The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation
Hooftman, Alexander, Angiari, Stefano, Hester, Svenja, Corcoran, Sarah E., Runtsch, Marah C., Ling, Chris, Ruzek, Melanie C., Slivka, Peter F., McGettrick, Anne F., Banahan, Kathy, Hughes, Mark M., Irvine, Alan D., Fischer, Roman, O’Neill, Luke A.J.
Published in Cell metabolism (01.09.2020)
Published in Cell metabolism (01.09.2020)
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Pharmacology of AMD3465: A small molecule antagonist of the chemokine receptor CXCR4
Bodart, Veronique, Anastassov, Virginia, Darkes, Marilyn C., Idzan, Stefan R., Labrecque, Jean, Lau, Gloria, Mosi, Renee M., Neff, Kathleen S., Nelson, Kim L., Ruzek, Melanie C., Patel, Ketan, Santucci, Zefferino, Scarborough, Robert, Wong, Rebecca S.Y., Bridger, Gary J., MacFarland, Ron T., Fricker, Simon P.
Published in Biochemical pharmacology (15.10.2009)
Published in Biochemical pharmacology (15.10.2009)
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Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages
Runtsch, Marah C., Angiari, Stefano, Hooftman, Alexander, Wadhwa, Ridhima, Zhang, Yanling, Zheng, Yunan, Spina, Joseph S., Ruzek, Melanie C., Argiriadi, Maria A., McGettrick, Anne F., Mendez, Rui Santalla, Zotta, Alessia, Peace, Christian G., Walsh, Aoife, Chirillo, Roberta, Hams, Emily, Fallon, Padraic G., Jayaraman, Ranjith, Dua, Kamal, Brown, Alexandra C., Kim, Richard Y., Horvat, Jay C., Hansbro, Philip M., Wang, Chu, O’Neill, Luke A.J.
Published in Cell metabolism (01.03.2022)
Published in Cell metabolism (01.03.2022)
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Journal Article
In vivo characterization of rabbit anti-mouse thymocyte globulin: a surrogate for rabbit anti-human thymocyte globulin
Ruzek, Melanie C, Neff, Kathleen S, Luong, Michael, Smith, Karen A, Culm-Merdek, Kerry, Richards, Susan M, Williams, John M, Perricone, Michael, Garman, Richard D
Published in Transplantation (27.07.2009)
Published in Transplantation (27.07.2009)
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Synovial Inflammatory Pathways Characterize Anti‐TNF–Responsive Rheumatoid Arthritis Patients
Wang, Jing, Conlon, Donna, Rivellese, Felice, Nerviani, Alessandra, Lewis, Myles J., Housley, William, Levesque, Marc C., Cao, Xiaohong, Cuff, Carolyn, Long, Andrew, Pitzalis, Costantino, Ruzek, Melanie C.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.12.2022)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.12.2022)
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Dual Blockade of Interleukin-1 β and Interleukin-17A Reduces Murine Arthritis Pathogenesis but Also Leads to Spontaneous Skin Infections in Nonhuman Primates
Ruzek, Melanie C, Huang, Lili, Zhang, Ting-Ting, Bryant, Shaughn, Slivka, Peter F, Cuff, Carolyn A, Tripp, Catherine, Blaich, Guenter
Published in The Journal of pharmacology and experimental therapeutics (01.03.2018)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2018)
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Biomarkers for the clinical development of antiviral therapies
Ng, Teresa I., Dorr, Patrick K., Krishnan, Preethi, Cohen, Daniel E., Rhee, Susan, Wang, Stanley X., Ruzek, Melanie C., Mensa, Federico J., Kati, Warren M.
Published in Cytometry Part B: Clinical Cytometry (01.01.2021)
Published in Cytometry Part B: Clinical Cytometry (01.01.2021)
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Murine antithymocyte globulin T-cell depletion is mediated predominantly by macrophages, but the Fas/FasL pathway selectively targets regulatory T cells
Neff, Kathleen S, Richards, Susan M, Williams, John M, Garman, Richard D, Ruzek, Melanie C
Published in Transplantation (15.09.2011)
Published in Transplantation (15.09.2011)
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Characterization of in vitro antimurine thymocyte globulin–induced regulatory T cells that inhibit graft-versus-host disease in vivo
Ruzek, Melanie C., Waire, James S., Hopkins, Deborah, LaCorcia, Gina, Sullivan, Jennifer, Roberts, Bruce L., Richards, Susan M., Nahill, Sharon R., Williams, John M., Scaria, Abraham, Dzuris, John, Shankara, Srinivas, Garman, Richard D.
Published in Blood (01.02.2008)
Published in Blood (01.02.2008)
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Homeostatic Role of Transforming Growth Factor-β in the Oral Cavity and Esophagus of Mice and Its Expression by Mast Cells in These Tissues
Vitsky, Allison, Waire, James, Pawliuk, Robert, Bond, Arden, Matthews, Douglas, LaCasse, Emily, Hawes, Michael L, Nelson, Carol, Richards, Susan, Piepenhagen, Peter A, Garman, Richard D, Andrews, Laura, Thurberg, Beth L, Lonning, Scott, Ledbetter, Steve, Ruzek, Melanie C
Published in The American journal of pathology (01.06.2009)
Published in The American journal of pathology (01.06.2009)
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NK cell functions restrain T cell responses during viral infections
Su, Helen C., Nguyen, Khuong B., Salazar‐Mather, Thais P., Ruzek, Melanie C., Dalod, Marc Y., Biron, Christine A.
Published in European journal of immunology (01.10.2001)
Published in European journal of immunology (01.10.2001)
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Journal Article
Ultrasound Imaging Accurately Detects Skin Thickening in a Mouse Scleroderma Model
Tedstone, Jennifer L, Richards, Susan M, Garman, Richard D, Ruzek, Melanie C
Published in Ultrasound in medicine & biology (01.08.2008)
Published in Ultrasound in medicine & biology (01.08.2008)
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Characterization of early cytokine responses and an interleukin (IL)-6-dependent pathway of endogenous glucocorticoid induction during murine cytomegalovirus infection
Ruzek, M C, Miller, A H, Opal, S M, Pearce, B D, Biron, C A
Published in The Journal of experimental medicine (07.04.1997)
Published in The Journal of experimental medicine (07.04.1997)
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Replication of Murine Cytomegalovirus in Differentiated Macrophages as a Determinant of Viral Pathogenesis
Hanson, L K, Slater, J S, Karabekian, Z, Virgin, 4th, H W, Biron, C A, Ruzek, M C, van Rooijen, N, Ciavarra, R P, Stenberg, R M, Campbell, A E
Published in Journal of Virology (01.07.1999)
Published in Journal of Virology (01.07.1999)
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Journal Article
Adenoviral Vectors Stimulate Murine Natural Killer Cell Responses and Demonstrate Antitumor Activities in the Absence of Transgene Expression
Ruzek, Melanie C, Kavanagh, Brian F, Scaria, Abraham, Richards, Susan M, Garman, Richard D
Published in Molecular therapy (01.02.2002)
Published in Molecular therapy (01.02.2002)
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Journal Article
Minimal Effects on Immune Parameters Following Chronic Anti-TGF-β Monoclonal Antibody Administration to Normal Mice
Ruzek, Melanie C., Hawes, Michael, Pratt, Bruce, McPherson, John, Ledbetter, Steve, Richards, Susan M., Garman, Richard D.
Published in Immunopharmacology and immunotoxicology (01.01.2003)
Published in Immunopharmacology and immunotoxicology (01.01.2003)
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