Identification and multidimensional optimization of an asymmetric bispecific IgG antibody mimicking the function of factor VIII cofactor activity
Sampei, Zenjiro, Igawa, Tomoyuki, Soeda, Tetsuhiro, Okuyama-Nishida, Yukiko, Moriyama, Chifumi, Wakabayashi, Tetsuya, Tanaka, Eriko, Muto, Atsushi, Kojima, Tetsuo, Kitazawa, Takehisa, Yoshihashi, Kazutaka, Harada, Aya, Funaki, Miho, Haraya, Kenta, Tachibana, Tatsuhiko, Suzuki, Sachiyo, Esaki, Keiko, Nabuchi, Yoshiaki, Hattori, Kunihiro
Published in PloS one (28.02.2013)
Published in PloS one (28.02.2013)
Get full text
Journal Article
A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model
Kitazawa, Takehisa, Igawa, Tomoyuki, Sampei, Zenjiro, Muto, Atsushi, Kojima, Tetsuo, Soeda, Tetsuhiro, Yoshihashi, Kazutaka, Okuyama-Nishida, Yukiko, Saito, Hiroyuki, Tsunoda, Hiroyuki, Suzuki, Tsukasa, Adachi, Hideki, Miyazaki, Taro, Ishii, Shinya, Kamata-Sakurai, Mika, Iida, Takeo, Harada, Aya, Esaki, Keiko, Funaki, Miho, Moriyama, Chifumi, Tanaka, Eriko, Kikuchi, Yasufumi, Wakabayashi, Tetsuya, Wada, Manabu, Goto, Masaaki, Toyoda, Takeshi, Ueyama, Atsunori, Suzuki, Sachiyo, Haraya, Kenta, Tachibana, Tatsuhiko, Kawabe, Yoshiki, Shima, Midori, Yoshioka, Akira, Hattori, Kunihiro
Published in Nature medicine (01.10.2012)
Published in Nature medicine (01.10.2012)
Get full text
Journal Article
Antibody engineering to generate SKY59, a long-acting anti-C5 recycling antibody
Sampei, Zenjiro, Haraya, Kenta, Tachibana, Tatsuhiko, Fukuzawa, Taku, Shida-Kawazoe, Meiri, Gan, Siok Wan, Shimizu, Yuichiro, Ruike, Yoshinao, Feng, Shu, Kuramochi, Taichi, Muraoka, Masaru, Kitazawa, Takehisa, Kawabe, Yoshiki, Igawa, Tomoyuki, Hattori, Kunihiro, Nezu, Junichi
Published in PloS one (28.12.2018)
Published in PloS one (28.12.2018)
Get full text
Journal Article
Anti-factor IXa/X bispecific antibody ACE910 prevents joint bleeds in a long-term primate model of acquired hemophilia A
Muto, Atsushi, Yoshihashi, Kazutaka, Takeda, Minako, Kitazawa, Takehisa, Soeda, Tetsuhiro, Igawa, Tomoyuki, Sampei, Zenjiro, Kuramochi, Taichi, Sakamoto, Akihisa, Haraya, Kenta, Adachi, Kenji, Kawabe, Yoshiki, Nogami, Keiji, Shima, Midori, Hattori, Kunihiro
Published in Blood (13.11.2014)
Published in Blood (13.11.2014)
Get full text
Journal Article
Engineering the variable region of therapeutic IgG antibodies
Igawa, Tomoyuki, Tsunoda, Hiroyuki, Kuramochi, Taichi, Sampei, Zenjiro, Ishii, Shinya, Hattori, Kunihiro
Published in mAbs (01.05.2011)
Published in mAbs (01.05.2011)
Get full text
Journal Article
Monte Carlo Thompson sampling-guided design for antibody engineering
Kakuzaki, Taro, Koga, Hikaru, Takizawa, Shuuki, Metsugi, Shoichi, Shiraiwa, Hirotake, Sampei, Zenjiro, Yoshida, Kenji, Tsunoda, Hiroyuki, Teramoto, Reiji
Published in mAbs (31.12.2023)
Published in mAbs (31.12.2023)
Get full text
Journal Article
Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases
Fukuzawa, Taku, Sampei, Zenjiro, Haraya, Kenta, Ruike, Yoshinao, Shida-Kawazoe, Meiri, Shimizu, Yuichiro, Gan, Siok Wan, Irie, Machiko, Tsuboi, Yoshinori, Tai, Hitoshi, Sakiyama, Tetsushi, Sakamoto, Akihisa, Ishii, Shinya, Maeda, Atsuhiko, Iwayanagi, Yuki, Shibahara, Norihito, Shibuya, Mitsuko, Nakamura, Genki, Nambu, Takeru, Hayasaka, Akira, Mimoto, Futa, Okura, Yuu, Hori, Yuji, Habu, Kiyoshi, Wada, Manabu, Miura, Takaaki, Tachibana, Tatsuhiko, Honda, Kiyofumi, Tsunoda, Hiroyuki, Kitazawa, Takehisa, Kawabe, Yoshiki, Igawa, Tomoyuki, Hattori, Kunihiro, Nezu, Junichi
