A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis
Krainz, Tanja, Gaschler, Michael M, Lim, Chaemin, Sacher, Joshua R, Stockwell, Brent R, Wipf, Peter
Published in ACS central science (28.09.2016)
Published in ACS central science (28.09.2016)
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Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy
Hinze, Laura, Labrosse, Roxane, Degar, James, Han, Teng, Schatoff, Emma M, Schreek, Sabine, Karim, Salmaan, McGuckin, Connor, Sacher, Joshua R, Wagner, Florence, Stanulla, Martin, Yuan, Chen, Sicinska, Ewa, Giannakis, Marios, Ng, Kimmie, Dow, Lukas E, Gutierrez, Alejandro
Published in Cancer discovery (01.11.2020)
Published in Cancer discovery (01.11.2020)
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Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia
Wagner, Florence F, Benajiba, Lina, Campbell, Arthur J, Weïwer, Michel, Sacher, Joshua R, Gale, Jennifer P, Ross, Linda, Puissant, Alexandre, Alexe, Gabriela, Conway, Amy, Back, Morgan, Pikman, Yana, Galinsky, Ilene, DeAngelo, Daniel J, Stone, Richard M, Kaya, Taner, Shi, Xi, Robers, Matthew B, Machleidt, Thomas, Wilkinson, Jennifer, Hermine, Olivier, Kung, Andrew, Stein, Adam J, Lakshminarasimhan, Damodharan, Hemann, Michael T, Scolnick, Edward, Zhang, Yan-Ling, Pan, Jen Q, Stegmaier, Kimberly, Holson, Edward B
Published in Science translational medicine (07.03.2018)
Published in Science translational medicine (07.03.2018)
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Journal Article
Effectiveness of Analogs of the GS-Nitroxide, JP4-039, as Total Body Irradiation Mitigators
Epperly, Michael W, Sacher, Joshua R, Krainz, Tanja, Zhang, Xiaolin, Wipf, Peter, Liang, Mary, Fisher, Renee, Li, Song, Wang, Hong, Greenberger, Joel S
Published in In vivo (Athens) (05.01.2017)
Published in In vivo (Athens) (05.01.2017)
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Journal Article
Synthesis of analogs of the radiation mitigator JP4-039 and visualization of BODIPY derivatives in mitochondria
Frantz, Marie-Celine, Skoda, Erin M., Sacher, Joshua R., Epperly, Michael W., Goff, Julie P., Greenberger, Joel S., Wipf, Peter
Published in Organic & biomolecular chemistry (07.07.2013)
Published in Organic & biomolecular chemistry (07.07.2013)
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An Uncharged Oxetanyl Sulfoxide as a Covalent Modifier for Improving Aqueous Solubility
Skoda, Erin M, Sacher, Joshua R, Kazancioglu, Mustafa Z, Saha, Jaideep, Wipf, Peter
Published in ACS medicinal chemistry letters (14.08.2014)
Published in ACS medicinal chemistry letters (14.08.2014)
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Journal Article
Characterization of Primary Muscle Tension Dysphonia Using Acoustic and Aerodynamic Voice Metrics
Shembel, Adrianna C., Lee, Jeon, Sacher, Joshua R., Johnson, Aaron M.
Published in Journal of voice (01.11.2023)
Published in Journal of voice (01.11.2023)
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Journal Article
SS-4 is a highly selective small molecule inhibitor of STAT3 tyrosine phosphorylation that potently inhibits GBM tumorigenesis in vitro and in vivo
Wang, Yinan, Yang, Chuanhe, Sims, Michelle M., Sacher, Joshua R., Raje, Mithun, Deokar, Hemantkumar, Yue, Peibin, Turkson, James, Buolamwini, John K., Pfeffer, Lawrence M.
Published in Cancer letters (01.05.2022)
Published in Cancer letters (01.05.2022)
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Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats
Escobales, Nelson, Nuñez, Rebeca E, Jang, Sehwan, Parodi-Rullan, Rebecca, Ayala-Peña, Sylvette, Sacher, Joshua R, Skoda, Erin M, Wipf, Peter, Frontera, Walter, Javadov, Sabzali
Published in Journal of molecular and cellular cardiology (01.12.2014)
Published in Journal of molecular and cellular cardiology (01.12.2014)
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Novel structural-related analogs of PFI-3 (SRAPs) that target the BRG1 catalytic subunit of the SWI/SNF complex increase the activity of temozolomide in glioblastoma cells
He, Yali, Yang, Chuanhe, Wang, Yinan, Sacher, Joshua R., Sims, Michelle M., Pfeffer, Lawrence M., Miller, Duane D.
