The Role of Ischemia/Reperfusion Injury in Early Hepatic Allograft Dysfunction
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Published in Liver transplantation (01.08.2020)
Published in Liver transplantation (01.08.2020)
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Regulatory T Cell Therapy Following Liver Transplantation
Yu, Jiongjie, Liu, Zhikun, Li, Changbiao, Wei, Qiang, Zheng, Shusen, Saeb‐Parsy, Kourosh, Xu, Xiao
Published in Liver transplantation (01.02.2021)
Published in Liver transplantation (01.02.2021)
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Regional Differences in Human Biliary Tissues and Corresponding In Vitro–Derived Organoids
Rimland, Casey A., Tilson, Samantha G., Morell, Carola M., Tomaz, Rute A., Lu, Wei‐Yu, Adams, Simone E., Georgakopoulos, Nikitas, Otaizo‐Carrasquero, Francisco, Myers, Timothy G., Ferdinand, John R., Gieseck, Richard L., Sampaziotis, Fotios, Tysoe, Olivia C., Ross, Alexander, Kraiczy, Judith M., Wesley, Brandon, Muraro, Daniele, Zilbauer, Matthias, Oniscu, Gabriel C., Hannan, Nicholas R.F., Forbes, Stuart J., Saeb‐Parsy, Kourosh, Wynn, Thomas A., Vallier, Ludovic
Published in Hepatology (Baltimore, Md.) (01.01.2021)
Published in Hepatology (Baltimore, Md.) (01.01.2021)
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Isolation and propagation of primary human cholangiocyte organoids for the generation of bioengineered biliary tissue
Tysoe, Olivia C, Justin, Alexander W, Brevini, Teresa, Chen, Si Emma, Mahbubani, Krishnaa T, Frank, Anna K, Zedira, Hajer, Melum, Espen, Saeb-Parsy, Kourosh, Markaki, Athina E, Vallier, Ludovic, Sampaziotis, Fotios
Published in Nature protocols (01.06.2019)
Published in Nature protocols (01.06.2019)
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Innovations, challenges, and minimal information for standardization of humanized mice
Stripecke, Renata, Münz, Christian, Schuringa, Jan Jacob, Bissig, Karl‐Dimiter, Soper, Brian, Meeham, Terrence, Yao, Li‐Chin, Di Santo, James P, Brehm, Michael, Rodriguez, Estefania, Wege, Anja Kathrin, Bonnet, Dominique, Guionaud, Silvia, Howard, Kristina E, Kitchen, Scott, Klein, Florian, Saeb‐Parsy, Kourosh, Sam, Johannes, Sharma, Amar Deep, Trumpp, Andreas, Trusolino, Livio, Bult, Carol, Shultz, Leonard
Published in EMBO molecular medicine (07.07.2020)
Published in EMBO molecular medicine (07.07.2020)
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RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state
Belenguer, Germán, Mastrogiovanni, Gianmarco, Pacini, Clare, Hall, Zoe, Dowbaj, Anna M, Arnes-Benito, Robert, Sljukic, Aleksandra, Prior, Nicole, Kakava, Sofia, Bradshaw, Charles R, Davies, Susan, Vacca, Michele, Saeb-Parsy, Kourosh, Koo, Bon-Kyoung, Huch, Meritxell
Published in Nature communications (17.01.2022)
Published in Nature communications (17.01.2022)
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Metabolomic Profiling in Acute ST‐Segment–Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia–Reperfusion Injury
Kohlhauer, Matthias, Dawkins, Sam, Costa, Ana S. H., Lee, Regent, Young, Timothy, Pell, Victoria R., Choudhury, Robin P., Banning, Adrian P., Kharbanda, Rajesh K., Saeb‐Parsy, Kourosh, Murphy, Michael P., Frezza, Christian, Krieg, Thomas, Channon, Keith M.
Published in Journal of the American Heart Association (17.04.2018)
Published in Journal of the American Heart Association (17.04.2018)
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Accelerating cryoprotectant diffusion kinetics improves cryopreservation of pancreatic islets
Dolezalova, Nikola, Gruszczyk, Anja, Barkan, Kerry, Gamble, John A, Galvin, Sam, Moreth, Till, O'Holleran, Kevin, Mahbubani, Krishnaa T, Higgins, Jackie A, Gribble, Fiona M, Reimann, Frank, Surmacki, Jakub, Andrews, Simon, Casey, John J, Pampaloni, Francesco, Murphy, Michael P, Ladds, Graham, Slater, Nigel K H, Saeb-Parsy, Kourosh
Published in Scientific reports (17.05.2021)
Published in Scientific reports (17.05.2021)
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Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73
Jarvis, Lorna B, Rainbow, Daniel B, Coppard, Valerie, Howlett, Sarah K, Georgieva, Zoya, Davies, Jessica L, Mullay, Harpreet Kaur, Hester, Joanna, Ashmore, Tom, Van Den Bosch, Aletta, Grist, James T, Coles, Alasdair J, Mousa, Hani S, Pluchino, Stefano, Mahbubani, Krishnaa T, Griffin, Julian L, Saeb-Parsy, Kourosh, Issa, Fadi, Peruzzotti-Jametti, Luca, Wicker, Linda S, Jones, Joanne L
Published in Communications biology (14.10.2021)
Published in Communications biology (14.10.2021)
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Use of human splenocytes in an innovative humanised mouse model for prediction of immunotherapy‐induced cytokine release syndrome
Matas‐Céspedes, Alba, Brown, Lee, Mahbubani, Krishnaa T, Bareham, Bethany, Higgins, Jackie, Curran, Michelle, de Haan, Lolke, Lapointe, Jean‐Martin, Stebbings, Richard, Saeb‐Parsy, Kourosh
Published in Clinical & translational immunology (2020)
Published in Clinical & translational immunology (2020)
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Somatic mutant clones colonize the human esophagus with age
Martincorena, Iñigo, Fowler, Joanna C, Wabik, Agnieszka, Lawson, Andrew R J, Abascal, Federico, Hall, Michael W J, Cagan, Alex, Murai, Kasumi, Mahbubani, Krishnaa, Stratton, Michael R, Fitzgerald, Rebecca C, Handford, Penny A, Campbell, Peter J, Saeb-Parsy, Kourosh, Jones, Philip H
Published in Science (American Association for the Advancement of Science) (23.11.2018)
Published in Science (American Association for the Advancement of Science) (23.11.2018)
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A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury
Chouchani, Edward T., Pell, Victoria R., James, Andrew M., Work, Lorraine M., Saeb-Parsy, Kourosh, Frezza, Christian, Krieg, Thomas, Murphy, Michael P.
