A novel highly potent autotaxin/ENPP2 inhibitor produces prolonged decreases in plasma lysophosphatidic acid formation in vivo and regulates urethral tension
Saga, Hiroshi, Ohhata, Akira, Hayashi, Akio, Katoh, Makoto, Maeda, Tatsuo, Mizuno, Hirotaka, Takada, Yuka, Komichi, Yuka, Ota, Hiroto, Matsumura, Naoya, Shibaya, Masami, Sugiyama, Tetsuya, Nakade, Shinji, Kishikawa, Katsuya
Published in PloS one (01.04.2014)
Published in PloS one (01.04.2014)
Get full text
Journal Article
Evaluations of the Selectivities of the Diacylglycerol Kinase Inhibitors R59022 and R59949 Among Diacylglycerol Kinase Isozymes Using a New Non-Radioactive Assay Method
Sato, Mayu, Liu, Ke, Sasaki, Saori, Kunii, Naoko, Sakai, Hiromichi, Mizuno, Hirotaka, Saga, Hiroshi, Sakane, Fumio
Published in Pharmacology (01.01.2013)
Published in Pharmacology (01.01.2013)
Get full text
Journal Article
Discovery of ONO-7300243 from a Novel Class of Lysophosphatidic Acid Receptor 1 Antagonists: From Hit to Lead
Terakado, Masahiko, Suzuki, Hidehiro, Hashimura, Kazuya, Tanaka, Motoyuki, Ueda, Hideyuki, Kohno, Hiroshi, Fujimoto, Taku, Saga, Hiroshi, Nakade, Shinji, Habashita, Hiromu, Takaoka, Yoshikazu, Seko, Takuya
Published in ACS medicinal chemistry letters (13.10.2016)
Published in ACS medicinal chemistry letters (13.10.2016)
Get full text
Journal Article
Changes in the Balance of Phosphoinositide 3-Kinase/Protein Kinase B (Akt) and the Mitogen-Activated Protein Kinases (ERK/p38MAPK) Determine a Phenotype of Visceral and Vascular Smooth Muscle Cells
Hayashi, Ken'ichiro, Takahashi, Masanori, Kimura, Kazuhiro, Nishida, Wataru, Saga, Hiroshi, Sobue, Kenji
Published in The Journal of cell biology (17.05.1999)
Published in The Journal of cell biology (17.05.1999)
Get full text
Journal Article
Differentiated Phenotype of Smooth Muscle Cells Depends on Signaling Pathways through Insulin-like Growth Factors and Phosphatidylinositol 3-Kinase
Hayashi, Ken'ichiro, Saga, Hiroshi, Chimori, Yoshihiro, Kimura, Kazuhiro, Yamanaka, Yuka, Sobue, Kenji
Published in The Journal of biological chemistry (30.10.1998)
Published in The Journal of biological chemistry (30.10.1998)
Get full text
Journal Article
Preparation and properties of transparent cellulose hydrogels
Saito, Hidenao, Sakurai, Akihiko, Sakakibara, Mikio, Saga, Hiroshi
Published in Journal of applied polymer science (09.12.2003)
Published in Journal of applied polymer science (09.12.2003)
Get full text
Journal Article
ONO-8430506: A Novel Autotaxin Inhibitor That Enhances the Antitumor Effect of Paclitaxel in a Breast Cancer Model
Iwaki, Yuzo, Ohhata, Akira, Nakatani, Shingo, Hisaichi, Katsuya, Okabe, Yasuyuki, Hiramatsu, Atsushi, Watanabe, Toshihide, Yamamoto, Shingo, Nishiyama, Taihei, Kobayashi, Juta, Hirooka, Yasuo, Moriguchi, Hideki, Maeda, Tatsuo, Katoh, Makoto, Komichi, Yuka, Ota, Hiroto, Matsumura, Naoya, Okada, Masahiro, Sugiyama, Tetsuya, Saga, Hiroshi, Imagawa, Akira
Published in ACS medicinal chemistry letters (11.06.2020)
Published in ACS medicinal chemistry letters (11.06.2020)
Get full text
Journal Article
Discovery of a Slow Tight Binding LPA1 Antagonist (ONO-0300302) for the Treatment of Benign Prostatic Hyperplasia
Terakado, Masahiko, Suzuki, Hidehiro, Hashimura, Kazuya, Tanaka, Motoyuki, Ueda, Hideyuki, Hirai, Keisuke, Asada, Masaki, Ikura, Masahiro, Matsunaga, Naoki, Saga, Hiroshi, Shinozaki, Koji, Karakawa, Naoko, Takada, Yuka, Minami, Masashi, Egashira, Hiromu, Sugiura, Yoshihiro, Yamada, Masanori, Nakade, Shinji, Takaoka, Yoshikazu
