Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β
Suberbielle, Elsa, Sanchez, Pascal E, Kravitz, Alexxai V, Wang, Xin, Ho, Kaitlyn, Eilertson, Kirsten, Devidze, Nino, Kreitzer, Anatol C, Mucke, Lennart
Published in Nature neuroscience (01.05.2013)
Published in Nature neuroscience (01.05.2013)
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Journal Article
Leveraging preclinical models for the development of Alzheimer disease therapeutics
Scearce-Levie, Kimberly, Sanchez, Pascal E., Lewcock, Joseph W.
Published in Nature reviews. Drug discovery (01.07.2020)
Published in Nature reviews. Drug discovery (01.07.2020)
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Journal Article
TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge
Nugent, Alicia A., Lin, Karin, van Lengerich, Bettina, Lianoglou, Steve, Przybyla, Laralynne, Davis, Sonnet S., Llapashtica, Ceyda, Wang, Junhua, Kim, Do Jin, Xia, Dan, Lucas, Anthony, Baskaran, Sulochanadevi, Haddick, Patrick C.G., Lenser, Melina, Earr, Timothy K., Shi, Ju, Dugas, Jason C., Andreone, Benjamin J., Logan, Todd, Solanoy, Hilda O., Chen, Hang, Srivastava, Ankita, Poda, Suresh B., Sanchez, Pascal E., Watts, Ryan J., Sandmann, Thomas, Astarita, Giuseppe, Lewcock, Joseph W., Monroe, Kathryn M., Di Paolo, Gilbert
Published in Neuron (Cambridge, Mass.) (04.03.2020)
Published in Neuron (Cambridge, Mass.) (04.03.2020)
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Journal Article
Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer’s disease model
Sanchez, Pascal E, Zhu, Lei, Verret, Laure, Vossel, Keith A, Orr, Anna G, Cirrito, John R, Devidze, Nino, Ho, Kaitlyn, Yu, Gui-Qiu, Palop, Jorge J, Mucke, Lennart
Published in Proceedings of the National Academy of Sciences - PNAS (16.10.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (16.10.2012)
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Journal Article
Standardized environmental enrichment supports enhanced brain plasticity in healthy rats and prevents cognitive impairment in epileptic rats
Fares, Raafat P, Belmeguenai, Amor, Sanchez, Pascal E, Kouchi, Hayet Y, Bodennec, Jacques, Morales, Anne, Georges, Béatrice, Bonnet, Chantal, Bouvard, Sandrine, Sloviter, Robert S, Bezin, Laurent
Published in PloS one (14.01.2013)
Published in PloS one (14.01.2013)
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Journal Article
Tau reduction prevents disease in a mouse model of Dravet syndrome
Gheyara, Ania L., Ponnusamy, Ravikumar, Djukic, Biljana, Craft, Ryan J., Ho, Kaitlyn, Guo, Weikun, Finucane, Mariel M., Sanchez, Pascal E., Mucke, Lennart
Published in Annals of neurology (01.09.2014)
Published in Annals of neurology (01.09.2014)
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Journal Article
Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice
Dubal, Dena B, Zhu, Lei, Sanchez, Pascal E, Worden, Kurtresha, Broestl, Lauren, Johnson, Erik, Ho, Kaitlyn, Yu, Gui-Qiu, Kim, Daniel, Betourne, Alexander, Kuro-O, Makoto, Masliah, Eliezer, Abraham, Carmela R, Mucke, Lennart
Published in The Journal of neuroscience (11.02.2015)
Published in The Journal of neuroscience (11.02.2015)
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Journal Article
Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer's disease mutations but not by inhibition of BACE1
Johnson, Erik C B, Ho, Kaitlyn, Yu, Gui-Qiu, Das, Melanie, Sanchez, Pascal E, Djukic, Biljana, Lopez, Isabel, Yu, Xinxing, Gill, Michael, Zhang, Weiping, Paz, Jeanne T, Palop, Jorge J, Mucke, Lennart
Published in Molecular neurodegeneration (14.09.2020)
Published in Molecular neurodegeneration (14.09.2020)
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Journal Article
Molecular architecture determines brain delivery of a transferrin receptor-targeted lysosomal enzyme
