Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program
Khacho, Mireille, Clark, Alysen, Svoboda, Devon S., Azzi, Joelle, MacLaurin, Jason G., Meghaizel, Cynthia, Sesaki, Hiromi, Lagace, Diane C., Germain, Marc, Harper, Mary-Ellen, Park, David S., Slack, Ruth S.
Published in Cell stem cell (04.08.2016)
Published in Cell stem cell (04.08.2016)
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Pathological Axonal Death through a MAPK Cascade that Triggers a Local Energy Deficit
Yang, Jing, Wu, Zhuhao, Renier, Nicolas, Simon, David J., Uryu, Kunihiro, Park, David S., Greer, Peter A., Tournier, Cathy, Davis, Roger J., Tessier-Lavigne, Marc
Published in Cell (15.01.2015)
Published in Cell (15.01.2015)
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Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment
Greene, Andrew W, Grenier, Karl, Aguileta, Miguel A, Muise, Stephanie, Farazifard, Rasoul, Haque, M Emdadul, McBride, Heidi M, Park, David S, Fon, Edward A
Published in EMBO reports (01.04.2012)
Published in EMBO reports (01.04.2012)
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Myocardial infarction accelerates breast cancer via innate immune reprogramming
Koelwyn, Graeme J., Newman, Alexandra A. C., Afonso, Milessa S., van Solingen, Coen, Corr, Emma M., Brown, Emily J., Albers, Kathleen B., Yamaguchi, Naoko, Narke, Deven, Schlegel, Martin, Sharma, Monika, Shanley, Lianne C., Barrett, Tessa J., Rahman, Karishma, Mezzano, Valeria, Fisher, Edward A., Park, David S., Newman, Jonathan D., Quail, Daniela F., Nelson, Erik R., Caan, Bette J., Jones, Lee W., Moore, Kathryn J.
Published in Nature medicine (01.09.2020)
Published in Nature medicine (01.09.2020)
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OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand
Patten, David A, Wong, Jacob, Khacho, Mireille, Soubannier, Vincent, Mailloux, Ryan J, Pilon-Larose, Karine, MacLaurin, Jason G, Park, David S, McBride, Heidi M, Trinkle-Mulcahy, Laura, Harper, Mary-Ellen, Germain, Marc, Slack, Ruth S
Published in The EMBO journal (18.11.2014)
Published in The EMBO journal (18.11.2014)
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Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA
Galehdar, Zohreh, Swan, Patrick, Fuerth, Benjamin, Callaghan, Steven M, Park, David S, Cregan, Sean P
Published in The Journal of neuroscience (15.12.2010)
Published in The Journal of neuroscience (15.12.2010)
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PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress
Huang, En, Qu, Dianbo, Huang, Tianwen, Rizzi, Nicoletta, Boonying, Wassamon, Krolak, Dorothy, Ciana, Paolo, Woulfe, John, Klein, Christine, Slack, Ruth S., Figeys, Daniel, Park, David S.
Published in Nature communications (09.11.2017)
Published in Nature communications (09.11.2017)
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Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson’s disease
Kim, Kwang Soo, Marcogliese, Paul C., Yang, Jungwoo, Callaghan, Steve M., Resende, Virginia, Abdel-Messih, Elizabeth, Marras, Connie, Visanji, Naomi P., Huang, Jana, Schlossmacher, Michael G., Trinkle-Mulcahy, Laura, Slack, Ruth S., Lang, Anthony E., Park, David S.
Published in Proceedings of the National Academy of Sciences - PNAS (29.05.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (29.05.2018)
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Cardiac Pressure Overload Decreases ETV1 Expression in the Left Atrium, Contributing to Atrial Electrical and Structural Remodeling
Yamaguchi, Naoko, Xiao, Junhua, Narke, Deven, Shaheen, Devin, Lin, Xianming, Offerman, Erik, Khodadadi-Jamayran, Alireza, Shekhar, Akshay, Choy, Alex, Wass, Sojin Y., Van Wagoner, David R., Chung, Mina K., Park, David S.
