A hierarchy of timescales in protein dynamics is linked to enzyme catalysis
Kern, Dorothee, Henzler-Wildman, Katherine A, Lei, Ming, Thai, Vu, Kerns, S. Jordan, Karplus, Martin
Published in Nature (06.12.2007)
Published in Nature (06.12.2007)
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Journal Article
Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation
Riglar, David T, Giessen, Tobias W, Baym, Michael, Kerns, S Jordan, Niederhuber, Matthew J, Bronson, Roderick T, Kotula, Jonathan W, Gerber, Georg K, Way, Jeffrey C, Silver, Pamela A
Published in Nature biotechnology (01.07.2017)
Published in Nature biotechnology (01.07.2017)
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Journal Article
Programmable bacteria detect and record an environmental signal in the mammalian gut
Kotula, Jonathan W., Kerns, S. Jordan, Shaket, Lev A., Siraj, Layla, Collins, James J., Way, Jeffrey C., Silver, Pamela A.
Published in Proceedings of the National Academy of Sciences - PNAS (01.04.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (01.04.2014)
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Journal Article
Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies
Kerns, S Jordan, Belgur, Chaitra, Petropolis, Debora, Kanellias, Marianne, Barrile, Riccardo, Sam, Johannes, Weinzierl, Tina, Fauti, Tanja, Freimoser-Grundschober, Anne, Eckmann, Jan, Hage, Carina, Geiger, Martina, Ng, Patrick Ray, Tien-Street, William, Manatakis, Dimitris V, Micallef, Virginie, Gerard, Regine, Bscheider, Michael, Breous-Nystrom, Ekaterina, Schneider, Anneliese, Giusti, Anna Maria, Bertinetti-Lapatki, Cristina, Grant, Heather Shannon, Roth, Adrian B, Hamilton, Geraldine A, Singer, Thomas, Karalis, Katia, Moisan, Annie, Bruenker, Peter, Klein, Christian, Bacac, Marina, Gjorevski, Nikolce, Cabon, Lauriane
Published in eLife (11.08.2021)
Published in eLife (11.08.2021)
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Journal Article
The energy landscape of adenylate kinase during catalysis
Kerns, S Jordan, Agafonov, Roman V, Cho, Young-Jin, Pontiggia, Francesco, Otten, Renee, Pachov, Dimitar V, Kutter, Steffen, Phung, Lien A, Murphy, Padraig N, Thai, Vu, Alber, Tom, Hagan, Michael F, Kern, Dorothee
Published in Nature structural & molecular biology (01.02.2015)
Published in Nature structural & molecular biology (01.02.2015)
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Journal Article
Enhanced Utilization of Induced Pluripotent Stem Cell–Derived Human Intestinal Organoids Using Microengineered Chips
Workman, Michael J, Gleeson, John P, Troisi, Elissa J, Estrada, Hannah Q, Kerns, S. Jordan, Hinojosa, Christopher D, Hamilton, Geraldine A, Targan, Stephan R, Svendsen, Clive N, Barrett, Robert J
Published in Cellular and molecular gastroenterology and hepatology (01.01.2018)
Published in Cellular and molecular gastroenterology and hepatology (01.01.2018)
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Journal Article
Probing the Transition State in Enzyme Catalysis by High-Pressure NMR Dynamics
Stiller, John B, Kerns, S Jordan, Hoemberger, Marc, Cho, Young-Jin, Otten, Renee, Hagan, Michael F, Kern, Dorothee
Published in Nature catalysis (01.08.2019)
Published in Nature catalysis (01.08.2019)
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Journal Article
Safety Profiling of Tumor-targeted T Cell-Bispecific Antibodies with Alveolus Lung- and Colon-on-Chip
Kerns, Jordan S, Belgur, Chaitra, Kanellias, Marianne, Manatakis, Dimitris V, Barrile, Riccardo, Tien-Street, Will, Ewart, Lorna, Gjorevski, Nikolche, Cabon, Lauriane
Published in Bio-protocol (05.01.2023)
Published in Bio-protocol (05.01.2023)
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Journal Article
A Novel Microphysiological Colon Platform to Decipher Mechanisms Driving Human Intestinal Permeability
