ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons
Fernandes, Hugo J.R., Hartfield, Elizabeth M., Christian, Helen C., Emmanoulidou, Evangelia, Zheng, Ying, Booth, Heather, Bogetofte, Helle, Lang, Charmaine, Ryan, Brent J., Sardi, S. Pablo, Badger, Jennifer, Vowles, Jane, Evetts, Samuel, Tofaris, George K., Vekrellis, Kostas, Talbot, Kevin, Hu, Michele T., James, William, Cowley, Sally A., Wade-Martins, Richard
Published in Stem cell reports (08.03.2016)
Published in Stem cell reports (08.03.2016)
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Journal Article
Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells
Smith, Amy M., Depp, Constanze, Ryan, Brent J., Johnston, Geoffrey I., Alegre‐Abarrategui, Javier, Evetts, Samuel, Rolinski, Michal, Baig, Fahd, Ruffmann, Claudio, Simon, Anna Katharina, Hu, Michele T. M., Wade‐Martins, Richard
Published in Movement disorders (01.10.2018)
Published in Movement disorders (01.10.2018)
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PARK2 Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived Neurons
Bogetofte, Helle, Jensen, Pia, Ryding, Matias, Schmidt, Sissel I, Okarmus, Justyna, Ritter, Louise, Worm, Christina S, Hohnholt, Michaela C, Azevedo, Carla, Roybon, Laurent, Bak, Lasse K, Waagepetersen, Helle, Ryan, Brent J, Wade-Martins, Richard, Larsen, Martin R, Meyer, Morten
Published in Frontiers in cellular neuroscience (05.07.2019)
Published in Frontiers in cellular neuroscience (05.07.2019)
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Journal Article
Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons
Hasan, Saadia, Fernandopulle, Michael S, Humble, Stewart W, Frankenfield, Ashley M, Li, Haorong, Prestil, Ryan, Johnson, Kory R, Ryan, Brent J, Wade-Martins, Richard, Ward, Michael E, Hao, Ling
Published in Molecular neurodegeneration (16.11.2023)
Published in Molecular neurodegeneration (16.11.2023)
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Journal Article
Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson’s disease GBA-N370S dopamine neurons
Bogetofte, Helle, Ryan, Brent J., Jensen, Pia, Schmidt, Sissel I., Vergoossen, Dana L.E., Barnkob, Mike B., Kiani, Lisa N., Chughtai, Uroosa, Heon-Roberts, Rachel, Caiazza, Maria Claudia, McGuinness, William, Márquez-Gómez, Ricardo, Vowles, Jane, Bunn, Fiona S., Brandes, Janine, Kilfeather, Peter, Connor, Jack P., Fernandes, Hugo J.R., Caffrey, Tara M., Meyer, Morten, Cowley, Sally A., Larsen, Martin R., Wade-Martins, Richard
Published in Cell reports (Cambridge) (28.03.2023)
Published in Cell reports (Cambridge) (28.03.2023)
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Journal Article
Correction: Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons
Hasan, Saadia, Fernandopulle, Michael S, Humble, Stewart W, Frankenfield, Ashley M, Li, Haorong, Prestil, Ryan, Johnson, Kory R, Ryan, Brent J, Wade-Martins, Richard, Ward, Michael E, Hao, Ling
Published in Molecular neurodegeneration (18.12.2023)
Published in Molecular neurodegeneration (18.12.2023)
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Journal Article
Autoantibodies to Posttranslational Modifications in Rheumatoid Arthritis
Ponchel, Frédérique, Emery, Paul, Nissim, Ahuva, Vital, Ed, Ryan, Brent J., Strollo, Rocky, Boissinot, Marjorie, Hunt, Laura, Burska, Agata N., Winyard, Paul G.
Published in Mediators of Inflammation (01.01.2014)
Published in Mediators of Inflammation (01.01.2014)
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Journal Article
Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol
Threlfell, Sarah, Mohammadi, Amir Saeid, Ryan, Brent J, Connor-Robson, Natalie, Platt, Nicola J, Anand, Rishi, Serres, Florence, Sharp, Trevor, Bengoa-Vergniory, Nora, Wade-Martins, Richard, Ewing, Andrew, Cragg, Stephanie J, Brimblecombe, Katherine R
Published in Frontiers in cellular neuroscience (15.04.2021)
Published in Frontiers in cellular neuroscience (15.04.2021)
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Journal Article
Mitochondrial Dysfunction and Mitophagy in Parkinson’s Disease: From Mechanism to Therapy
Malpartida, Ana Belen, Williamson, Matthew, Narendra, Derek P., Wade-Martins, Richard, Ryan, Brent J.
