Search Results - "SACHIN SURADE" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Beyond affinity: selection of antibody variants with optimal biophysical properties and reduced immunogenicity from mammalian display libraries

Beyond affinity: selection of antibody variants with optimal biophysical properties and reduced immunogenicity from mammalian display libraries

by Dyson, Michael R, Masters, Edward, Pazeraitis, Deividas, Perera, Rajika L, Syrjanen, Johanna L, Surade, Sachin, Thorsteinson, Nels, Parthiban, Kothai, Jones, Philip C, Sattar, Maheen, Wozniak-Knopp, Gordana, Rueker, Florian, Leah, Rachael, McCafferty, John
Published in mAbs (01.01.2020)

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A comprehensive search of functional sequence space using large mammalian display libraries created by gene editing

A comprehensive search of functional sequence space using large mammalian display libraries created by gene editing

by Parthiban, Kothai, Perera, Rajika L, Sattar, Maheen, Huang, Yanchao, Mayle, Sophie, Masters, Edward, Griffiths, Daniel, Surade, Sachin, Leah, Rachael, Dyson, Michael R, McCafferty, John
Published in mAbs (04.07.2019)

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Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses

Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses

by Bullen, Georgia, Galson, Jacob D, Hall, Gareth, Villar, Pedro, Moreels, Lien, Ledsgaard, Line, Mattiuzzo, Giada, Bentley, Emma M, Masters, Edward W, Tang, David, Millett, Sophie, Tongue, Danielle, Brown, Richard, Diamantopoulos, Ioannis, Parthiban, Kothai, Tebbutt, Claire, Leah, Rachael, Chaitanya, Krishna, Ergueta-Carballo, Sandra, Pazeraitis, Deividas, Surade, Sachin B, Ashiru, Omodele, Crippa, Lucia, Cowan, Richard, Bowler, Matthew W, Campbell, Jamie I, Lee, Wing-Yiu Jason, Carr, Mark D, Matthews, David, Pfeffer, Paul, Hufton, Simon E, Sawmynaden, Kovilen, Osbourn, Jane, McCafferty, John, Karatt-Vellatt, Aneesh
Published in Frontiers in immunology (15.06.2021)

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Application of Fragment Screening and Merging to the Discovery of Inhibitors of the Mycobacterium tuberculosis Cytochrome P450 CYP121

Application of Fragment Screening and Merging to the Discovery of Inhibitors of the Mycobacterium tuberculosis Cytochrome P450 CYP121

by Hudson, Sean A., McLean, Kirsty J., Surade, Sachin, Yang, Yong-Qing, Leys, David, Ciulli, Alessio, Munro, Andrew W., Abell, Chris
Published in Angewandte Chemie International Edition (10.09.2012)

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Comparative analysis and “expression space” coverage of the production of prokaryotic membrane proteins for structural genomics

Comparative analysis and “expression space” coverage of the production of prokaryotic membrane proteins for structural genomics

by Surade, Sachin, Klein, Markus, Stolt‐Bergner, Peggy C., Muenke, Cornelia, Roy, Ankita, Michel, Hartmut
Published in Protein science (01.09.2006)

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Structural Biology and Drug Discovery of Difficult Targets: The Limits of Ligandability

Structural Biology and Drug Discovery of Difficult Targets: The Limits of Ligandability

by Surade, Sachin, Blundell, Tom L.
Published in Chemistry & biology (27.01.2012)

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Virtual Screening and X‑ray Crystallography Identify Non-Substrate Analog Inhibitors of Flavin-Dependent Thymidylate Synthase

Virtual Screening and X‑ray Crystallography Identify Non-Substrate Analog Inhibitors of Flavin-Dependent Thymidylate Synthase

by Luciani, Rosaria, Saxena, Puneet, Surade, Sachin, Santucci, Matteo, Venturelli, Alberto, Borsari, Chiara, Marverti, Gaetano, Ponterini, Glauco, Ferrari, Stefania, Blundell, Tom L, Costi, Maria Paola
Published in Journal of medicinal chemistry (13.10.2016)

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A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters

A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters

by Nikiforov, Petar O., Surade, Sachin, Blaszczyk, Michal, Delorme, Vincent, Brodin, Priscille, Baulard, Alain R., Blundell, Tom L., Abell, Chris
Published in Organic & biomolecular chemistry (21.02.2016)

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Knotbodies: A New Generation of Ion Channel Therapeutic Biologics Created by Fusing Knottin Toxins into Antibodies

Knotbodies: A New Generation of Ion Channel Therapeutic Biologics Created by Fusing Knottin Toxins into Antibodies

by Bell, Damian C., Karratt-Vellatt, Aneesh, Surade, Sachin, Luetkens, Tim, Masters, Edward W., Sørensen, Naja M., Butt, Neil, McCafferty, John
Published in Biophysical journal (02.02.2018)

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Generating Potent and Selective Inhibitors of Kv1.3 Ion Channel by Fusing Knottins (Venom Derived Mini Proteins) into Peripheral CDR Loops of Antibodies

Generating Potent and Selective Inhibitors of Kv1.3 Ion Channel by Fusing Knottins (Venom Derived Mini Proteins) into Peripheral CDR Loops of Antibodies

by Karatt-Vellatt, Aneesh, Bell, Damian C., Surade, Sachin B., Luetkens, Tim, Masters, Ed W., Luther, Alice M., Sørensen, Naja Møller M., Butt, Neil J., McCafferty, John
Published in Biophysical journal (15.02.2019)

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Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors

Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors

by Kavanagh, Madeline E, Coyne, Anthony G, McLean, Kirsty J, James, Guy G, Levy, Colin W, Marino, Leonardo B, de Carvalho, Luiz Pedro S, Chan, Daniel S. H, Hudson, Sean A, Surade, Sachin, Leys, David, Munro, Andrew W, Abell, Chris
Published in Journal of medicinal chemistry (14.04.2016)

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Structure-guided engineering of immunotherapies targeting TRBC1 and TRBC2 in T cell malignancies

Structure-guided engineering of immunotherapies targeting TRBC1 and TRBC2 in T cell malignancies

by Ferrari, Mathieu, Righi, Matteo, Baldan, Vania, Wawrzyniecka, Patrycja, Bulek, Anna, Kinna, Alexander, Ma, Biao, Bughda, Reyisa, Akbar, Zulaikha, Srivastava, Saket, Gannon, Isaac, Robson, Mathew, Sillibourne, James, Jha, Ram, El-Kholy, Mohamed, Amin, Oliver Muhammad, Kokalaki, Evangelia, Banani, Mohammed Amin, Hussain, Rehan, Day, William, Lim, Wen Chean, Ghongane, Priyanka, Hopkins, Jade R., Jungherz, Dennis, Herling, Marco, Welin, Martin, Surade, Sachin, Dyson, Michael, McCafferty, John, Logan, Derek, Cordoba, Shaun, Thomas, Simon, Sewell, Andrew, Maciocia, Paul, Onuoha, Shimobi, Pule, Martin
Published in Nature communications (21.02.2024)

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A structure-guided fragment-based approach for the discovery of allosteric inhibitors targeting the lipophilic binding site of transcription factor EthR

A structure-guided fragment-based approach for the discovery of allosteric inhibitors targeting the lipophilic binding site of transcription factor EthR

by Surade, Sachin, Ty, Nancy, Hengrung, Narin, Lechartier, Benoit, Cole, Stewart T, Abell, Chris, Blundell, Tom L
Published in Biochemical journal (01.03.2014)

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Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays

Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays

by Nikiforov, Petar O, Blaszczyk, Michal, Surade, Sachin, Boshoff, Helena I, Sajid, Andaleeb, Delorme, Vincent, Deboosere, Nathalie, Brodin, Priscille, Baulard, Alain R, Blundell, Tom L, Abell, Chris
Published in ACS chemical biology (19.05.2017)

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Investigations into Protein Crystallization in the Presence of a Strong Magnetic Field

Investigations into Protein Crystallization in the Presence of a Strong Magnetic Field

by Surade, Sachin, Ochi, Takashi, Nietlispach, Daniel, Chirgadze, Dima, Moreno, Abel
Published in Crystal growth & design (03.02.2010)

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Heterologous production and functional and thermodynamic characterization of cation diffusion facilitator (CDF) transporters of mesophilic and hyperthermophilic origin

Heterologous production and functional and thermodynamic characterization of cation diffusion facilitator (CDF) transporters of mesophilic and hyperthermophilic origin

by Goswami, Devrishi, Kaur, Jagdeep, Surade, Sachin, Grell, Ernst, Michel, Hartmut
Published in Biological chemistry (01.07.2012)

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A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boostersElectronic supplementary information (ESI) available: Experimental procedures, spectral data of new compounds, see DOI: 10.1039/c5ob02630j. Additional data related to this publication is available at the University of Cambridge data repository (https://www.repository.cam.ac.uk/handle/1810/253375)

A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boostersElectronic supplementary information (ESI) available: Experimental procedures, spectral data of new compounds, see DOI: 10.1039/c5ob02630j. Additional data related to this publication is available at the University of Cambridge data repository (https://www.repository.cam.ac.uk/handle/1810/253375)

by Nikiforov, Petar O, Surade, Sachin, Blaszczyk, Michal, Delorme, Vincent, Brodin, Priscille, Baulard, Alain R, Blundell, Tom L, Abell, Chris
Year of Publication 09.02.2016

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A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosisEthR for use as ethionamide boosters

A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosisEthR for use as ethionamide boosters

by Nikiforov, Petar O, Surade, Sachin, Blaszczyk, Michal, Delorme, Vincent, Brodin, Priscille, Baulard, Alain R, Blundell, Tom L, Abell, Chris
Published in Organic & biomolecular chemistry (01.02.2016)

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A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters† †Electronic supplementary information (ESI) available: Experimental procedures, spectral data of new compounds, see DOI: 10.1039/c5ob02630j. Additional data related to this publication is available at the University of Cambridge data repository (https://www.repository.cam.ac.uk/handle/1810/253375). Click here for additional data file

A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters† †Electronic supplementary information (ESI) available: Experimental procedures, spectral data of new compounds, see DOI: 10.1039/c5ob02630j. Additional data related to this publication is available at the University of Cambridge data repository (https://www.repository.cam.ac.uk/handle/1810/253375). Click here for additional data file

by Nikiforov, Petar O., Surade, Sachin, Blaszczyk, Michal, Delorme, Vincent, Brodin, Priscille, Baulard, Alain R., Blundell, Tom L., Abell, Chris
Published in Organic & biomolecular chemistry (25.01.2016)

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Overcoming the Limitations of Fragment Merging: Rescuing a Strained Merged Fragment Series Targeting Mycobacterium tuberculosis CYP121

Overcoming the Limitations of Fragment Merging: Rescuing a Strained Merged Fragment Series Targeting Mycobacterium tuberculosis CYP121

by Hudson, Sean A., Surade, Sachin, Coyne, Anthony G., McLean, Kirsty J., Leys, David, Munro, Andrew W., Abell, Chris
Published in ChemMedChem (01.09.2013)

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