A single dose of self-transcribing and replicating RNA-based SARS-CoV-2 vaccine produces protective adaptive immunity in mice
de Alwis, Ruklanthi, Gan, Esther S., Chen, Shiwei, Leong, Yan Shan, Tan, Hwee Cheng, Zhang, Summer L., Yau, Clement, Low, Jenny G.H., Kalimuddin, Shirin, Matsuda, Daiki, Allen, Elizabeth C., Hartman, Paula, Park, Kyoung-Joo Jenny, Alayyoubi, Maher, Bhaskaran, Hari, Dukanovic, Adrian, Bao, Yanjie, Clemente, Brenda, Vega, Jerel, Roberts, Scott, Gonzalez, Jose A., Sablad, Marciano, Yelin, Rodrigo, Taylor, Wendy, Tachikawa, Kiyoshi, Parker, Suezanne, Karmali, Priya, Davis, Jared, Sullivan, Brian M., Sullivan, Sean M., Hughes, Steve G., Chivukula, Pad, Ooi, Eng Eong
Published in Molecular therapy (02.06.2021)
Published in Molecular therapy (02.06.2021)
Get full text
Journal Article
Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation
Soroosh, Pejman, Wu, Jiejun, Xue, Xiaohua, Song, Jiao, Sutton, Steven W., Sablad, Marciano, Yu, Jingxue, Nelen, Marina I., Liu, Xuejun, Castro, Glenda, Luna, Rosa, Crawford, Shelby, Banie, Homayon, Dandridge, Rose A., Deng, Xiaohu, Bittner, Anton, Kuei, Chester, Tootoonchi, Mandana, Rozenkrants, Natasha, Herman, Krystal, Gao, Jingjin, Yang, Xia V., Sachen, Kacey, Ngo, Karen, Fung-Leung, Wai-Ping, Nguyen, Steven, de Leon-Tabaldo, Aimee, Blevitt, Jonathan, Zhang, Yan, Cummings, Maxwell D., Rao, Tadimeti, Mani, Neelakandha S., Liu, Changlu, McKinnon, Murray, Milla, Marcos E., Fourie, Anne M., Sun, Siquan
Published in Proceedings of the National Academy of Sciences - PNAS (19.08.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (19.08.2014)
Get full text
Journal Article
Development of an mRNA replacement therapy for phenylketonuria
Perez-Garcia, Carlos G., Diaz-Trelles, Ramon, Vega, Jerel Boyd, Bao, Yanjie, Sablad, Marciano, Limphong, Patty, Chikamatsu, Simon, Yu, Hailong, Taylor, Wendy, Karmali, Priya P., Tachikawa, Kiyoshi, Chivukula, Padmanabh
Published in Molecular therapy. Nucleic acids (14.06.2022)
Published in Molecular therapy. Nucleic acids (14.06.2022)
Get full text
Journal Article
Restoring ornithine transcarbamylase (OTC) activity in an OTC‐deficient mouse model using LUNAR‐OTC mRNA
Yu, Hailong, Brewer, Edward, Shields, Michael, Crowder, Michael, Sacchetti, Cristiano, Soontornniyomkij, Benchawanna, Dou, Dandan, Clemente, Brenda, Sablad, Marciano, Chivukula, Padmanabh, Hughes, Steve, Roberts, Scott, Rajappan, Kumar, Tannis, Steve, Sekulovich, Rose, Parker, Suezanne, Limphong, Pattraranee
Published in Clinical and translational discovery (01.06.2022)
Published in Clinical and translational discovery (01.06.2022)
Get full text
Journal Article
Lipid nanoparticle delivers phenylalanine ammonia lyase mRNA to the liver leading to catabolism and clearance of phenylalanine in a phenylketonuria mouse model
Diaz-Trelles, Ramon, Lee, Sharon, Kuakini, Kristen, Park, Jenny, Dukanovic, Adrian, Gonzalez, Jose A., Dam, Thanhchau, Kim, Jae Heon, Vega, Jerel Boyd, Sablad, Marciano, Karmali, Priya P., Tachikawa, Kiyoshi, Chivukula, Padmanabh
Published in Molecular genetics and metabolism reports (01.09.2022)
Published in Molecular genetics and metabolism reports (01.09.2022)
Get full text
Journal Article
Urinary parameters predictive of cisplatin-induced acute renal injury in dogs
McDuffie, J. Eric, Sablad, Marciano, Ma, JingYing, Snook, Sandra
Published in Cytokine (Philadelphia, Pa.) (01.12.2010)
Published in Cytokine (Philadelphia, Pa.) (01.12.2010)
Get full text
Journal Article
Time course of renal proximal tubule injury, reversal, and related biomarker changes in rats following cisplatin administration
