Importance of cholesterol and oxysterols metabolism in the pharmacology of tamoxifen and other AEBS ligands
de Medina, Philippe, Paillasse, Michael R., Ségala, Gregory, Khallouki, Farid, Brillouet, Severine, Dalenc, Florence, Courbon, Frederic, Record, Michel, Poirot, Marc, Silvente-Poirot, Sandrine
Published in Chemistry and physics of lipids (01.09.2011)
Published in Chemistry and physics of lipids (01.09.2011)
Get full text
Journal Article
Identification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligands
de Medina, Philippe, Paillasse, Michael R., Segala, Gregory, Poirot, Marc, Silvente-Poirot, Sandrine, Mangelsdorf, David J.
Published in Proceedings of the National Academy of Sciences - PNAS (27.07.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (27.07.2010)
Get full text
Journal Article
Monoubiquitination of Histone H2B Blocks Eviction of Histone Variant H2A.Z from Inducible Enhancers
Segala, Gregory, Bennesch, Marcela A., Pandey, Deo Prakash, Hulo, Nicolas, Picard, Didier
Published in Molecular cell (20.10.2016)
Published in Molecular cell (20.10.2016)
Get full text
Journal Article
The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis
Joshi, Abhinav, Dai, Li, Liu, Yanxin, Lee, Jungsoon, Ghahhari, Nastaran Mohammadi, Segala, Gregory, Beebe, Kristin, Jenkins, Lisa M, Lyons, Gaelyn C, Bernasconi, Lilia, Tsai, Francis T F, Agard, David A, Neckers, Len, Picard, Didier
Published in BMC biology (27.01.2020)
Published in BMC biology (27.01.2020)
Get full text
Journal Article
Ligand-dependent transcriptional induction of lethal autophagy: A new perspective for cancer treatment
Silvente-Poirot, Sandrine, Segala, Gregory, Poirot, Mathias C., Poirot, Marc
Published in Autophagy (04.03.2018)
Published in Autophagy (04.03.2018)
Get full text
Journal Article
Dendrogenin A drives LXR to trigger lethal autophagy in cancers
Segala, Gregory, David, Marion, de Medina, Philippe, Poirot, Mathias C., Serhan, Nizar, Vergez, François, Mougel, Aurelie, Saland, Estelle, Carayon, Kevin, Leignadier, Julie, Caron, Nicolas, Voisin, Maud, Cherier, Julia, Ligat, Laetitia, Lopez, Frederic, Noguer, Emmanuel, Rives, Arnaud, Payré, Bruno, Saati, Talal al, Lamaziere, Antonin, Despres, Gaëtan, Lobaccaro, Jean-Marc, Baron, Silvere, Demur, Cecile, de Toni, Fabienne, Larrue, Clément, Boutzen, Helena, Thomas, Fabienne, Sarry, Jean-Emmanuel, Tosolini, Marie, Picard, Didier, Record, Michel, Récher, Christian, Poirot, Marc, Silvente-Poirot, Sandrine
Published in Nature communications (04.12.2017)
Published in Nature communications (04.12.2017)
Get full text
Journal Article
Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling
Segala, Gregory, Bennesch, Marcela A., Ghahhari, Nastaran Mohammadi, Pandey, Deo Prakash, Echeverria, Pablo C., Karch, François, Maeda, Robert K., Picard, Didier
Published in Nature communications (23.04.2019)
Published in Nature communications (23.04.2019)
Get full text
Journal Article
5,6-Epoxy-cholesterols contribute to the anticancer pharmacology of Tamoxifen in breast cancer cells
Segala, Gregory, de Medina, Philippe, Iuliano, Luigi, Zerbinati, Chiara, Paillasse, Michael R., Noguer, Emmanuel, Dalenc, Florence, Payré, Bruno, Jordan, V. Craig, Record, Michel, Silvente-Poirot, Sandrine, Poirot, Marc
Published in Biochemical pharmacology (01.07.2013)
Published in Biochemical pharmacology (01.07.2013)
Get full text
Journal Article
Dendrogenin A Synergizes with Cytarabine to Kill Acute Myeloid Leukemia Cells In Vitro and In Vivo
