Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice
Alexopoulos, Stephanie J., Chen, Sing-Young, Brandon, Amanda E., Salamoun, Joseph M., Byrne, Frances L., Garcia, Christopher J., Beretta, Martina, Olzomer, Ellen M., Shah, Divya P., Philp, Ashleigh M., Hargett, Stefan R., Lawrence, Robert T., Lee, Brendan, Sligar, James, Carrive, Pascal, Tucker, Simon P., Philp, Andrew, Lackner, Carolin, Turner, Nigel, Cooney, Gregory J., Santos, Webster L., Hoehn, Kyle L.
Published in Nature communications (14.05.2020)
Published in Nature communications (14.05.2020)
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2‑Aminobenzoxazole Derivatives as Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spinster Homolog 2 (Spns2)
Burgio, Ariel L., Shrader, Christopher W., Kharel, Yugesh, Huang, Tao, Salamoun, Joseph M., Lynch, Kevin R., Santos, Webster L.
Published in Journal of medicinal chemistry (27.04.2023)
Published in Journal of medicinal chemistry (27.04.2023)
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Design, synthesis, and biological evaluation of imidazo[4,5-b]pyridine mitochondrial uncouplers for the treatment of metabolic dysfunction-associated steatohepatitis (MASH)
Salamoun, Joseph M., Krinos, Emily L., Foutz, Mary A., Hargett, Stefan R., Beretta, Martina, Shrestha, Riya, Hoehn, Kyle L., Santos, Webster L.
Published in European journal of medicinal chemistry (15.12.2024)
Published in European journal of medicinal chemistry (15.12.2024)
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SD-208, a novel protein kinase D inhibitor, blocks prostate cancer cell proliferation and tumor growth in vivo by inducing G2/M cell cycle arrest
Tandon, Manuj, Salamoun, Joseph M, Carder, Evan J, Farber, Elisa, Xu, Shuping, Deng, Fan, Tang, Hua, Wipf, Peter, Wang, Q Jane
Published in PloS one (06.03.2015)
Published in PloS one (06.03.2015)
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Oxadiazolopyridine Derivatives as Efficacious Mitochondrial Uncouplers in the Prevention of Diet-Induced Obesity
Murray, Jacob H., Burgio, Ariel L., Beretta, Martina, Hargett, Stefan R., Harris, Thurl E., Olzomer, Ellen, Grams, R. Justin, Garcia, Christopher J., Li, Catherine, Salamoun, Joseph M., Hoehn, Kyle L., Santos, Webster L.
Published in Journal of medicinal chemistry (23.03.2023)
Published in Journal of medicinal chemistry (23.03.2023)
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Conversion of oxadiazolo[3,4-b]pyrazines to imidazo[4,5-b]pyrazines via a tandem reduction-cyclization sequence generates new mitochondrial uncouplers
Dai, Yumin, Santiago-Rivera, José A., Hargett, Stefan, Salamoun, Joseph M., Hoehn, Kyle L., Santos, Webster L.
Published in Bioorganic & medicinal chemistry letters (01.10.2022)
Published in Bioorganic & medicinal chemistry letters (01.10.2022)
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[1,2,5]Oxadiazolo[3,4‑b]pyrazine-5,6-diamine Derivatives as Mitochondrial Uncouplers for the Potential Treatment of Nonalcoholic Steatohepatitis
Childress, Elizabeth S, Salamoun, Joseph M, Hargett, Stefan R, Alexopoulos, Stephanie J, Chen, Sing-Young, Shah, Divya P, Santiago-Rivera, José, Garcia, Christopher J, Dai, Yumin, Tucker, Simon P, Hoehn, Kyle L, Santos, Webster L
Published in Journal of medicinal chemistry (12.03.2020)
Published in Journal of medicinal chemistry (12.03.2020)
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6-Amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol Derivatives as Efficacious Mitochondrial Uncouplers in STAM Mouse Model of Nonalcoholic Steatohepatitis
Salamoun, Joseph M., Garcia, Christopher J., Hargett, Stefan R., Murray, Jacob H., Chen, Sing-Young, Beretta, Martina, Alexopoulos, Stephanie J., Shah, Divya P., Olzomer, Ellen M., Tucker, Simon P., Hoehn, Kyle L., Santos, Webster L.
Published in Journal of medicinal chemistry (11.06.2020)
Published in Journal of medicinal chemistry (11.06.2020)
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Head-to-head comparison of BAM15, semaglutide, rosiglitazone, NEN, and calorie restriction on metabolic physiology in female db/db mice
Chen, Sing-Young, Beretta, Martina, Olzomer, Ellen M., Alexopoulos, Stephanie J., Shah, Divya P., Byrne, Frances L., Salamoun, Joseph M., Garcia, Christopher J., Smith, Greg C., Larance, Mark, Philp, Andrew, Turner, Nigel, Santos, Webster L., Cantley, James, Hoehn, Kyle L.
