoni, FRIGOLÉ VIVAS, Marta, SALVATELLA GIRALT, Xavier, RUFFONI, Alessandro, BANUELOS, Carmen Adriana, MAWJI, Nasrin
Year of Publication 30.03.2023
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Year of Publication 30.03.2023
Patent