A randomised study in healthy volunteers to investigate the safety, tolerability and pharmacokinetics of idarucizumab, a specific antidote to dabigatran
Glund, Stephan, Moschetti, Viktoria, Norris, Stephen, Stangier, Joachim, Schmohl, Michael, van Ryn, Joanne, Lang, Benjamin, Ramael, Steven, Reilly, Paul
Published in Thrombosis and haemostasis (01.05.2015)
Published in Thrombosis and haemostasis (01.05.2015)
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Journal Article
Dabigatran etexilate--a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity
van Ryn, Joanne, Stangier, Joachim, Haertter, Sebastian, Liesenfeld, Karl-Heinz, Wienen, Wolfgang, Feuring, Martin, Clemens, Andreas
Published in Thrombosis and haemostasis (01.06.2010)
Published in Thrombosis and haemostasis (01.06.2010)
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Journal Article
Idarucizumab for Dabigatran Reversal — Full Cohort Analysis
Pollack, Charles V, Reilly, Paul A, van Ryn, Joanne, Eikelboom, John W, Glund, Stephan, Bernstein, Richard A, Dubiel, Robert, Huisman, Menno V, Hylek, Elaine M, Kam, Chak-Wah, Kamphuisen, Pieter W, Kreuzer, Jörg, Levy, Jerrold H, Royle, Gordon, Sellke, Frank W, Stangier, Joachim, Steiner, Thorsten, Verhamme, Peter, Wang, Bushi, Young, Laura, Weitz, Jeffrey I
Published in The New England journal of medicine (03.08.2017)
Published in The New England journal of medicine (03.08.2017)
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Journal Article
Safety, tolerability, and efficacy of idarucizumab for the reversal of the anticoagulant effect of dabigatran in healthy male volunteers: a randomised, placebo-controlled, double-blind phase 1 trial
Glund, Stephan, Dr, Stangier, Joachim, PhD, Schmohl, Michael, PhD, Gansser, Dietmar, PhD, Norris, Stephen, PhD, van Ryn, Joanne, PhD, Lang, Benjamin, Dipl Math oec, Ramael, Steven, MD, Moschetti, Viktoria, MD, Gruenenfelder, Fredrik, DVM, Reilly, Paul, PhD, Kreuzer, Jörg, Prof
Published in The Lancet (British edition) (15.08.2015)
Published in The Lancet (British edition) (15.08.2015)
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Journal Article
Reversal of dabigatran anticoagulation ex vivo: Porcine study comparing prothrombin complex concentrates and idarucizumab
Honickel, Markus, Treutler, Stefanie, van Ryn, Joanne, Tillmann, Sabine, Rossaint, Rolf, Grottke, Oliver
Published in Thrombosis and haemostasis (01.07.2015)
Published in Thrombosis and haemostasis (01.07.2015)
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Journal Article
Interpretation of Point-of-care INR Results in Patients Treated with Dabigatran
van Ryn, Joanne, PhD, Baruch, Lawrence, MD, Clemens, Andreas, MD
Published in The American journal of medicine (01.04.2012)
Published in The American journal of medicine (01.04.2012)
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Journal Article
Off‐target effects of oral anticoagulants – vascular effects of vitamin K antagonist and non‐vitamin K antagonist oral anticoagulant dabigatran etexilate
Gorp, Rick H., Dijkgraaf, Ingrid, Bröker, Vanessa, Bauwens, Matthias, Leenders, Peter, Jennen, Danyel, Dweck, Marc R., Bucerius, Jan, Briedé, Jacco J., Ryn, Joanne, Brandenburg, Vincent, Mottaghy, Felix, Spronk, Henri M. H., Reutelingsperger, Chris P., Schurgers, Leon J.
