Biochemical characterization of tirabrutinib and other irreversible inhibitors of Bruton's tyrosine kinase reveals differences in on - and off - target inhibition
Liclican, Albert, Serafini, Loredana, Xing, Weimei, Czerwieniec, Gregg, Steiner, Bart, Wang, Ting, Brendza, Katherine M., Lutz, Justin D., Keegan, Kathleen S., Ray, Adrian S., Schultz, Brian E., Sakowicz, Roman, Feng, Joy Y.
Published in Biochimica et biophysica acta. General subjects (01.04.2020)
Published in Biochimica et biophysica acta. General subjects (01.04.2020)
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Journal Article
The KN-93 Molecule Inhibits Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII) Activity by Binding to Ca2+/CaM
Wong, Melanie H., Samal, Alexandra B., Lee, Mike, Vlach, Jiri, Novikov, Nikolai, Niedziela-Majka, Anita, Feng, Joy Y., Koltun, Dmitry O., Brendza, Katherine M., Kwon, Hyock Joo, Schultz, Brian E., Sakowicz, Roman, Saad, Jamil S., Papalia, Giuseppe A.
Published in Journal of molecular biology (29.03.2019)
Published in Journal of molecular biology (29.03.2019)
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Journal Article
Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells
Li, Ruidong, Liclican, Albert, Xu, Yili, Pitts, Jared, Niu, Congrong, Zhang, Jingyu, Kim, Cynthia, Zhao, Xiaofeng, Soohoo, Daniel, Babusis, Darius, Yue, Qin, Ma, Bin, Murray, Bernard P, Subramanian, Raju, Xie, Xuping, Zou, Jing, Bilello, John P, Li, Li, Schultz, Brian E, Sakowicz, Roman, Smith, Bill J, Shi, Pei-Yong, Murakami, Eisuke, Feng, Joy Y
Published in Antimicrobial agents and chemotherapy (17.08.2021)
Published in Antimicrobial agents and chemotherapy (17.08.2021)
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Journal Article
Src phosphorylation of cortactin enhances actin assembly
Tehrani, Shandiz, Tomasevic, Nenad, Weed, Scott, Sakowicz, Roman, Cooper, John A
Published in Proceedings of the National Academy of Sciences - PNAS (17.07.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (17.07.2007)
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Journal Article
Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells
Balakrishnan, Mini, Yant, Stephen R, Tsai, Luong, O'Sullivan, Christopher, Bam, Rujuta A, Tsai, Angela, Niedziela-Majka, Anita, Stray, Kirsten M, Sakowicz, Roman, Cihlar, Tomas
Published in PloS one (09.09.2013)
Published in PloS one (09.09.2013)
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Journal Article
Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus
Feng, Joy Y, Xu, Yili, Barauskas, Ona, Perry, Jason K, Ahmadyar, Shekeba, Stepan, George, Yu, Helen, Babusis, Darius, Park, Yeojin, McCutcheon, Krista, Perron, Michel, Schultz, Brian E, Sakowicz, Roman, Ray, Adrian S
Published in Antimicrobial agents and chemotherapy (01.02.2016)
Published in Antimicrobial agents and chemotherapy (01.02.2016)
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Journal Article
Direct binding of ledipasvir to HCV NS5A: mechanism of resistance to an HCV antiviral agent
Kwon, Hyock Joo, Xing, Weimei, Chan, Katie, Niedziela-Majka, Anita, Brendza, Katherine M, Kirschberg, Thorsten, Kato, Darryl, Link, John O, Cheng, Guofeng, Liu, Xiaohong, Sakowicz, Roman
Published in PloS one (09.04.2015)
Published in PloS one (09.04.2015)
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Journal Article
Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Polymerase activity and mechanisms of action of nucleotide analogs
Barauskas, Ona, Xing, Weimei, Aguayo, Esmeralda, Willkom, Madeleine, Sapre, Annapurna, Clarke, Michael, Birkus, Gabriel, Schultz, Brian E, Sakowicz, Roman, Kwon, HyockJoo, Feng, Joy Y
Published in PloS one (11.10.2017)
Published in PloS one (11.10.2017)
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Journal Article
A Trimer of Dimers Is the Basic Building Block for Human Immunodeficiency Virus-1 Capsid Assembly
Tsiang, Manuel, Niedziela-Majka, Anita, Hung, Magdeleine, Jin, Debi, Hu, Eric, Yant, Stephen, Samuel, Dharmaraj, Liu, Xiaohong, Sakowicz, Roman
Published in Biochemistry (Easton) (05.06.2012)
Published in Biochemistry (Easton) (05.06.2012)
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Journal Article
Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Endonuclease activity and evaluation of inhibitors
Xing, Weimei, Barauskas, Ona, Kirschberg, Thorsten, Niedziela-Majka, Anita, Clarke, Michael, Birkus, Gabriel, Weissburg, Perry, Liu, Xiaohong, Schultz, Brian E, Sakowicz, Roman, Kwon, HyockJoo, Feng, Joy Y
