Leukemic stem cell frequency: a strong biomarker for clinical outcome in acute myeloid leukemia
Terwijn, Monique, Zeijlemaker, Wendelien, Kelder, Angèle, Rutten, Arjo P, Snel, Alexander N, Scholten, Willemijn J, Pabst, Thomas, Verhoef, Gregor, Löwenberg, Bob, Zweegman, Sonja, Ossenkoppele, Gert J, Schuurhuis, Gerrit J
Published in PloS one (22.09.2014)
Published in PloS one (22.09.2014)
Get full text
Journal Article
Attenuation of microRNA-126 Expression That Drives CD34+38― Stem/Progenitor Cells in Acute Myeloid Leukemia Leads to Tumor Eradication
DE LEEUW, David C, DENKERS, Fedor, OLTHOF, Marjolein C, RUTTEN, Arjo P, POUWELS, Walter, SCHUURHUIS, Gerrit Jan, OSSENKOPPELE, Gert J, SMIT, Linda
Published in Cancer research (Chicago, Ill.) (01.04.2014)
Published in Cancer research (Chicago, Ill.) (01.04.2014)
Get full text
Journal Article
Relationship between CD34/CD38 and side population (SP) defined leukemia stem cell compartments in acute myeloid leukemia
Moshaver, Bijan, Wouters, Rolf F., Kelder, Angèle, Ossenkoppele, Gert J., Westra, Guus A.H., Kwidama, Zinia, Rutten, Arjo R., Kaspers, Gert J.L., Zweegman, Sonja, Cloos, Jacqueline, Schuurhuis, Gerrit J.
Published in Leukemia research (01.06.2019)
Published in Leukemia research (01.06.2019)
Get full text
Journal Article
The Novel Oral BET‐CBP/p300 Dual Inhibitor NEO2734 Is Highly Effective in Eradicating Acute Myeloid Leukemia Blasts and Stem/Progenitor Cells
Gils, Noortje, Martiañez Canales, Tania, Vermue, Eline, Rutten, Arjo, Denkers, Fedor, Deure, Tiem, Ossenkoppele, Gert J., Giles, Francis, Smit, Linda
Published in HemaSphere (01.08.2021)
Published in HemaSphere (01.08.2021)
Get full text
Journal Article
IGFBP7 Induces Differentiation and Loss of Survival of Human Acute Myeloid Leukemia Stem Cells without Affecting Normal Hematopoiesis
Verhagen, Han J.M.P., van Gils, Noortje, Martiañez, Tania, van Rhenen, Anna, Rutten, Arjo, Denkers, Fedor, de Leeuw, David C., Smit, Marjon A., Tsui, Mei-Ling, de Vos Klootwijk, Louise L.E., Menezes, Renee X., Çil, Meyram, Roemer, Margaretha G.M., Vermue, Eline, Heukelom, Stan, Zweegman, Sonja, Janssen, Jeroen J.W.M., Ossenkoppele, Gert J., Schuurhuis, Gerrit Jan, Smit, Linda
Published in Cell reports (Cambridge) (11.12.2018)
Published in Cell reports (Cambridge) (11.12.2018)
Get full text
Journal Article
Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters
van Gils, Noortje, Verhagen, Han J.M.P., Broux, Michaël, Martiáñez, Tania, Denkers, Fedor, Vermue, Eline, Rutten, Arjo, Csikós, Tamás, Demeyer, Sofie, Çil, Meryem, Al, Marjon, Cools, Jan, Janssen, Jeroen J.W.M., Ossenkoppele, Gert J., Menezes, Renee X., Smit, Linda
Published in iScience (16.09.2022)
Published in iScience (16.09.2022)
Get full text
Journal Article
Uncoupling DNA damage from chromatin damage to detoxify doxorubicin
Qiao, Xiaohang, van der Zanden, Sabina Y., Wander, Dennis P. A., Borràs, Daniel M., Song, Ji-Ying, Li, Xiaoyang, van Duikeren, Suzanne, van Gils, Noortje, Rutten, Arjo, van Herwaarden, Tessa, van Tellingen, Olaf, Giacomelli, Elisa, Bellin, Milena, Orlova, Valeria, Tertoolen, Leon G. J., Gerhardt, Sophie, Akkermans, Jimmy J., Bakker, Jeroen M., Zuur, Charlotte L., Pang, Baoxu, Smits, Anke M., Mummery, Christine L., Smith, Linda, Arens, Ramon, Li, Junmin, Overkleeft, Hermen S., Neefjes, Jacques
Published in Proceedings of the National Academy of Sciences - PNAS (30.06.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (30.06.2020)
Get full text
Journal Article
Immunophenotypic aberrant hematopoietic stem cells in myelodysplastic syndromes: a biomarker for leukemic progression
van Spronsen, Margot F., Hanekamp, Diana, Westers, Theresia M., van Gils, Noortje, Vermue, Eline, Rutten, Arjo, Jansen, Joop H., Lissenberg-Witte, Birgit I., Smit, Linda, Schuurhuis, Gerrit J., van de Loosdrecht, Arjan A.