Published in Journal of thrombosis and haemostasis (01.05.2021)
Published in Journal of thrombosis and haemostasis (01.05.2021)
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Journal Article
Idarucizumab, a Specific Dabigatran Reversal Agent, Reduces Blood Loss in a Porcine Model of Trauma With Dabigatran Anticoagulation
Grottke, Oliver, MD, PhD, Honickel, Markus, MD, van Ryn, Joanne, PhD, ten Cate, Hugo, MD, PhD, Rossaint, Rolf, MD, Spronk, Henri M., PhD
Published in Journal of the American College of Cardiology (29.09.2015)
Published in Journal of the American College of Cardiology (29.09.2015)
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Therapy with activated prothrombin complex concentrate is effective in reducing dabigatran-associated blood loss in a porcine polytrauma model
Honickel, Markus, Maron, Benjamin, van Ryn, Joanne, Braunschweig, Till, ten Cate, Hugo, Spronk, Henri M H, Rossaint, Rolf, Grottke, Oliver
Published in Thrombosis and haemostasis (2016)
Published in Thrombosis and haemostasis (2016)
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Idarucizumab, a Specific Reversal Agent for Dabigatran: Mode of Action, Pharmacokinetics and Pharmacodynamics, and Safety and Efficacy in Phase 1 Subjects
Reilly, Paul A., PhD, van Ryn, Joanne, PhD, Grottke, Oliver, MD, PhD, Glund, Stephan, PhD, Stangier, Joachim, PhD
Published in The American journal of medicine (01.11.2016)
Published in The American journal of medicine (01.11.2016)
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Journal Article
Idarucizumab, but not procoagulant concentrates, fully restores dabigatran‐altered platelet and fibrin components of hemostasis
Arellano‐Rodrigo, Eduardo, Fernandez‐Gallego, Victor, López‐Vilchez, Irene, Molina, Patricia, Díaz‐Ricart, Maribel, Zafar, M. Urooj, Badimon, Juan J., Ryn, Joanne, Escolar, Ginés
Published in Transfusion (Philadelphia, Pa.) (01.07.2019)
Published in Transfusion (Philadelphia, Pa.) (01.07.2019)
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Journal Article
A specific antidote for dabigatran: functional and structural characterization
Schiele, Felix, van Ryn, Joanne, Canada, Keith, Newsome, Corey, Sepulveda, Eliud, Park, John, Nar, Herbert, Litzenburger, Tobias
Published in Blood (02.05.2013)
Published in Blood (02.05.2013)
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Journal Article
Restarting Dabigatran Etexilate 24 h After Reversal With Idarucizumab and Redosing Idarucizumab in Healthy Volunteers
Glund, Stephan, PhD, Stangier, Joachim, PhD, van Ryn, Joanne, PhD, Schmohl, Michael, PhD, Moschetti, Viktoria, MD, Haazen, Wouter, MD, De Smet, Marina, PhD, Gansser, Dietmar, PhD, Norris, Stephen, PhD, Lang, Benjamin, Dipl-Math oec, Reilly, Paul, PhD, Kreuzer, Jörg, MD
Published in Journal of the American College of Cardiology (05.04.2016)
Published in Journal of the American College of Cardiology (05.04.2016)
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Journal Article
Effects of Dabigatran in Mouse Models of Aging and Cerebral Amyloid Angiopathy
Michael, Neethu, Grigoryan, Mher Mahoney, Kilday, Kelley, Sumbria, Rachita K, Vasilevko, Vitaly, van Ryn, Joanne, Cribbs, David H, Paganini-Hill, Annlia, Fisher, Mark J
Published in Frontiers in neurology (27.09.2019)
Published in Frontiers in neurology (27.09.2019)
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Journal Article
Idarucizumab, a Specific Reversal Agent for Dabigatran: Mode of Action, Pharmacokinetics and Pharmacodynamics, and Safety and Efficacy in Phase 1 Subjects
Reilly, Paul A., PhD, van Ryn, Joanne, PhD, Grottke, Oliver, MD, PhD, Glund, Stephan, PhD, Stangier, Joachim, PhD
Published in The American journal of emergency medicine (01.11.2016)
Published in The American journal of emergency medicine (01.11.2016)
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Journal Article
Use of dabigatran etexilate to reduce breast cancer progression
DeFeo, Karen, Hayes, Candace, Chernick, Michael, Van Ryn, Joanne, Gilmour, Susan K.
Published in Cancer biology & therapy (15.11.2010)
Published in Cancer biology & therapy (15.11.2010)
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Journal Article
The Renal Elimination Pathways of the Dabigatran Reversal Agent Idarucizumab and its Impact on Dabigatran Elimination
Glund, Stephan, Gan, Guanfa, Moschetti, Viktoria, Reilly, Paul, Honickel, Markus, Grottke, Oliver, Van Ryn, Joanne
Published in Clinical and applied thrombosis/hemostasis (01.07.2018)
Published in Clinical and applied thrombosis/hemostasis (01.07.2018)
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Journal Article
Thrombin promotes diet-induced obesity through fibrin-driven inflammation
Kopec, Anna K, Abrahams, Sara R, Thornton, Sherry, Palumbo, Joseph S, Mullins, Eric S, Divanovic, Senad, Weiler, Hartmut, Owens, 3rd, A Phillip, Mackman, Nigel, Goss, Ashley, van Ryn, Joanne, Luyendyk, James P, Flick, Matthew J
Published in The Journal of clinical investigation (01.08.2017)
Published in The Journal of clinical investigation (01.08.2017)
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