McDuffie, James Eric, Ma, Jing Ying, Sablad, Marciano, Sonee, Manisha, Varacallo, Lynn, Louden, Calvert, Guy, Antonio, Vegas, Jennifer, Liu, Xuejun, La, David, Snook, Sandra
Published in International journal of toxicology (01.07.2013)
Published in International journal of toxicology (01.07.2013)
Get more information
Journal Article
Delayed stress-induced colonic hypersensitivity in male Wistar rats: role of neurokinin-1 and corticotropin-releasing factor-1 receptors
Schwetz, Ines, Bradesi, Sylvie, McRoberts, James A, Sablad, Marciano, Miller, Jerry C, Zhou, Huping, Ohning, Gordon, Mayer, Emeran A
Published in American journal of physiology: Gastrointestinal and liver physiology (01.04.2004)
Published in American journal of physiology: Gastrointestinal and liver physiology (01.04.2004)
Get full text
Journal Article
KLYP956 Is a Non-Imidazole-Based Orally Active Inhibitor of Nitric-Oxide Synthase Dimerization
Symons, Kent T, Massari, Mark E, Nguyen, Phan M, Lee, Tom T, Roppe, Jeffrey, Bonnefous, Céline, Payne, Joseph E, Smith, Nicholas D, Noble, Stewart A, Sablad, Marciano, Rozenkrants, Natasha, Zhang, Yan, Rao, Tadimeti S, Shiau, Andrew K, Hassig, Christian A
Published in Molecular pharmacology (01.07.2009)
Published in Molecular pharmacology (01.07.2009)
Get full text
Journal Article
Property-Driven Design and Development of Lipids for Efficient Delivery of siRNA
Rajappan, Kumar, Tanis, Steven P, Mukthavaram, Rajesh, Roberts, Scott, Nguyen, Michelle, Tachikawa, Kiyoshi, Sagi, Amit, Sablad, Marciano, Limphong, Pattraranee, Leu, Angel, Yu, Hailong, Chivukula, Padmanabh, Payne, Joseph E, Karmali, Priya
Published in Journal of medicinal chemistry (12.11.2020)
Published in Journal of medicinal chemistry (12.11.2020)
Get full text
Journal Article
Pharmacologic modulation of RORγt translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis
Xue, Xiaohua, Soroosh, Pejman, De Leon-Tabaldo, Aimee, Luna-Roman, Rosa, Sablad, Marciano, Rozenkrants, Natasha, Yu, Jingxue, Castro, Glenda, Banie, Homayon, Fung-Leung, Wai-Ping, Santamaria-Babi, Luis, Schlueter, Thomas, Albers, Michael, Leonard, Kristi, Budelsky, Alison L., Fourie, Anne M.
Published in Scientific reports (01.12.2016)
Published in Scientific reports (01.12.2016)
Get full text
Journal Article
Discovery of Dual Inducible/Neuronal Nitric Oxide Synthase (iNOS/nNOS) Inhibitor Development Candidate 4-((2-Cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) Part 2: Identification of a Novel, Potent, and Selective Series of Benzimidazole-Quinolinone iNOS/nNOS Dimerization Inhibitors That Are Orally Active in Pain Models
Payne, Joseph E, Bonnefous, Céline, Symons, Kent T, Nguyen, Phan M, Sablad, Marciano, Rozenkrants, Natasha, Zhang, Yan, Wang, Li, Yazdani, Nahid, Shiau, Andrew K, Noble, Stewart A, Rix, Peter, Rao, Tadimeti S, Hassig, Christian A, Smith, Nicholas D
Published in Journal of medicinal chemistry (11.11.2010)
Published in Journal of medicinal chemistry (11.11.2010)
Get full text
Journal Article
Discovery of Inducible Nitric Oxide Synthase (iNOS) Inhibitor Development Candidate KD7332, Part 1: Identification of a Novel, Potent, and Selective Series of Quinolinone iNOS Dimerization Inhibitors that are Orally Active in Rodent Pain Models
Bonnefous, Céline, Payne, Joseph E, Roppe, Jeffrey, Zhuang, Hui, Chen, Xiaohong, Symons, Kent T, Nguyen, Phan M, Sablad, Marciano, Rozenkrants, Natasha, Zhang, Yan, Wang, Li, Severance, Daniel, Walsh, John P, Yazdani, Nahid, Shiau, Andrew K, Noble, Stewart A, Rix, Peter, Rao, Tadimeti S, Hassig, Christian A, Smith, Nicholas D