Published in Circulation (New York, N.Y.) (23.02.2021)
Published in Circulation (New York, N.Y.) (23.02.2021)
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Comparative analysis of Parkinson's disease–associated genes in mice reveals altered survival and bioenergetics of Parkin-deficient dopamine neurons
Giguère, Nicolas, Pacelli, Consiglia, Saumure, Caroline, Bourque, Marie-Josée, Matheoud, Diana, Levesque, Daniel, Slack, Ruth S., Park, David S., Trudeau, Louis-Éric
Published in The Journal of biological chemistry (22.06.2018)
Published in The Journal of biological chemistry (22.06.2018)
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Genetically engineered SCN5A mutant pig hearts exhibit conduction defects and arrhythmias
Park, David S, Cerrone, Marina, Morley, Gregory, Vasquez, Carolina, Fowler, Steven, Liu, Nian, Bernstein, Scott A, Liu, Fang-Yu, Zhang, Jie, Rogers, Christopher S, Priori, Silvia G, Chinitz, Larry A, Fishman, Glenn I
Published in The Journal of clinical investigation (01.01.2015)
Published in The Journal of clinical investigation (01.01.2015)
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Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures
Hakimi, Mansoureh, Selvanantham, Thirumahal, Swinton, Erika, Padmore, Ruth F., Tong, Youren, Kabbach, Ghassan, Venderova, Katerina, Girardin, Stephen E., Bulman, Dennis E., Scherzer, Clemens R., LaVoie, Matthew J., Gris, Denis, Park, David S., Angel, Jonathan B., Shen, Jie, Philpott, Dana J., Schlossmacher, Michael G.
Published in Journal of Neural Transmission (01.05.2011)
Published in Journal of Neural Transmission (01.05.2011)
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Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP
Haque, M. Emdadul, Thomas, Kelly J, D'Souza, Cheryl, Callaghan, Steve, Kitada, Tohru, Slack, Ruth S, Fraser, Paul, Cookson, Mark R, Tandon, Anurag, Park, David S
Published in Proceedings of the National Academy of Sciences - PNAS (05.02.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (05.02.2008)
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PFTK1 kinase regulates axogenesis during development via RhoA activation
González, Yasmilde Rodríguez, Kamkar, Fatemeh, Jafar-nejad, Paymaan, Wang, Suzi, Qu, Dianbo, Alvarez, Leticia Sanchez, Hawari, Dina, Sonnenfeld, Margaret, Slack, Ruth S, Albert, Paul R, Park, David S, Joselin, Alvin
Published in BMC biology (31.10.2023)
Published in BMC biology (31.10.2023)
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Fhf2 gene deletion causes temperature-sensitive cardiac conduction failure
Park, David S., Shekhar, Akshay, Marra, Christopher, Lin, Xianming, Vasquez, Carolina, Solinas, Sergio, Kelley, Kevin, Morley, Gregory, Goldfarb, Mitchell, Fishman, Glenn I.
Published in Nature communications (04.10.2016)
Published in Nature communications (04.10.2016)
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BAG2 Gene-mediated Regulation of PINK1 Protein Is Critical for Mitochondrial Translocation of PARKIN and Neuronal Survival
Qu, Dianbo, Hage, Ali, Don-Carolis, Katie, Huang, En, Joselin, Alvin, Safarpour, Farzaneh, Marcogliese, Paul C., Rousseaux, Maxime W.C., Hewitt, Sarah J., Huang, Tianwen, Im, Doo-Soon, Callaghan, Steve, Dewar-Darch, Danielle, Figeys, Daniel, Slack, Ruth S., Park, David S.
Published in The Journal of biological chemistry (18.12.2015)
Published in The Journal of biological chemistry (18.12.2015)
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Opposing Regulation of Sox2 by Cell-Cycle Effectors E2f3a and E2f3b in Neural Stem Cells
Julian, Lisa M., Vandenbosch, Renaud, Pakenham, Catherine A., Andrusiak, Matthew G., Nguyen, Angela P., McClellan, Kelly A., Svoboda, Devon S., Lagace, Diane C., Park, David S., Leone, Gustavo, Blais, Alexandre, Slack, Ruth S.
Published in Cell stem cell (04.04.2013)
Published in Cell stem cell (04.04.2013)
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The Mitochondrial Inner Membrane GTPase, Optic Atrophy 1 (Opa1), Restores Mitochondrial Morphology and Promotes Neuronal Survival following Excitotoxicity
Jahani-Asl, Arezu, Pilon-Larose, Karine, Xu, William, MacLaurin, Jason G., Park, David S., McBride, Heidi M., Slack, Ruth S.
Published in The Journal of biological chemistry (11.02.2011)
Published in The Journal of biological chemistry (11.02.2011)
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The pro-death role of Cited2 in stroke is regulated by E2F1/4 transcription factors
Huang, Tianwen, González, Yasmilde Rodríguez, Qu, Dianbo, Huang, En, Safarpour, Farzaneh, Wang, Eugene, Joselin, Alvin, Im, Doo Soon, Callaghan, Steve M., Boonying, Wassamon, Julian, Lisa, Dunwoodie, Sally L., Slack, Ruth S., Park, David S.
Published in The Journal of biological chemistry (24.05.2019)
Published in The Journal of biological chemistry (24.05.2019)
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