Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit
Hall, Matthew D, Anderson, James M, Anderson, Annaliesa, Baker, David, Bradner, Jay, Brimacombe, Kyle R, Campbell, Elizabeth A, Corbett, Kizzmekia S, Carter, Kara, Cherry, Sara, Chiang, Lillian, Cihlar, Tomas, de Wit, Emmie, Denison, Mark, Disney, Matthew, Fletcher, Courtney V, Ford-Scheimer, Stephanie L, Götte, Matthias, Grossman, Abigail C, Hayden, Frederick G, Hazuda, Daria J, Lanteri, Charlotte A, Marston, Hilary, Mesecar, Andrew D, Moore, Stephanie, Nwankwo, Jennifer O, O’Rear, Jules, Painter, George, Singh Saikatendu, Kumar, Schiffer, Celia A, Sheahan, Timothy P, Shi, Pei-Yong, Smyth, Hugh D, Sofia, Michael J, Weetall, Marla, Weller, Sandra K, Whitley, Richard, Fauci, Anthony S, Austin, Christopher P, Collins, Francis S, Conley, Anthony J, Davis, Mindy I
Published in The Journal of infectious diseases (15.07.2021)
Published in The Journal of infectious diseases (15.07.2021)
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Conference Proceeding
TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma
Nakayama, Kazuhide, Szewczyk, Magdalena M, Dela Sena, Carlo, Wu, Hong, Dong, Aiping, Zeng, Hong, Li, Fengling, de Freitas, Renato Ferreira, Eram, Mohammad S, Schapira, Matthieu, Baba, Yuji, Kunitomo, Mihoko, Cary, Douglas R, Tawada, Michiko, Ohashi, Akihiro, Imaeda, Yasuhiro, Saikatendu, Kumar Singh, Grimshaw, Charles E, Vedadi, Masoud, Arrowsmith, Cheryl H, Barsyte-Lovejoy, Dalia, Kiba, Atsushi, Tomita, Daisuke, Brown, Peter J
Published in Oncotarget (06.04.2018)
Published in Oncotarget (06.04.2018)
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Donated chemical probes for open science
Müller, Susanne, Ackloo, Suzanne, Arrowsmith, Cheryl H, Bauser, Marcus, Baryza, Jeremy L, Blagg, Julian, Böttcher, Jark, Bountra, Chas, Brown, Peter J, Bunnage, Mark E, Carter, Adrian J, Damerell, David, Dötsch, Volker, Drewry, David H, Edwards, Aled M, Edwards, James, Elkins, Jon M, Fischer, Christian, Frye, Stephen V, Gollner, Andreas, Grimshaw, Charles E, IJzerman, Adriaan, Hanke, Thomas, Hartung, Ingo V, Hitchcock, Steve, Howe, Trevor, Hughes, Terry V, Laufer, Stefan, Li, Volkhart Mj, Liras, Spiros, Marsden, Brian D, Matsui, Hisanori, Mathias, John, O'Hagan, Ronan C, Owen, Dafydd R, Pande, Vineet, Rauh, Daniel, Rosenberg, Saul H, Roth, Bryan L, Schneider, Natalie S, Scholten, Cora, Singh Saikatendu, Kumar, Simeonov, Anton, Takizawa, Masayuki, Tse, Chris, Thompson, Paul R, Treiber, Daniel K, Viana, Amélia Yi, Wells, Carrow I, Willson, Timothy M, Zuercher, William J, Knapp, Stefan, Mueller-Fahrnow, Anke
Published in eLife (20.04.2018)
Published in eLife (20.04.2018)
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Severe Acute Respiratory Syndrome Coronavirus Papain-Like Protease: Structure of a Viral Deubiquitinating Enzyme
Ratia, Kiira, Saikatendu, Kumar Singh, Santarsiero, Bernard D., Barretto, Naina, Baker, Susan C., Stevens, Raymond C., Mesecar, Andrew D.