Published in Scientific reports (24.04.2017)
Published in Scientific reports (24.04.2017)
Get full text
Journal Article
A bispecific antibody NXT007 exerts a hemostatic activity in hemophilia A monkeys enough to keep a nonhemophilic state
Teranishi-Ikawa, Yuri, Soeda, Tetsuhiro, Koga, Hikaru, Yamaguchi, Kazuki, Kato, Kazuki, Esaki, Keiko, Asanuma, Kentaro, Funaki, Miho, Ichiki, Mina, Ikuta, Yuri, Ito, Shunsuke, Joyashiki, Eri, Komatsu, Shun-Ichiro, Muto, Atsushi, Nishimura, Kei, Okuda, Momoko, Sanada, Hisakazu, Sato, Motohiko, Shibahara, Norihito, Wakabayashi, Tetsuya, Yamaguchi, Koji, Matsusaki, Akiko, Sampei, Zenjiro, Shiraiwa, Hirotake, Konishi, Hiroko, Kawabe, Yoshiki, Hattori, Kunihiro, Kitazawa, Takehisa, Igawa, Tomoyuki
Published in Journal of thrombosis and haemostasis (01.02.2024)
Published in Journal of thrombosis and haemostasis (01.02.2024)
Get full text
Journal Article
Rapid in vitro assessment of the immunogenicity potential of engineered antibody therapeutics through detection of CD4 + T cell interleukin-2 secretion
Arata, Yoshiyuki, Motoyama, Shigeki, Yano, Mariko, Ikuno, Tatsuya, Ito, Shunsuke, Matsushita, Tomochika, Takeiri, Akira, Nishito, Yukari, Yabuki, Nami, Mizuno, Hideaki, Sampei, Zenjiro, Mishima, Masayuki, Honda, Masaki, Kiyokawa, Jumpei, Suzuki, Hiromi, Chiba, Shuichi, Tabo, Mitsuyasu, Kubo, Chiyomi
Published in mAbs (31.12.2023)
Published in mAbs (31.12.2023)
Get full text
Journal Article
Efficient production of bispecific antibody by FAST-IgTM and its application to NXT007 for the treatment of hemophilia A
Koga, Hikaru, Yamano, Takashi, Betancur, Juan, Nagatomo, Satoko, Ikeda, Yousuke, Yamaguchi, Kazuki, Nabuchi, Yoshiaki, Sato, Kazuki, Teranishi-Ikawa, Yuri, Sato, Motohiko, Hirayama, Hiroyuki, Hayasaka, Akira, Torizawa, Takuya, Haraya, Kenta, Sampei, Zenjiro, Shiraiwa, Hirotake, Kitazawa, Takehisa, Igawa, Tomoyuki, Kuramochi, Taichi
Published in mAbs (01.12.2023)
Published in mAbs (01.12.2023)
Get full text
Journal Article
Elimination of plasma soluble antigen in cynomolgus monkeys by combining pH-dependent antigen binding and novel Fc engineering
Hori, Yuji, Ohmine, Ken, Katada, Hitoshi, Noguchi, Yuki, Sato, Kazuki, Nambu, Takeru, Adeline, Lam Runyi, Wan, Gan Siok, Haraya, Kenta, Ozeki, Kazuhisa, Nanami, Masahiko, Tachibana, Tatsuhiko, Sampei, Zenjiro, Kuramochi, Taichi, Nezu, Junichi, Hattori, Kunihiro, Igawa, Tomoyuki
Published in mAbs (2022)
Published in mAbs (2022)
Get full text
Journal Article
In vitro human helper T-cell assay to screen antibody drug candidates for immunogenicity
Ito, Shunsuke, Ikuno, Tatsuya, Mishima, Masayuki, Yano, Mariko, Hara, Toshiko, Kuramochi, Taichi, Sampei, Zenjiro, Wakabayashi, Tetsuya, Tabo, Mitsuyasu, Chiba, Shuichi, Kubo, Chiyomi
Published in Journal of immunotoxicology (01.01.2019)
Published in Journal of immunotoxicology (01.01.2019)
Get full text
Journal Article
Complement Activation by an Anti-Dengue/Zika Antibody with Impaired Fcγ Receptor Binding Provides Strong Efficacy and Abrogates Risk of Antibody-Dependent Enhancement
Sampei, Zenjiro, Koo, Christine Xing'er, Teo, Frannie Jiuyi, Toh, Ying Xiu, Fukuzawa, Taku, Gan, Siok Wan, Nambu, Takeru, Ho, Adrian, Honda, Kiyofumi, Igawa, Tomoyuki, Ahmed, Fariyal, Wang, Cheng-I, Fink, Katja, Nezu, Junichi
Published in Antibodies (Basel) (15.05.2023)
Published in Antibodies (Basel) (15.05.2023)
Get full text
Journal Article