Published in Cell metabolism (09.02.2016)
Published in Cell metabolism (09.02.2016)
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The landscape of somatic mutation in normal colorectal epithelial cells
Lee-Six, Henry, Olafsson, Sigurgeir, Ellis, Peter, Osborne, Robert J, Sanders, Mathijs A, Moore, Luiza, Georgakopoulos, Nikitas, Torrente, Franco, Noorani, Ayesha, Goddard, Martin, Robinson, Philip, Coorens, Tim H H, O'Neill, Laura, Alder, Christopher, Wang, Jingwei, Fitzgerald, Rebecca C, Zilbauer, Matthias, Coleman, Nicholas, Saeb-Parsy, Kourosh, Martincorena, Inigo, Campbell, Peter J, Stratton, Michael R
Published in Nature (London) (01.10.2019)
Published in Nature (London) (01.10.2019)
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Human primary liver cancer-derived organoid cultures for disease modeling and drug screening
Broutier, Laura, Mastrogiovanni, Gianmarco, Verstegen, Monique Ma, Francies, Hayley E, Gavarró, Lena Morrill, Bradshaw, Charles R, Allen, George E, Arnes-Benito, Robert, Sidorova, Olga, Gaspersz, Marcia P, Georgakopoulos, Nikitas, Koo, Bon-Kyoung, Dietmann, Sabine, Davies, Susan E, Praseedom, Raaj K, Lieshout, Ruby, IJzermans, Jan N M, Wigmore, Stephen J, Saeb-Parsy, Kourosh, Garnett, Mathew J, van der Laan, Luc Jw, Huch, Meritxell
Published in Nature Medicine (01.12.2017)
Published in Nature Medicine (01.12.2017)
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The mutational landscape of normal human endometrial epithelium
Moore, Luiza, Leongamornlert, Daniel, Coorens, Tim H H, Sanders, Mathijs A, Ellis, Peter, Dentro, Stefan C, Dawson, Kevin J, Butler, Tim, Rahbari, Raheleh, Mitchell, Thomas J, Maura, Francesco, Nangalia, Jyoti, Tarpey, Patrick S, Brunner, Simon F, Lee-Six, Henry, Hooks, Yvette, Moody, Sarah, Mahbubani, Krishnaa T, Jimenez-Linan, Mercedes, Brosens, Jan J, Iacobuzio-Donahue, Christine A, Martincorena, Inigo, Saeb-Parsy, Kourosh, Campbell, Peter J, Stratton, Michael R
Published in Nature (London) (30.04.2020)
Published in Nature (London) (30.04.2020)
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Clonal dynamics of haematopoiesis across the human lifespan
Mitchell, Emily, Spencer Chapman, Michael, Williams, Nicholas, Dawson, Kevin J, Mende, Nicole, Calderbank, Emily F, Jung, Hyunchul, Mitchell, Thomas, Coorens, Tim H H, Spencer, David H, Machado, Heather, Lee-Six, Henry, Davies, Megan, Hayler, Daniel, Fabre, Margarete A, Mahbubani, Krishnaa, Abascal, Federico, Cagan, Alex, Vassiliou, George S, Baxter, Joanna, Martincorena, Inigo, Stratton, Michael R, Kent, David G, Chatterjee, Krishna, Parsy, Kourosh Saeb, Green, Anthony R, Nangalia, Jyoti, Laurenti, Elisa, Campbell, Peter J
Published in Nature (London) (09.06.2022)
Published in Nature (London) (09.06.2022)
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Distinct microbial and immune niches of the human colon
James, Kylie R, Gomes, Tomas, Elmentaite, Rasa, Kumar, Nitin, Gulliver, Emily L, King, Hamish W, Stares, Mark D, Bareham, Bethany R, Ferdinand, John R, Petrova, Velislava N, Polański, Krzysztof, Forster, Samuel C, Jarvis, Lorna B, Suchanek, Ondrej, Howlett, Sarah, James, Louisa K, Jones, Joanne L, Meyer, Kerstin B, Clatworthy, Menna R, Saeb-Parsy, Kourosh, Lawley, Trevor D, Teichmann, Sarah A
Published in Nature immunology (01.03.2020)
Published in Nature immunology (01.03.2020)
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