Caveolae-Mediated Endocytosis as a Novel Mechanism of Resistance to Trastuzumab Emtansine (T-DM1)
Sung, Matthew, Tan, Xingzhi, Lu, Bingwen, Golas, Jonathan, Hosselet, Christine, Wang, Fang, Tylaska, Laurie, King, Lindsay, Zhou, Dahui, Dushin, Russell, Myers, Jeremy S, Rosfjord, Edward, Lucas, Judy, Gerber, Hans-Peter, Loganzo, Frank
Published in Molecular cancer therapeutics (01.01.2018)
Published in Molecular cancer therapeutics (01.01.2018)
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Kinetically guided radical-based synthesis of C(sp³)–C(sp³) linkages on DNA
Wang, Jie, Lundberg, Helena, Asai, Shota, Martín-Acosta, Pedro, Chen, Jason S., Brown, Stephen, Farrell, William, Dushin, Russell G., O’Donnell, Christopher J., Ratnayake, Anokha S., Richardson, Paul, Liu, Zhiqing, Qin, Tian, Blackmond, Donna G., Baran, Phil S.
Published in Proceedings of the National Academy of Sciences - PNAS (10.07.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (10.07.2018)
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Journal Article
Cycloisomerization of Olefins in Water
Matos, Jeishla L. M., Green, Samantha A., Chun, Yuge, Dang, Vuong Q., Dushin, Russell G., Richardson, Paul, Chen, Jason S., Piotrowski, David W., Paegel, Brian M., Shenvi, Ryan A.
Published in Angewandte Chemie International Edition (27.07.2020)
Published in Angewandte Chemie International Edition (27.07.2020)
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A general approach to site-specific antibody drug conjugates
Tian, Feng, Lu, Yingchun, Manibusan, Anthony, Sellers, Aaron, Tran, Hon, Sun, Ying, Phuong, Trung, Barnett, Richard, Hehli, Brad, Song, Frank, DeGuzman, Michael J., Ensari, Semsi, Pinkstaff, Jason K., Sullivan, Lorraine M., Biroc, Sandra L., Ho Cho, Schultz, Peter G., DiJoseph, John, Dougher, Maureen, Ma, Dangshe, Dushin, Russell, Leal, Mauricio, Tchistiakova, Lioudmila, Feyfant, Eric, Gerber, Hans-Peter, Sapra, Puja
Published in Proceedings of the National Academy of Sciences - PNAS (04.02.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (04.02.2014)
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A PTK7-targeted antibody-drug conjugate reduces tumor-initiating cells and induces sustained tumor regressions
Damelin, Marc, Bankovich, Alexander, Bernstein, Jeffrey, Lucas, Justin, Chen, Liang, Williams, Samuel, Park, Albert, Aguilar, Jorge, Ernstoff, Elana, Charati, Manoj, Dushin, Russell, Aujay, Monette, Lee, Christina, Ramoth, Hanna, Milton, Milly, Hampl, Johannes, Lazetic, Sasha, Pulito, Virginia, Rosfjord, Edward, Sun, Yongliang, King, Lindsay, Barletta, Frank, Betts, Alison, Guffroy, Magali, Falahatpisheh, Hadi, O'Donnell, Christopher J, Stull, Robert, Pysz, Marybeth, Escarpe, Paul, Liu, David, Foord, Orit, Gerber, Hans Peter, Sapra, Puja, Dylla, Scott J
Published in Science translational medicine (11.01.2017)
Published in Science translational medicine (11.01.2017)
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Journal Article
Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design
Dorywalska, Magdalena, Dushin, Russell, Moine, Ludivine, Farias, Santiago E, Zhou, Dahui, Navaratnam, Thayalan, Lui, Victor, Hasa-Moreno, Adela, Casas, Meritxell Galindo, Tran, Thomas-Toan, Delaria, Kathy, Liu, Shu-Hui, Foletti, Davide, O'Donnell, Christopher J, Pons, Jaume, Shelton, David L, Rajpal, Arvind, Strop, Pavel
Published in Molecular cancer therapeutics (01.05.2016)
Published in Molecular cancer therapeutics (01.05.2016)
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Journal Article
