Evaluation of Efficacy, Biodistribution, and Inflammation for a Potent siRNA Nanoparticle: Effect of Dexamethasone Co-treatment
Abrams, Marc T, Koser, Martin L, Seitzer, Jessica, Williams, Stephanie C, DiPietro, Martha A, Wang, Weimin, Shaw, Andrew W, Mao, Xianzhi, Jadhav, Vasant, Davide, Joseph P, Burke, Paul A, Sachs, Alan B, Stirdivant, Steven M, Sepp-Lorenzino, Laura
Published in Molecular therapy (01.01.2010)
Published in Molecular therapy (01.01.2010)
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Journal Article
High Resolution Discovery Proteomics Reveals Candidate Disease Progression Markers of Alzheimer's Disease in Human Cerebrospinal Fluid
Hendrickson, Ronald C, Lee, Anita Y H, Song, Qinghua, Liaw, Andy, Wiener, Matt, Paweletz, Cloud P, Seeburger, Jeffrey L, Li, Jenny, Meng, Fanyu, Deyanova, Ekaterina G, Mazur, Matthew T, Settlage, Robert E, Zhao, Xuemei, Southwick, Katie, Du, Yi, Holder, Dan, Sachs, Jeffrey R, Laterza, Omar F, Dallob, Aimee, Chappell, Derek L, Snyder, Karen, Modur, Vijay, King, Elizabeth, Joachim, Catharine, Bondarenko, Andrey Y, Shearman, Mark, Soper, Keith A, Smith, A David, Potter, William Z, Koblan, Ken S, Sachs, Alan B, Yates, Nathan A
Published in PloS one (13.08.2015)
Published in PloS one (13.08.2015)
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Journal Article
Mechanistically Probing Lipid-siRNA Nanoparticle-associated Toxicities Identifies Jak Inhibitors Effective in Mitigating Multifaceted Toxic Responses
Tao, Weikang, Mao, Xianzhi, Davide, Joseph P, Ng, Bruce, Cai, Mingmei, Burke, Paul A, Sachs, Alan B, Sepp-Lorenzino, Laura
Published in Molecular therapy (01.03.2011)
Published in Molecular therapy (01.03.2011)
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Journal Article
siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids[S]
Tadin-Strapps, Marija, Peterson, Laurence B., Cumiskey, Anne-Marie, Rosa, Raymond L., Mendoza, Vivienne Halili, Castro-Perez, Jose, Puig, Oscar, Zhang, Liwen, Strapps, Walter R., Yendluri, Satyasri, Andrews, Lori, Pickering, Victoria, Rice, Julie, Luo, Lily, Chen, Zhu, Tep, Samnang, Ason, Brandon, Somers, Elizabeth Polizzi, Sachs, Alan B., Bartz, Steven R., Tian, Jenny, Chin, Jayne, Hubbard, Brian K., Wong, Kenny K., Mitnaul, Lyndon J.
Published in Journal of lipid research (01.06.2011)
Published in Journal of lipid research (01.06.2011)
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Journal Article
MicroRNA-like off-target transcript regulation by siRNAs is species specific
Burchard, Julja, Jackson, Aimee L, Malkov, Vladislav, Needham, Rachel H V, Tan, Yejun, Bartz, Steven R, Dai, Hongyue, Sachs, Alan B, Linsley, Peter S
Published in RNA (Cambridge) (01.02.2009)
Published in RNA (Cambridge) (01.02.2009)
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Journal Article
Quantitative evaluation of siRNA delivery in vivo
Pei, Yi, Hancock, Paula J, Zhang, Hangchun, Bartz, René, Cherrin, Craig, Innocent, Nathalie, Pomerantz, Colin J, Seitzer, Jessica, Koser, Martin L, Abrams, Marc T, Xu, Yan, Kuklin, Nelly A, Burke, Paul A, Sachs, Alan B, Sepp-Lorenzino, Laura, Barnett, Stanley F
Published in RNA (Cambridge) (01.12.2010)
Published in RNA (Cambridge) (01.12.2010)
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Journal Article
Starting at the Beginning, Middle, and End: Translation Initiation in Eukaryotes
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Book Review
Journal Article
RNA-induced silencing complex-bound small interfering RNA is a determinant of RNA interference-mediated gene silencing in mice
Wei, Jie, Jones, Jeffrey, Kang, Jing, Card, Ananda, Krimm, Michael, Hancock, Paula, Pei, Yi, Ason, Brandon, Payson, Elmer, Dubinina, Natalya, Cancilla, Mark, Stroh, Mark, Burchard, Julja, Sachs, Alan B, Hochman, Jerome H, Flanagan, W Michael, Kuklin, Nelly A
Published in Molecular pharmacology (01.06.2011)
Published in Molecular pharmacology (01.06.2011)
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Journal Article
Improved efficacy for ezetimibe and rosuvastatin by attenuating the induction of PCSK9[S]
Ason, Brandon, Tep, Samnang, Davis, Jr. Harry R., Xu, Yiming, Tetzloff, Glen, Galinski, Beverly, Soriano, Ferdie, Dubinina, Natalya, Zhu, Lei, Stefanni, Alice, Wong, Kenny K., Tadin-Strapps, Marija, Bartz, Steven R., Hubbard, Brian, Ranalletta, Mollie, Sachs, Alan B., Flanagan, W. Michael, Strack, Alison, Kuklin, Nelly A.