Published in PloS one (15.08.2017)
Published in PloS one (15.08.2017)
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Journal Article
Mechanism of Inhibition of Human KSP by Ispinesib
Lad, Latesh, Luo, Lusong, Carson, Jeffrey D., Wood, Kenneth W., Hartman, James J., Copeland, Robert A., Sakowicz, Roman
Published in Biochemistry (Easton) (18.03.2008)
Published in Biochemistry (Easton) (18.03.2008)
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Journal Article
Large-scale functional purification of recombinant HIV-1 capsid
Hung, Magdeleine, Niedziela-Majka, Anita, Jin, Debi, Wong, Melanie, Leavitt, Stephanie, Brendza, Katherine M, Liu, Xiaohong, Sakowicz, Roman
Published in PloS one (05.03.2013)
Published in PloS one (05.03.2013)
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Journal Article
Differential Regulation of WASP and N-WASP by Cdc42, Rac1, Nck, and PI(4,5)P2
Tomasevic, Nenad, Jia, Zhiheng, Russell, Alan, Fujii, Toby, Hartman, James J, Clancy, Sheila, Wang, Manping, Beraud, Christophe, Wood, Kenneth W, Sakowicz, Roman
Published in Biochemistry (Easton) (20.03.2007)
Published in Biochemistry (Easton) (20.03.2007)
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Journal Article
Antitumor activity of a kinesin inhibitor
SAKOWICZ, Roman, FINER, Jeffrey T, CHABALA, John C, GONZALES, Paul, ROTH, Stephanie, WEITMAN, Steve, WOOD, Kenneth W, BERAUD, Christophe, CROMPTON, Anne, LEWIS, Evan, FRITSCH, Alex, LEE, Yan, MAK, John, MOODY, Robert, TURINCIO, Rebecca
Published in Cancer research (Chicago, Ill.) (01.05.2004)
Published in Cancer research (Chicago, Ill.) (01.05.2004)
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Journal Article
Structural and regulatory elements of HCV NS5B polymerase--β-loop and C-terminal tail--are required for activity of allosteric thumb site II inhibitors
Boyce, Sarah E, Tirunagari, Neeraj, Niedziela-Majka, Anita, Perry, Jason, Wong, Melanie, Kan, Elaine, Lagpacan, Leanna, Barauskas, Ona, Hung, Magdeleine, Fenaux, Martijn, Appleby, Todd, Watkins, William J, Schmitz, Uli, Sakowicz, Roman
Published in PloS one (2014)
Published in PloS one (2014)
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Journal Article
The HCV non-nucleoside inhibitor Tegobuvir utilizes a novel mechanism of action to inhibit NS5B polymerase function
Hebner, Christy M, Han, Bin, Brendza, Katherine M, Nash, Michelle, Sulfab, Maisoun, Tian, Yang, Hung, Magdeleine, Fung, Wanchi, Vivian, Randall W, Trenkle, James, Taylor, James, Bjornson, Kyla, Bondy, Steven, Liu, Xiaohong, Link, John, Neyts, Johan, Sakowicz, Roman, Zhong, Weidong, Tang, Hengli, Schmitz, Uli
Published in PloS one (13.06.2012)
Published in PloS one (13.06.2012)
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Journal Article
Crystal Structure of the Mitotic Spindle Kinesin Eg5 Reveals a Novel Conformation of the Neck-linker
Turner, J, Anderson, R, Guo, J, Beraud, C, Fletterick, R, Sakowicz, R
Published in The Journal of biological chemistry (06.07.2001)
Published in The Journal of biological chemistry (06.07.2001)
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Journal Article
Functional Label-Free Assays for Characterizing the in Vitro Mechanism of Action of Small Molecule Modulators of Capsid Assembly
Lad, Latesh, Clancy, Sheila, Koditek, David, Wong, Melanie H, Jin, Debi, Niedziela-Majka, Anita, Papalia, Giuseppe A, Hung, Magdeleine, Yant, Stephen, Somoza, John R, Hu, Eric, Chou, Chienhung, Tse, Winston, Halcomb, Randall, Sakowicz, Roman, Pagratis, Nikos
Published in Biochemistry (Easton) (07.04.2015)
Published in Biochemistry (Easton) (07.04.2015)
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Journal Article
Affinities between the Binding Partners of the HIV-1 Integrase Dimer-Lens Epithelium-derived Growth Factor (IN Dimer-LEDGF) Complex
Tsiang, Manuel, Jones, Gregg S., Hung, Magdeleine, Mukund, Susmith, Han, Bin, Liu, Xiaohong, Babaoglu, Kerim, Lansdon, Eric, Chen, Xiaowu, Todd, Jacob, Cai, Terrence, Pagratis, Nikos, Sakowicz, Roman, Geleziunas, Romas
Published in The Journal of biological chemistry (27.11.2009)
Published in The Journal of biological chemistry (27.11.2009)
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Journal Article
A Mechanism for Microtubule Depolymerization by KinI Kinesins
Moores, Carolyn A., Yu, Ming, Guo, Jun, Beraud, Christophe, Sakowicz, Roman, Milligan, Ronald A.
Published in Molecular cell (01.04.2002)
Published in Molecular cell (01.04.2002)
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