Published in Leukemia (01.03.2023)
Published in Leukemia (01.03.2023)
Get full text
Journal Article
Abstract PO-125: Targeting histone methylation to overrule transcriptionally driven drug resistance in myeloid leukemia
van Gils, Noortje, Verhagen, Han J.M.P., Martiáñez, Tània, Denkers, Fedor, Vermue, Eline, Rutten, Arjo, Csikós, Tamás, Çil, Meyrem, Al, Marjon, van Gemert, Frank, Janssen, Jeroen J.W.M., Ossenkoppele, Gert J., Menezes, Renee X., Smit, Linda
Published in Cancer research (Chicago, Ill.) (01.11.2020)
Published in Cancer research (Chicago, Ill.) (01.11.2020)
Get full text
Journal Article
Primary acute myeloid leukemia cells with overexpression of EVI-1 are sensitive to all-trans retinoic acid
Verhagen, Han J.M.P., Smit, Marjon A., Rutten, Arjo, Denkers, Fedor, Poddighe, Pino J., Merle, Pauline A., Ossenkoppele, Gert J., Smit, Linda
Published in Blood (28.01.2016)
Published in Blood (28.01.2016)
Get full text
Journal Article
Targeting miRNA-551b, a “Stemness”-like microRNA, to Eradicate AML (Stem) Cells
Martiáñez, Tània, Van Gils, Noortje, De Leeuw, David Christian, Vermue, Eline, Rutten, Arjo, Denkers, Fedor, Verhagen, Han J.M.P., Janssen, Jeroen J. W.M., Ossenkoppele, Gert J., Jimenez, Connie, Smit, Linda
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
Get full text
Journal Article
Insulin-like Growth Factor Binding Protein 7 Activates the Retinoid Acid Differentiation Pathway in Acute Myeloid Leukemia Cells
Van Gils, Noortje, Verhagen, Han J.M.P., Rutten, Arjo, Menezes, Renee X., Tsui, Mei-Ling, Dekens, Esmee, Denkers, Fedor, Vermue, E, Janssen, Jeroen J. W.M., Ossenkoppele, Gert J., Smit, Linda
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
Get full text
Journal Article
Abstract 1114: IGFBP7 reduces acute myeloid leukemia stem cell survival without affecting normal hematopoiesis
Verhagen, Han J., Gils, Noortje van, Rhenen, Anna van, Rutten, Arjo, Smit, Marjon, Tsui, Mei-Ling, Klootwijk, Louise L. de Vos, Menezes, Renee X., Cil, Meyram, Roemer, Margaretha G., Brocco, Fabio, Denkers, Fedor, Vermue, Eline, Heukelom, Stan, Zweegman, Sonja, Janssen, Jeroen J., Ossenkoppele, Gert J., Schuurhuis, Gerrit Jan, Smit, Linda
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Get full text
Journal Article
Abstract 2339: IGFBP7 eradicates leukemic stem and progenitor cells in acute myeloid leukemia
Verhagen, Han, Smit, Marjon, de Leeuw, David, Rutten, Arjo, Tsui, Mei-Ling, Denkers, Fedor, Terwijn, Monique, Celie, Patrick, Ossenkoppele, Gert, Schuurhuis, Gerrit Jan, Smit, Linda
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Get full text
Journal Article
IGFBP7 activates retinoid acid–induced responses in acute myeloid leukemia stem and progenitor cells
van Gils, Noortje, Verhagen, Han J.M.P., Rutten, Arjo, Menezes, Renee X., Tsui, Mei-Ling, Vermue, Eline, Dekens, Esmée, Brocco, Fabio, Denkers, Fedor, Kessler, Floortje L., Ossenkoppele, Gert J., Janssen, Jeroen J.W.M., Smit, Linda
Published in Blood advances (22.12.2020)
Published in Blood advances (22.12.2020)
Get full text
Journal Article
The Prognostic Value of CD34 Expression In Acute Myeloid Leukemia. A Mystery Solved
Schuurhuis, Gerrit J., Kelder, Angèle, Terwijn, Monique, Rutten, Arjo P, Smit, Linda, Zweegman, Sonja, Ossenkoppele, Gert
Published in Blood (19.11.2010)
Published in Blood (19.11.2010)
Get full text
Journal Article
Accurate Detection of Residual Leukemic Stem Cells In Remission Bone Marrow Predicts Relapse In Acute Myeloid Leukemia Patients
Terwijn, Monique, Rutten, Arjo P, Kelder, Angèle, Snel, Alexander N, Scholten, Willemijn J, Zweegman, Sonja, Ossenkoppele, Gert J, Schuurhuis, Gerrit J
Published in Blood (19.11.2010)
Published in Blood (19.11.2010)
Get full text
Journal Article
Specificity of Markers of Leukemia Initiating Cells with a New Multiparameter Flow Cytometry Based Appraoch; Impact for Prognostic and Therapeutic Applications
Schuurhuis, Gerrit J., Wouters, Rolf, Kelder, Angèle, Rutten, Arjo P, Snel, Alexander N, Terwijn, Monique, Noordhuis, Paul, Zweegman, Sonja, Ossenkoppele, Gert J.
Published in Blood (19.11.2010)
Published in Blood (19.11.2010)
Get full text
Journal Article
Leukemic Stem Cell Assessment in Remission Bone Marrow of Acute Myeloid Leukemia Patients Is a New Prognostic Parameter
Terwijn, Monique, Kelder, Angèle, Rutten, Arjo P, Snel, Alexander N, Scholten, Willemijn, Zweegman, Sonja, Ossenkoppele, Gert, Schuurhuis, Gerrit Jan
Published in Blood (20.11.2009)
Published in Blood (20.11.2009)
Get full text
Journal Article