HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target
Fok, Jacqueline H L, Hedayat, Somaieh, Zhang, Lei, Aronson, Lauren I, Mirabella, Fabio, Pawlyn, Charlotte, Bright, Michael D, Wardell, Christopher P, Keats, Jonathan J, De Billy, Emmanuel, Rye, Carl S, Chessum, Nicola E A, Jones, Keith, Morgan, Gareth J, Eccles, Suzanne A, Workman, Paul, Davies, Faith E
Published in Clinical cancer research (15.05.2018)
Published in Clinical cancer research (15.05.2018)
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Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen
Cheeseman, Matthew D, Chessum, Nicola E. A, Rye, Carl S, Pasqua, A. Elisa, Tucker, Michael J, Wilding, Birgit, Evans, Lindsay E, Lepri, Susan, Richards, Meirion, Sharp, Swee Y, Ali, Salyha, Rowlands, Martin, O’Fee, Lisa, Miah, Asadh, Hayes, Angela, Henley, Alan T, Powers, Marissa, te Poele, Robert, De Billy, Emmanuel, Pellegrino, Loredana, Raynaud, Florence, Burke, Rosemary, van Montfort, Rob L. M, Eccles, Suzanne A, Workman, Paul, Jones, Keith
Published in Journal of medicinal chemistry (12.01.2017)
Published in Journal of medicinal chemistry (12.01.2017)
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HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies
Pasqua, A. Elisa, Sharp, Swee Y., Chessum, Nicola E. A., Hayes, Angela, Pellegrino, Loredana, Tucker, Michael J., Miah, Asadh, Wilding, Birgit, Evans, Lindsay E., Rye, Carl S., Mok, N. Yi, Liu, Manjuan, Henley, Alan T., Gowan, Sharon, De Billy, Emmanuel, te Poele, Robert, Powers, Marissa, Eccles, Suzanne A., Clarke, Paul A., Raynaud, Florence I., Workman, Paul, Jones, Keith, Cheeseman, Matthew D.
Published in Journal of medicinal chemistry (27.04.2023)
Published in Journal of medicinal chemistry (27.04.2023)
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A model beta-sheet interaction and thermodynamic analysis of beta-strand mimetics
Robinson, Colin W., Rye, Carl S., Chessum, Nicola E. A., Jones, Keith
Published in Organic & biomolecular chemistry (21.07.2015)
Published in Organic & biomolecular chemistry (21.07.2015)
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Privileged Structures and Polypharmacology within and between Protein Families
Meyers, Joshua, Chessum, Nicola E. A, Ali, Salyha, Mok, N. Yi, Wilding, Birgit, Pasqua, A. Elisa, Rowlands, Martin, Tucker, Michael J, Evans, Lindsay E, Rye, Carl S, O’Fee, Lisa, Le Bihan, Yann-Vaï, Burke, Rosemary, Carter, Michael, Workman, Paul, Blagg, Julian, Brown, Nathan, van Montfort, Rob L. M, Jones, Keith, Cheeseman, Matthew D
Published in ACS medicinal chemistry letters (13.12.2018)
Published in ACS medicinal chemistry letters (13.12.2018)
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Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9
Rye, Carl S, Chessum, Nicola E A, Lamont, Scott, Pike, Kurt G, Faulder, Paul, Demeritt, Julie, Kemmitt, Paul, Tucker, Julie, Zani, Lorenzo, Cheeseman, Matthew D, Isaac, Rosie, Goodwin, Louise, Boros, Joanna, Raynaud, Florence, Hayes, Angela, Henley, Alan T, de Billy, Emmanuel, Lynch, Christopher J, Sharp, Swee Y, Te Poele, Robert, Fee, Lisa O', Foote, Kevin M, Green, Stephen, Workman, Paul, Jones, Keith
Published in MedChemComm (01.08.2016)
Published in MedChemComm (01.08.2016)
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Structure-Guided Rescaffolding of Selective Antagonists of BCL‑XL
Koehler, Michael F. T, Bergeron, Philippe, Choo, Edna F, Lau, Kevin, Ndubaku, Chudi, Dudley, Danette, Gibbons, Paul, Sleebs, Brad E, Rye, Carl S, Nikolakopoulos, George, Bui, Chinh, Kulasegaram, Sanji, Kersten, Wilhelmus J. A, Smith, Brian J, Czabotar, Peter E, Colman, Peter M, Huang, David C. S, Baell, Jonathan B, Watson, Keith G, Hasvold, Lisa, Tao, Zhi-Fu, Wang, Le, Souers, Andrew J, Elmore, Steven W, Flygare, John A, Fairbrother, Wayne J, Lessene, Guillaume
Published in ACS medicinal chemistry letters (12.06.2014)
Published in ACS medicinal chemistry letters (12.06.2014)
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Correction: Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9. See DOI: 10.1039/c6md00159a
Rye, Carl S, Chessum, Nicola E. A, Lamont, Scott, Pike, Kurt G, Faulder, Paul, Demeritt, Julie, Kemmitt, Paul, Tucker, Julie, Zani, Lorenzo, Cheeseman, Matthew D, Isaac, Rosie, Goodwin, Louise, Boros, Joanna, Raynaud, Florence, Hayes, Angela, Henley, Alan T, de Billy, Emmanuel, Lynch, Christopher J, Sharp, Swee Y, te Poele, Robert, Fee, Lisa O', Foote, Kevin M, Green, Stephen, Workman, Paul, Jones, Keith
Published in MedChemComm (14.09.2016)
Published in MedChemComm (14.09.2016)
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Abstract LB-304: Discovery of chemical probe CCT251236: An orally bioavailable efficacious pirin ligand from an HSF1 phenotypic screen
Cheeseman, Matthew D., Chessum, Nicola E., Rye, Carl S., Pasqua, Elisa A., Tucker, Michael J., Wilding, Birgit, Evans, Lindsay E., Lepri, Susan, Richards, Meirion, Sharp, Swee Y., Ali, Salyha, Rowlands, Martin, O'Fee, Lisa, Miah, Asadh, Hayes, Angela, Henley, Alan T., Powers, Marissa, Poele, Robert te, Billy, Emmanuel De, Pellegrino, Loredana, Raynaud, Florence, Burke, Rosemary, Montfort, Robert L. van, Eccles, Suzanne A., Jones, Keith, Workman, Paul
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Structure-Guided Rescaffolding of Selective Antagonists of BCL-X L
Koehler, Michael F. T., Bergeron, Philippe, Choo, Edna F., Lau, Kevin, Ndubaku, Chudi, Dudley, Danette, Gibbons, Paul, Sleebs, Brad E., Rye, Carl S., Nikolakopoulos, George, Bui, Chinh, Kulasegaram, Sanji, Kersten, Wilhelmus J. A., Smith, Brian J., Czabotar, Peter E., Colman, Peter M., Huang, David C. S., Baell, Jonathan B., Watson, Keith G., Hasvold, Lisa, Tao, Zhi-Fu, Wang, Le, Souers, Andrew J., Elmore, Steven W., Flygare, John A., Fairbrother, Wayne J., Lessene, Guillaume
Published in ACS medicinal chemistry letters (12.06.2014)
Published in ACS medicinal chemistry letters (12.06.2014)
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