One-Pot Oxidation and Rearrangement of Propargylamines and in Situ Pyrazole Synthesis
Chen, Jinshan, Properzi, Roberta, Uccello, Daniel P, Young, Jennifer A, Dushin, Russell G, Starr, Jeremy T
Published in Organic letters (15.08.2014)
Published in Organic letters (15.08.2014)
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Journal Article
Preclinical Efficacy and Safety Comparison of CD3 Bispecific and ADC Modalities Targeting BCMA for the Treatment of Multiple Myeloma
Panowski, Siler H, Kuo, Tracy C, Zhang, Yi, Chen, Amy, Geng, Tao, Aschenbrenner, Laura, Kamperschroer, Cris, Pascua, Edward, Chen, Wei, Delaria, Kathy, Farias, Santiago, Bateman, Marjorie, Dushin, Russell G, Chin, Sherman M, Van Blarcom, Thomas J, Yeung, Yik Andy, Lindquist, Kevin C, Chunyk, Allison G, Kuang, Bing, Han, Bora, Mirsky, Michael, Pardo, Ingrid, Buetow, Bernard, Martin, Thomas G, Wolf, Jeffrey L, Shelton, David, Rajpal, Arvind, Strop, Pavel, Chaparro-Riggers, Javier, Sasu, Barbra J
Published in Molecular cancer therapeutics (01.11.2019)
Published in Molecular cancer therapeutics (01.11.2019)
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Journal Article
Site-Dependent Degradation of a Non-Cleavable Auristatin-Based Linker-Payload in Rodent Plasma and Its Effect on ADC Efficacy
Dorywalska, Magdalena, Strop, Pavel, Melton-Witt, Jody A, Hasa-Moreno, Adela, Farias, Santiago E, Galindo Casas, Meritxell, Delaria, Kathy, Lui, Victor, Poulsen, Kris, Sutton, Janette, Bolton, Gary, Zhou, Dahui, Moine, Ludivine, Dushin, Russell, Tran, Thomas-Toan, Liu, Shu-Hui, Rickert, Mathias, Foletti, Davide, Shelton, David L, Pons, Jaume, Rajpal, Arvind
Published in PloS one (10.07.2015)
Published in PloS one (10.07.2015)
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Dual irreversible kinase inhibitors: Quinazoline-based inhibitors incorporating two independent reactive centers with each targeting different cysteine residues in the kinase domains of EGFR and VEGFR-2
Wissner, Allan, Fraser, Heidi L., Ingalls, Charles L., Dushin, Russell G., Floyd, M. Brawner, Cheung, Kinwang, Nittoli, Thomas, Ravi, Malini R., Tan, Xingzhi, Loganzo, Frank
Published in Bioorganic & medicinal chemistry (01.06.2007)
Published in Bioorganic & medicinal chemistry (01.06.2007)
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Journal Article
Location Matters: Site of Conjugation Modulates Stability and Pharmacokinetics of Antibody Drug Conjugates
Strop, Pavel, Liu, Shu-Hui, Dorywalska, Magdalena, Delaria, Kathy, Dushin, Russell G., Tran, Thomas-Toan, Ho, Wei-Hsien, Farias, Santiago, Casas, Meritxell Galindo, Abdiche, Yasmina, Zhou, Dahui, Chandrasekaran, Ramalakshmi, Samain, Caroline, Loo, Carole, Rossi, Andrea, Rickert, Mathias, Krimm, Stellanie, Wong, Teresa, Chin, Sherman Michael, Yu, Jessica, Dilley, Jeanette, Chaparro-Riggers, Javier, Filzen, Gary F., O’Donnell, Christopher J., Wang, Fang, Myers, Jeremy S., Pons, Jaume, Shelton, David L., Rajpal, Arvind
Published in Chemistry & biology (21.02.2013)
Published in Chemistry & biology (21.02.2013)
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Journal Article
Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor which significantly decreases tumor volume in a mouse xenograft model
Zapf, Christoph W., Bloom, Jonathan D., Li, Zhong, Dushin, Russell G., Nittoli, Thomas, Otteng, Mercy, Nikitenko, Antonia, Golas, Jennifer M., Liu, Hao, Lucas, Judy, Boschelli, Frank, Vogan, Erik, Olland, Andrea, Johnson, Mark, Levin, Jeremy I.
