NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts
Marlein, Christopher R., Zaitseva, Lyubov, Piddock, Rachel E., Robinson, Stephen D., Edwards, Dylan R., Shafat, Manar S., Zhou, Zhigang, Lawes, Matthew, Bowles, Kristian M., Rushworth, Stuart A.
Published in Blood (05.10.2017)
Published in Blood (05.10.2017)
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CD38-Driven Mitochondrial Trafficking Promotes Bioenergetic Plasticity in Multiple Myeloma
Marlein, Christopher R, Piddock, Rachel E, Mistry, Jayna J, Zaitseva, Lyubov, Hellmich, Charlotte, Horton, Rebecca H, Zhou, Zhigang, Auger, Martin J, Bowles, Kristian M, Rushworth, Stuart A
Published in Cancer research (Chicago, Ill.) (01.05.2019)
Published in Cancer research (Chicago, Ill.) (01.05.2019)
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Journal Article
Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment
Shafat, Manar S., Oellerich, Thomas, Mohr, Sebastian, Robinson, Stephen D., Edwards, Dylan R., Marlein, Christopher R., Piddock, Rachel E., Fenech, Matthew, Zaitseva, Lyubov, Abdul-Aziz, Amina, Turner, Jeremy, Watkins, Johnathan A., Lawes, Matthew, Bowles, Kristian M., Rushworth, Stuart A.
Published in Blood (09.03.2017)
Published in Blood (09.03.2017)
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Journal Article
The bone marrow microenvironment – Home of the leukemic blasts
Shafat, Manar S, Gnaneswaran, Bruno, Bowles, Kristian M, Rushworth, Stuart A
Published in Blood reviews (01.09.2017)
Published in Blood reviews (01.09.2017)
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Journal Article
Free fatty-acid transport via CD36 drives β-oxidation-mediated hematopoietic stem cell response to infection
Mistry, Jayna J., Hellmich, Charlotte, Moore, Jamie A., Jibril, Aisha, Macaulay, Iain, Moreno-Gonzalez, Mar, Di Palma, Federica, Beraza, Naiara, Bowles, Kristian M., Rushworth, Stuart A.
Published in Nature communications (08.12.2021)
Published in Nature communications (08.12.2021)
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Journal Article
HSC-derived fatty acid oxidation in steady-state and stressed hematopoiesis
Mistry, Jayna J., Bowles, Kristian, Rushworth, Stuart A.
Published in Experimental hematology (01.01.2023)
Published in Experimental hematology (01.01.2023)
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Journal Article
ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem cells in response to infection
Mistry, Jayna J., Marlein, Christopher R., Moore, Jamie A., Hellmich, Charlotte, Wojtowicz, Edyta E., Smith, James G. W., Macaulay, Iain, Sun, Yu, Morfakis, Adam, Patterson, Angela, Horton, Rebecca H., Divekar, Devina, Morris, Christopher J., Haestier, Anna, Di Palma, Federica, Beraza, Naiara, Bowles, Kristian M., Rushworth, Stuart A.
Published in Proceedings of the National Academy of Sciences - PNAS (03.12.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (03.12.2019)
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Journal Article
LC3-associated phagocytosis in bone marrow macrophages suppresses acute myeloid leukemia progression through STING activation
Moore, Jamie A, Mistry, Jayna J, Hellmich, Charlotte, Horton, Rebecca H, Wojtowicz, Edyta E, Jibril, Aisha, Jefferson, Matthew, Wileman, Thomas, Beraza, Naiara, Bowles, Kristian M, Rushworth, Stuart A
Published in The Journal of clinical investigation (01.03.2022)
Published in The Journal of clinical investigation (01.03.2022)
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Journal Article
In Vivo Imaging of Bone Marrow Long-Chain Fatty Acid Uptake
Mistry, Jayna J, Rushworth, Stuart A
Published in Methods in molecular biology (Clifton, N.J.) (2023)
Published in Methods in molecular biology (Clifton, N.J.) (2023)
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Journal Article
Mitochondrial oxidative phosphorylation in cutaneous melanoma
Kumar, Prakrit R., Moore, Jamie A., Bowles, Kristian M., Rushworth, Stuart A., Moncrieff, Marc D.
Published in British journal of cancer (05.01.2021)
Published in British journal of cancer (05.01.2021)
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Journal Article
Identification of Bruton's tyrosine kinase as a therapeutic target in acute myeloid leukemia
Rushworth, Stuart A., Murray, Megan Y., Zaitseva, Lyubov, Bowles, Kristian M., MacEwan, David J.
Published in Blood (20.02.2014)
Published in Blood (20.02.2014)
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Journal Article
ARQ531: the therapy that targets multiple pathways in acute myeloid leukemia
Hellmich, Charlotte, Bowles, Kristian, Rushworth, Stuart
Published in Haematologica (Roma) (01.10.2020)
Published in Haematologica (Roma) (01.10.2020)
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Lipopolysaccharide-Induced Expression of NAD(P)H:Quinone Oxidoreductase 1 and Heme Oxygenase-1 Protects against Excessive Inflammatory Responses in Human Monocytes
Rushworth, Stuart A, MacEwan, David J, O'Connell, Maria A
Published in The Journal of immunology (1950) (15.11.2008)
Published in The Journal of immunology (1950) (15.11.2008)
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Journal Article
Acute myeloid leukemia induces protumoral p16INK4a-driven senescence in the bone marrow microenvironment
Abdul-Aziz, Amina M., Sun, Yu, Hellmich, Charlotte, Marlein, Christopher R., Mistry, Jayna, Forde, Eoghan, Piddock, Rachel E., Shafat, Manar S., Morfakis, Adam, Mehta, Tarang, Di Palma, Federica, Macaulay, Iain, Ingham, Christopher J., Haestier, Anna, Collins, Angela, Campisi, Judith, Bowles, Kristian M., Rushworth, Stuart A.
Published in Blood (31.01.2019)
Published in Blood (31.01.2019)
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Acute myeloid leukemia-driven IL-3-dependent upregulation of BCL2 in non-malignant hematopoietic stem and progenitor cells increases venetoclax-induced cytopenias
Fowler-Shorten, Dominic J, Maynard, Rebecca S, Hampton, Katherine, Altera, Annalisa, Markham, Matthew, Ehikioya, Martha, Wojtowicz, Edyta E, Bowles, Kristian M, Rushworth, Stuart A, Hellmich, Charlotte
Published in Haematologica (Roma) (01.05.2024)
Published in Haematologica (Roma) (01.05.2024)
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Journal Article
PGC-1α induced mitochondrial biogenesis in stromal cells underpins mitochondrial transfer to melanoma
Kumar, Prakrit R., Saad, Mona, Hellmich, Charlotte, Mistry, Jayna J., Moore, Jamie A., Conway, Shannon, Morris, Christopher J., Bowles, Kristian M., Moncrieff, Marc D., Rushworth, Stuart A.
Published in British journal of cancer (01.07.2022)
Published in British journal of cancer (01.07.2022)
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