Published in Bioorganic & medicinal chemistry (01.01.2022)
Published in Bioorganic & medicinal chemistry (01.01.2022)
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Multimodal small-molecule screening for human prion protein binders
Reidenbach, Andrew G., Mesleh, Michael F., Casalena, Dominick, Vallabh, Sonia M., Dahlin, Jayme L., Leed, Alison J., Chan, Alix I., Usanov, Dmitry L., Yehl, Jenna B., Lemke, Christopher T., Campbell, Arthur J., Shah, Rishi N., Shrestha, Om K., Sacher, Joshua R., Rangel, Victor L., Moroco, Jamie A., Sathappa, Murugappan, Nonato, Maria Cristina, Nguyen, Kong T., Wright, S. Kirk, Liu, David R., Wagner, Florence F., Kaushik, Virendar K., Auld, Douglas S., Schreiber, Stuart L., Minikel, Eric Vallabh
Published in The Journal of biological chemistry (25.09.2020)
Published in The Journal of biological chemistry (25.09.2020)
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Journal Article
Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects
Wagner, Florence F, Bishop, Joshua A, Gale, Jennifer P, Shi, Xi, Walk, Michelle, Ketterman, Joshua, Patnaik, Debasis, Barker, Doug, Walpita, Deepika, Campbell, Arthur J, Nguyen, Shannon, Lewis, Michael, Ross, Linda, Weïwer, Michel, An, W. Frank, Germain, Andrew R, Nag, Partha P, Metkar, Shailesh, Kaya, Taner, Dandapani, Sivaraman, Olson, David E, Barbe, Anne-Laure, Lazzaro, Fanny, Sacher, Joshua R, Cheah, Jaime H, Fei, David, Perez, Jose, Munoz, Benito, Palmer, Michelle, Stegmaier, Kimberly, Schreiber, Stuart L, Scolnick, Edward, Zhang, Yan-Ling, Haggarty, Stephen J, Holson, Edward B, Pan, Jen Q
Published in ACS chemical biology (15.07.2016)
Published in ACS chemical biology (15.07.2016)
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Virtual screening for small-molecule pathway regulators by image-profile matching
Rohban, Mohammad H., Fuller, Ashley M., Tan, Ceryl, Goldstein, Jonathan T., Syangtan, Deepsing, Gutnick, Amos, DeVine, Ann, Nijsure, Madhura P., Rigby, Megan, Sacher, Joshua R., Corsello, Steven M., Peppler, Grace B., Bogaczynska, Marta, Boghossian, Andrew, Ciotti, Gabrielle E., Hands, Allison T., Mekareeya, Aroonroj, Doan, Minh, Gale, Jennifer P., Derynck, Rik, Turbyville, Thomas, Boerckel, Joel D., Singh, Shantanu, Kiessling, Laura L., Schwarz, Thomas L., Varelas, Xaralabos, Wagner, Florence F., Kafri, Ran, Eisinger-Mathason, T.S. Karin, Carpenter, Anne E.
Published in Cell systems (21.09.2022)
Published in Cell systems (21.09.2022)
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Functionally Biased D2R Antagonists: Targeting the β‑Arrestin Pathway to Improve Antipsychotic Treatment
Weïwer, Michel, Xu, Qihong, Gale, Jennifer P, Lewis, Michael, Campbell, Arthur J, Schroeder, Frederick A, Van de Bittner, Genevieve C, Walk, Michelle, Amaya, Aldo, Su, Ping, D̵ordevic, Luka, Sacher, Joshua R, Skepner, Adam, Fei, David, Dennehy, Kelly, Nguyen, Shannon, Faloon, Patrick W, Perez, Jose, Cottrell, Jeffrey R, Liu, Fang, Palmer, Michelle, Pan, Jen Q, Hooker, Jacob M, Zhang, Yan-Ling, Scolnick, Edward, Wagner, Florence F, Holson, Edward B
Published in ACS chemical biology (20.04.2018)
Published in ACS chemical biology (20.04.2018)
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Novel Fluorescence-Based High-Throughput FLIPR Assay Utilizing Membrane-Tethered Genetic Calcium Sensors to Identify T‑Type Calcium Channel Modulators
Zhang, Yan-Ling, Moran, Sean P., Allen, Andrew, Baez-Nieto, David, Xu, Qihong, Wang, Lei A., Martenis, William E., Sacher, Joshua R., Gale, Jennifer P., Weïwer, Michel, Wagner, Florence F., Pan, Jen Q.
Published in ACS pharmacology & translational science (11.03.2022)
Published in ACS pharmacology & translational science (11.03.2022)
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