Published in Trends in biochemical sciences (Amsterdam. Regular ed.) (01.04.2021)
Published in Trends in biochemical sciences (Amsterdam. Regular ed.) (01.04.2021)
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Journal Article
Haplotype-specific MAPT exon 3 expression regulated by common intronic polymorphisms associated with Parkinsonian disorders
Lai, Mang Ching, Bechy, Anne-Laure, Denk, Franziska, Collins, Emma, Gavriliouk, Maria, Zaugg, Judith B, Ryan, Brent J, Wade-Martins, Richard, Caffrey, Tara M
Published in Molecular neurodegeneration (30.10.2017)
Published in Molecular neurodegeneration (30.10.2017)
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Journal Article
Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes
Lang, Charmaine, Campbell, Kieran R., Ryan, Brent J., Carling, Phillippa, Attar, Moustafa, Vowles, Jane, Perestenko, Olga V., Bowden, Rory, Baig, Fahd, Kasten, Meike, Hu, Michele T., Cowley, Sally A., Webber, Caleb, Wade-Martins, Richard
Published in Cell stem cell (03.01.2019)
Published in Cell stem cell (03.01.2019)
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Journal Article
CRISPRi: a way to integrate iPSC-derived neuronal models
Franks, Sarah N J, Heon-Roberts, Rachel, Ryan, Brent J
Published in Biochemical Society transactions (24.04.2024)
Published in Biochemical Society transactions (24.04.2024)
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Journal Article
Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons
Zambon, Federico, Cherubini, Marta, Fernandes, Hugo J R, Lang, Charmaine, Ryan, Brent J, Volpato, Viola, Bengoa-Vergniory, Nora, Vingill, Siv, Attar, Moustafa, Booth, Heather D E, Haenseler, Walther, Vowles, Jane, Bowden, Rory, Webber, Caleb, Cowley, Sally A, Wade-Martins, Richard
Published in Human molecular genetics (15.06.2019)
Published in Human molecular genetics (15.06.2019)
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Journal Article
REST Protects Dopaminergic Neurons from Mitochondrial and α-Synuclein Oligomer Pathology in an Alpha Synuclein Overexpressing BAC-Transgenic Mouse Model
Ryan, Brent J, Bengoa-Vergniory, Nora, Williamson, Matthew, Kirkiz, Ecem, Roberts, Rosalind, Corda, Gabriele, Sloan, Maximilian, Saqlain, Saba, Cherubini, Marta, Poppinga, Josse, Bogtofte, Helle, Cioroch, Milena, Hester, Svenja, Wade-Martins, Richard
Published in The Journal of neuroscience (21.04.2021)
Published in The Journal of neuroscience (21.04.2021)
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Journal Article
A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance
Bailey, Jade, Shaw, Andrew, Fischer, Roman, Ryan, Brent J., Kessler, Benedikt M., McCullagh, James, Wade-Martins, Richard, Channon, Keith M., Crabtree, Mark J.
Published in Free radical biology & medicine (01.03.2017)
Published in Free radical biology & medicine (01.03.2017)
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Journal Article
Mitochondrial dysfunction and mitophagy defects in LRRK2-R1441C Parkinson’s disease models
Williamson, Matthew G, Madureira, Marta, McGuinness, William, Heon-Roberts, Rachel, Mock, Elliot D, Naidoo, Kalina, Cramb, Kaitlyn M L, Caiazza, Maria-Claudia, Malpartida, Ana B, Lavelle, Martha, Savory, Katrina, Humble, Stewart W, Patterson, Ryan, Davis, John B, Connor-Robson, Natalie, Ryan, Brent J, Wade-Martins, Richard
Published in Human molecular genetics (05.09.2023)
Published in Human molecular genetics (05.09.2023)
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Journal Article
Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function
Carling, Phillippa J, Ryan, Brent J, McGuinness, William, Kataria, Shikha, Humble, Stewart W, Milde, Stefan, Duce, James A, Kapadia, Nirav, Zuercher, William J, Davis, John B., Di Daniel, Elena, Wade-Martins, Richard
Published in Autophagy (01.02.2023)
Published in Autophagy (01.02.2023)
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