Regulation of autophagy by ATF4 in response to severe hypoxia
Rzymski, T, Milani, M, Pike, L, Buffa, F, Mellor, H R, Winchester, L, Pires, I, Hammond, E, Ragoussis, I, Harris, A L
Published in Oncogene (05.08.2010)
Published in Oncogene (05.08.2010)
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The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress
Rzymski, T, Petry, A, Kračun, D, Rieß, F, Pike, L, Harris, A L, Görlach, A
Published in Oncogene (02.08.2012)
Published in Oncogene (02.08.2012)
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An oncogenic role of eIF3e INT6 in human breast cancer
Grzmil, M, Rzymski, T, Milani, M, Harris, A L, Capper, R G, Saunders, N J, Salhan, A, Ragoussis, J, Norbury, C J
Published in Oncogene (15.07.2010)
Published in Oncogene (15.07.2010)
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P501: CLI120‐001 PHASE1B DOSE ESCALATION STUDY OF RVU120 IN PATIENTS WITH AML OR HIGH RISK MDS SAFETY AND EFFICACY DATA UPDATE
Abboud, C., Jan Maciej, Z., Borthakur, G., Solomon, S., Howard, B., Bradley, T., Mouhayar, E., Angelosanto, N., Nogai, H., Glasmacher, A., Dudziak, R., Brzozka, K., Rzymski, T., Littlewood, P., Maranda, E.‐L.
Published in HemaSphere (01.06.2022)
Published in HemaSphere (01.06.2022)
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P450: PRECLINICAL AND CLINICAL SIGNS OF RVU120 EFFICACY, A SPECIFIC CDK8/19 INHIBITOR IN DNMT3A MUTATION POSITIVE AML AND HR‐MDS
Pakulska, U., Angelosanto, N., Mikula, M., Nogai, H., Dudziak, R., Abboud, C., Obacz, M., Goller, K., Cybulska, M., Mazan, M., Kozakowska, M., Rzymski, T.
Published in HemaSphere (01.06.2022)
Published in HemaSphere (01.06.2022)
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SEL120–34A, a specific, potent and orally bioavailable inhibitor of CDK8, targets STAT-dependent gene transcription in leukemia and lymphoma models
Zylkiewicz, E, Rzymski, T, Mikula, M, Dreas, A, Wiklik, K, Wrobel, A, Golas, A, Dolata, I, Wojcik, K, Masiejczyk, M, Statkiewicz, M, Kuklinska, U, Goryca, K, Grochowsk, A, Cabaj, A, Bialas, A, Mikulski, M, Windak, R, Ostrowski, J, Brzozka, K
Published in European journal of cancer (1990) (01.12.2016)
Published in European journal of cancer (1990) (01.12.2016)
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518 Development of Selective CDK8 Inhibitors for Colorectal Cancer Treatment
Brzozka, K, Zarebski, A, Windak, R, Krawczynska, K, Klosowska, A, Dreas, A, Fogt, J, Cholody, M, Milik, M, Rzymski, T
Published in European journal of cancer (1990) (01.11.2012)
Published in European journal of cancer (1990) (01.11.2012)
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The Caenorhabditis elegans ortholog of human PHF5a shows a muscle-specific expression domain and is essential for C. elegans morphogenetic development
Trappe, R, Schulze, E, Rzymski, T, Fröde, S, Engel, W
Published in Biochemical and biophysical research communications (04.10.2002)
Published in Biochemical and biophysical research communications (04.10.2002)
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34 (PB022): Phase I/II trial of RVU120, a CDK8/CDK19 inhibitor in patients with relapsed/refractory metastatic or advanced solid tumors
Jedrzejewski, J., Blaszkowska, M., Dziadziuszko, R., Alonso, G., Fałkowski, A., Rzymski, T., Wilkinson, G., Kuklík, R., Nogai, H., Ługowska, I., Dawidowska, A., Boni, V., Rojas, K., Pretelli, G., Garralda, E.
Published in European journal of cancer (1990) (01.10.2024)
Published in European journal of cancer (1990) (01.10.2024)
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417 (PB405): Exploring Synthetic Lethality and novel drug combinations in Patient-Derived Cells
Dulęba, M., Zimoląg, E., Szuszkiewicz, J., Serocki, M., Krawczyk, J., Bryzghalov, O., Stachowicz, A., Wieęckowska, I., Chmiel, M., Kurzejamski, A., Lipert, B., Wojtowicz, K., Chronowski, M., Otrocka, M., Mikula, M., Dziadziuszko, R., Brzózka, K., Rzymski, T., Mazan, A.
Published in European journal of cancer (1990) (01.10.2024)
Published in European journal of cancer (1990) (01.10.2024)
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RVU120, a small molecule inhibitor of CDK8/19 kinases, enhances rituximab-driven NK cells-mediated cytotoxicity both in vitro and in vivo
Białopiotrowicz-Data, E., Dziedzic, K., Podkalicka, P., Grycuk, K., Gołas, A., Dolata, I., Chmielewski, S., Pilch, Z., Nowis, D., Juszczyński, P., Rzymski, T.
