Morphinan Evolution: The Impact of Advances in Biochemistry and Molecular Biology
Kajino, Keita, Tokuda, Akihisa, Saitoh, Tsuyoshi
Published in Journal of biochemistry (Tokyo) (25.03.2024)
Published in Journal of biochemistry (Tokyo) (25.03.2024)
Get more information
Journal Article
Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models
Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Tominaga, Hiromu, Ishikawa, Yukiko, Hosokawa, Naoto, Ambai, Shinobu, Kawabe, Yuki, Uchida, Shuntaro, Nakajima, Ryo, Saitoh, Tsuyoshi, Kanda, Takeshi, Vogt, Kaspar, Sakurai, Takeshi, Nagase, Hiroshi, Yanagisawa, Masashi
Published in Proceedings of the National Academy of Sciences - PNAS (30.05.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (30.05.2017)
Get full text
Journal Article
Anodic Oxidation of Phenols: A Key Step for the Synthesis of Natural Products
Yamamoto, Takashi, Saitoh, Tsuyoshi, Einaga, Yasuaki, Nishiyama, Shigeru
Published in Chemical record (01.09.2021)
Published in Chemical record (01.09.2021)
Get full text
Journal Article
Controlled decoration of boron-doped diamond electrodes by electrochemical click reaction (e−CLICK)
Yamamoto, Takashi, Akahori, Miku, Natsui, Keisuke, Saitoh, Tsuyoshi, Einaga, Yasuaki
Published in Carbon (New York) (01.04.2018)
Published in Carbon (New York) (01.04.2018)
Get full text
Journal Article
Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists
Nagahara, Takashi, Saitoh, Tsuyoshi, Kutsumura, Noriki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Kuroda, Daisuke, Gouda, Hiroaki, Kumagai, Hidetoshi, Fujii, Hideaki, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Journal of medicinal chemistry (22.10.2015)
Published in Journal of medicinal chemistry (22.10.2015)
Get full text
Journal Article
A solvent-directed stereoselective and electrocatalytic synthesis of diisoeugenol
Yamamoto, Takashi, Riehl, Barbara, Naba, Keisuke, Nakahara, Kenshin, Wiebe, Anton, Saitoh, Tsuyoshi, Waldvogel, Siegfried R, Einaga, Yasuaki
Published in Chemical communications (Cambridge, England) (2018)
Published in Chemical communications (Cambridge, England) (2018)
Get full text
Journal Article
Differences in Mechanisms for Fretting Wear Reduction between Oil and Grease Lubrication
Maruyama, Taisuke, Saitoh, Tsuyoshi, Yokouchi, Atsushi
Published in Tribology transactions (04.05.2017)
Published in Tribology transactions (04.05.2017)
Get full text
Journal Article
Design and Synthesis of Orexin 1 Receptor-Selective Agonists
Iio, Keita, Hashimoto, Kao, Nagumo, Yasuyuki, Amezawa, Mao, Hasegawa, Taisei, Yamamoto, Naoshi, Kutsumura, Noriki, Takeuchi, Katsuhiko, Ishikawa, Yukiko, Yamamoto, Hikari, Tokuda, Akihisa, Sato, Tetsu, Uchida, Yasuo, Inoue, Asuka, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi, Saitoh, Tsuyoshi
Published in Journal of medicinal chemistry (27.04.2023)
Published in Journal of medicinal chemistry (27.04.2023)
Get full text
Journal Article
OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy
Yamamoto, Hikari, Nagumo, Yasuyuki, Ishikawa, Yukiko, Irukayama-Tomobe, Yoko, Namekawa, Yukiko, Nemoto, Tsuyoshi, Tanaka, Hiromu, Takahashi, Genki, Tokuda, Akihisa, Saitoh, Tsuyoshi, Nagase, Hiroshi, Funato, Hiromasa, Yanagisawa, Masashi
Published in PloS one (22.07.2022)
Published in PloS one (22.07.2022)
Get full text
Journal Article
Topical administration of the kappa opioid receptor agonist nalfurafine suppresses corneal neovascularization and inflammation
Shokirova, Hurramhon, Inomata, Takenori, Saitoh, Tsuyoshi, Zhu, Jun, Fujio, Kenta, Okumura, Yuichi, Yanagawa, Ai, Fujimoto, Keiichi, Sung, Jaemyoung, Eguchi, Atsuko, Miura, Maria, Nagino, Ken, Hirosawa, Kunihiko, Kuwahara, Mizu, Akasaki, Yasutsugu, Nagase, Hiroshi, Murakami, Akira