Published in Proceedings of the National Academy of Sciences - PNAS (11.04.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (11.04.2006)
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Ribonucleocapsid Formation of Severe Acute Respiratory Syndrome Coronavirus through Molecular Action of the N-Terminal Domain of N Protein
KUMAR SINGH SAIKATENDU, JOSEPH, Jeremiah S, SUBRAMANIAN, Vanitha, NEUMAN, Benjamin W, BUCHMEIER, Michael J, STEVENS, Raymond C, KUHN, Peter
Published in Journal of Virology (01.04.2007)
Published in Journal of Virology (01.04.2007)
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Target 2035 - an update on private sector contributions
Ackloo, Suzanne, Antolin, Albert A, Bartolome, Jose Manuel, Beck, Hartmut, Bullock, Alex, Betz, Ulrich A. K, Böttcher, Jark, Brown, Peter J, Chaturvedi, Menorca, Crisp, Alisa, Daniels, Danette, Dreher, Jan, Edfeldt, Kristina, Edwards, Aled M, Egner, Ursula, Elkins, Jon, Fischer, Christian, Glendorf, Tine, Goldberg, Steven, Hartung, Ingo V, Hillisch, Alexander, Homan, Evert, Knapp, Stefan, Köster, Markus, Krämer, Oliver, Llaveria, Josep, Lessel, Uta, Lindemann, Sven, Linderoth, Lars, Matsui, Hisanori, Michel, Maurice, Montel, Florian, Mueller-Fahrnow, Anke, Müller, Susanne, Owen, Dafydd R, Saikatendu, Kumar Singh, Santhakumar, Vijayaratnam, Sanderson, Wendy, Scholten, Cora, Schapira, Matthieu, Sharma, Sujata, Shireman, Brock, Sundström, Michael, Todd, Matthew H, Tredup, Claudia, Venable, Jennifer, Willson, Timothy M, Arrowsmith, Cheryl H
Published in MedChemComm (22.06.2023)
Published in MedChemComm (22.06.2023)
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Discovery of Novel and Highly Selective Cyclopropane ALK Inhibitors through a Fragment-Assisted, Structure-Based Drug Design
Fujimori, Ikuo, Wakabayashi, Takeshi, Murakami, Morio, Okabe, Atsutoshi, Ishii, Tsuyoshi, McGrath, Aaron, Zou, Hua, Saikatendu, Kumar Singh, Imoto, Hiroshi
Published in ACS omega (15.12.2020)
Published in ACS omega (15.12.2020)
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Crystal Structure of Nonstructural Protein 10 from the Severe Acute Respiratory Syndrome Coronavirus Reveals a Novel Fold with Two Zinc-Binding Motifs
JOSEPH, Jeremiah S, KUMAR SINGH SAIKATENDU, STEVENS, Raymond C, KUHN, Peter, SUBRAMANIAN, Vanitha, NEUMAN, Benjamin W, BROOUN, Alexei, GRIFFITH, Mark, MOY, Kin, YADAV, Maneesh K, VELASQUEZ, Jeffrey, BUCHMEIER, Michael J
Published in Journal of Virology (01.08.2006)
Published in Journal of Virology (01.08.2006)
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Journal Article
Crystal Structure of a Monomeric Form of Severe Acute Respiratory Syndrome Coronavirus Endonuclease nsp15 Suggests a Role for Hexamerization as an Allosteric Switch
Joseph, Jeremiah S, Saikatendu, Kumar Singh, Subramanian, Vanitha, Neuman, Benjamin W, Buchmeier, Michael J, Stevens, Raymond C, Kuhn, Peter
Published in Journal of Virology (01.06.2007)
Published in Journal of Virology (01.06.2007)
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Crystal structure of MtnX phosphatase from Bacillus subtilis at 2.0 Å resolution provides a structural basis for bipartite phosphomonoester hydrolysis of 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
Xu, Qingping, Saikatendu, Kumar Singh, Krishna, S. Sri, McMullan, Daniel, Abdubek, Polat, Agarwalla, Sanjay, Ambing, Eileen, Astakhova, Tamara, Axelrod, Herbert L., Carlton, Dennis, Chiu, Hsiu-Ju, Clayton, Thomas, DiDonato, Michael, Duan, Lian, Elsliger, Marc-André, Feuerhelm, Julie, Grzechnik, Slawomir K., Hale, Joanna, Hampton, Eric, Han, Gye Won, Haugen, Justin, Jaroszewski, Lukasz, Jin, Kevin K., Klock, Heath E., Knuth, Mark W., Koesema, Eric, Miller, Mitchell D., Morse, Andrew T., Nigoghossian, Edward, Okach, Linda, Oommachen, Silvya, Paulsen, Jessica, Reyes, Ron, Rife, Christopher L., Schwarzenbacher, Robert, van den Bedem, Henry, White, Aprilfawn, Wolf, Guenter, Hodgson, Keith O., Wooley, John, Deacon, Ashley M., Godzik, Adam, Lesley, Scott A., Wilson, Ian A.
Published in Proteins, structure, function, and bioinformatics (01.11.2007)
Published in Proteins, structure, function, and bioinformatics (01.11.2007)
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Accelerating antiviral drug discovery: lessons from COVID-19
von Delft, Annette, Hall, Matthew D., Kwong, Ann D., Purcell, Lisa A., Saikatendu, Kumar Singh, Schmitz, Uli, Tallarico, John A., Lee, Alpha A.