Arguello, Annie, Mahon, Cathal S, Calvert, Meredith E K, Chan, Darren, Dugas, Jason C, Pizzo, Michelle E, Thomsen, Elliot R, Chau, Roni, Damo, Lorna A, Duque, Joseph, Fang, Meng, Giese, Tina, Kim, Do Jin, Liang, Nicholas, Nguyen, Hoang N, Solanoy, Hilda, Tsogtbaatar, Buyankhishig, Ullman, Julie C, Wang, Junhua, Dennis, Mark S, Diaz, Dolores, Gunasekaran, Kannan, Henne, Kirk R, Lewcock, Joseph W, Sanchez, Pascal E, Troyer, Matthew D, Harris, Jeffrey M, Scearce-Levie, Kimberly, Shan, Lu, Watts, Ryan J, Thorne, Robert G, Henry, Anastasia G, Kariolis, Mihalis S
Published in The Journal of experimental medicine (07.03.2022)
Published in The Journal of experimental medicine (07.03.2022)
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Journal Article
Ablation of cellular prion protein does not ameliorate abnormal neural network activity or cognitive dysfunction in the J20 line of human amyloid precursor protein transgenic mice
Cissé, Moustapha, Sanchez, Pascal E, Kim, Daniel H, Ho, Kaitlyn, Yu, Gui-Qiu, Mucke, Lennart
Published in The Journal of neuroscience (20.07.2011)
Published in The Journal of neuroscience (20.07.2011)
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Journal Article
Cross-species translation of the Morris maze for Alzheimer's disease
Possin, Katherine L, Sanchez, Pascal E, Anderson-Bergman, Clifford, Fernandez, Roland, Kerchner, Geoffrey A, Johnson, Erica T, Davis, Allyson, Lo, Iris, Bott, Nicholas T, Kiely, Thomas, Fenesy, Michelle C, Miller, Bruce L, Kramer, Joel H, Finkbeiner, Steven
Published in The Journal of clinical investigation (01.02.2016)
Published in The Journal of clinical investigation (01.02.2016)
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Journal Article
Discovery of DNL343: A Potent, Selective, and Brain-Penetrant eIF2B Activator Designed for the Treatment of Neurodegenerative Diseases
Craig, Robert A., De Vicente, Javier, Estrada, Anthony A., Feng, Jianwen A., Lexa, Katrina W., Canet, Mark J., Dowdle, William E., Erickson, Rebecca I., Flores, Brittany N., Haddick, Patrick C. G., Kane, Lesley A., Lewcock, Joseph W., Moerke, Nathan J., Poda, Suresh B., Sweeney, Zachary, Takahashi, Ryan H., Tong, Vincent, Wang, Jing, Yulyaningsih, Ernie, Solanoy, Hilda, Scearce-Levie, Kimberly, Sanchez, Pascal E., Tang, Liwei, Xu, Musheng, Zhang, Rui, Osipov, Maksim
Published in Journal of medicinal chemistry (11.04.2024)
Published in Journal of medicinal chemistry (11.04.2024)
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Journal Article
Thermal stability analysis of Cu-11.8 wt%Al milled samples by TEM and HT-XRD
Sanchez Pascal, N.N., Giordana, M.F., Napolitano, F., Esquivel, M.R., Zelaya, E.
Published in Advanced powder technology : the international journal of the Society of Powder Technology, Japan (01.10.2017)
Published in Advanced powder technology : the international journal of the Society of Powder Technology, Japan (01.10.2017)
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Journal Article
Targeting the transferrin receptor to transport antisense oligonucleotides across the mammalian blood-brain barrier
Barker, Scarlett J, Thayer, Mai B, Kim, Chaeyoung, Tatarakis, David, Simon, Matthew J, Dial, Rebekah, Nilewski, Lizanne, Wells, Robert C, Zhou, Yinhan, Afetian, Megan, Akkapeddi, Padma, Chappell, Alfred, Chew, Kylie S, Chow, Johann, Clemens, Allisa, Discenza, Claire B, Dugas, Jason C, Dwyer, Chrissa, Earr, Timothy, Ha, Connie, Ho, Yvonne S, Huynh, David, Lozano, Edwin I, Jayaraman, Srini, Kwan, Wanda, Mahon, Cathal, Pizzo, Michelle, Robles-Colmenares, Yaneth, Roche, Elysia, Sanders, Laura, Stergioulis, Alexander, Tong, Raymond, Tran, Hai, Zuchero, Y, Estrada, Anthony A, Gadkar, Kapil, Koth, Christopher M M, Sanchez, Pascal E, Thorne, Robert G, Watts, Ryan J, Sandmann, Thomas, Kane, Lesley A, Rigo, Frank, Dennis, Mark S, Lewcock, Joseph W, DeVos, Sarah L
Published in Science translational medicine (14.08.2024)
Published in Science translational medicine (14.08.2024)