Published in Journal of lipid research (01.04.2011)
Published in Journal of lipid research (01.04.2011)
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Journal Article
LRRTM3 Promotes Processing of Amyloid-Precursor Protein by BACE1 and Is a Positional Candidate Gene for Late-Onset Alzheimer's Disease
Majercak, John, Ray, William J., Espeseth, Amy, Simon, Adam, Shi, Xiao-Ping, Wolffe, Carrie, Getty, Krista, Marine, Shane, Stec, Erica, Ferrer, Marc, Strulovici, Berta, Bartz, Steven, Gates, Adam, Xu, Min, Huang, Qian, Ma, Lei, Shughrue, Paul, Burchard, Julja, Colussi, Dennis, Pietrak, Beth, Kahana, Jason, Beher, Dirk, Rosahl, Thomas, Shearman, Mark, Hazuda, Daria, Sachs, Alan B., Koblan, Kenneth S., Seabrook, Guy R., Stone, David J.
Published in Proceedings of the National Academy of Sciences - PNAS (21.11.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (21.11.2006)
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Journal Article
ApoB siRNA-induced Liver Steatosis is Resistant to Clearance by the Loss of Fatty Acid Transport Protein 5 (Fatp5)
Ason, Brandon, Castro-Perez, Jose, Tep, Samnang, Stefanni, Alice, Tadin-Strapps, Marija, Roddy, Thomas, Hankemeier, Thomas, Hubbard, Brian, Sachs, Alan B., Michael Flanagan, W., Kuklin, Nelly A., Mitnaul, Lyndon J.
Published in Lipids (01.11.2011)
Published in Lipids (01.11.2011)
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Journal Article
One-step affinity purification of the yeast ribosome and its associated proteins and mRNAs
INADA, TOSHIFUMI, WINSTALL, ERIC, TARUN, SALVADOR Z., YATES, JOHN R., SCHIELTZ, DAVE, SACHS, ALAN B.
Published in RNA (Cambridge) (01.07.2002)
Published in RNA (Cambridge) (01.07.2002)
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Journal Article
Development and characterization of a reconstituted yeast translation initiation system
ALGIRE, MIKKEL A., MAAG, DAVID, SAVIO, PETER, ACKER, MICHAEL G., TARUN, SALVADOR Z., SACHS, ALAN B., ASANO, KATSURA, NIELSEN, KLAUS H., OLSEN, DEANNE S., PHAN, LON, HINNEBUSCH, ALAN G., LORSCH, JON R.
Published in RNA (Cambridge) (01.03.2002)
Published in RNA (Cambridge) (01.03.2002)
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Journal Article
Biodistribution of Small Interfering RNA at the Organ and Cellular Levels after Lipid Nanoparticle-mediated Delivery
Shi, Bin, Keough, Ed, Matter, Andrea, Leander, Karen, Young, Stephanie, Carlini, Ed, Sachs, Alan B., Tao, Weikang, Abrams, Marc, Howell, Bonnie, Sepp-Lorenzino, Laura
Published in The journal of histochemistry and cytochemistry (01.08.2011)
Published in The journal of histochemistry and cytochemistry (01.08.2011)
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Journal Article
Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5'-terminal phosphorylation both in vitro and in vivo
Kenski, Denise M, Cooper, Abby J, Li, Jenny J, Willingham, Aarron T, Haringsma, Henry J, Young, Tracy A, Kuklin, Nelly A, Jones, Jeffrey J, Cancilla, Mark T, McMasters, Daniel R, Mathur, Melina, Sachs, Alan B, Flanagan, W. Michael
Published in Nucleic acids research (01.01.2010)
Published in Nucleic acids research (01.01.2010)
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Journal Article
Circularization of mRNA by Eukaryotic Translation Initiation Factors
Wells, Sandra E., Hillner, Paul E., Vale, Ronald D., Sachs, Alan B.
Published in Molecular cell (01.07.1998)
Published in Molecular cell (01.07.1998)
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Journal Article
Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels
Cervino, Alessandra C., Li, Guoya, Edwards, Steve, Zhu, Jun, Laurie, Cathy, Tokiwa, George, Lum, Pek Yee, Wang, Susanna, Castellini, Lawrence W., Lusis, Aldons J., Carlson, Sonia, Sachs, Alan B., Schadt, Eric E.
Published in Genomics (San Diego, Calif.) (01.11.2005)
Published in Genomics (San Diego, Calif.) (01.11.2005)
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