Published in Nature reviews. Drug discovery (01.07.2023)
Published in Nature reviews. Drug discovery (01.07.2023)
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Journal Article
Identification of PARP14 inhibitors using novel methods for detecting auto-ribosylation
Yoneyama-Hirozane, Mariko, Matsumoto, Shin-ichi, Toyoda, Yukio, Saikatendu, Kumar Singh, Zama, Yumi, Yonemori, Kazuko, Oonishi, Motomi, Ishii, Tsuyoshi, Kawamoto, Tomohiro
Published in Biochemical and biophysical research communications (06.05.2017)
Published in Biochemical and biophysical research communications (06.05.2017)
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Target 2035 - update on the quest for a probe for every protein
Müller, Susanne, Ackloo, Suzanne, Al Chawaf, Arij, Al-Lazikani, Bissan, Antolin, Albert, Baell, Jonathan B, Beck, Hartmut, Beedie, Shaunna, Betz, Ulrich A K, Bezerra, Gustavo Arruda, Brennan, Paul E, Brown, David, Brown, Peter J, Bullock, Alex N, Carter, Adrian J, Chaikuad, Apirat, Chaineau, Mathilde, Ciulli, Alessio, Collins, Ian, Dreher, Jan, Drewry, David, Edfeldt, Kristina, Edwards, Aled M, Egner, Ursula, Frye, Stephen V, Fuchs, Stephen M, Hall, Matthew D, Hartung, Ingo V, Hillisch, Alexander, Hitchcock, Stephen H, Homan, Evert, Kannan, Natarajan, Kiefer, James R, Knapp, Stefan, Kostic, Milka, Kubicek, Stefan, Leach, Andrew R, Lindemann, Sven, Marsden, Brian D, Matsui, Hisanori, Meier, Jordan L, Merk, Daniel, Michel, Maurice, Morgan, Maxwell R, Mueller-Fahrnow, Anke, Owen, Dafydd R, Perry, Benjamin G, Rosenberg, Saul H, Saikatendu, Kumar Singh, Schapira, Matthieu, Scholten, Cora, Sharma, Sujata, Simeonov, Anton, Sundström, Michael, Superti-Furga, Giulio, Todd, Matthew H, Tredup, Claudia, Vedadi, Masoud, von Delft, Frank, Willson, Timothy M, Winter, Georg E, Workman, Paul, Arrowsmith, Cheryl H
Published in MedChemComm (27.01.2022)
Published in MedChemComm (27.01.2022)
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CACHE (Critical Assessment of Computational Hit-finding Experiments): A public–private partnership benchmarking initiative to enable the development of computational methods for hit-finding
Ackloo, Suzanne, Al-awar, Rima, Amaro, Rommie E., Arrowsmith, Cheryl H., Azevedo, Hatylas, Batey, Robert A., Bengio, Yoshua, Betz, Ulrich A. K., Bologa, Cristian G., Chodera, John D., Cornell, Wendy D., Dunham, Ian, Ecker, Gerhard F., Edfeldt, Kristina, Edwards, Aled M., Gilson, Michael K., Gordijo, Claudia R., Hessler, Gerhard, Hillisch, Alexander, Hogner, Anders, Irwin, John J., Jansen, Johanna M., Kuhn, Daniel, Leach, Andrew R., Lee, Alpha A., Lessel, Uta, Morgan, Maxwell R., Moult, John, Muegge, Ingo, Oprea, Tudor I., Perry, Benjamin G., Riley, Patrick, Rousseaux, Sophie A. L., Saikatendu, Kumar Singh, Santhakumar, Vijayaratnam, Schapira, Matthieu, Scholten, Cora, Todd, Matthew H., Vedadi, Masoud, Volkamer, Andrea, Willson, Timothy M.
Published in Nature reviews. Chemistry (01.04.2022)
Published in Nature reviews. Chemistry (01.04.2022)
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Structural Basis of Severe Acute Respiratory Syndrome Coronavirus ADP-Ribose-1″-Phosphate Dephosphorylation by a Conserved Domain of nsP3
Saikatendu, Kumar Singh, Joseph, Jeremiah S., Subramanian, Vanitha, Clayton, Tom, Griffith, Mark, Moy, Kin, Velasquez, Jeffrey, Neuman, Benjamin W., Buchmeier, Michael J., Stevens, Raymond C., Kuhn, Peter
Published in Structure (London) (01.11.2005)
Published in Structure (London) (01.11.2005)
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Journal Article
Structure of a conserved hypothetical protein SA1388 from S. aureus reveals a capped hexameric toroid with two PII domain lids and a dinuclear metal center
Saikatendu, Kumar Singh, Zhang, Xuejun, Kinch, Lisa, Leybourne, Matthew, Grishin, Nick V., Zhang, Hong
Published in BMC structural biology (15.10.2015)
Published in BMC structural biology (15.10.2015)
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Journal Article
Crystal structure of a monomeric form of severe acute respiratory syndrome coronavirus endonuclease nspl5 suggests a role for hexamerization as an allosteric switch
JOSEPH, Jeremiah S, KUMAR SINGH SAIKATENDU, SUBRAMANIAN, Vanitha, NEUMAN, Benjamin W, BUCHMEIER, Michael J, STEVENS, Raymond C, KUHN, Peter
Published in Journal of virology (2007)
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Published in Journal of virology (2007)
Journal Article
Structure of a conserved hypothetical protein SA1388 from S. aureus reveals a capped hexameric toroid with two PII domain lids and a dinuclear metal center
Saikatendu, Kumar Singh, Zhang, Xuejun, Kinch, Lisa, Leybourne, Matthew, Grishin, Nick V, Zhang, Hong
Published in BMC structural biology (23.12.2006)
Published in BMC structural biology (23.12.2006)
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