Published in ACS medicinal chemistry letters (14.12.2017)
Published in ACS medicinal chemistry letters (14.12.2017)
Get full text
Journal Article
Discovery of a Slow Tight Binding LPA1 Antagonist (ONO-0300302) for the eTreatment of Benign Prostatic Hyperplasia
Terakado, Masahiko, Suzuki, Hidehiro, Hashimura, Kazuya, Tanaka, Motoyuki, Ueda, Hideyuki, Hirai, Keisuke, Asada, Masaki, Ikura, Masahiro, Matsunaga, Naoki, Saga, Hiroshi, Shinozaki, Koji, Karakawa, Naoko, Takada, Yuka, Minami, Masashi, Egashira, Hiromu, Sugiura, Yoshihiro, Yamada, Masanori, Nakade, Shinji, Takaoka, Yoshikazu
Published in ACS medicinal chemistry letters (01.12.2017)
Published in ACS medicinal chemistry letters (01.12.2017)
Get full text
Journal Article
Transcriptional Regulation of the Chicken Caldesmon Gene
Yano, Hajime, Hayashi, Ken'ichiro, Momiyama, Takuya, Saga, Hiroshi, Haruna, Masaki, Sobue, Kenji
Published in The Journal of biological chemistry (06.10.1995)
Published in The Journal of biological chemistry (06.10.1995)
Get full text
Journal Article
S1P RECEPTOR BINDING-ABILITY POSSESSING COMPOUND AND MEDICAL USE THEREOF
KURATA HARUTO, HABASHITA HIROSHI, MIZUNO HIROKI, ONO TAKEJI, KOMIYA TAKAKI, SAGA HIROSHI, NAKADE SHINJI, OTSUKI KAZUHIRO, KUSUMI KENSUKE, MINAMI SHINJI, HAGIYA HIROSHI
Year of Publication 25.12.2014
Get full text
Year of Publication 25.12.2014
Patent
N-Acylimidazoles–Trifluoroacetic Acid System as the Acylating Agent for Aromatic Hydrocarbons
Keumi, Takashi, Saga, Hiroshi, Kitajima, Hidehiko
Published in Bulletin of the Chemical Society of Japan (01.06.1980)
Published in Bulletin of the Chemical Society of Japan (01.06.1980)
Get full text
Journal Article
An Outbreak of Porcine Pleuropneumonia due to Actinobacillus pleuropneumoniae Serotype 1 on an Integrated Swine Farm
YASUDA, Masaaki, ITOH, Ryu, KAKINO, Jun, Saga, Hiroshi, Sasaki, Kouhei, Kimura, ATSUMU, KAGABU, Yukio
Published in Journal of the Japan Veterinary Medical Association (20.05.1995)
Published in Journal of the Japan Veterinary Medical Association (20.05.1995)
Get full text
Journal Article
COMPOUND CAPABLE OF BINDING S1P RECEPTOR AND PHARMACEUTICAL USE THEREOF
KURATA HARUTO, HABASHITA HIROMU, ONO TAKEJI, OHTSUKI KAZUHIRO, KOMIYA TAKAKI, SAGA HIROSHI, NAKADE SHINJI, MIZUNO HIROTAKA, KUSUMI KENSUKE, MINAMI MASASHI, HAGIYA HIROSHI
Year of Publication 30.12.2011
Get full text
Year of Publication 30.12.2011
Patent
AN OUTLINE OF HEAVY RAINFALL DISASTERS IN HIDAKA REGION, HOKKAIDO, BY TYPHOON NO.10, 2003
HASEGAWA, Kazuyoshi, ARAYAE, Tohru, OGAWA, Takehiro, KIKUCHI, Shunichi, KUROKI, Mikio, KOMATSU, Toshimitsu, SAGA, Hiroshi, SHIMIZU, Osamu, SUZUKI, Hiroyuki, SUZUKI, Yuichi, TANAKA, Gaku, TANAKA, Hitoshi, TOHMA, Satoshi, NAKATSUGAWA, Makoto, HATTA, Shigemi, MURAKAMI, Yasuhiro, YAMASHITA, Toshiko, YAMADA, Takashi, WATANABE, Yasuharu, WATANABE, Yasunori, FUJITA, Mutsuhiro
Published in PROCEEDINGS OF HYDRAULIC ENGINEERING (2005)
Published in PROCEEDINGS OF HYDRAULIC ENGINEERING (2005)
Get full text
Journal Article
Stimulation of Cyclic AMP Formation by Pituitary Adenylate Cyclase-Activating Polypeptide Is Attenuated by Glutamate in Rat Brain Slices
Kondo, Kaoru, Hashimoto, Hitoshi, Sakata, Kazuko, Saga, Hiroshi, Kitanaka, Jun-ichi, Baba, Akemichi
Published in Japanese Journal of Pharmacology (1995)
Published in Japanese Journal of Pharmacology (1995)
Get full text
Journal Article