Published in Biochimica et biophysica acta. Molecular basis of disease (01.01.2024)
Published in Biochimica et biophysica acta. Molecular basis of disease (01.01.2024)
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Targeting axonal guidance dependencies in glioblastoma with ROBO1 CAR T cells
Chokshi, Chirayu R., Shaikh, Muhammad Vaseem, Brakel, Benjamin, Rossotti, Martin A., Tieu, David, Maich, William, Anand, Alisha, Chafe, Shawn C., Zhai, Kui, Suk, Yujin, Kieliszek, Agata M., Miletic, Petar, Mikolajewicz, Nicholas, Chen, David, McNicol, Jamie D., Chan, Katherine, Tong, Amy H. Y., Kuhlmann, Laura, Liu, Lina, Alizada, Zahra, Mobilio, Daniel, Tatari, Nazanin, Savage, Neil, Aghaei, Nikoo, Grewal, Shan, Puri, Anish, Subapanditha, Minomi, McKenna, Dillon, Ignatchenko, Vladimir, Salamoun, Joseph M., Kwiecien, Jacek M., Wipf, Peter, Sharlow, Elizabeth R., Provias, John P., Lu, Jian-Qiang, Lazo, John S., Kislinger, Thomas, Lu, Yu, Brown, Kevin R., Venugopal, Chitra, Henry, Kevin A., Moffat, Jason, Singh, Sheila K.
Published in Nature medicine (02.08.2024)
Published in Nature medicine (02.08.2024)
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Specific RITA Modification Produces Hyperselective Cytotoxicity While Maintaining In Vivo Antitumor Efficacy
Peyser, Brian D, Hermone, Ann, Salamoun, Joseph M, Burnett, James C, Hollingshead, Melinda G, McGrath, Connor F, Gussio, Rick, Wipf, Peter
Published in Molecular cancer therapeutics (01.10.2019)
Published in Molecular cancer therapeutics (01.10.2019)
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A chemical genetics approach identifies PTP4A3 as a regulator of colon cancer cell adhesion
McQueeney, Kelley E, Salamoun, Joseph M, Ahn, Jennifer G, Pekic, Paula, Blanco, Isabella K, Struckman, Heather L, Sharlow, Elizabeth R, Wipf, Peter, Lazo, John S
Published in The FASEB journal (01.10.2018)
Published in The FASEB journal (01.10.2018)
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Journal Article
Mitochondrial uncoupler SHC517 reverses obesity in mice without affecting food intake
Chen, Sing-Young, Beretta, Martina, Alexopoulos, Stephanie J., Shah, Divya P., Olzomer, Ellen M., Hargett, Stefan R., Childress, Elizabeth S., Salamoun, Joseph M., Aleksovska, Isabella, Roseblade, Ariane, Cranfield, Charles, Rawling, Tristan, Quinlan, Kate G.R., Morris, Margaret J., Tucker, Simon P., Santos, Webster L., Hoehn, Kyle L.
Published in Metabolism, clinical and experimental (01.04.2021)
Published in Metabolism, clinical and experimental (01.04.2021)
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Journal Article
Targeting negative energy balance with calorie restriction and mitochondrial uncoupling in db/db mice
Chen, Sing-Young, Beretta, Martina, Olzomer, Ellen M., Shah, Divya P., Wong, Derek Y.H., Alexopoulos, Stephanie J., Aleksovska, Isabella, Salamoun, Joseph M., Garcia, Christopher J., Cochran, Blake J., Rye, Kerry-Anne, Smith, Greg C., Byrne, Frances L., Morris, Margaret J., Santos, Webster L., Cantley, James, Hoehn, Kyle L.
Published in Molecular metabolism (Germany) (01.03.2023)
Published in Molecular metabolism (Germany) (01.03.2023)
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Targeting ovarian cancer and endothelium with an allosteric PTP4A3 phosphatase inhibitor
McQueeney, Kelley E, Salamoun, Joseph M, Burnett, James C, Barabutis, Nektarios, Pekic, Paula, Lewandowski, Sophie L, Llaneza, Danielle C, Cornelison, Robert, Bai, Yunpeng, Zhang, Zhong-Yin, Catravas, John D, Landen, Charles N, Wipf, Peter, Lazo, John S, Sharlow, Elizabeth R
Published in Oncotarget (02.02.2018)
Published in Oncotarget (02.02.2018)
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Journal Article
Abstract 202: Depletion of PTP4A3 phosphatase disrupts colorectal cancer cell adhesion and extracellular matrix interactions
McQueeney, Kelley E., Pekic, Paula, Salamoun, Joseph M., Ahn, Jennifer, Sharlow, Elizabeth R., Wipf, Peter, Lazo, John S.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Abstract A65: Combination of a thioxodihydroquinazolinone compound with cisplatin eliminates ovarian cancer stem cell-like cells (CSC-LCs) and shows preclinical potential
Ma, Jing, Salamoun, Joseph, Wipf, Peter, Edwards, Robert, Houten, Bennett Van, Qian, Wei
Published in Clinical cancer research (01.08.2018)
Published in Clinical cancer research (01.08.2018)
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The combination of thioxodihydroquinazolinones and platinum drugs reverses platinum resistance in tumor cells by inducing mitochondrial apoptosis independent of Bax and Bak
Qian, Wei, Salamoun, Joseph, Wang, Jingnan, Roginskaya, Vera, Van Houten, Bennett, Wipf, Peter
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
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