Published in Scientific reports (21.04.2021)
Published in Scientific reports (21.04.2021)
Get full text
Journal Article
Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring
Iio, Keita, Saitoh, Tsuyoshi, Ohshita, Ryuichiro, Hino, Tsubasa, Amezawa, Mao, Takayama, Yoshiaki, Nagumo, Yasuyuki, Yamamoto, Naoshi, Kutsumura, Noriki, Irukayama-Tomobe, Yoko, Ishikawa, Yukiko, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Bioorganic & medicinal chemistry letters (15.03.2022)
Published in Bioorganic & medicinal chemistry letters (15.03.2022)
Get full text
Journal Article
Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton
Hino, Tsubasa, Saitoh, Tsuyoshi, Nagumo, Yasuyuki, Yamamoto, Naoshi, Kutsumura, Noriki, Irukayama-Tomobe, Yoko, Ishikawa, Yukiko, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Bioorganic & medicinal chemistry letters (01.03.2022)
Published in Bioorganic & medicinal chemistry letters (01.03.2022)
Get full text
Journal Article
Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors
Wang, Yibing, Cao, Liqin, Lee, Chia-Ying, Matsuo, Tomohiko, Wu, Kejia, Asher, Greg, Tang, Lijun, Saitoh, Tsuyoshi, Russell, Jamie, Klewe-Nebenius, Daniela, Wang, Li, Soya, Shingo, Hasegawa, Emi, Chérasse, Yoan, Zhou, Jiamin, Li, Yuwenbin, Wang, Tao, Zhan, Xiaowei, Miyoshi, Chika, Irukayama, Yoko, Cao, Jie, Meeks, Julian P., Gautron, Laurent, Wang, Zhiqiang, Sakurai, Katsuyasu, Funato, Hiromasa, Sakurai, Takeshi, Yanagisawa, Masashi, Nagase, Hiroshi, Kobayakawa, Reiko, Kobayakawa, Ko, Beutler, Bruce, Liu, Qinghua
Published in Nature communications (23.05.2018)
Published in Nature communications (23.05.2018)
Get full text
Journal Article
Essential structure of orexin 1 receptor antagonist YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in d-nor-nalfurafine derivatives
Katoh, Koki, Kutsumura, Noriki, Yamamoto, Naoshi, Nagumo, Yasuyuki, Saitoh, Tsuyoshi, Ishikawa, Yukiko, Irukayama-Tomobe, Yoko, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Bioorganic & medicinal chemistry letters (01.03.2022)
Published in Bioorganic & medicinal chemistry letters (01.03.2022)
Get full text
Journal Article
Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands
Iio, Keita, Kutsumura, Noriki, Nagumo, Yasuyuki, Saitoh, Tsuyoshi, Tokuda, Akihisa, Hashimoto, Kao, Yamamoto, Naoshi, Kise, Ryoji, Inoue, Asuka, Mizoguchi, Hirokazu, Nagase, Hiroshi
Published in Bioorganic & medicinal chemistry letters (15.01.2022)
Published in Bioorganic & medicinal chemistry letters (15.01.2022)
Get full text
Journal Article
Optochemical control of slow-wave sleep in the nucleus accumbens of male mice by a photoactivatable allosteric modulator of adenosine A2A receptors
Roy, Koustav, Zhou, Xuzhao, Otani, Rintaro, Yuan, Ping-Chuan, Ioka, Shuji, Vogt, Kaspar E., Kondo, Tamae, Farag, Nouran H. T., Ijiri, Haruto, Wu, Zhaofa, Chitose, Youhei, Amezawa, Mao, Uygun, David S., Cherasse, Yoan, Nagase, Hiroshi, Li, Yulong, Yanagisawa, Masashi, Abe, Manabu, Basheer, Radhika, Wang, Yi-Qun, Saitoh, Tsuyoshi, Lazarus, Michael
Published in Nature communications (30.04.2024)
Published in Nature communications (30.04.2024)
Get full text
Journal Article
Effect of removal of the 14-hydroxy group on the affinity of the 4,5-epoxymorphinan derivatives for orexin and opioid receptors
Katoh, Koki, Yamamoto, Naoshi, Ishikawa, Yukiko, Irukayama-Tomobe, Yoko, Tanimura, Ryuji, Saitoh, Tsuyoshi, Nagumo, Yasuyuki, Kutsumura, Noriki, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Bioorganic & medicinal chemistry letters (01.03.2022)
Published in Bioorganic & medicinal chemistry letters (01.03.2022)
Get full text
Journal Article