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Journal Article
Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys
Kariolis, Mihalis S, Wells, Robert C, Getz, Jennifer A, Kwan, Wanda, Mahon, Cathal S, Tong, Raymond, Kim, Do Jin, Srivastava, Ankita, Bedard, Catherine, Henne, Kirk R, Giese, Tina, Assimon, Victoria A, Chen, Xiaocheng, Zhang, Yin, Solanoy, Hilda, Jenkins, Katherine, Sanchez, Pascal E, Kane, Lesley, Miyamoto, Takashi, Chew, Kylie S, Pizzo, Michelle E, Liang, Nicholas, Calvert, Meredith E K, DeVos, Sarah L, Baskaran, Sulochanadevi, Hall, Sejal, Sweeney, Zachary K, Thorne, Robert G, Watts, Ryan J, Dennis, Mark S, Silverman, Adam P, Zuchero, Y Joy Yu
Published in Science translational medicine (27.05.2020)
Published in Science translational medicine (27.05.2020)
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Journal Article
Optimal neuroprotection by erythropoietin requires elevated expression of its receptor in neurons
Sanchez, Pascal E, Fares, Raafat P, Risso, Jean-Jacques, Bonnet, Chantal, Bouvard, Sandrine, Le-Cavorsin, Marion, Georges, Béatrice, Moulin, Colette, Belmeguenai, Amor, Bodennec, Jacques, Morales, Anne, Pequignot, Jean-Marc, Baulieu, Etienne-Emile, Levine, Robert A, Bezin, Laurent
Published in Proceedings of the National Academy of Sciences - PNAS (16.06.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (16.06.2009)
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Journal Article
Network dysfunction in α‐synuclein transgenic mice and human Lewy body dementia
Morris, Meaghan, Sanchez, Pascal E., Verret, Laure, Beagle, Alexander J., Guo, Weikun, Dubal, Dena, Ranasinghe, Kamalini G., Koyama, Akihiko, Ho, Kaitlyn, Yu, Gui‐Qiu, Vossel, Keith A., Mucke, Lennart
Published in Annals of clinical and translational neurology (01.11.2015)
Published in Annals of clinical and translational neurology (01.11.2015)
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Journal Article
Fibrillar Aβ causes profound microglial metabolic perturbations in a novel APP knock‐in mouse model
Xia, Dan, Lianoglou, Steve, Sandmann, Thomas, Calvert, Meredith, Suh, Jung, Thomsen, Elliot, Dugas, Jason, Pizzo, Michelle E., DeVos, Sarah L., Earr, Timothy K., Lin, Chia‐Ching, Davis, Sonnet, Ha, Connie, Nguyen, Hoang, Chau, Roni, Yulyaningsih, Ernie, Solanoy, Hilda, Masoud, Shababa T., Liang, Richard, Lin, Karin, Thorne, Robert G., Garceau, Dylan, Whitesell, Jennifer D, Sasner, Michael, Harris, Julie A, Scearce‐Levie, Kimberly, Lewcock, Joseph W., Paolo, Gilbert Di, Sanchez, Pascal E.
Published in Alzheimer's & dementia (01.12.2021)
Published in Alzheimer's & dementia (01.12.2021)
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Journal Article
Iduronate-2-sulfatase transport vehicle rescues behavioral and skeletal phenotypes in a mouse model of Hunter syndrome
Arguello, Annie, Meisner, René, Thomsen, Elliot R, Nguyen, Hoang N, Ravi, Ritesh, Simms, Jeffrey, Lo, Iris, Speckart, Jessica, Holtzman, Julia, Gill, Thomas M, Chan, Darren, Cheng, Yuhsiang, Chiu, Chi-Lu, Dugas, Jason C, Fang, Meng, Lopez, Isabel A, Solanoy, Hilda, Tsogtbaatar, Buyankhishig, Zhu, Yuda, Bhalla, Akhil, Henne, Kirk R, Henry, Anastasia G, Delucchi, Anthony, Costanzo, Simona, Harris, Jeffrey M, Diaz, Dolores, Scearce-Levie, Kimberly, Sanchez, Pascal E
Published in JCI insight (08.10.2021)
Published in JCI insight (08.10.2021)
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Journal Article
Neuroprotective effects of erythropoietin in the rat hippocampus after pilocarpine-induced status epilepticus
Nadam, Jérémie, Navarro, Fabrice, Sanchez, Pascal, Moulin, Colette, Georges, Béatrice, Laglaine, Aël, Pequignot, Jean-Marc, Morales, Anne, Ryvlin, Philippe, Bezin, Laurent
Published in Neurobiology of disease (01.02.2007)
Published in Neurobiology of disease (01.02.2007)
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