Published in Journal of medicinal chemistry (14.05.2009)
Published in Journal of medicinal chemistry (14.05.2009)
Get full text
Journal Article
Oxysterols are agonist ligands of ROR[Gamma]t and drive Th17 cell differentiation
Soroosh, Pejman, Wu, Jiejun, Xue, Xiaohua, Song, Jiao, Sutton, Steven W, Sablad, Marciano, Yu, Jingxue, Nelen, Marina I, Liu, Xuejun, Castro, Glenda, Luna, Rosa, Crawford, Shelby, Banie, Homayon, Dandridge, Rose A, Deng, Xiaohu, Bittner, Anton, Kuei, Chester, Tootoonchi, Mandana, Rozenkrants, Natasha, Herman, Krystal, Gao, Jingjin, Yang, Xia V, Sachen, Kacey, Ngo, Karen, Fung-Leung, Wai-Ping, Nguyen, Steven, de Leon-Tabaldo, Aimee, Blevitt, Jonathan, Zhang, Yan, Cummings, Maxwell D, Rao, Tadimeti, Mani, Neelakandha S, Liu, Changlu, McKinnon, Murray, Milla, Marcos E, Fourie, Anne M, Sun, Siquan
Published in Proceedings of the National Academy of Sciences - PNAS (19.08.2014)
Get full text
Published in Proceedings of the National Academy of Sciences - PNAS (19.08.2014)
Journal Article
Identification and SAR of selective inducible nitric oxide synthase (iNOS) dimerization inhibitors
Gahman, Timothy C., Herbert, Mark R., Lang, Henk, Thayer, Angie, Symons, Kent T., Nguyen, Phan Manh, Massari, Mark E., Dozier, Sara, Zhang, Yan, Sablad, Marciano, Rao, Tadimeti S., Noble, Stewart A., Shiau, Andrew K., Hassig, Christian A.
Published in Bioorganic & medicinal chemistry letters (15.11.2011)
Published in Bioorganic & medicinal chemistry letters (15.11.2011)
Get full text
Journal Article
Heteroaromatic-aminomethyl quinolones: Potent and selective iNOS inhibitors
Durón, Sergio G., Lindstrom, Andrew, Bonnefous, Céline, Zhang, Hui, Chen, Xiaohong, Symons, Kent T., Sablad, Marciano, Rozenkrants, Natasha, Zhang, Yan, Wang, Li, Yazdani, Nahid, Shiau, Andrew K., Noble, Stewart A., Rix, Peter, Rao, Tadimeti S., Hassig, Christian A., Smith, Nicholas D.
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Get full text
Journal Article
Pharmacologic modulation of ROR[gamma]t translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis
Xue, Xiaohua, Soroosh, Pejman, De Leon-tabaldo, Aimee, Luna-roman, Rosa, Sablad, Marciano, Rozenkrants, Natasha, Yu, Jingxue, Castro, Glenda, Banie, Homayon, Fung-leung, Wai-ping, Santamaria-babi, Luis, Schlueter, Thomas, Albers, Michael, Leonard, Kristi, Budelsky, Alison L, Fourie, Anne M
Published in Scientific reports (01.12.2016)
Published in Scientific reports (01.12.2016)
Get full text
Journal Article
Pharmacological characterization of KLYP961, a dual inhibitor of inducible and neuronal nitric-oxide synthases
Symons, Kent T, Nguyen, Phan M, Massari, Mark E, Anzola, John V, Staszewski, Lena M, Wang, Li, Yazdani, Nahid, Dorow, Steven, Muhammad, Jerry, Sablad, Marciano, Rozenkrants, Natasha, Bonefous, Celine, Payne, Joseph E, Rix, Peter J, Shiau, Andrew K, Noble, Stewart A, Smith, Nicholas D, Hassig, Christian A, Zhang, Yan, Rao, Tadimeti S
Published in The Journal of pharmacology and experimental therapeutics (01.02.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2011)
Get full text
Journal Article
Delayed stress-induced colinic hypersensitivity in male Wistar rats: Role of neurokinin-1 and corticotropin-releasing factor-1 receptors
Schwetz, Ines, Bradesi, Sylvie, McRoberts, James A, Marciano Sablad
Published in American journal of physiology: Gastrointestinal and liver physiology (01.04.2004)
Get full text
Published in American journal of physiology: Gastrointestinal and liver physiology (01.04.2004)
Journal Article