Serhan, Nizar, Mouchel, Pierre-Luc, de Medina, Philippe, Segala, Gregory, Mougel, Aurélie, Saland, Estelle, Rives, Arnaud, Lamaziere, Antonin, Despres, Gaëtan, Sarry, Jean-Emmanuel, Larrue, Clément, Vergez, François, Largeaud, Laetitia, Record, Michel, Récher, Christian, Silvente-Poirot, Sandrine, Poirot, Marc
Published in Cancers (01.07.2020)
Published in Cancers (01.07.2020)
Get full text
Journal Article
Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor
Voisin, Maud, de Medina, Philippe, Mallinger, Arnaud, Dalenc, Florence, Huc-Claustre, Emilie, Leignadier, Julie, Serhan, Nizar, Soules, Régis, Ségala, Grégory, Mougel, Aurélie, Noguer, Emmanuel, Mhamdi, Loubna, Bacquié, Elodie, Iuliano, Luigi, Zerbinati, Chiara, Lacroix-Triki, Magali, Chaltiel, Léonor, Filleron, Thomas, Cavaillès, Vincent, Saati, Talal Al, Rochaix, Philippe, Duprez-Paumier, Raphaelle, Franchet, Camille, Ligat, Laetitia, Lopez, Fréderic, Record, Michel, Poirot, Marc, Silvente-Poirot, Sandrine
Published in Proceedings of the National Academy of Sciences - PNAS (31.10.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (31.10.2017)
Get full text
Journal Article
LSD1 engages a corepressor complex for the activation of the estrogen receptor α by estrogen and cAMP
Bennesch, Marcela A, Segala, Gregory, Wider, Diana, Picard, Didier
Published in Nucleic acids research (14.10.2016)
Published in Nucleic acids research (14.10.2016)
Get full text
Journal Article
Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties
de Medina, Philippe, Paillasse, Michael R., Segala, Gregory, Voisin, Maud, Mhamdi, Loubna, Dalenc, Florence, Lacroix-Triki, Magali, Filleron, Thomas, Pont, Frederic, Saati, Talal Al, Morisseau, Christophe, Hammock, Bruce D., Silvente-Poirot, Sandrine, Poirot, Marc
Published in Nature communications (2013)
Published in Nature communications (2013)
Get full text
Journal Article
Abstract 1662: Dendrogenin A is a newly identified mammalian steroidal alkaloid that induced autophagic cell death in melanoma cells through an LXRbeta-, Nur77- and Nor1-dependent way
Segala, Gregory, Poirot, Mathias C., de Medina, Philippe, Paillasse, Michael, Lobaccaro, Jean-Marc, Silvente-Poirot, Sandrine, Poirot, Marc
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Get full text
Journal Article
Abstract 956: The liver-X-receptor-α is involved in the induction by Tamoxifen of breast cancer cell differentiation and death
Segala, Gregory, de Medina, Philippe, Paillasse, Michael, Jordan, V. Craig, Silvente-Poirot, Sandrine, Poirot, Marc
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Get full text
Journal Article
Abstract 2918: Molecular identification of the cholesterol-5,6-epoxide hydrolase: A new target for selective estrogen receptor modulators and unsaturated fatty acids
Poirot, Marc, de Medina, Philippe, Paillasse, Michael, Segala, Gregory, Silvente-Poirot, Sandrine
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Get full text
Journal Article
Technical note: Hapten synthesis, antibody production and development of an enzyme-linked immunosorbent assay for detection of the natural steroidal alkaloid Dendrogenin A
de Medina, Philippe, Paillasse, Michael R., Segala, Gregory, Al Saati, Talal, Boyes, Jeannine, Delsol, Georges, Allal, Cuider, Marsili, Sabrina, Silvente-Poirot, Sandrine, Poirot, Marc
Published in Biochimie (01.03.2013)
Published in Biochimie (01.03.2013)
Get full text
Journal Article
Abstract 938: Discovery of Dendrogenin A as the first endogenous alkylaminooxysterol present in mammals with potent cell differentiation and anticancer activity
Poirot, Marc, de Medina, Philippe, Paillasse, Michael R., Segala, Grégory, Saati, Tallal Al, Silvente-Poirot, Sandrine
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Get full text
Journal Article