Apostolou, Athanasia, Panchakshari, Rohit A., Banerjee, Antara, Manatakis, Dimitris V., Paraskevopoulou, Maria D., Luc, Raymond, Abu-Ali, Galeb, Dimitriou, Alexandra, Lucchesi, Carolina, Kulkarni, Gauri, Maulana, Tengku Ibrahim, Kasendra, Magdalena, Kerns, Jordan S., Bleck, Bertram, Ewart, Lorna, Manolakos, Elias S., Hamilton, Geraldine A., Giallourakis, Cosmas, Karalis, Katia
Published in Cellular and molecular gastroenterology and hepatology (01.01.2021)
Published in Cellular and molecular gastroenterology and hepatology (01.01.2021)
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Journal Article
Inflamed Intestine-Chip: Mimicking the Mucosal Microenvironment to Understand the Pathogenesis of Ulcerative Colitis
Jordan Kerns, S, Umiker, Benjamin, Obrigewitch, Jenifer, Puerta, Jefferson, Salmon, Michael, Alves, Stephen, Hamilton, Geraldine A, Karalis, Katia P
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
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Journal Article
Altered Gut Microbiome and Inflammasome Activation in Corticotropin Releasing Hormone (CRH)- Deficient Mice Indicate a Novel Role for the Stress Hormone in the Maintenance of Intestinal Homeostasis
Apostolou, Athanasia P, Giannogonas, Panagiotis, Manousopoulou, Antigoni, Jordan Kerns, S, Hamilton, Geraldine A, Garbis, Spiros, Karalis, Katia P
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
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Journal Article
Abstract LB066: Assessing the safety liability of t-cell bispecific (TCB) antibodies using Ogans-on-Chips technology
Kerns, S. Jordan, Kujala, Ville, Kanellias, Marianne, Sauld, John, Tien-Street, William, Grant, Heather S., Karalis, Katia A., Hamilton, Geraldine A., Ewart, Lorna, Roth, Adrian B., Moisan, Annie, Gjorevski, Nikolche
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Su1963 - Inflamed Intestine-Chip: Mimicking the Mucosal Microenvironment to Understand the Pathogenesis of Ulcerative Colitis
Jordan Kerns, S., Umiker, Benjamin, Obrigewitch, Jenifer, Puerta, Jefferson, Salmon, Michael, Alves, Stephen, Hamilton, Geraldine A., Karalis, Katia P.
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
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Journal Article
199 - Intestine-Chip: A New Model to Understand the Role of the Intestinal Epithelium in IBD by Combining Microengineering Technology and IPSC-Derived Human Intestinal Organoids
Workman, Michael, Troisi, Elissa, Kerns, S. Jordan, Hamilton, Geraldine A., Svendsen, Clive, Targan, Stephan R., Barrett, Robert J.
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
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Journal Article
Tu1776 - Altered Gut Microbiome and Inflammasome Activation in Corticotropin Releasing Hormone (CRH)- Deficient Mice Indicate a Novel Role for the Stress Hormone in the Maintenance of Intestinal Homeostasis
Apostolou, Athanasia P., Giannogonas, Panagiotis, Manousopoulou, Antigoni, Jordan Kerns, S., Hamilton, Geraldine A., Garbis, Spiros, Karalis, Katia P.
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
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Journal Article
Intestine-Chip: A New Model to Understand the Role of the Intestinal Epithelium in IBD by Combining Microengineering Technology and IPSC-Derived Human Intestinal Organoids
Workman, Michael, Troisi, Elissa, Kerns, S. Jordan, Hamilton, Geraldine A, Svendsen, Clive, Targan, Stephan R, Barrett, Robert J
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
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Journal Article
Engineered bacteria function in the mammalian gut as long term live diagnostics of inflammation
Riglar, David T, Giessen, Tobias W, Baym, Michael, Kerns, S Jordan, Niederhuber, Matthew J, Bronson, Roderick T, Kotula, Jonathan W, Gerber, Georg K, Way, Jeffrey C, Silver, Pamela A
Published in Nature biotechnology (29.05.2017)
Published in Nature biotechnology (29.05.2017)
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Journal Article