Published in Bioorganic & medicinal chemistry letters (01.08.2011)
Published in Bioorganic & medicinal chemistry letters (01.08.2011)
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Journal Article
Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design
Tsao, Désirée H.H., Sutherland, Alan G., Jennings, Lee. D., Li, Yuanhong, Rush, Thomas S., Alvarez, Juan C., Ding, Weidong, Dushin, Elizabeth G., Dushin, Russell G., Haney, Steve A., Kenny, Cynthia H., Karl Malakian, A., Nilakantan, Ramaswamy, Mosyak, Lidia
Published in Bioorganic & medicinal chemistry (01.12.2006)
Published in Bioorganic & medicinal chemistry (01.12.2006)
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Journal Article
Abstract 2640: RN927C, a potent site-specific Trop-2 antibody-drug-conjugate (ADC) for treatment of solid tumors
Liu, Shu-Hui, Strop, Pavel, Tran, Thomas-Toan, Dorywalska, Magdalena, Delaria, Katherine, Ho, Wei-Hsien, Dushin, Russell, Pons, Jaume, Rajpal, Arvind, Shelton, Dave
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Cycloisomerization of Olefins in Water
Matos, Jeishla L. M., Green, Samantha A., Chun, Yuge, Dang, Vuong Q., Dushin, Russell G., Richardson, Paul, Chen, Jason S., Piotrowski, David W., Paegel, Brian M., Shenvi, Ryan A.
Published in Angewandte Chemie (27.07.2020)
Published in Angewandte Chemie (27.07.2020)
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Journal Article
Mechanism of Action of the Mannopeptimycins, a Novel Class of Glycopeptide Antibiotics Active against Vancomycin-Resistant Gram-Positive Bacteria
RUZIN, Alexey, SINGH, Guy, BRADFORD, Patricia A, SEVERIN, Anatoly, YOUJUN YANG, DUSHIN, Russell G, SUTHERLAND, Alan G, MINNICK, Albert, GREENSTEIN, Michael, MAY, Michael K, SHLAES, David M
Published in Antimicrobial Agents and Chemotherapy (01.03.2004)
Published in Antimicrobial Agents and Chemotherapy (01.03.2004)
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Journal Article
Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity
Zapf, Christoph W., Bloom, Jonathan D., McBean, Jamie L., Dushin, Russell G., Nittoli, Thomas, Ingalls, Charles, Sutherland, Alan G., Sonye, John P., Eid, Clark N., Golas, Jennifer, Liu, Hao, Boschelli, Frank, Hu, Yongbo, Vogan, Erik, Levin, Jeremy I.
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
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Journal Article
Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model
Zapf, Christoph W., Bloom, Jonathan D., McBean, Jamie L., Dushin, Russell G., Golas, Jennifer M., Liu, Hao, Lucas, Judy, Boschelli, Frank, Vogan, Erik, Levin, Jeremy I.
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
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Journal Article
Comparative In Vitro Activities of AC98-6446, a Novel Semisynthetic Glycopeptide Derivative of the Natural Product Mannopeptimycin α, and Other Antimicrobial Agents against Gram-Positive Clinical Isolates
PETERSEN, Peter J, WANG, T. Z, DUSHIN, Russell G, BRADFORD, Patricia A
Published in Antimicrobial Agents and Chemotherapy (01.03.2004)
Published in Antimicrobial Agents and Chemotherapy (01.03.2004)
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Journal Article
Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity
Zapf, Christoph W., Bloom, Jonathan D., McBean, Jamie L., Dushin, Russell G., Nittoli, Thomas, Otteng, Mercy, Ingalls, Charles, Golas, Jennifer M., Liu, Hao, Lucas, Judy, Boschelli, Frank, Hu, Yongbo, Vogan, Erik, Levin, Jeremy I.
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
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