Published in European journal of cancer (1990) (01.10.2022)
Published in European journal of cancer (1990) (01.10.2022)
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Phase I/II trial of RVU120, a CDK8/CDK19 inhibitor in patients with relapsed/refractory metastatic or advanced solid tumors
Dziadziuszko, R., Garralda Cabanas, E., Rojas, K., Chelstowska, M., Blaszkowska, M., Dudziak, R., Rzymski, T., Angelosanto, N., Littlewood, P., Nogai, H., Boni, V., Lugowska, I.
Published in European journal of cancer (1990) (01.10.2022)
Published in European journal of cancer (1990) (01.10.2022)
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672P Phase I/II trial of RVU120 (SEL120), CDK8/CDK19 inhibitor in patients with relapsed/refractory metastatic or advanced solid tumors
Dziadziuszko, R., Lugowska, I., Garralda, E., Rojas Laimito, K.I., Rzymski, T., Dudziak, R., Littlewood, P., Nogai, H., Boni, V., Fuentes Antras, J., Alonso, G., Saavedra Santa Gadea, O., Kuklík, R.
Published in Annals of oncology (01.10.2023)
Published in Annals of oncology (01.10.2023)
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Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses
Huang, Fan, Gonçalves, Christophe, Bartish, Margarita, Rémy-Sarrazin, Joelle, Issa, Mark E, Cordeiro, Brendan, Guo, Qianyu, Emond, Audrey, Attias, Mikhael, Yang, William, Plourde, Dany, Su, Jie, Gimeno, Marina Godoy, Zhan, Yao, Galán, Alba, Rzymski, Tomasz, Mazan, Milena, Masiejczyk, Magdalena, Faber, Jacek, Khoury, Elie, Benoit, Alexandre, Gagnon, Natascha, Dankort, David, Journe, Fabrice, Ghanem, Ghanem E, Krawczyk, Connie M, Saragovi, H Uri, Piccirillo, Ciriaco A, Sonenberg, Nahum, Topisirovic, Ivan, Rudd, Christopher E, Miller, Jr, Wilson H, Del Rincón, Sonia V
Published in The Journal of clinical investigation (15.04.2021)
Published in The Journal of clinical investigation (15.04.2021)
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402 - SEL120–34A, a specific, potent and orally bioavailable inhibitor of CDK8, targets STAT-dependent gene transcription in leukemia and lymphoma models
Zylkiewicz, E., Rzymski, T., Mikula, M., Dreas, A., Wiklik, K., Wrobel, A., Golas, A., Dolata, I., Wojcik, K., Masiejczyk, M., Statkiewicz, M., Kuklinska, U., Goryca, K., Grochowsk, A., Cabaj, A., Bialas, A., Mikulski, M., Windak, R., Ostrowski, J., Brzozka, K.
Published in European journal of cancer (1990) (01.12.2016)
Published in European journal of cancer (1990) (01.12.2016)
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Small Molecule Screens Identify CDK8-Inhibitors As Candidate Diamond-Blackfan Anemia Drugs
Chen, Jun, Siva, Kavitha, Rzymski, Tomasz, Johansson, Lars, Lundbäck, Thomas, Nunez Villacis, Lorena, Ek, Fredrik, Wang, Bingrui, George, Amee J, Wan, Yang, Shi, Lihong, IIsley, Melissa, Subramaniam, Agatheeswaran, Jain, Mayur, Debnath, Shubhranshu, Ghani Alattar, Abdul, Axelsson, Hanna, Mazan, Milena, Majewska, Eliza, Tedgard, Ulf R., Wlodarski, Marcin W., Gustavsson, Anna-Lena, Olsson, Roger, Mikula, Michal, Zhu, Xiaofan, Brzózka, Krzysztof, Hannan, Ross, Flygare, Johan
Published in BLOOD (29.11.2018)
Published in BLOOD (29.11.2018)
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Conference Proceeding
EVALUATION OF SERINE BIOSYNTHESIS PATHWAY AS A POTENTIAL THERAPEUTIC TARGET IN BURKITT LYMPHOMA: PF524
Noyszewska-Kania, M., Bialopiotrowicz, E., Cybulska, M., Grochowska, A., Kopczynski, M., Mikula, M., Kachamakova-Trojanowska, N., Loboda, A., Prochorec-Sobieszek, M., Szumera-Ciećkiewicz, A., Firczuk, M., Graczyk-Jarzynka, A., Zagozdzon, R., Zabek, A., Mlynarz, P., Gorniak, P., Szydlowski, M., Jablonska, E., Polak, A., Kowalczyk, P., Piechna, K., Rzymski, T., Brzozka, K., Juszczynski, P.
Published in HemaSphere (01.06.2019)
Published in HemaSphere (01.06.2019)
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